KEGG   ENZYME: 4.1.1.28Help
Entry
EC 4.1.1.28                 Enzyme                                 
Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643]
Product
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780]
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
Pathway
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Indole alkaloid biosynthesis
Isoquinoline alkaloid biosynthesis
Betalain biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01593  
aromatic-L-amino-acid decarboxylase
Genes
HSA: 
1644(DDC)
PTR: 
463409(DDC)
PPS: 
GGO: 
PON: 
MCC: 
693677(DDC)
MMU: 
13195(Ddc)
RNO: 
24311(Ddc)
CFA: 
606852(DDC)
AML: 
FCA: 
101082989(DDC)
BTA: 
280762(DDC)
SSC: 
396857(DDC)
ECB: 
100052557(DDC)
MDO: 
100030001(DDC)
SHR: 
100917570(DDC)
OAA: 
100074589
GGA: 
420947(DDC)
MGP: 
100542576(DDC)
TGU: 
100226623(DDC)
ACS: 
100564794(ddc)
XLA: 
100126640(ddc)
XTR: 
496742(ddc)
DRE: 
406651(ddc)
TRU: 
101070663
OLA: 
100301599(ddc)
BFO: 
BRAFLDRAFT_102098 BRAFLDRAFT_99569
CIN: 
100101815(hdcl)
SPU: 
577767 593847 757080 764126
DME: 
Dmel_CG10697(Ddc)
DPO: 
Dpse_GA10503(Dpse_Ddc)
DAN: 
Dana_GF15210
DER: 
Dere_GG21650
DPE: 
Dper_GL21129
DSE: 
Dsec_GM17029
DSI: 
Dsim_GD21778(Dsim_Ddc)
DWI: 
Dwil_GK24237(Dwil_Ddc)
DYA: 
Dyak_GE12670
DGR: 
Dgri_GH13483
DMO: 
Dmoj_GI17235
DVI: 
Dvir_GJ17995(Dvir_Ddc)
AGA: 
AgaP_AGAP009091
AAG: 
AaeL_AAEL003475 AaeL_AAEL014238
CQU: 
CpipJ_CPIJ010568 CpipJ_CPIJ013307
AME: 
410638(Ddc) 410948(Tdc2)
NVI: 
100118460(NV18137) 100119990(NV11109)
TCA: 
661480 662962(Ddc)
API: 
100160466 100168964
PHU: 
Phum_PHUM248840 Phum_PHUM258570
CEL: 
CELE_C05D2.3(basl-1) CELE_K01C8.3(tdc-1) CELE_ZK829.2(hdl-1)
CBR: 
CBG00668(Cbr-tdc-1)
BMY: 
Bm1_42020
TSP: 
Tsp_00610
SMM: 
Smp_171580
NVE: 
NEMVE_v1g204120 NEMVE_v1g98001
HMG: 
100208951 100212300 100215034(ddc)
TAD: 
TRIADDRAFT_21756
RCU: 
RCOM_0036170 RCOM_0320800 RCOM_2158430
POP: 
POPTR_789810
VVI: 
100247842
PPP: 
PHYPADRAFT_133364 PHYPADRAFT_187201
CRE: 
CHLREDRAFT_116869(DDC1)
NCR: 
NCU08275
SMP: 
SMAC_00940
FGR: 
FG05295.1
NHE: 
NECHADRAFT_50494 NECHADRAFT_55523
SSL: 
SS1G_02607
BFU: 
BC1G_01168
ANI: 
AN2357.2
NFI: 
NFIA_003370
AFM: 
AFUA_3G02240
AOR: 
AOR_1_88074(AO090038000057)
ANG: 
ANI_1_2316014(An01g02000)
AFV: 
AFLA_125240
ACT: 
ACLA_062170
PCS: 
Pc14g00240
CIM: 
CIMG_08453
CPW: 
CPC735_061220
URE: 
UREG_02527
ABE: 
ARB_03722
TVE: 
TRV_07554
PNO: 
SNOG_10747
PTE: 
PTT_10253
TML: 
GSTUM_00010987001
CNE: 
CND00950
CNB: 
CNBD5350
LBC: 
LACBIDRAFT_190337
MPR: 
MPER_08945
CCI: 
CC1G_02020
SCM: 
SCHCODRAFT_15828
UMA: 
UM06083.1
MGL: 
MGL_3372
NGR: 
NAEGRDRAFT_70090
TET: 
TTHERM_00929550
PTM: 
GSPATT00035189001
YPE: 
YPO1193
YPK: 
y2996(dcd)
YPA: 
YPA_0905
YPN: 
YPN_2783
YPM: 
YP_0943(dcd1)
YPP: 
YPDSF_2502
YPG: 
YpAngola_A1334
YPZ: 
YPZ3_1100
YPT: 
A1122_19855
YPD: 
YPD4_1061
YPX: 
YPD8_1086
YPH: 
YPC_3018
YPS: 
YPTB1234
YPI: 
YpsIP31758_2788
YPY: 
YPK_2867
YPB: 
YPTS_1322
PPU: 
PP_2552
PPF: 
Pput_3163
PPG: 
PputGB1_3364
PPW: 
PputW619_2223
PFC: 
PflA506_1055(ddc)
PEN: 
PSEEN2370
NOC: 
Noc_2983
BUR: 
Bcep18194_B2911
DVU: 
DVU0867
DVL: 
Dvul_2115
DVM: 
DvMF_2916
DVG: 
Deval_0798
DDE: 
Dde_1124
AFW: 
Anae109_1428
SUR: 
STAUR_7203
MLO: 
mll0712
MCI: 
Mesci_4037
RHI: 
NGR_b20140
ARA: 
Arad_0017
NWI: 
Nwi_1102
XAU: 
Xaut_0071
MET: 
M446_1957
MNO: 
Mnod_1238
RVA: 
Rvan_3231
SIL: 
SPO3687
SIT: 
TM1040_3466
JAN: 
Jann_3501
MMR: 
Mmar10_1409
PGV: 
SL003B_3591
FRA: 
Francci3_2867
GOB: 
Gobs_3209
SEN: 
SACE_2888
PDX: 
Psed_3994
AMI: 
Amir_5685
VMA: 
VAB18032_26310
RXY: 
Rxyl_1038
ABA: 
Acid345_2160
SUS: 
Acid_1182
MTT: 
Ftrac_1992
GAU: 
GAU_3087
CYP: 
PCC8801_0883
CYH: 
Cyan8802_0909
CAU: 
Caur_2842
CAG: 
Cagg_1126
CHL: 
Chy400_3078
MRB: 
Mrub_1738
MSV: 
Mesil_1832
 » show all
Taxonomy
Reference
1  [PMID:4536745]
  Authors
Christenson JG, Dairman W, Udenfriend S.
  Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
  Journal
Proc. Natl. Acad. Sci. U. S. A. 69 (1972) 343-7.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Oryctolagus cuniculus
Reference
2  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J. Biol. Chem. 237 (1962) 89-93.
  Organism
Cavia porcellus
Reference
3
  Authors
McGilvery, R.W. and Cohen, P.P.
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J. Biol. Chem. 174 (1948) 813-816.
Reference
4
  Authors
Sekeris, C.E.
  Title
Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifitat der DOPA-Decarboxylase.
  Journal
Hoppe-Seyler's Z. Physiol. Chem. 332 (1963) 70-78.
Reference
5  [PMID:13462983]
  Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
  Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
  Journal
J. Biol. Chem. 227 (1957) 617-24.
  Organism
Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9042-64-2
DBGET integrated database retrieval system