KEGG   ENZYME: 4.1.1.32Help
Entry
EC 4.1.1.32                 Enzyme                                 
Name phosphoenolpyruvate carboxykinase (GTP);
phosphoenolpyruvate carboxylase;
phosphopyruvate carboxylase;
phosphopyruvate (guanosine triphosphate) carboxykinase;
phosphoenolpyruvic carboxykinase (GTP);
phosphopyruvate carboxylase (GTP);
phosphoenolpyruvic carboxylase (GTP);
phosphoenolpyruvic carboxykinase;
phosphoenolpyruvate carboxykinase;
PEP carboxylase;
GTP:oxaloacetate carboxy-lyase (transphosphorylating)
Class Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname GTP:oxaloacetate carboxy-lyase (adding GTP;
phosphoenolpyruvate-forming)
Reaction(IUBMB) GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2 [RN:R00431]
Reaction(KEGG) R00431;
(other) R00726
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Substrate GTP [CPD:C00044];
oxaloacetate [CPD:C00036]
Product GDP [CPD:C00035];
phosphoenolpyruvate [CPD:C00074];
CO2 [CPD:C00011]
Comment ITP can act as phosphate donor.
Pathway PATH: ec00010  Glycolysis / Gluconeogenesis
PATH: ec00020  Citrate cycle (TCA cycle)
PATH: ec00620  Pyruvate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01596  phosphoenolpyruvate carboxykinase (GTP)
Genes HSA: 5105(PCK1) 5106(PCK2)
PTR: 452807(PCK2) 458362(PCK1)
MCC: 696207(PCK1) 714922
MMU: 18534(Pck1) 74551(Pck2)
RNO: 361042(Pck2) 362282(Pck1)
CFA: 403560(PCK1) 480255(PCK2)
BTA: 282855(PCK1) 282856(PCK2)
SSC: 100144531(CH242-37G9.2) 403165(PCK2)
ECB: 100054903 100055710
MDO: 100027540 100030700
OAA: 100073969 100088404
GGA: 396457(PEPCK-M) 396458(PCK1)
TGU: 100224850
XLA: 379637 379844(pck1) 399424(pck2)
XTR: 394790(pck1) 733907
DRE: 378727(pck1) 406473
BFO: BRAFLDRAFT_68589
CIN: 100177066
SPU: 584898 752532
DME: Dmel_CG10924 Dmel_CG17725(Pepck)
DPO: Dpse_GA10647 Dpse_GA14628
DAN: Dana_GF11970 Dana_GF11971
DER: Dere_GG21903 Dere_GG21904
DPE: Dper_GL17082
DSE: Dsec_GM21894 Dsec_GM21895
DSI: Dsim_GD11391 Dsim_GD11392
DYA: Dyak_GE11979 Dyak_GE11980
DGR: Dgri_GH22961 Dgri_GH22963
DMO: Dmoj_GI18449 Dmoj_GI18450
AGA: AgaP_AGAP003350
AAG: AaeL_AAEL000006 AaeL_AAEL000025 AaeL_AAEL000080
CQU: CpipJ_CPIJ010515
AME: 412843(Pepck)
NVI: 100115526
TCA: 661705
API: 100160700
ISC: IscW_ISCW001902
CEL: R11A5.4
CBR: CBG08279
BMY: Bm1_25195
SMM: Smp_005880
NVE: NEMVE_v1g103590
HMG: 100199843
TAD: TRIADDRAFT_49773
DDI: DDB_0230145
