KEGG   Homo sapiens (human): 65267
Entry
65267             CDS       T01001                                 
Symbol
WNK3, MRXS2, PRKWNK3, PRS
Name
(RefSeq) WNK lysine deficient protein kinase 3
  KO
K08867  WNK lysine deficient protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    65267 (WNK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    65267 (WNK3)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    65267 (WNK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     65267 (WNK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  Wnk family
   65267 (WNK3)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     65267 (WNK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr OSR1_C
Other DBs
NCBI-GeneID: 65267
NCBI-ProteinID: NP_065973
OMIM: 300358
HGNC: 14543
Ensembl: ENSG00000196632
UniProt: Q9BYP7
Structure
Position
X:complement(54192823..54358900)
AA seq 1800 aa
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
NT seq 5403 nt   +upstreamnt  +downstreamnt
atggccactgattcaggggatccagccagcacagaagattctgagaaacctgatggaatt
tcatttgaaaacagagttccccaggtcgctgcaactttgacagtagaagctagactaaag
gagaaaaacagtaccttctctgcttctggggaaactgtagaaaggaagagatttttccga
aagagtgttgaaatgacggaagatgacaaagttgccgaatcatcccccaaagatgagaga
attaaggctgcaatgaatattccaagagtagataagcttccttcaaatgtgttgagaggt
ggacaagaagttaaatatgaacagtgttcaaagtcaacctcagaaatctcaaaagattgt
ttcaaggagaaaaatgaaaaggaaatggaagaagaagcagaaatgaaggctgtagctact
tctcctagtggcagattcctgaaatttgacatagaactaggaagaggagcatttaaaaca
gtatataaaggactggacactgaaacatgggttgaggttgcttggtgtgagctgcaggac
cgaaagttaaccaaagctgagcagcaaagattcaaggaagaagcagagatgttgaagggt
ctccagcaccccaatatagttcgattttatgattcctgggaatctatattaaaaggaaag
aaatgtattgtattagtgactgaactaatgacatctgggaccttaaagacgtacttaaaa
cgatttaaagtcatgaaaccaaaggtcttaaggagctggtgcaggcaaattttaaagggg
ttgcagttcttgcacactaggactcctcctattattcaccgggatctgaagtgtgacaat
attttcatcacgggacccactggatctgtgaagattggtgatctaggattagccacctta
atgcgtacctcatttgctaagagtgtcattggaactcctgagtttatggctccagagatg
tatgaagaacactatgatgaatccgtagatgtttatgcttttggaatgtgtatgctggaa
atggccacatcggagtatccttattctgagtgtcagaatgcagctcaaatataccggaaa
gtaactagtggcataaaaccagccagcttcaataaagtcactgatcctgaagtcaaagaa
atcattgaaggatgtattcgtcaaaacaaatctgaaaggttgtctatcagggacctatta
aaccatgcattttttgctgaggatacaggactgagggtggagttagcagaagaagatgat
tgctcaaattcatcccttgctttaagactctgggttgaagaccctaaaaaattgaaaggc
aaacacaaagacaatgaagctattgaatttagtttcaacttagaaacagatacacctgag
gaagtagcatatgaaatggtcaagtctgggttcttccatgaaagtgattccaaagctgtt
gctaaatccattagagaccgggtgacgccaataaagaagacaagagagaagaagcctgct
ggctgtttggaagaacgcagggattctcagtgcaagtctatggggaatgtattccctcag
ccccagaatacaactttaccccttgctcccgctcagcaaactggggctgaatgtgaagaa
actgaagttgatcaacatgttagacaacagcttctacaaagaaaaccacagcagcactgc
tcctctgttacaggtgacaatttgtctgaggcaggagctgcatcagttatacattcagat
acttcaagtcagcccagtgtagcctattcctcaaatcaaacgatgggctctcaaatggtt
tctaatatcccgcaggctgaagtaaatgttccagggcaaatttattcatctcagcaacta
gtaggacattaccagcaagtttcagggttacagaagcattcaaagctgactcagccgcag
attttgcctttggttcaaggtcagtccactgttttacctgtacatgtccttggaccgaca
gttgtttcacaaccccaggtttccccattaactgttcagaaggtcccacagataaagcct
gtatcccaaccagttggagctgaacaacaagcagctcttctaaaaccagatttagttcga
agcttgaatcaagatgtggcaactacgaaggaaaacgtcagtagccctgataacccaagt
ggaaatggcaaacaggatcggatcaaacagagaagagcttcctgtccccgaccagagaag
gggactaaatttcagcttaccgtccttcaggtatcaacctctggagataacatggtagag
tgtcagctggagacacacaacaacaagatggtcaccttcaagtttgatgttgatggtgat
gcgccagaggatattgcagactatatggttgaagataactttgtgctggaaagtgagaaa
