KEGG   Homo sapiens (human): 10978
Entry
10978             CDS       T01001                                 
Symbol
CLP1, HEAB, hClp1
Name
(RefSeq) cleavage factor polyribonucleotide kinase subunit 1
  KO
K14399  polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
Disease
H00897  Pontocerebellar hypoplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    10978 (CLP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    10978 (CLP1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.78  polynucleotide 5'-hydroxyl-kinase
     10978 (CLP1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Pre-mRNA cleavage factor IIm (CFIIm)
     10978 (CLP1)
SSDB
Motif
Pfam: CLP1_P CLP1_N Clp1 ATP_bind_1 MMR_HSR1 AAA_18 TniB AAA_16 AAA_22 nSTAND3 CbiA
Other DBs
NCBI-GeneID: 10978
NCBI-ProteinID: NP_006822
OMIM: 608757
HGNC: 16999
Ensembl: ENSG00000172409
UniProt: Q92989
Structure
Position
11:57657762..57661865
AA seq 425 aa
MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLTGMAEIFGTELTRNKKFTFDAG
AKVAVFTWHGCSVQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVV
GPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSI
QAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQ
ALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDER
IREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRD
MVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIR
FMDLK
NT seq 1278 nt   +upstreamnt  +downstreamnt
atgggagaagaggctaatgatgacaagaagccaaccactaaatttgaactagagcgagaa
acagaacttcgctttgaggtggaggcatctcagtcagttcagttggagttgttgactggc
atggcagagatctttggcacagagctgacccgaaacaagaaattcacctttgatgctggt
gccaaggtggctgttttcacttggcatggctgttctgtgcaactgagcggccgcactgag
gtggcttatgtctccaaggacactcctatgttgctttacctcaacactcacacagccttg
gaacagatgcggaggcaagcggaaaaggaagaagagcgaggtccccgagtgatggtagtg
ggccccactgatgtgggcaagtctacagtgtgtcgccttctgctcaactacgcagtgcgt
ttgggccgccgtcccacttatgtggagctggatgtgggccagggttctgtgtccatccct
ggtaccatgggggccctctacatcgagcggcctgcagatgtcgaagagggtttctctatc
caggcccctctggtgtatcattttggttccaccactcctggcactaacatcaagctttat
aataagattacatctcgtttagcagatgtgttcaaccaaaggtgtgaggtgaaccgaagg
gcatctgtgagtggctgtgtcattaacacctgtggctgggtcaagggctctggttaccag
gctctggtgcatgcagcctcagcttttgaggtggatgtcgttgttgttctggatcaagaa
cgactgtacaatgaactgaaacgggacctcccccactttgtacgcactgtgctgctccct
aaatctgggggtgtggtggagcgctccaaggacttccggcgggaatgtagggatgagcgt
atccgtgagtatttttatggattccgaggctgtttctatccccatgccttcaatgtcaaa
ttttcagatgtgaaaatctacaaagttggggcacccaccatcccagactcctgtttacct
ttgggcatgtctcaagaggataatcagctcaagctagtacctgtcactcctgggcgagat
atggtgcaccacctactgagtgttagcactgccgagggtacagaggagaacctgtccgag
acaagtgtagctggcttcattgtggtgaccagtgtggacctggagcatcaggtgtttact
gttctgtctccagcccctcgcccactgcctaagaacttccttctcatcatggatatccgg
ttcatggatctgaagtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (12)   
   RefSeq(nuc) (2)   
   GenBank (5)   
   EMBL (5)   
3D Structure (2)   
   PDB (2)   
Protein domain (11)   
   Pfam (11)   
All databases (59)   

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