KEGG   ENZYME: 3.4.21.94Help
Entry
EC 3.4.21.94                Enzyme                                 

Name
proprotein convertase 2;
neuroendocrine convertase 2;
PC2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.94 created 1996
Orthology
K01360  
proprotein convertase subtilisin/kexin type 2
Genes
HSA: 
5126(PCSK2)
PTR: 
458106(PCSK2)
PPS: 
100995237(PCSK2)
GGO: 
101144581(PCSK2)
PON: 
100171744(PCSK2)
MCC: 
695730(PCSK2)
MCF: 
102139968(PCSK2)
MMU: 
18549(Pcsk2)
RNO: 
25121(Pcsk2)
CGE: 
HGL: 
101710029(Pcsk2)
TUP: 
102496906(PCSK2)
CFA: 
485757(PCSK2)
AML: 
FCA: 
101098130(PCSK2)
BTA: 
281968(PCSK2)
BOM: 
SSC: 
445533(PC2)
CFR: 
ECB: 
100050755(PCSK2)
MYB: 
102239561(PCSK2)
MDO: 
SHR: 
100925659(PCSK2)
OAA: 
100085012(PCSK2)
GGA: 
395136(PCSK2)
MGP: 
TGU: 
100223337(PCSK2)
FAB: 
101808403(PCSK2)
PHI: 
102111890(PCSK2)
APLA: 
101791329(PCSK2)
FPG: 
101924281(PCSK2)
FCH: 
102046561(PCSK2)
CLV: 
102088621(PCSK2)
ASN: 
102373017(PCSK2)
PSS: 
102463058(PCSK2)
ACS: 
XLA: 
373675(pcsk2) 444586
XTR: 
100036632(pcsk2)
DRE: 
100004460(pcsk2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352855(PCSK2)
BFO: 
CIN: 
100181292(cipc2)
SPU: 
579017(PCSK2)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408835(amon)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG09536(Cbr-egl-3)
BMY: 
LOA: 
TSP: 
SMM: 
 » show all
Taxonomy
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA. Cell. Biol. 9 (1990) 415-24.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[mmu:18549]
Reference
2  [PMID:2154467]
  Authors
Smeekens SP, Steiner DF.
  Title
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
  Journal
J. Biol. Chem. 265 (1990) 2997-3000.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5126]
Reference
3  [PMID:8159732]
  Authors
Rouille Y, Westermark G, Martin SK, Steiner DF.
  Title
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 3242-6.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods. Enzymol. 244 (1994) 175-88.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
388092-42-0

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