KEGG   ENZYME: 4.1.1.28Help
Entry
EC 4.1.1.28                 Enzyme                                 

Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643]
Product
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780]
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
Pathway
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Indole alkaloid biosynthesis
Isoquinoline alkaloid biosynthesis
Betalain biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01593  
aromatic-L-amino-acid decarboxylase
Genes
HSA: 
1644(DDC)
PTR: 
463409(DDC)
PPS: 
GGO: 
PON: 
MCC: 
693677(DDC)
MCF: 
MMU: 
13195(Ddc)
RNO: 
24311(Ddc)
CGE: 
HGL: 
TUP: 
CFA: 
606852(DDC)
AML: 
FCA: 
BTA: 
280762(DDC)
BOM: 
PHD: 
CHX: 
SSC: 
396857(DDC)
ECB: 
MDO: 
SHR: 
OAA: 
GGA: 
420947(DDC)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
ACS: 
XLA: 
XTR: 
496742(ddc)
DRE: 
406651(ddc)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
100101815(hdcl)
SPU: 
DME: 
DPO: 
Dpse_GA10503(Dpse_Ddc)
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsim_GD21778(Dsim_Ddc)
DWI: 
Dwil_GK24237(Dwil_Ddc)
DYA: 
DGR: 
DMO: 
DVI: 
Dvir_GJ17995(Dvir_Ddc)
AGA: 
AAG: 
CQU: 
AME: 
410638(Ddc) 410948(Tdc2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CELE_C05D2.3(basl-1) CELE_K01C8.3(tdc-1) CELE_ZK829.2(hdl-1)
CBR: 
CBG00668(Cbr-tdc-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
RCU: 
POP: 
VVI: 
PPP: 
CRE: 
NCR: 
SMP: 
FGR: 
NHE: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_88074(AO090038000057)
ANG: 
ANI_1_2316014(An01g02000)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
URE: 
ABE: 
TVE: 
PNO: 
PTE: 
TML: 
CNE: 
CNB: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
TET: 
PTM: 
NGR: 
YPE: 
YPK: 
y2996(dcd)
YPA: 
YPN: 
YPM: 
YP_0943(dcd1)
YPP: 
YPG: 
YPZ: 
YPT: 
YPD: 
YPX: 
YPH: 
YPS: 
YPI: 
YPY: 
YPB: 
PPU: 
PPF: 
PPG: 
PPW: 
PFC: 
PEN: 
NOC: 
BUR: 
DVU: 
DVL: 
DVM: 
DVG: 
DDE: 
AFW: 
SUR: 
MLO: 
MCI: 
RHI: 
ARA: 
NWI: 
XAU: 
MET: 
MNO: 
RVA: 
SIL: 
SIT: 
JAN: 
MMR: 
PGV: 
FRA: 
GOB: 
SEN: 
PDX: 
AMI: 
VMA: 
RXY: 
ABA: 
SUS: 
GAU: 
CYP: 
CYH: 
MTT: 
CAU: 
CAG: 
CHL: 
MRB: 
MSV: 
 » show all
Taxonomy
Reference
1  [PMID:4536745]
  Authors
Christenson JG, Dairman W, Udenfriend S.
  Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
  Journal
Proc. Natl. Acad. Sci. U. S. A. 69 (1972) 343-7.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Oryctolagus cuniculus
Reference
2  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J. Biol. Chem. 237 (1962) 89-93.
  Organism
Cavia porcellus
Reference
3
  Authors
McGilvery, R.W. and Cohen, P.P.
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J. Biol. Chem. 174 (1948) 813-816.
Reference
4
  Authors
Sekeris, C.E.
  Title
Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifitat der DOPA-Decarboxylase.
  Journal
Hoppe-Seyler's Z. Physiol. Chem. 332 (1963) 70-78.
Reference
5  [PMID:13462983]
  Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
  Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
  Journal
J. Biol. Chem. 227 (1957) 617-24.
  Organism
Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9042-64-2

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