KEGG   ENZYME: 6.3.5.1Help
Entry
EC 6.3.5.1                  Enzyme                                 
Name NAD+ synthase (glutamine-hydrolysing);
NAD synthetase (glutamine-hydrolysing);
nicotinamide adenine dinucleotide synthetase (glutamine);
desamidonicotinamide adenine dinucleotide amidotransferase;
DPN synthetase
Class Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
BRITE hierarchy
Sysname deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
Reaction(IUBMB) ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ +
L-glutamate [RN:R00257]
Reaction(KEGG) R00257;
(other) R00189
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Substrate ATP [CPD:C00002];
deamido-NAD+ [CPD:C00857];
L-glutamine [CPD:C00064];
H2O [CPD:C00001]
Product AMP [CPD:C00020];
diphosphate [CPD:C00013];
NAD+ [CPD:C00003];
L-glutamate [CPD:C00025]
Comment NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).
Pathway PATH: ec00760  Nicotinate and nicotinamide metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01950  NAD+ synthase (glutamine-hydrolysing)
Genes HSA: 55191(NADSYN1)
PTR: 451395(NADSYN1)
MCC: 707652(NADSYN1)
MMU: 78914(Nadsyn1)
RNO: 353255(Nadsyn1)
CFA: 483674(NADSYN1)
BTA: 513400(NADSYN1)
ECB: 100061284
OAA: 100073480
GGA: 422983(NADSYN1)
XTR: 100145482
DRE: 798974
BFO: BRAFLDRAFT_275067
CIN: 100181628
SPU: 575432
DME: Dmel_CG9940
DPO: Dpse_GA22140
DAN: Dana_GF22350
DER: Dere_GG19493
DPE: Dper_GL19852
DSE: Dsec_GM17596
DYA: Dyak_GE16145
DGR: Dgri_GH11939
DMO: Dmoj_GI14143
AGA: AgaP_AGAP000112
AAG: AaeL_AAEL008302
CQU: CpipJ_CPIJ018507
AME: 409487
NVI: 100120553
TCA: 663765
API: 100164528
ISC: IscW_ISCW004036
CEL: C24F3.4
CBR: CBG03392
SMM: Smp_075060 Smp_162660
NVE: NEMVE_v1g173435
HMG: 100211195
TAD: TRIADDRAFT_54321
ATH: AT1G55090
POP: POPTR_751166 POPTR_757664
RCU: RCOM_1312290
VVI: 100263393(GSVIVT00006686001)
OSA: 4342490(Os07g0167100)
SBI: SORBI_02g009640(SORBIDRAFT_02g009640)
PPP: PHYPADRAFT_128157
CRE: CHLREDRAFT_127918
OLU: OSTLU_33475
CME: CMT488C
SCE: YHR074W(QNS1)
AGO: AGOS_AGR358W
KLA: KLLA0D13024g
LTH: KLTH0H15004g
DHA: DEHA0A01969g
PIC: PICST_40885(QNS1)
PPA: PAS_chr4_0233
VPO: Kpol_364p6
LEL: LELG_01129
ZRO: ZYRO0D10714g
CAL: CaO19.1460
CTP: CTRG_01244
CDU: CD36_16380
CGR: CAGL0J10758g
YLI: YALI0A20108g
SPO: SPCC553.02
NCR: NCU04648
PAN: PODANSg8100
MGR: MGG_04178
