| Entry |
|
|---|
| Name |
nitrilase;
acetonitrilase;
benzonitrilase |
|---|
| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
 |
|---|
| Sysname |
nitrile aminohydrolase |
|---|
| Reaction(IUBMB) |
a nitrile + 2 H2O = a carboxylate + NH3 [RN:R00540] |
|---|
| Reaction(KEGG) |
R00540 > R01887 R03093 R03542 R05591 R07855
 |
|---|
| Substrate |
nitrile [CPD:C00726];
H2O [CPD:C00001] |
|---|
| Product |
carboxylate [CPD:C00060];
NH3 [CPD:C00014] |
|---|
| Comment |
Acts on a wide range of aromatic nitriles including
(indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and
on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase. |
|---|
| Pathway |
PATH: ec00380 Tryptophan metabolism
PATH: ec00460 Cyanoamino acid metabolism
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec00643 Styrene degradation
PATH: ec00910 Nitrogen metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01501 nitrilase
KO: K13035 beta-cyano-L-alanine hydratase/nitrilase |
|---|
| Genes |
CEL: ZK1058.6(nit-1)
ATH: AT3G44300(NIT2) AT3G44310(NIT1) AT3G44320(NIT3) AT5G22300(NIT4)
POP: POPTR_782522(NIT1)
RCU: RCOM_1282320
VVI: 100250098
OSA: 4330076(Os02g0635000) 4330077(Os02g0635200)
SBI: SORBI_04g026950(SORBIDRAFT_04g026950)
ZMA: 542573(NIT1)
PPP: PHYPADRAFT_88254
DHA: DEHA0D01628g
PIC: PICST_36697(NIT1)
CGR: CAGL0G01210g
NCR: NCU05387
MGR: MGG_03280
ANI: AN7367.2
AFM: AFUA_6G13450
AOR: AO090003000470
ANG: An06g01960 An12g01260
UMA: UM03453.1
TBR: Tb09.160.0770
TCR: 509979.150 510039.40
LMA: LmjF26.2280
DDA: Dd703_3697
VHA: VIBHAR_03679
PAP: PSPA7_3027
PPU: PP_4463
PFL: PFL_2909
PFO: Pfl01_2571
PFS: PFLU2708
PEN: PSEEN1080 PSEEN3513
PAR: Psyc_0202
PCR: Pcryo_0222
SSE: Ssed_0525
SPL: Spea_2863
SHL: Shal_2959
PHA: PSHAa2676
PAT: Patl_0189 Patl_2399
MAQ: Maqu_2722
LPC: LPC_2337(nitA)
MCA: MCA0381
NOC: Noc_2655
AEH: Mlg_0411
HHA: Hhal_2135
TGR: Tgr7_2268
ASA: ASA_2402
AFE: Lferr_0706
AFR: AFE_0551
NMC: NMC1720
CVI: CV_2097
LHK: LHK_02142
RSO: RSc2658
RPI: Rpic_2895
RPF: Rpic12D_2489
REU: Reut_A1028
REH: H16_A1125(nit)
RME: Rmet_0992
CTI: RALTA_A1105
BMA: BMA2336
BMV: BMASAVP1_A0489
BML: BMA10229_A1110
BMN: BMA10247_2217
BPS: BPSL2837
BPM: BURPS1710b_3333(opaA)
BPL: BURPS1106A_3322
BPD: BURPS668_3289
BTE: BTH_I1297
BVI: Bcep1808_0666 Bcep1808_0701
BUR: Bcep18194_A3790 Bcep18194_A3828
BCN: Bcen_0220 Bcen_0256
BCH: Bcen2424_0704 Bcen2424_0740
BCM: Bcenmc03_0671 Bcenmc03_0710
BCJ: BCAL3280 BCAL3323
BAM: Bamb_0595 Bamb_0633
BAC: BamMC406_0620 BamMC406_0658
BMU: Bmul_2644 Bmul_2680
BMJ: BMULJ_00558 BMULJ_00594
BXE: Bxe_A3971
BGL: bglu_1g01570
PNU: Pnuc_1777
BBR: BB1116
BPT: Bpet2740
RFR: Rfer_0849
POL: Bpro_3376
PNA: Pnap_3896 Pnap_4743
AJS: Ajs_4017
VEI: Veis_0781
MPT: Mpe_A0244
HAR: HEAR0861
MMS: mma_2480
NEU: NE1327
NET: Neut_1264
AZO: azo1295
MFA: Mfla_1745
APP: CAP2UW1_4066
CJE: Cj1056c
CJR: CJE1199
CJJ: CJJ81176_1076
CFF: CFF8240_0615
CCV: CCV52592_0982
CHA: CHAB381_0911
SFU: Sfum_2312
MES: Meso_0079
RLG: Rleg_5502
OAN: Oant_4151
BJA: blr3397(nit)
RPA: RPA4166
RPT: Rpal_4645
XAU: Xaut_1567
AZC: AZC_1804
MEA: Mex_2p1120
BID: Bind_3461
MSL: Msil_3811
CAK: Caul_5248
RSP: RSP_3399
RSH: Rsph17029_3044
RSK: RSKD131_3564
JAN: Jann_3735
MMR: Mmar10_1113
ZMO: ZMO1207
SWI: Swit_2469
GBE: GbCGDNIH1_0330
ACR: Acry_3060
GDI: GDI_0018
GDJ: Gdia_1775
MGM: Mmc1_1403
CDF: CD2842
CKL: CKL_2025
CKR: CKR_1770
NTH: Nther_1072
MSM: MSMEG_5373
RHA: RHA1_ro03332 RHA1_ro03335 RHA1_ro03530
AAU: AAur_0337
FAL: FRAAL1968
RXY: Rxyl_0235
SYF: Synpcc7942_0839
SYR: SynRCC307_1156
SYX: SynWH7803_1035
PMB: A9601_06711
PMC: P9515_06801
PMF: P9303_18921
PMG: P9301_06411 P9301_13131
PME: NATL1_06731
CPB: Cphamn1_1310
MMA: MM_1229
HMA: pNG7354(nitB)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:21655]
Harper DB.
Microbial metabolism of aromatic nitriles. Enzymology of C-N
cleavage by Nocardia sp. (Rhodochrous group) N.C.I.B. 11216.
Biochem. J. 165 (1977) 309-19.
Nocardia sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14165487]
THIMANN KV, MAHADEVAN S.
NITRILASE. I. OCCURRENCE, PREPARATION, AND GENERAL PROPERTIES OF THE
ENZYME.
Arch. Biochem. Biophys. 105 (1964) 133-41.
Hordeum vulgare |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:11380987]
Pace HC, Brenner C.
The nitrilase superfamily: classification, structure and function.
Genome. Biol. 2 (2001) REVIEWS0001.
Saccharomyces cerevisiae [GN:sce], Caenorhabditis elegans [GN:cel] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.5.5.1
IUBMB Enzyme Nomenclature: 3.5.5.1
ExPASy - ENZYME nomenclature database: 3.5.5.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.1
BRENDA, the Enzyme Database: 3.5.5.1
CAS: 9024-90-2 |
|---|
