KEGG   ENZYME: 3.4.21.77Help
Entry
EC 3.4.21.77                Enzyme                                 

Name
semenogelase;
prostate-specific antigen;
alpha-seminoprotein;
seminin;
P-30 antigen;
antigen (human clone HPSA-1 prostate-specific protein moiety reduced);
gamma-seminoglycoprotein (human protein moiety reduced);
gamma-SM;
antigen PSA (human prostate-specific);
human glandular kallikrein;
antigen PSA (human clone 5P1 protein moiety reduced)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: -Tyr!
Comment
A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by alpha1-antichymotrypsin
History
EC 3.4.21.77 created 1993
Orthology
K01351  
semenogelase
Genes
HSA: 
354(KLK3)
PTR: 
493182(KLK3)
PPS: 
100996069(KLK3)
MCC: 
719444(KLK3)
MCF: 
102138599(KLK3)
Taxonomy
Reference
1  [PMID:2467258]
  Authors
Digby M, Zhang XY, Richards RI.
  Title
Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1.
  Journal
Nucleic. Acids. Res. 17 (1989) 2137.
  Sequence
[hsa:354]
Reference
2  [PMID:1702714]
  Authors
Christensson A, Laurell CB, Lilja H.
  Title
Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.
  Journal
Eur. J. Biochem. 194 (1990) 755-63.
  Sequence
[hsa:354]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110157-83-0 95829-41-7

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