FGR: FG07398.1
ANI: AN8203.2
AFM: AFUA_5G03350
AOR: AO090102000540
ANG: An09g05660
AFV: AFLA_006120
PCS: Pc21g16060
NFI: NFIA_038760
CIM: CIMG_03037
URE: UREG_02914
SSL: SS1G_13042
BFU: BC1G_14351
CNE: CNK02550
CNB: CNBK1000
LBC: LACBIDRAFT_305496
MPR: MPER_06014
UMA: UM03555.1
MGL: MGL_1838
DDI: DDB_0231365
EHI: EHI_134830
EDI: EDI_339200
PFA: PFI1310w
PFD: PFDG_02548
PFH: PFHG_04418
PYO: PY00252
PCB: PC000737.01.0
PKN: PKH_072430
PVX: PVX_099765
TGO: TGME49_069800
TET: TTHERM_00474780
PTM: GSPATT00017670001
TBR: Tb11.01.6500
TCR: 427789.30 506221.80
LMA: LmjF32.1670
LIF: LinJ32.2070
LBZ: LbrM32_V2.1840
GLA: GL50803_31530
TVA: TVAG_188330
PTI: PHATRDRAFT_45509
TPS: THAPS_269255
YPE: YPO2912(nadE)
YPK: y1316(nadE)
YPM: YP_2544(nadE)
YPA: YPA_2352(nadE)
YPN: YPN_1225(nadE)
YPG: YpAngola_A3630
YPP: YPDSF_2257(nadE)
YPS: YPTB2873(nadE)
YPI: YpsIP31758_1154
YPY: YPK_1261
YPB: YPTS_2982
YEN: YE1038(nadE)
PAY: PAU_01329(nadE)
SPE: Spro_3650
PMR: PMI1871(nadE)
EIC: NT01EI_0892
ETR: ETAE_0778(nadE)
HDE: HDEF_0212(nadE)
XFA: XF1961(nadE)
XFT: PD0839
XFM: Xfasm12_1011
XFN: XfasM23_0887
XCA: xccb100_1100(nadE)
XCV: XCV3345(nadE)
XOP: PXO_04876
SML: Smlt3751(nadE)
SMT: Smal_3162
PSP: PSPPH_2956
CJA: CJA_3207(adgA)
AVN: Avin_11920
PAR: Psyc_0270(nadE)
PCR: Pcryo_0296
PRW: PsycPRwf_1882
ACI: ACIAD2888
ACB: A1S_0859
ABM: ABSDF2577
ABY: ABAYE2955
ABC: ACICU_00809
ABN: AB57_0905(nadE)
ABB: ABBFA_002755
SDE: Sde_2553
MAQ: Maqu_0876
TTU: TERTU_1053(nadE)
CBU: CBU_0858(nadE)
CBS: COXBURSA331_A1093(nadE)
CBD: CBUD_0922(nadE)
CBG: CbuG_1143(nadE)
CBC: CbuK_0726(nadE)
LPN: lpg0734
LPF: lpl0771
LPP: lpp0800
LPC: LPC_2558(nadE)
MCA: MCA0969
TCX: Tcr_1372
NOC: Noc_2095(nadE)
AEH: Mlg_2549
HHA: Hhal_2238
TGR: Tgr7_0811
HNA: Hneap_1990
HCH: HCH_05923
CSA: Csal_0495
ABO: ABO_0474
MMW: Mmwyl1_2961
AHA: AHA_0697(nadE)
ASA: ASA_0694(nadE)
TAU: Tola_0587
AFE: Lferr_0590
AFR: AFE_0428(nadE)
RMA: Rmag_0520
VOK: COSY_0477(nadE)
KKO: Kkor_1079
CVI: CV_1616(nadE)
RSO: RSc2347(nadE)
RPI: Rpic_2562
RPF: Rpic12D_2158
REU: Reut_A2610(nadE)
REH: H16_A0749(nadE)
RME: Rmet_0680(nadE)
CTI: RALTA_A0735(nadE)
BMA: BMA0741(nadE)
BMV: BMASAVP1_A2272(nadE)
BML: BMA10229_A3012(nadE)
BMN: BMA10247_1585(nadE)
BPS: BPSL1026(nadE)
BPM: BURPS1710b_1242(nadE)
BPL: BURPS1106A_1089(nadE)
BPD: BURPS668_1084(nadE)
BPR: GBP346_A1081(nadE_1)