GLA: GL50803_10623
TVA: TVAG_139300 TVAG_213710 TVAG_310250 TVAG_479540
ACI: ACIAD2842(pckG)
ACB: A1S_2668
ABM: ABSDF0809(pckG)
ABY: ABAYE0818(pckG)
ABC: ACICU_02913
ABN: AB57_3085
ABB: ABBFA_000807
HHA: Hhal_1673
RSO: RSc0017(pckA)
RPI: Rpic_3739
RPF: Rpic12D_3416
REU: Reut_A3420
REH: H16_A3711(pepck)
RME: Rmet_3577
CTI: RALTA_A3167(pckG)
BMA: BMA3042(pckA)
BMV: BMASAVP1_A1250(pckG)
BML: BMA10229_A0620(pckG)
BMN: BMA10247_0533(pckG)
BPS: BPSL1324(pckG)
BPM: BURPS1710b_1574
BPL: BURPS1106A_1475(pckG)
BPD: BURPS668_1446(pckG)
BPR: GBP346_A1478
BTE: BTH_I2808
BVI: Bcep1808_4996
BUR: Bcep18194_B1511
BCN: Bcen_3922
BCH: Bcen2424_4445
BCM: Bcenmc03_5861
BCJ: BCAM1581(pckG)
BAM: Bamb_3877
BAC: BamMC406_4337
BMU: Bmul_4179
BMJ: BMULJ_04326(pckA)
BXE: Bxe_A4422
BPH: Bphy_0030
BPY: Bphyt_0304
BGL: bglu_1g11130
PNU: Pnuc_2083
PNE: Pnec_1782
BPA: BPP1368(pckG)
BBR: BB2434(pckG)
BPT: Bpet2915(pckA)
BAV: BAV1626(pckG)
POL: Bpro_0160
PNA: Pnap_0102
AAV: Aave_0138
AJS: Ajs_0078
DAC: Daci_0114
DIA: Dtpsy_0097
VAP: Vapar_0147
CTT: CtCNB1_0071
MPT: Mpe_A3705
LCH: Lcho_3945
EBA: ebA4040(ppcK)
AZO: azo0820(pckG)
DAR: Daro_0665
TMZ: Tmz1t_1092
APP: CAP2UW1_0771 CAP2UW1_1298
GSU: GSU3385(pckA)
GME: Gmet_2638
GUR: Gura_0870
GLO: Glov_3462
GBM: Gbem_0734
GEO: Geob_1021
GEM: GM21_0749
PCA: Pcar_1766
DPS: DP1093
DOL: Dole_0376
DAT: HRM2_41160(pckG)
ADE: Adeh_3676
ACP: A2cp1_3817
AFW: Anae109_3803
ANK: AnaeK_3734
MXA: MXAN_1264(pckG)
SCL: sce3007(pckA1) sce4201(pckG) sce4794(pckA2)
SFU: Sfum_0901
PZU: PHZ_c2232
SWI: Swit_5171
RRU: Rru_A3419
MAG: amb0785
CTH: Cthe_2874
CCE: Ccel_0212
ATE: Athe_0393
CSC: Csac_0274
MTU: Rv0211(pckA)
MTC: MT0221(pckA)
MRA: MRA_0219(pckA)
MTF: TBFG_10213
MTB: TBMG_00212(TBMG_00212.1)
MBO: Mb0217(pckA)
MBB: BCG_0248(pckA)
MBT: JTY_0217(pckA)
MLE: ML2624(pckA)
MLB: MLBr_02624(pckA)
MPA: MAP3646(pckA)
MAV: MAV_4963 MAV_5106
MSM: MSMEG_0255
MUL: MUL_1101(pckA)
MVA: Mvan_0201
MGI: Mflv_0451
MAB: MAB_2561c MAB_4502c
MMC: Mmcs_0176
MKM: Mkms_0185
MJL: Mjls_0165
MMI: MMAR_0451(pckA)
CGL: NCgl2765(cgl2863)
CGB: cg3169(pck)
CGT: cgR_2751
CEF: CE2691(pck)
CDI: DIP2180(pckG)
CJK: jk0151(pck)
CUR: cur_0173
CAR: cauri_2359(pck)
CKP: ckrop_0253(pck)
NFA: nfa54790(pckA)
RHA: RHA1_ro05180
RER: RER_10900(pckG)
ROP: ROP_52300(pckG)
GBR: Gbro_4475
SCO: SCO4979(2SCK36.02)
SMA: SAV_3287(pck)
SGR: SGR_2556
LXX: Lxx04240(pckG)
