KEGG   ENZYME: 4.1.1.21Help
Entry
EC 4.1.1.21                 Enzyme                                 

Name
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
Reaction(IUBMB)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209]
Reaction(KEGG)
Substrate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751]
Product
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011]
Comment
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
History
EC 4.1.1.21 created 1961, modified 2000, modified 2006
Pathway
Purine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01587  
phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase
K11808  
phosphoribosylaminoimidazole carboxylase
Genes
HSA: 
10606(PAICS)
PTR: 
471236(PAICS)
PPS: 
100993147(PAICS)
GGO: 
101132763(PAICS)
PON: 
100190835(PAICS)
MCF: 
MMU: 
67054(Paics)
RNO: 
140946(Paics)
CGE: 
HGL: 
101721606(Paics)
TUP: 
102484181(PAICS)
CFA: 
100855769(PAICS)
AML: 
100482672(PAICS)
FCA: 
101084705(PAICS)
PTG: 
102951236(PAICS)
BTA: 
404170(PAICS)
BOM: 
102281546(PAICS)
PHD: 
102334474(PAICS)
CHX: 
102182773(PAICS)
OAS: 
101117419(PAICS)
SSC: 
100521281(PAICS)
CFR: 
102522524(PAICS)
BACU: 
103009147(PAICS)
LVE: 
103076533(PAICS)
ECB: 
100058501(PAICS)
MYB: 
102239537(PAICS)
MYD: 
102757395(PAICS)
PALE: 
102899036(PAICS)
MDO: 
100012535(PAICS)
SHR: 
OAA: 
100086365(PAICS)
GGA: 
396534(PAICS)
MGP: 
TGU: 
100225152(PAICS)
FAB: 
101808142(PAICS)
PHI: 
102111686(PAICS)
APLA: 
FPG: 
101919014(PAICS)
FCH: 
102046009(PAICS)
CLV: 
102094220(PAICS)
ASN: 
102380243(PAICS)
AMJ: 
102565809(PAICS)
PSS: 
102446966(PAICS)
CMY: 
102937919(PAICS)
ACS: 
PBI: 
XLA: 
379855(paics) 444677(paics.1)
XTR: 
DRE: 
321193(paics)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102354332(PAICS)
CMK: 
103178180(paics)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE16201(Dyak_ade5)
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551966(ade5)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
TSP: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0199900-01(Os01g0199900)
OBR: 
BDI: 
SBI: 
SORBI_03g002690(SORBIDRAFT_03g002690)
ZMA: 
SITA: 
ATR: 
s00177p00010960(AMTR_s00177p00010960)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
SCE: 
YOR128C(ADE2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0H02150(NCAS0H02150)
NDI: 
NDAI_0C01500(NDAI0C01500)
TPF: 
TPHA_0J02670(TPHA0J02670)
TBL: 
TBLA_0A02680(TBLA0A02680)
TDL: 
TDEL_0D02460(TDEL0D02460)
KAF: 
KAFR_0D05120(KAFR0D05120)
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_552184(AO090009000333)
ANG: 
ANI_1_1076014(An01g08090)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT63686(AGABI1DRAFT_63686)
ABV: 
AGABI2DRAFT230061(AGABI2DRAFT_230061)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
MBR: 
PTI: 
TPS: 
PIF: 
EHX: 
MPH: 
MLP_03890(purC)
 » show all
Taxonomy
Reference
1  [PMID:13672967]
  Authors
LUKENS LN, BUCHANAN JM.
  Title
Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
  Journal
J. Biol. Chem. 234 (1959) 1799-805.
  Organism
Gallus gallus
Reference
2  [PMID:7918411]
  Authors
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
  Title
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms.
  Journal
Biochemistry. 33 (1994) 11927-34.
  Organism
Escherichia coli, Gallus gallus
Reference
3  [PMID:9500840]
  Authors
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ.
  Title
Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
  Journal
Arch. Biochem. Biophys. 351 (1998) 123-34.
  Organism
Escherichia coli, Gallus gallus, Cryptococcus neoformans
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-04-6

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