BTE: BTH_I0882(nadE) BTH_II0919(nadE)
BVI: Bcep1808_2500(nadE)
BUR: Bcep18194_A5739(nadE)
BCN: Bcen_1800(nadE)
BCH: Bcen2424_2412(nadE)
BCM: Bcenmc03_2416
BCJ: BCAL2617
BAM: Bamb_2457(nadE)
BAC: BamMC406_2322
BMU: Bmul_0878
BMJ: BMULJ_02380(nadE)
BXE: Bxe_A3396(nadE)
BPH: Bphy_2169(nadE)
BPY: Bphyt_1117
BGL: bglu_1g27840 bglu_2g12930
PNU: Pnuc_0684
PNE: Pnec_1165
BPE: BP2700(nadE)
BPA: BPP1435(nadE)
BBR: BB2509(nadE)
BPT: Bpet2868(nadE)
BAV: BAV1637(nadE)
RFR: Rfer_1699
POL: Bpro_2309
PNA: Pnap_1709 Pnap_3718
AAV: Aave_3120
AJS: Ajs_1761
VEI: Veis_1737
DAC: Daci_4875 Daci_5607
DIA: Dtpsy_1961
VAP: Vapar_2360 Vapar_6284
CTT: CtCNB1_0649 CtCNB1_1649
MPT: Mpe_A2113
HAR: HEAR1014(nadE)
MMS: mma_1150(nadE1)
LCH: Lcho_2968
NEU: NE1896(nadE)
NET: Neut_2008
NMU: Nmul_A2535
EBA: ebA7049(nadE)
AZO: azo1360(nadE)
TMZ: Tmz1t_1759
TBD: Tbd_0807
MMB: Mmol_0679
MEI: Msip34_0908
APP: CAP2UW1_2302
NIS: NIS_0538
SUN: SUN_0674
PCA: Pcar_2216(nadE)
PPD: Ppro_2164(nadE)
DVU: DVU1610(nadE)
DVL: Dvul_1524
DVM: DvMF_0449
DDS: Ddes_0752
DMA: DMR_31100(nadE)
DSA: Desal_2869
LIP: LI0244(nadE)
DRT: Dret_0426
BBA: Bd3836(nadE)
DPS: DP2919
DAL: Dalk_2633 Dalk_4950
DAT: HRM2_37420(nadE)
ADE: Adeh_0285
ACP: A2cp1_0307
AFW: Anae109_0311
ANK: AnaeK_0296
MXA: MXAN_6851
SCL: sce9007
HOH: Hoch_3633
SAT: SYN_01307(nadE)
SFU: Sfum_0572
AMA: AM416(nadE)
AMF: AMF_305(nadE)
ACN: ACIS_00881(nadE)
APH: APH_0852
ERU: Erum2710(nadE)
ERW: ERWE_CDS_02760(nadE)
ERG: ERGA_CDS_02710(nadE)
ECN: Ecaj_0261
ECH: ECH_0822(nadE)
NRI: NRI_0093(nadE)
MES: Meso_4206(nadE)
PLA: Plav_1103
SMD: Smed_1566(nadE)
ATU: Atu1657(nadE)
ATC: AGR_C_3052
ARA: Arad_2676(nadE)
AVI: Avi_2040(nadE)
RET: RHE_CH02371(nadE)
REC: RHECIAT_CH0002460(nadE)
RLE: RL2688(nadE)
RLT: Rleg2_2003
RLG: Rleg_2221
RHI: NGR_c16950(nadE2)
LAS: CLIBASIA_04500(nadE)
BME: BMEI0969(nadE)
BMC: BAbS19_I09590
BMT: BSUIS_A1058(nadE)
BCS: BCAN_A1030(nadE)
BMR: BMI_I1017(nadE)
OAN: Oant_2097
BJA: bll4547(nadE)
BRA: BRADO4702 BRADO6555(nadE)
BBT: BBta_0979(nadE)
OCA: OCAR_6522
BBK: BARBAKC583_0606(nadE)
BTR: Btr_0937(nadE)
BGR: Bgr_07300(nadE)
MEX: Mext_4035(nadE)
MEA: Mex_1p4425(nadE)
MDI: METDI5029(nadE)
MRD: Mrad2831_3750(nadE)
MET: M446_4906(nadE)
MPO: Mpop_4517(nadE)
MCH: Mchl_4405(nadE)
MNO: Mnod_2890
CCR: CC_3619(nadE)
CCS: CCNA_03734
CAK: Caul_4914(nadE)
