KEGG   Homo sapiens (human): 23530
Entry
23530             CDS       T01001                                 
Symbol
NNT, GCCD4
Name
(RefSeq) nicotinamide nucleotide transhydrogenase
  KO
K00323  proton-translocating NAD(P)+ transhydrogenase [EC:7.1.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
Disease
H00256  Familial glucocorticoid deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    23530 (NNT)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.1  proton-translocating NAD(P)+ transhydrogenase
     23530 (NNT)
SSDB
Motif
Pfam: PNTB AlaDh_PNT_C AlaDh_PNT_N PNTB_4TM Pyr_redox_2 ADH_zinc_N
Other DBs
NCBI-GeneID: 23530
NCBI-ProteinID: NP_036475
OMIM: 607878
HGNC: 7863
Ensembl: ENSG00000112992
UniProt: Q13423
Structure
Position
5:43602675..43707396
AA seq 1086 aa
MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVG
VPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVL
ASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQV
PRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGL
ASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAE
MKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPG
ELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMG
HVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYT
AGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAV
GGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLL
PAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLA
ATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIA
EYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLL
NAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNS
YSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGG
KPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRF
GIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDP
NSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKV
RESYQK
NT seq 3261 nt   +upstreamnt  +downstreamnt
atggcaaacctattgaaaacagtggtgactggctgctcgtgtcctctacttagcaatttg
gggtcctgtaagggtctacgtgtgaagaaggattttttacgaacattttatactcaccaa
gaactgtggtgtaaagcgcctgtaaaaccaggaattccatataagcaactgactgttgga
gtccccaaagagatattccaaaatgagaagcgagtggcattgtctcctgctggtgttcag
aacttggtcaagcagggttttaatgttgtcgtggaatcgggtgcgggcgaagcttccaag
ttctcagatgatcactatagagtggcaggtgcccaaatccaaggggcaaaggaagtgctg
gcttctgatttggtggtcaaagtgcgagcccctatggttaatccaacattaggtgttcat
gaagctgaccttttaaagacatcaggaacgctgattagttttatttacccagcccaaaat
ccagagttgctaaataaactttcccaaagaaaaactacagttctggcaatggaccaggtt
ccaagagtcacaattgctcagggatatgatgcgctaagctccatggccaacattgcgggt
tataaggctgttgtcctagcagcaaatcattttggacgtttttttactggtcagatcaca
gctgctggaaaagttcctccagctaagattctgatagttggtggtggtgttgctgggctt
gcttctgcaggcgcagcaaagtcgatgggtgcaattgttcgaggatttgacacaagagct
gcagctttggaacagttcaagtctcttggtgctgagcccttggaggtggacttgaaggaa
tctggtgagggacaaggaggatatgcaaaagagatgtccaaagagttcattgaagctgaa
atgaaactctttgctcaacaatgcaaggaggtagacatccttatcagcacagcacttatt
ccaggtaaaaaagctccagttttatttaataaagaaatgattgagtcaatgaaggaaggt
tcagttgttgtggatttagctgctgaggctggtggaaactttgaaaccactaagccagga
gaactctacattcataagggaattactcacataggctacacagacctgcccagccgaatg
gccactcaggccagcaccctatattccaacaacatcaccaaactcctgaaggccatcagc
ccggacaaagataatttttattttgatgtgaaagatgactttgactttggtacgatgggt
catgtcattagaggaactgtagtgatgaaagatggtaaagtgattttcccagctcccaca
ccgaaaaatattcctcaaggtgccccagtaaaacagaagacagtggctgagctggaagct
gaaaaagcagctaccattacacccttcaggaagacaatgtcaacggcttctgcatataca
gcaggtctcacagggatactgggtttgggcattgcggctcccaatctagccttttctcag
atggtgaccacttttggcttggctggcattgtggggtatcataccgtctggggagtgacc
cctgctctccactcaccactgatgtctgtgacaaatgcaatctcagggctgactgcagtt
ggtgggttggcactgatgggaggacatttgtatccttccacaacttctcagggccttgct
gctcttgctgcattcatatcctctgtcaacattgcaggtggctttctggtgactcagaga
atgctggacatgttcaagcgtcccactgaccccccagaatacaactacctgtacctgctc
cctgccggcacctttgttggtggatatttagctgccctctacagtggttataacattgaa
cagatcatgtacctaggctcgggtttgtgctgtgtcggtgccttggctggcctctccacc
cagggaacagcacgtcttggcaatgcactgggcatgattggggttgctggaggactggca
gccaccctcggagtcctaaaaccgggcccagaattactagctcagatgtctggagcgatg
gctttgggtggtaccattggattgacaattgccaaacgcatccagatttctgatttacct
caattagttgctgcttttcacagtttagtgggtttggcagctgtacttacttgcatagct
gagtacattatagaatatccacattttgctacggatgcagcagcaaatctcaccaagatt
gtggcctacctcggcacttacattggtggcgtcacctttagtgggtctctcattgcctat
ggaaaattgcagggtctcctgaaatctgcccctctcctactgcctggaaggcacttactc
aatgcaggcttactggctgctagtgtgggcgggataatcccattcatggtggacccaagc
tttactactggcatcacctgtctgggttcagtgtctgctctctctgctgtcatgggtgtg
actttgacagctgctattgggggtgctgacatgcccgtcgttatcactgtgctgaacagc
tactcaggctgggccctgtgtgcagagggcttcctgctcaacaacaatctgctgaccatc
gtgggtgcactcataggctcgtctggtgctatcctgtcatacatcatgtgtgtggcaatg
aatcgctccctggctaatgtgattcttggaggctatggcaccacttcaacagctggtgga
aaacccatggaaatttctggcacacatacggaaatcaaccttgacaatgcaattgacatg
attcgagaagctaatagcattattattacaccaggctatggtctctgtgcagccaaagct
caataccccattgctgatttggtaaagatgctcactgagcaaggcaaaaaagtcaggttt
ggaattcacccagttgcaggccgaatgcctggtcagcttaatgtgctgctggctgaggct
ggtgtgccatatgacattgtgttggaaatggatgagatcaaccatgattttccagatact
gatttggtccttgtaattggagctaatgacactgttaattcagcagctcaagaagatccc
aactctattattgcaggcatgccagtccttgaggtctggaaatcaaagcaggtgattgtt
atgaagaggtctttgggtgttggctatgctgcagtggacaatccaatcttctacaaacct
aacacggccatgcttctaggtgatgccaagaaaacatgtgacgcgctccaggcgaaagtt
agagaatcctatcagaagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (37)   
   RefSeq(nuc) (13)   
   GenBank (12)   
   EMBL (12)   
3D Structure (3)   
   PDB (3)   
Protein domain (6)   
   Pfam (6)   
All databases (95)   

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