KEGG   Heterocephalus glaber (naked mole-rat): 101698482
Entry
101698482         CDS       T02812                                 
Symbol
Prkaa2
Name
(RefSeq) protein kinase AMP-activated catalytic subunit alpha 2
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl04068  FoxO signaling pathway
hgl04140  Autophagy - animal
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04152  AMPK signaling pathway
hgl04211  Longevity regulating pathway
hgl04213  Longevity regulating pathway - multiple species
hgl04371  Apelin signaling pathway
hgl04530  Tight junction
hgl04710  Circadian rhythm
hgl04714  Thermogenesis
hgl04910  Insulin signaling pathway
hgl04920  Adipocytokine signaling pathway
hgl04921  Oxytocin signaling pathway
hgl04922  Glucagon signaling pathway
hgl04931  Insulin resistance
hgl04932  Non-alcoholic fatty liver disease
hgl04936  Alcoholic liver disease
hgl05410  Hypertrophic cardiomyopathy
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    101698482 (Prkaa2)
   04068 FoxO signaling pathway
    101698482 (Prkaa2)
   04151 PI3K-Akt signaling pathway
    101698482 (Prkaa2)
   04152 AMPK signaling pathway
    101698482 (Prkaa2)
   04150 mTOR signaling pathway
    101698482 (Prkaa2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101698482 (Prkaa2)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    101698482 (Prkaa2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    101698482 (Prkaa2)
   04922 Glucagon signaling pathway
    101698482 (Prkaa2)
   04920 Adipocytokine signaling pathway
    101698482 (Prkaa2)
   04921 Oxytocin signaling pathway
    101698482 (Prkaa2)
  09149 Aging
   04211 Longevity regulating pathway
    101698482 (Prkaa2)
   04213 Longevity regulating pathway - multiple species
    101698482 (Prkaa2)
  09159 Environmental adaptation
   04710 Circadian rhythm
    101698482 (Prkaa2)
   04714 Thermogenesis
    101698482 (Prkaa2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    101698482 (Prkaa2)
   05410 Hypertrophic cardiomyopathy
    101698482 (Prkaa2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101698482 (Prkaa2)
   04932 Non-alcoholic fatty liver disease
    101698482 (Prkaa2)
   04931 Insulin resistance
    101698482 (Prkaa2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101698482 (Prkaa2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hgl04131]
    101698482 (Prkaa2)
   03029 Mitochondrial biogenesis [BR:hgl03029]
    101698482 (Prkaa2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.31  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
     101698482 (Prkaa2)
Protein kinases [BR:hgl01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   101698482 (Prkaa2)
Membrane trafficking [BR:hgl04131]
 Autophagy
  Other autophagy associated proteins
   Others
    101698482 (Prkaa2)
Mitochondrial biogenesis [BR:hgl03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    101698482 (Prkaa2)
  Mitophagy factors
   Other mitophagy factors
    101698482 (Prkaa2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AMPK_alpha_AID AdenylateSensor Kinase-like ABC1 Kdo APH Haspin_kinase
Other DBs
NCBI-GeneID: 101698482
NCBI-ProteinID: XP_004869686
Position
Un
AA seq 552 aa
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPNYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTVSSASPRLGSHTMDFF
EMCASLITTLAR
NT seq 1659 nt   +upstreamnt  +downstreamnt
atggctgagaagcagaagcacgacgggcgggtgaagattggacactatgtgctgggggac
acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattgacaggtcat
aaagtggcagttaaaatattaaatagacagaagattcgcagtttagatgttgttggaaaa
ataaaacgagaaattcagaatctgaaactctttcgtcatcctcatattatcaaactatac
caggtaatcagcactccaacagacttttttatggtaatggagtatgtgtctggaggtgaa
ttatttgactacatctgtaaacatggacgggttgaagagatggaagccaggaggctgttc
cagcagattttatctgctgtggattattgtcataggcatatggttgttcatcgagaccta
aaaccagagaatgtgctattggatgcacagatgaatgccaagatagctgattttggatta
tctaatatgatgtcagatggagagtttctacgaactagttgtggatctccaaattatgca
gcacctgaagtcatctcaggcaggttatatgcaggccctgaagttgatatctggagctgt
ggtgtcatcttgtatgcccttctgtgtggcaccctcccatttgatgatgagcacgttcct
acactgtttaagaagatccgcgggggtgtgttttatatcccggaatatctcaatcgctca
gttgccactcttctgatgcatatgctgcaggttgaccctctgaaacgagcaactatcaaa
gacataagagagcatgaatggtttaaacaagatttacccaattacttatttcctgaagac
ccctcttatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt
gagtgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaggaccagctt
gcggtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc
tacctcgcctctagtcctccaactgggtcttttatggatgatagtgccatgcatattccc
ccaggcctgaaacctcatccagaaaggatgccacccctcatagcagacagtcccaaagca
cgatgcccattggatgcactgaatacaactaagcccaaatctttagctgtgaagaaggcc
aagtggcatcttggaatccgaagccagagtaaaccatacgacatcatggctgaagtttac
cgagctatgaaacagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta
agaaggaaaaatccagtgactggcaattatgtgaaaatgagcttacaactttacctggtt
gacaataggagctatcttttggattttaagagcattgatgatgaggtggtggagcagagg
tctggttcctcaacacctcagcgttcctgttctgctgctggtttacacagaccgagatca
agttttgattctacgactgcggaaagccattcgctctctggctccctcactggctccttg
actggaagcacagtgtcttcagcatcccctcgcctgggtagtcacaccatggattttttt
gagatgtgtgccagtctcatcaccactttagctcgttga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (9)   
   Pfam (9)   
All databases (53)   

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