PZU: PHZ_c1931(nadE)
SIL: SPO0426(nadE)
RDE: RD1_1215(nadE)
HNE: HNE_2577(nadE)
HBA: Hbal_1841
SWI: Swit_2595(nadE)
ELI: ELI_08405(nadE)
GOX: GOX1121(nadE)
GBE: GbCGDNIH1_0287(nadE)
GDI: GDI_0919(nadE)
GDJ: Gdia_1103(nadE)
APT: APA01_26510
RCE: RC1_0958(nadE)
MAG: amb1233(nadE)
MGM: Mmc1_3593
CAC: CAC1050(nadE) CAC1782(nadE)
CPE: CPE1058(nadE)
CPF: CPF_1314(nadE)
CPR: CPR_1130(nadE)
CTC: CTC00679(nadE)
CNO: NT01CX_0103(nadE)
CTH: Cthe_0325(nadE)
CBO: CBO0537(nadE)
CBA: CLB_0577(nadE)
CBH: CLC_0461(nadE)
CBY: CLM_0639(nadE)
CBL: CLK_3747(nadE)
CBK: CLL_A1089(nadE)
CBB: CLD_0212(nadE)
CBI: CLJ_B0614(nadE)
CBT: CLH_1023(nadE)
CBF: CLI_0616(nadE)
CBE: Cbei_1044
CKL: CKL_0992(nadE)
CKR: CKR_0896
CPY: Cphy_3426
CCE: Ccel_1200
ATE: Athe_0223
DRM: Dred_1460
DAE: Dtox_1036
PTH: PTH_0918
DAU: Daud_0150
HMO: HM1_2802
APR: Apre_0507
EEL: EUBELI_01289
ERE: EUBREC_1358
TTE: TTE0640(nadE)
TEX: Teth514_2296
TPD: Teth39_1646
MTA: Moth_0553
CSC: Csac_0122
CPO: COPRO5265_0801
POY: PAM123 PAM124(nadE)
AYW: AYWB_598(qns)
PML: ATP_00183(qns)
PAL: PAa_0763(nadE)
ACL: ACL_0558(nadE)
MTU: Rv2438c(nadE)
MTC: MT2513(nadE)
MRA: MRA_2464(nadE)
MTF: TBFG_12465(nadE)
MTB: TBMG_01534(TBMG_01534.1)
MBO: Mb2464c(nadE)
MBB: BCG_2457c(nadE)
MBT: JTY_2451(nadE)
MLE: ML1463(nadE)
MLB: MLBr_01463
MPA: MAP2258c(nadE)
MAV: MAV_1737(nadE)
MSM: MSMEG_4617(nadE)
MUL: MUL_3705(nadE)
MVA: Mvan_3940(nadE)
MGI: Mflv_2642(nadE)
MMC: Mmcs_3543(nadE)
MKM: Mkms_3616(nadE)
MJL: Mjls_3548(nadE)
MMI: MMAR_3759(nadE)
GBR: Gbro_3909
SCO: SCO2238(nadE)
SMA: SAV_5948(nadE)
SGR: SGR_5258
BCV: Bcav_1848
BFA: Bfae_28360
JDE: Jden_1488
XCE: Xcel_3271
PAC: PPA2266(nadE)
NCA: Noca_2044(nadE)
TFU: Tfu_0983
TCU: Tcur_3108
SRO: Sros_2601
FRA: Francci3_3146
FRE: Franean1_1765
FAL: FRAAL3251(nadE)
ACE: Acel_0918
NML: Namu_0483
KRA: Krad_3297
SEN: SACE_1610(nadE)
SVI: Svir_07390
AMI: Amir_0908
STP: Strop_3340
SAQ: Sare_3585
CAI: Caci_5214
BLO: BL0953(nadE)
BLJ: BLD_0695
BLN: Blon_1717
BAD: BAD_0994(nadE)
BLA: BLA_0699 BLA_0965(nadE)
BLC: Balac_1085 Balac_1583
BLT: Balat_1085 Balat_1583
RXY: Rxyl_2763
AFO: Afer_0246
CCU: Ccur_11710
SHI: Shel_19800
APV: Apar_0182 Apar_0896
ELE: Elen_2828
BBZ: BbuZS7_0531(nadE)
BGA: BG0531
BAF: BAPKO_0547
BTU: BT0522
BHR: BH0522
BDU: BDU_522
BRE: BRE_525
TPA: TP0780(nadE)
TPP: TPASS_0780(nadE)
TDE: TDE1400(nadE)
