KEGG   Felis catus (domestic cat): 493807
Entry
493807            CDS       T02385                                 
Symbol
SLC8A1
Name
(RefSeq) sodium/calcium exchanger 1 precursor
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
fca  Felis catus (domestic cat)
Pathway
fca04020  Calcium signaling pathway
fca04022  cGMP-PKG signaling pathway
fca04260  Cardiac muscle contraction
fca04261  Adrenergic signaling in cardiomyocytes
fca04371  Apelin signaling pathway
fca04740  Olfactory transduction
fca04961  Endocrine and other factor-regulated calcium reabsorption
fca04974  Protein digestion and absorption
fca04978  Mineral absorption
fca05410  Hypertrophic cardiomyopathy
fca05412  Arrhythmogenic right ventricular cardiomyopathy
fca05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    493807 (SLC8A1)
   04020 Calcium signaling pathway
    493807 (SLC8A1)
   04022 cGMP-PKG signaling pathway
    493807 (SLC8A1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    493807 (SLC8A1)
   04261 Adrenergic signaling in cardiomyocytes
    493807 (SLC8A1)
  09154 Digestive system
   04974 Protein digestion and absorption
    493807 (SLC8A1)
   04978 Mineral absorption
    493807 (SLC8A1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    493807 (SLC8A1)
  09157 Sensory system
   04740 Olfactory transduction
    493807 (SLC8A1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    493807 (SLC8A1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    493807 (SLC8A1)
   05414 Dilated cardiomyopathy
    493807 (SLC8A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:fca02000]
    493807 (SLC8A1)
   00536 Glycosaminoglycan binding proteins [BR:fca00536]
    493807 (SLC8A1)
Transporters [BR:fca02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   493807 (SLC8A1)
Glycosaminoglycan binding proteins [BR:fca00536]
 Heparan sulfate / Heparin
  Others
   493807 (SLC8A1)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex_C Na_Ca_ex DnaG_DnaB_bind
Other DBs
NCBI-GeneID: 493807
NCBI-ProteinID: NP_001009848
EnsemblRapid: ENSFCTG00005018526
UniProt: P48767
Position
A3:107247269..107574062
AA seq 970 aa
MLRLRLSPTFSVGFHLLAFVPLLFSHVDLISADTEMEGEGNETGECTGSYYCKKGVILPI
WEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETT
KTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII
ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP
ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDNF
LDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAF
YRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCG
TVALTILRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD
IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFE
EPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIV
KTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRK
VHAREHPIPSTVITIAEECDAKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFK
STVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTV
FWKVLFAFVPPTEYWNGWACFIVSILMIGILTAFIGDLASHFGCTIGLKDSVTAVVFVAL
GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVS
PGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSS
LEAYCHIKGF
NT seq 2913 nt   +upstreamnt  +downstreamnt
atgctgcgattaagactctcacctacattttcagtgggatttcatctgttagccttcgtg
cctctcttattttcccatgtggaccttataagtgctgacacagaaatggaaggagaaggc
aatgaaactggcgagtgtaccggctcatattactgtaagaagggggtgatcttacccatt
tgggagccccaagacccttcctttggagacaaaattgctagagctaccgtgtatttcgtg
gccatggtctacatgtttctcggagtctctatcattgccgaccggttcatgtcctctata
gaagtcatcacgtctcaagaaaaagaaataaccataaagaaacccaatggagagaccacc
aagaccactgtgaggatctggaatgagaccgtttcgaacctgaccttgatggccctggga
tcttctgctccagagattctcctttcggtaattgaagtgtgtggccataacttcactgcg
ggagacctaggtcccagcaccatcgtgggaagtgctgcgttcaatatgttcatcattatc
gcgctttgtgtttacgtggtcccagatggagagacgaggaagattaagcatttgcgtgtg
ttctttgtgacagcagcctggagcatctttgcctatacttggctttacattattttgtct
gtcatctctcctggggtcgtggaggtgtgggaaggtttgcttactttcttcttctttccc
atctgtgttgtgttcgcttgggtagcagataggaggcttctgttttacaagtatgtctac
aagaggtatcgggctggcaagcagaggggaatgattattgaacatgaaggagacaggcca
tcttccaagactgaaattgaaatggatgggaaagtggtcaattcccacgttgacaatttc
ttagatggtgccctggttctggaggttgacgagagggaccaagatgatgaagaggccagg
cgagaaatggctaggattctgaaggagctcaagcagaaacatccggagaaagaaatagag
caattaatagaattagctaactaccaagtcctaagtcagcagcaaaaaagtcgagcattt
taccgcatccaagctactcgcttgatgactggagctggcaacattttaaagaggcatgca
gctgaccaggcaaggaaggcagtcagcatgcatgaggtcaacactgaagtggctgaaaat
gaccctgttagtaagatcttctttgaacaagggacataccagtgtctggagaactgtggt
actgtagccctgaccattctccgcagaggtggtgatttgaccaacactgtgtttgttgac
ttcagaacagaagatggcacagccaatgctgggtctgattacgaatttaccgaaggaact
gtggtctttaagcctggtgagacccagaaggaaatcagagttggcatcattgatgacgat
atctttgaggaggatgaaaatttccttgtgcatctgagcaacgttaaagtatcttccgaa
gcctcagaagatggcatcctggaagccaatcatgtttctacactcgcttgcctcggctct
ccctccactgccactgtgactatctttgatgatgaccacgctggcatctttacttttgag
gaacctgtgactcatgtgagcgagagcattggcattatggaggtgaaggtattgagaaca
tctggagctcgaggaaatgttatcgttccctataaaaccatcgaagggactgccagaggt
ggtggggaggactttgaggacacttgcggagagctcgagttccagaacgacgaaattgtc
aaaacaatatcagtcaaggtaattgatgatgaggagtatgagaaaaacaagaccttcttc
cttgagattggagagccccgcctggtggagatgagtgagaagaaagccctgttactgaat
gagcttggtggcttcacaataacaggaaaatacctgtacggccagcctgtcttccggaaa
gttcatgctagagaacatccgatcccttctactgtaatcaccattgcagaggaatgtgat
gcaaagcagccgctgaccagcaaagaggaagaggagaggcgcattgcagaaatggggcgc
cccattctgggagaacacaccaagctggaagtgatcattgaagaatcctacgaattcaag
agtaccgtggacaaacttattaagaagacaaacttagcccttgtggttgggacaaacagc
tggagagagcagtttatcgaagccatcactgtcagcgctggggaagatgacgacgatgat
gaatgtggggaggagaagctaccctcctgtttcgattatgtgatgcatttcctgactgtg
ttctggaaggtcctcttcgccttcgtcccccctacagaatactggaacggctgggcctgt
ttcattgtctccatcctcatgatcggcatactgacagctttcattggagacctggcttcc
cacttcggatgcaccattggcctgaaagattctgtgactgcggtagtgttcgtcgcgctt
ggaacttcggtaccagatacgtttgcaagcaaagtggccgccacccaggaccagtacgca
gatgcatccataggtaacgtcactggcagcaacgcggtgaacgtcttcctgggaatcggc
gtggcctggtccatcgctgccatctaccacgcagccaacggggaacagttcaaagtgtcc
cctggcacgctagctttctctgtcactctcttcaccatttttgctttcatcaatgtgggg
gtgctgctgtatcggcgaaggccagagatcggaggtgagctgggtgggccccggactgcc
aagctcctcacatcctgcctcttcgtgctcctatggctcttgtacattttcttctcctcc
ctggaggcctactgccacataaaaggcttctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ENSEMBLRAPID (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (4)   
   Pfam (4)   
All databases (37)   

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