CMI: CMM_1473(pckA)
CMS: CMS_1507(pckG)
ART: Arth_0667
AAU: AAur_0832
ACH: Achl_0814
RSA: RSal33209_0029
KRH: KRH_03260(pckG)
MLU: Mlut_03380
BCV: Bcav_3601
XCE: Xcel_0386
NCA: Noca_0190 Noca_4168 Noca_4472
TFU: Tfu_0083
TCU: Tcur_2819
SRO: Sros_8530
FRA: Francci3_3897
FRE: Franean1_0833 Franean1_4382
FAL: FRAAL6204(pckG)
NML: Namu_5314
KRA: Krad_3537
SEN: SACE_7274(pckA)
SVI: Svir_39080
AMI: Amir_6994
STP: Strop_0861
SAQ: Sare_0807
CAI: Caci_0734
AFO: Afer_0693
CTR: CT710(pckA)
CTA: CTA_0772(pckA)
CTB: CTL0079(pckA)
CTL: CTLon_0079(pckA)
CTJ: JALI_7151(pckA)
CMU: TC0083(pckA)
CPN: CPn0851(pckA)
CPA: CP1018
CPJ: CPj0851(pckA)
CPT: CpB0880
CCA: CCA00916(pckA)
CAB: CAB884
CFE: CF0098(pckA)
PCU: pc1371(pckG)
TPA: TP0122
TPP: TPASS_0122(pckA)
BHY: BHWA1_01100
ABA: Acid345_0537
FSU: Fisuc_2949
OTE: Oter_0718
AMU: Amuc_1210
RSD: TGRD_334
CTE: CT2232(pckA)
CPC: Cpar_0047
CCH: Cag_2012
CPH: Cpha266_0051
CPB: Cphamn1_0033
CLI: Clim_0031
PVI: Cvib_0027
PLT: Plut_0023
PPH: Ppha_0050
PAA: Paes_0052
CTS: Ctha_1390
RRS: RoseRS_2496
RCA: Rcas_2846
CAU: Caur_2331
CAG: Cagg_3060
CHL: Chy400_2513
HAU: Haur_0429
TAC: Ta0123
TVO: TVN0200
PHO: PH0312
PAB: PAB1253
PFU: PF0289
TKO: TK1405
TON: TON_0192
TGA: TGAM_1771(pckG)
TSI: TSIB_0151
DKA: DKAM_1379
HBU: Hbut_1445
SSO: SSO2537
STO: ST1058
SAI: Saci_1100
SIS: LS215_0433
SIA: M1425_0395
SIM: M1627_0409
SID: M164_0433
SIY: YG5714_0393
SIN: YN1551_2639
MSE: Msed_1452
CMA: Cmaq_0716
TPE: Tpen_1532
Taxonomy
Structures PDB: 1II2  1KHB  1KHE  1KHF  1KHG  1M51  1NHX  2FAF  2FAH  2GMV  
     2QEW  2QEY  2QF1  2QF2  2QZY  2RK7  2RK8  2RKA  2RKD  2RKE  
     2ZCI  3DT2  3DT4  3DT7  3DTB  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:5911620]
Chang HC, Lane MD.
The enzymatic carboxylation of phosphoenolpyruvate. II. Purification
and properties of liver mitochondrial phosphoenolpyruvate
carboxykinase.
J. Biol. Chem. 241 (1966) 2413-20.
Sus scofa [GN:ssc]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:13438893]
KURAHASHI K, PENNINGTON RJ, UTTER MF.
Nucleotide specificity of oxalacetic carboxylase.
J. Biol. Chem. 226 (1957) 1059-75.
Gallus gallus [GN:gga]
Other DBs ExplorEnz - The Enzyme Database: 4.1.1.32
IUBMB Enzyme Nomenclature: 4.1.1.32
ExPASy - ENZYME nomenclature database: 4.1.1.32
BRENDA, the Enzyme Database: 4.1.1.32
CAS: 9013-08-5
DBGET integrated database retrieval system