LIL: LA2989(nadE)
LIC: LIC11075(nadE)
LBJ: LBJ_2102(nadE)
LBL: LBL_0949(nadE)
LBI: LEPBI_I1331
LBF: LBF_1277(nadE)
BHY: BHWA1_00485(nadE)
ACA: ACP_0671(nadE)
BTH: BT_0205(nadE)
BFR: BF3182(nadE)
BFS: BF3022(nadE)
BVU: BVU_2365(nadE)
PGI: PG0531(nadE)
PGN: PGN_1441(nadE)
PDI: BDI_0318(nadE)
APS: CFPG_118
SRU: SRU_0403
RMR: Rmar_2312
CHU: CHU_2417
DFE: Dfer_2832
CPI: Cpin_0217
PHE: Phep_0411
FSU: Fisuc_1819 Fisuc_2753
OTE: Oter_1045 Oter_3756
MIN: Minf_0725(nadE)
AMU: Amuc_0620
RBA: RB5671(nadE)
EMI: Emin_0652
RSD: TGRD_548
SYW: SYNW0502(nadE)
SYE: Syncc9902_0495
SYR: SynRCC307_1870(nadE)
SYX: SynWH7803_2009(nadE)
SYP: SYNPCC7002_A1784(nadE)
CYA: CYA_0206(nadE)
CYB: CYB_1248(nadE)
MAR: MAE_34920
CYT: cce_2756
CYP: PCC8801_0268
CYC: PCC7424_0290
CYN: Cyan7425_2239
CYH: Cyan8802_0268
GVI: glr2587
NPU: Npun_F5712
PMA: Pro1599(nadE)
PMM: PMM1446
PMT: PMT1461
PMN: PMN2A_0977
PMI: PMT9312_1539
PMB: A9601_16481(nadE)
PMC: P9515_16251(nadE)
PMF: P9303_04891(nadE)
PMG: P9301_16361(nadE)
PMH: P9215_17141(nadE)
PMJ: P9211_15651
PME: NATL1_18451(nadE)
AMR: AM1_4899(nadE)
DET: DET1122
DEH: cbdb_A1049(nadE)
DEB: DehaBAV1_0951
DEV: DhcVS_940(nadE)
RRS: RoseRS_2679(nadE)
RCA: Rcas_2204
CAU: Caur_1374(nadE)
CAG: Cagg_2533
CHL: Chy400_1498
HAU: Haur_4289
TRO: trd_0459
AAE: aq_959(nadE)
HYA: HY04AAS1_1409
SUL: SYO3AOP1_1558
SAF: SULAZ_1252
PMX: PERMA_0609(nadE)
TMA: TM1253
TPT: Tpet_1518
TLE: Tlet_1537
TRQ: TRQ2_1567
TNA: CTN_1321
TNP: Tnap_1541
TME: Tmel_1404
TAF: THA_1720(nadE2)
FNO: Fnod_0767
PMO: Pmob_1869
KOL: Kole_1614
DTH: DICTH_0172 DICTH_1909
DTU: Dtur_0182
TYE: THEYE_A0448
MTP: Mthe_0727
MEM: Memar_1435
HWA: HQ2580A(nadE)
Taxonomy
Structures PDB: 1EE1  1FYD  1IFX  1IH8  1KQP  1NSY  2NSY  3DLA  3ILV  
Reference
  Authors
  Title

  Journal
 1  [PMID:13717628]
IMSANDE J.
Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia
coli.
J. Biol. Chem. 236 (1961) 1494-7.
Reference
  Authors
  Title

  Journal
 2  [PMID:13717627]
IMSANDE J, HANDLER P.
Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid
mononucleotide pyrophos-phorylase.
J. Biol. Chem. 236 (1961) 525-30.
Other DBs ExplorEnz - The Enzyme Database: 6.3.5.1
IUBMB Enzyme Nomenclature: 6.3.5.1
ExPASy - ENZYME nomenclature database: 6.3.5.1
BRENDA, the Enzyme Database: 6.3.5.1
CAS: 37318-70-0
DBGET integrated database retrieval system