KEGG T02385: TH

Felis catus (domestic cat): 101090720

Entry

101090720         CDS       T02385

Symbol

Name

(RefSeq) tyrosine 3-monooxygenase

K00501

tyrosine 3-monooxygenase [EC:1.14.16.2]

Organism

fca Felis catus (domestic cat)

Pathway

fca00350

Tyrosine metabolism

fca00790

Folate biosynthesis

fca01100

Metabolic pathways

fca04728

Dopaminergic synapse

fca04917

Prolactin signaling pathway

fca05012

Parkinson disease

fca05030

Cocaine addiction

fca05031

Amphetamine addiction

fca05034

Alcoholism

Module

fca_M00042

Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline

Brite

KEGG Orthology (KO) [BR:fca00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    101090720 (TH)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    101090720 (TH)
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    101090720 (TH)
  09156 Nervous system
   04728 Dopaminergic synapse
    101090720 (TH)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101090720 (TH)
  09165 Substance dependence
   05030 Cocaine addiction
    101090720 (TH)
   05031 Amphetamine addiction
    101090720 (TH)
   05034 Alcoholism
    101090720 (TH)
Enzymes [BR:fca01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     101090720 (TH)

SSDB

Motif

Pfam:

Biopterin_H TH_ACT TOH_N LTP_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

Position

D1:113653179..113660610

AA seq 494 aa
MPTPNAASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAAGAASS
EPGDPLETAVFKEKDGKATLNLIFTLRGAKASLSRAVKAFETFEAQIRHLETRPAQRPRA
GGPHLEYFVCCEVPSADLPALLSSVRRVAEDVRGARENKVFWFPRKVSELDKCHHLVTKF
DPDLDLGHPGFSDQAYRRRRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKGLY
VTHACREYLEAFQLLERFSGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASL
AFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEI
EKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPYQ
DQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRSLQGVQ
DELHTLTHALSAIG

NT seq 1485 nt +upstreamnt +downstreamnt
atgcccactcccaacgccgcctcgccgcaggccaagggcttccgcagggccgtctccgag
ctggacgccaagcaggccgaagccatcatgtccccgcgcttcatcgggcgacggcagagc
ctcatcgaggacgctcgcaaggagcgagagaaggcagaggccgcgggggccgcctcctcg
gagcccggggaccccctggagaccgcagtgttcaaggagaaggacggaaaggccacgctc
aacttgatcttcaccctgcggggcgccaaagcctcactgtcccgggccgtgaaggcgttc
gagacgtttgaggcccaaatccggcacctggagacccggccggcccagaggccgcgcgca
gggggcccccacctggaatactttgtgtgctgtgaggtgcccagcgcggacctgcccgcc
ctgctcagctccgtgcgccgggtggctgaggacgtgcggggcgccagggagaacaaggtc
ttctggttcccaaggaaagtttccgagctggacaagtgccaccacctggtcaccaagttt
gaccctgacctggacttgggtcacccgggtttctccgaccaggcgtaccggcggcgcagg
aagctgatcgccgagatagccttccagtacaagcatggtgaccccattccccgtgtggag
tacacggccgaggagatcgccacctggaaggaggtctacaccaccctcaagggcctctac
gtcactcacgcctgccgggaatacctggaggctttccagctgctggagcgtttcagcggg
taccgggaggacagcatccctcagctggaagacgtgtcccgcttcctgaaggagcggaca
gggttccagctgcggcccgtggccggcctgctgtccgcccgggacttcctggccagcctg
gccttccgagtgttccagtgcacccagtacatccgacacgcctcctcgcccatgcactcc
ccggagccggactgctgccacgagctgctggggcacgtgcccatgctggccgaccgcacc
ttcgctcagttctcccaggacatcgggctcgcgtccttgggggcttccgacgaggagatt
gagaagctgtccacgctgtactggttcacggtggagtttgggctgtgcaagcagaatggg
gaggtgaaggcctacggcgctggactgctgtcctcctatggggagctcctgcactccctg
tctgaggagcccgagatccgggccttcgacccggatgctgcagccgtacagccttaccag
gaccagacttaccagcccgtctacttcgtgtccgagagtttcagcgacgccaaggacaaa
ctcaggaactatgcttcccgcatccagcgccccttctccgtgaagtttgacccgtacacg
ctggccatcgacgtgctggacagtccccatgccatccggcgctccctgcagggcgtccag
gacgagctgcacaccctcacccatgcgctgagcgccatcggctag

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