KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101145772
Entry
101145772         CDS       T02442                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00670  One carbon pool by folate
ggo01100  Metabolic pathways
ggo01240  Biosynthesis of cofactors
Module
ggo_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101145772 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ggo04147]
    101145772 (MTHFD1)
Enzymes [BR:ggo01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     101145772 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     101145772 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     101145772 (MTHFD1)
Exosome [BR:ggo04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101145772 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH OCD_Mu_crystall
Other DBs
NCBI-GeneID: 101145772
NCBI-ProteinID: XP_018865094
Ensembl: ENSGGOG00000005251
UniProt: G3QRA5
Position
14:45096183..45168411
AA seq 991 aa
MRHRVCGGRSGQGRRRSSVIPWPVPKHVGWVVLLGCGGSGTSILVVSIVGSGLIKAMAPA
EILNGKEISAQIRARLKNQVAQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIG
IKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDV
DGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDL
LLWNNATVTTCHSKTANLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDD
KKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWM
IQYNNLNFKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLK
HRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGA
AGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVN
GVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKI
TIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAED
LGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGF
VVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYI
QENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVK
CTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPE
AQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLV
GTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2976 nt   +upstreamnt  +downstreamnt
atgcgccaccgcgtctgcggggggagaagcgggcaggggcgcaggcgcagtagtgtgatc
ccctggccagtccctaagcacgtgggttgggttgtcctgcttggctgcggagggagtgga
acctcgatattggtggtgtccatcgtgggcagcggactaataaaggccatggcgccagca
gaaatcctgaacgggaaggagatctccgcgcaaataagggcgagactgaaaaatcaagtc
gctcagttgaaggagcaagtacctggtttcacaccacgcctggcaatattacaggttggc
aacagagatgattccaatctttatataaatgtgaagctgaaggctgctgaagagattggg
atcaaagccactcatattaagttaccaagaacaaccacagaatctgaggtgatgaagtac
attacatctttgaatgaagactctactgtacacgggttcttagtgcagctacctttagat
tcagaaaattccattaacactgaagaagtgatcaatgctattgcacccgagaaggatgtg
gatggattgactagcatcaatgctgggaaacttgctagaggtgacctcaatgactgtttc
attccttgtacgcctaagggatgcttggaactcatcaaagagacaggggtgccgattgcc
ggaaggcatgctgtggtggttgggcgcagtaaaatagttggggccccgatgcatgacttg
cttctgtggaacaatgccacagtgaccacctgccactccaagactgccaatctggatgag
gaggtaaataaaggtgacatcctggtggttgcaactggtcagcctgaaatggttaaaggg
gagtggatcaaacctggggcaatagtcatcgactgtggaatcaattatgtcccagatgat
aaaaaaccaaatgggagaaaagttgtgggtgatgtggcgtacgacgaggccaaagagagg
gcaagcttcatcactcctgttcctggcggcgtagggcccatgacagttgcaatgctcatg
cagagcacagtagagagtgccaagcgtttcctggagaaatttaagccaggaaagtggatg
attcagtataacaaccttaacttcaagacacctgttccaagtgacattgatatatcacga
tcttgtaaaccgaagcccattggtaagctggctcgagagattggtctgctgtctgaagag
gtagaattatatggtgaaacaaaggccaaagttctgctgtcagcactagaacgcctgaag
caccggcctgatgggaaatacgtggtggtgactggaataactccaacacccctgggagaa
gggaaaagcacaactacaattgggctagtgcaagcccttggtgcccatctctaccagaat
gtctttgcgtgtgtgcgacagccttctcagggccccacctttggaataaaaggtggcgct
gcaggaggcggctactcccaggtcattcctatggaagagtttaatctccacctcacaggt
gacatccatgccatcactgcagctaataacctcgttgctgcggccattgatgctcggata
tttcatgaactgacccagacagacaaggctctctttaatcgtttggtgccatcagtaaat
ggagtgagaaggttctctgacatccaaatccgaaggttaaagagactaggcattgaaaag
actgaccctaccacactgacagatgaagagataaacagatttgcaagattggacattgat
ccagaaaccataacttggcaaagagtgttggataccaatgatagattcctgaggaagatc
acgattggacaggctccaacggagaagggtcacacacggacggcccagtttgatatctct
gtggccagtgaaattatggctgtcctggctctcaccacttctctagaagacatgagagag
agactgggcaaaatggtggtggcatccagtaagaaaggagagcccgtcagtgccgaagat
ctgggggtaagtggtgcactgacagtgcttatgaaggacgcaatcaagcccaatctcatg
cagacactggagggcactccagtgtttgtccatgctggcccgtttgccaacatcgcacat
ggcaattcctccatcattgcagaccggatcgcactcaagcttgttggcccagaagggttt
gtagtgacggaagcgggatttggagcagacattggaatggaaaagttttttaacatcaaa
tgccggtattccggcctctgccctcacgtggtggtgcttgttgccactgtcagggctctc
aagatgcacgggggcggccccacggtcactgctggactgcctcttcccaaggcttacata
caggagaacctggagctggttgaaaaaggcttcagtaacttgaagaaacaaattgaaaat
gccagaatgtttggaattccagtagtagtggccgtgaatgcattcaagacagatacagag
tctgagctggacctcatcagccgcctttccagagaacatggggcttttgatgccgtgaag
tgcactcactgggcagaagggggcaagggtgccttagccctggctcaggccgtccagaga
gcagcacaagcacccagcagcttccagctcctttatgacctcaagctcccagttgaggat
aaaatcaggattattgcacagaagatctatggagcagatgacattgaattacttcccgaa
gctcaacacaaagctgaagtctacacgaagcagggctttgggaatctccccatctgcatg
gctaaaacacacttgtctttgtctcacaacccagagcaaaaaggtgtccctacaggcttc
gttctgcccattcgtgacatccgcgccagcgttggggctggttttctgtaccccttagta
ggaacgatgagcacaatgcctggactccccacccggccctgtttttatgatattgatttg
gaccctgaaacagaacaggtgaatggattattctaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (4)   
   Pfam (4)   
All databases (44)   

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