| Entry |
|
|---|
| Name |
phosphoribosylaminoimidazole carboxylase;
5-phosphoribosyl-5-aminoimidazole carboxylase;
5-amino-1-ribosylimidazole 5-phosphate carboxylase;
AIR carboxylase;
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase;
ADE2;
class II PurE;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
|---|
| Sysname |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
[5-amino-1-(5-phospho-D-ribosyl)imidazole-forming] |
|---|
| Reaction(IUBMB) |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate =
5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 [RN:R04209] |
|---|
| Reaction(KEGG) |
R04209
 |
|---|
| Substrate |
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate [CPD:C04751] |
|---|
| Product |
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:C03373];
CO2 [CPD:C00011] |
|---|
| Comment |
While this is the reaction that occurs in vertebrates during purine
biosynthesis, two enzymes are required to carry out the same
reaction in Escherichia coli, namely EC 6.3.4.18,
5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18,
5-(carboxyamino)imidazole ribonucleotide mutase [3].
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate. |
|---|
| Pathway |
PATH: ec00230 Purine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01587 phosphoribosylaminoimidazole carboxylase /
phosphoribosylaminoimidazole-succinocarboxamide synthase
KO: K11808 phosphoribosylaminoimidazole carboxylase |
|---|
| Genes |
HSA: 10606(PAICS)
PTR: 471236(PAICS)
MCC: 717732
MMU: 67054(Paics)
RNO: 140946(Paics)
CFA: 475150(PAICS)
BTA: 404170(PAICS)
ECB: 100058501
MDO: 100012535
OAA: 100086365
GGA: 396534(PAICS)
TGU: 100225152(PAICS)
XLA: 379855(paics) 444677
DRE: 321193(paics)
SPU: 575874
DME: Dmel_CG3989(ade5)
DPO: Dpse_GA17827
AGA: AgaP_AGAP000180
AAG: AaeL_AAEL003606
CEL: B0286.3
NVE: NEMVE_v1g142804
ATH: AT2G37690
POP: POPTR_834540
RCU: RCOM_0607690
VVI: 100250122
OSA: 4327345(Os01g0199900)
SBI: SORBI_03g002690(SORBIDRAFT_03g002690)
PPP: PHYPADRAFT_189585
CRE: CHLREDRAFT_196726
OLU: OSTLU_33376
SCE: YOR128C(ADE2)
AGO: AGOS_ACR210C
KLA: KLLA0E02640g
LTH: KLTH0F15532g
DHA: DEHA0G14641g
PIC: PICST_81265(ADE2)
PPA: PAS_chr3_0085
VPO: Kpol_440p3
LEL: LELG_02667
ZRO: ZYRO0G04400g
CAL: CaO19.13327(ADE2) CaO19.5906(ADE2)
CTP: CTRG_02291
CDU: CD36_84460
CGR: CAGL0K10340g
YLI: YALI0B23188g
SPO: SPCC1322.13(ade6)
NCR: NCU03194
PAN: PODANSg5612
MGR: MGG_01256
FGR: FG10669.1
ANI: AN3626.2
AFM: AFUA_4G12600
AOR: AO090009000333
ANG: An01g08090
AFV: AFLA_051370
PCS: Pc22g04460
NFI: NFIA_103710
CIM: CIMG_00790
SSL: SS1G_09902
BFU: BC1G_15666
CNE: CNE02500
CNB: CNBE2520
LBC: LACBIDRAFT_318305
MPR: MPER_11161
UMA: UM00993.1
MGL: MGL_2675
MBR: MONBRDRAFT_9068
PTI: PHATRDRAFT_56626
TPS: THAPSDRAFT_21670
 |
|---|
| Structures |
PDB: 1B6R 1B6S 1D7A 1O4V 1QCZ 1XMP 2ATE 2H31 2NSH 2NSJ
2NSL 2YWX 2Z04 3ETH 3ETJ 3K5H 3K5I 3KUU |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13672967]
LUKENS LN, BUCHANAN JM.
Biosynthesis of the purines. XXIV. The enzymatic synthesis of
5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from
5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.
J. Biol. Chem. 234 (1959) 1799-805.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7918411]
Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ.
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases
from Escherichia coli and Gallus gallus: a case for divergent
catalytic mechanisms.
Biochemistry. 33 (1994) 11927-34.
Escherichia coli [GN:eco], Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9500840]
Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR,
Davisson VJ.
Biochemical role of the Cryptococcus neoformans ADE2 protein in
fungal de novo purine biosynthesis.
Arch. Biochem. Biophys. 351 (1998) 123-34.
Escherichia coli [GN:eco], Gallus gallus [GN:gga], Cryptococcus
neoformans |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.1.21
IUBMB Enzyme Nomenclature: 4.1.1.21
ExPASy - ENZYME nomenclature database: 4.1.1.21
BRENDA, the Enzyme Database: 4.1.1.21
CAS: 9032-04-6 |
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