KEGG   Felis catus (domestic cat): 101096568
Entry
101096568         CDS       T02385                                 
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
  KO
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00270  Cysteine and methionine metabolism
fca00480  Glutathione metabolism
fca01100  Metabolic pathways
fca01240  Biosynthesis of cofactors
fca04216  Ferroptosis
Module
fca_M00118  Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:fca00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    101096568 (GCLC)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    101096568 (GCLC)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    101096568 (GCLC)
Enzymes [BR:fca01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     101096568 (GCLC)
SSDB
Motif
Pfam: GCS GCS2
Other DBs
NCBI-GeneID: 101096568
NCBI-ProteinID: XP_023109831
EnsemblRapid: ENSFCTG00005020690
Position
B2:complement(50879406..50929367)
AA seq 637 aa
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKRVQLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPLEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFMETFPEDEEAARASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNSYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
RGMFYFRKDICKGGNTVVDGYGKVQNTSELTTEDYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFISNHPDYKRDSVITDEMNYS
LILKCNQIADELCECPELLGPAFRKVKYSGSKTDPSN
NT seq 1914 nt   +upstreamnt  +downstreamnt
atggggctgctgtcccagggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtgtcttttgatcat
gaaaataagagagtccagttggtcctgtctggagaagaagttcttgaaactctacaagaa
aagggggaaaggacaaacccaaaccatcctaccctgtggagaccagagtatggcagttac
atgattgaaggcacacctggacaaccgtacggaggaactatgtccgagttcaacacagtt
gaagacaacatgagaaaacgccggaaggaggcgacctctttattaggagaaaatcaggct
ctttgcacaataacttcatttcccagattaggctgtcctgggttcacgctgccagagttt
aaacccaatccactcgaaggaggagcttccaagtccctcttctttcctgatgaagccata
aacaagcatccccgcttcagtaccctaacaagaaatatccgacacaggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccatctccatttatggaaaca
tttcctgaggatgaggaggcagcaagggcttccaagcctgatcatatttacatggatgcc
atgggatttgggatgggtaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaggccagatacctttatgatcagctggccaccatctgtccaattgtcatggctttgagt
gctgcgtctcctttttaccgaggctatgtgtcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaat
agctataggatcagtaaatcccgatatgattcaatagacagttatttatctgagtgtggg
gagaaatacaatgacatcgacttgacaattgataaagaaatctacgaacagctgctgcag
gaaggcattgatcatctcctggcccagcacgtcgctcatctcttcatcagagacccactg
actctgtttgaagagaaaatacacttggatgatgccaatgaatcggaccattttgagaac
attcagtccacaaattggcagacaatgagatttaagccccctcctccaaactctgacatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaactctgca
tatgtggtgtttgtggtgctgcttacaagagtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaacatgaaagttgcacagaaacgagatgctgtcttg
cggggaatgttttatttcaggaaagatatttgcaaaggtgggaacactgtggtggatggc
tacgggaaggtccagaacacctcggaactgaccacggaggactacaccctgatgagcata
gacaccatcatcaacgggaaggagggtgtgtttcctgggctgatcccgattctgaactct
taccttgaaaacatggaggtggatgtggacactagatgtagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgacagttgcccgatggatgagagagttt
atctcaaaccatcctgactataagcgagacagtgtaatcactgatgaaatgaactatagc
ctcatcttaaagtgtaaccaaattgcagacgaattgtgtgagtgcccagagttacttgga
ccagcgtttaggaaagtaaaatacagtggaagtaaaacggacccttccaactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ENSEMBLRAPID (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (40)   

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