gaaaaatttgtagaagaattgagagctattgtaggtcaagcccaggagatccttcatgtc
cactttgccacagaaagagccactggagttgattctattactgtggactccaacagtagc
cagacagggtcatctgaacaagtacagataaattctacatctactcaaaccagcaatgaa
tctgctcctcagtcatccccagttggtcggtggcgattctgtatcaatcagacgataaga
aaccgtgagactcagtctcctccttctcttcagcattccatgtctgcggttcctggccga
catccacttcctagtccaaaaaacacaagtaataaggaaatatcacgggacacattgctc
actatagaaaataatccatgccaccgtgcacttttcacctccaaatcagaacacaaggat
gtggttgatggtaagatttctgaatgtgctagtgtagaaaccaagcagccagctatactt
tatcaagtggaagataacaggcagataatggcaccagttactaatagttccagttactct
actacttcagttcgtgcagttccagctgaatgtgagggactcaccaaacaagcaagcata
ttcatacctgtgtatccatgtcaccaaactgccagtcaggctgatgcacttatgtcccat
cctggcgaatcaactcagacttctggtaactctcttacaactctggcatttgatcaaaag
cctcaaaccttatcagtacagcagccagctatggatgcagagtttatttctcaagaagga
gaaactacagtgaacactgaagcaagttctcctaagacagtcattcccactcagacccct
ggccttgaaccaactacccttcaacccactactgtcctggaatcagatggagaaagacct
ccaaaactggagtttgcagacaaccgaattaaaactctggatgaaaaattaagaaacttg
ctctatcaggagcacagcatctctagcatctatcccgagagtcagaaggatacccaaagc
atagactctccattttcttcctctgctgaagataccctctcctgtccagtgacagaagtc
atagccatcagtcactgtggaattaaagatagccctgtacaatcccctaatttccaacag
acaggctctaagcttctgtccaatgtggctgcaagtcagcctgctaatatatcagtgttc
aaaagggacctgaatgtgataacttctgtacccagcgaattgtgtttacatgagatgtcc
tcagatgcttcacttccaggggatccagaggcctatcctgctgctgtgtcaagcggtgga
gccattcatctgcagacaggaggtggatattttggcctaagctttacttgtcctagtctc
aaaaatcctattagcaagaaatcctggactcgcaaattaaaaagctgggcatacaggcta
cggcagtcaaccagctttttcaagagatcaaaagtccgtcaagtggaaacagaagagatg
agatcagcaattgctcctgatcccattcctctgacacgggagtccacagctgatactagg
gctttgaatagatgtaaagcgatgagtggatcatttcagcggggtcggttccaggtgatt
acaattcctcagcagcagtcagcaaaaatgacatcttttggaatagaacacatatcagtg
ttcagtgagacaaaccattctagtgaagaagcctttattaaaacagcaaagtctcagttg
gtagaaatagaacctgccacacaaaatccaaaaacttcgttttcttatgagaagttacaa
gctcttcaggaaacctgtaaagaaaataaaggagttcccaaacaaggtgacaacttctta
tctttcagcgcagcttgtgagactgatgtatcttcagtgaccccagaaaaggaatttgaa
gaaacttcagccacaggaagtagcatgcagtctggatctgaactgttgcttaaagagaga
gagatattgactgctgggaaacagcctagctctgatagtgaattttcagccagtcttgct
ggcagtggaaagtcagtggcaaagactggtccagagagtaatcagtgcttaccacaccac
gaagaacaagcttatgctcaaacacagagttcactcttctattcgccatcttccccaatg
agcagtgatgatgaatcagaaatagaggatgaggacttgaaggtggagcttcaaagatta
cgagaaaaacacattcaggaggtggtaaatcttcaaacccagcagaataaggagctgcag
gagctctatgaacgccttcggtcaattaaagatagcaaaacccaatctactgagattcct
ttgccacctgcatcaccacgtcgaccaagatctttcaaaagcaaacttcgaagccgcccc
cagtccttgacacatgtggacaatggcatagttgctacagggaaaagctgccttataaat
gagttggaaaatccactgtgtgtggagagtaatgcagcatcatgccaacagtctccagcc
agtaaaaaagggatgttcacagatgacttacacaagctggtggatgactggacaaaggaa
gcagtaggaaattctcttattaagccaagtttaaaccaacttaaacaaagtcaacacaaa
ctagagacagaaaactggaataaagtatctgaaaatactccgtctactatgggctacaca
tcaacatggatttcttctctgtcccaaatccgtggagctgtcccaacttccttgccacaa
ggactctcactcccttcatttcctgggccattatcatcatatggaatgcctcacgtttgt
cagtataatgctgtggcgggggcggggtatccagtacagtgggtaggaatttcaggaaca
acacaacaatctgtagtaattcccgcccaatctgggggaccattccagccagggatgaat
atgcaggcatttccaacttcatcagtgcagaatcctgccacaatccctcctggtcctaaa
tga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (43)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (41)   
DNA sequence (57)   
   RefSeq(nuc) (41)   
   GenBank (8)   
   EMBL (8)   
3D Structure (8)   
   PDB (8)   
Protein domain (3)   
   Pfam (3)   
All databases (136)   

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