KEGG   PATHWAY: hsa04062Help
Entry
hsa04062                    Pathway                                

Name
Chemokine signaling pathway - Homo sapiens (human)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Chemokine signaling pathway
hsa04062

All organismsOrtholog table
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00540  
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)
H00645  
Incontinentia pigmenti
H00821  
Macular degeneration
H00882  
Cocoon syndrome
H00931  
Growth hormone insensitivity with immunodeficiency
H01109  
Chronic mucocutaneous candidiasis (CMC)
Drug
D03252  
Bosutinib (USAN)
D04696  
Lestaurtinib (USAN/INN)
D06297  
Vicriviroc maleate (USAN)
D06557  
Aplaviroc hydrochloride (USAN)
D06670  
Maraviroc (JAN/INN)
D08524  
Sorafenib (USAN/INN)
D08971  
Plerixafor (USAN/INN)
D08984  
Reparixin (USAN/INN)
D09664  
Saracatinib (USAN/INN)
D09665  
Saracatinib difumarate (USAN)
D09728  
Bosutinib hydrate (JAN)
D09761  
Mogamulizumab (genetical recombination) (JAN)
D09783  
Tofacitinib citrate (JAN/USAN)
D09877  
Carlumab (USAN)
D09959  
Ruxolitinib (USAN/INN)
D09960  
Ruxolitinib phosphate (JAN/USAN)
D09970  
Tofacitinib (USAN)
D10075  
Navarixin (USAN)
D10332  
Elubrixin (USAN)
D10378  
Vercirnon (USAN/INN)
D10379  
Vercirnon sodium (USAN)
D10387  
Danirixin (USAN/INN)
D10420  
Elubrixin tosylate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2919  
CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [KO:K05505]
2920  
CXCL2; chemokine (C-X-C motif) ligand 2 [KO:K05505]
2921  
CXCL3; chemokine (C-X-C motif) ligand 3 [KO:K05505]
6374  
CXCL5; chemokine (C-X-C motif) ligand 5 [KO:K05506]
6372  
CXCL6; chemokine (C-X-C motif) ligand 6 [KO:K05506]
5473  
PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) [KO:K10029]
3576  
CXCL8; chemokine (C-X-C motif) ligand 8 [KO:K10030]
4283  
CXCL9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
3627  
CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
6373  
CXCL11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
6387  
CXCL12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
10563  
CXCL13; chemokine (C-X-C motif) ligand 13 [KO:K10032]
58191  
CXCL16; chemokine (C-X-C motif) ligand 16 [KO:K10035]
5196  
PF4; platelet factor 4 [KO:K05407]
5197  
PF4V1; platelet factor 4 variant 1 [KO:K05407]
9547  
CXCL14; chemokine (C-X-C motif) ligand 14 [KO:K10033]
6375  
XCL1; chemokine (C motif) ligand 1 [KO:K05507]
6846  
XCL2; chemokine (C motif) ligand 2 [KO:K05507]
6376  
CX3CL1; chemokine (C-X3-C motif) ligand 1 [KO:K05508]
6347  
CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
6348  
CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
6349  
CCL3L1; chemokine (C-C motif) ligand 3-like 1 [KO:K05408]
414062  
CCL3L3; chemokine (C-C motif) ligand 3-like 3 [KO:K05408]
6351  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
9560  
CCL4L2; chemokine (C-C motif) ligand 4-like 2 [KO:K12964]
388372  
CCL4L1; chemokine (C-C motif) ligand 4-like 1 [KO:K12964]
6352  
CCL5; chemokine (C-C motif) ligand 5 [KO:K12499]
6354  
CCL7; chemokine (C-C motif) ligand 7 [KO:K05509]
6355  
CCL8; chemokine (C-C motif) ligand 8 [KO:K16596]
6356  
CCL11; chemokine (C-C motif) ligand 11 [KO:K16597]
6357  
CCL13; chemokine (C-C motif) ligand 13 [KO:K16595]
6359  
CCL15; chemokine (C-C motif) ligand 15 [KO:K05511]
6368  
CCL23; chemokine (C-C motif) ligand 23 [KO:K05511]
6363  
CCL19; chemokine (C-C motif) ligand 19 [KO:K05512]
6364  
CCL20; chemokine (C-C motif) ligand 20 [KO:K14625]
6366  
CCL21; chemokine (C-C motif) ligand 21 [KO:K16062]
6370  
CCL25; chemokine (C-C motif) ligand 25 [KO:K13072]
10850  
CCL27; chemokine (C-C motif) ligand 27 [KO:K16598]
56477  
CCL28; chemokine (C-C motif) ligand 28 [KO:K05513]
6346  
CCL1; chemokine (C-C motif) ligand 1 [KO:K05514]
6358  
CCL14; chemokine (C-C motif) ligand 14 [KO:K05514]
6360  
CCL16; chemokine (C-C motif) ligand 16 [KO:K05514]
6361  
CCL17; chemokine (C-C motif) ligand 17 [KO:K05514]
6362  
CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) [KO:K05514]
6367  
CCL22; chemokine (C-C motif) ligand 22 [KO:K05514]
6369  
CCL24; chemokine (C-C motif) ligand 24 [KO:K05514]
10344  
CCL26; chemokine (C-C motif) ligand 26 [KO:K05514]
3579  
CXCR2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
3577  
CXCR1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
2833  
CXCR3; chemokine (C-X-C motif) receptor 3 [KO:K04188]
7852  
CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
643  
CXCR5; chemokine (C-X-C motif) receptor 5 [KO:K04190]
10663  
CXCR6; chemokine (C-X-C motif) receptor 6 [KO:K04191]
2829  
XCR1; chemokine (C motif) receptor 1 [KO:K04193]
1524  
CX3CR1; chemokine (C-X3-C motif) receptor 1 [KO:K04192]
1237  
CCR8; chemokine (C-C motif) receptor 8 [KO:K04183]
1235  
CCR6; chemokine (C-C motif) receptor 6 [KO:K04181]
10803  
CCR9; chemokine (C-C motif) receptor 9 [KO:K04184]
1233  
CCR4; chemokine (C-C motif) receptor 4 [KO:K04179]
1236  
CCR7; chemokine (C-C motif) receptor 7 [KO:K04182]
729230  
CCR2; chemokine (C-C motif) receptor 2 [KO:K04177]
1234  
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene) [KO:K04180]
1230  
CCR1; chemokine (C-C motif) receptor 1 [KO:K04176]
1232  
CCR3; chemokine (C-C motif) receptor 3 [KO:K04178]
2826  
CCR10; chemokine (C-C motif) receptor 10 [KO:K04185]
3717  
JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
3718  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
6772  
STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
6773  
STAT2; signal transducer and activator of transcription 2, 113kDa [KO:K11221]
6774  
STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
6777  
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
2770  
GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [KO:K04630]
2773  
GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
2771  
GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
107  
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108  
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
4067  
LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
3055  
HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
2268  
FGR; FGR proto-oncogene, Src family tyrosine kinase [KO:K08891] [EC:2.7.10.2]
6714  
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
6464  
SHC1; SHC (Src homology 2 domain containing) transforming protein 1 [KO:K06279]
25759  
SHC2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K17447]
53358  
SHC3; SHC (Src homology 2 domain containing) transforming protein 3 [KO:K17448]
399694  
SHC4; SHC (Src homology 2 domain containing) family, member 4 [KO:K17449]
2885  
GRB2; growth factor receptor-bound protein 2 [KO:K04364]
6654  
SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
6655  
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
2309  
FOXO3; forkhead box O3 [KO:K09408]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
4792  
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
4793  
NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
4790  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
5970  
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
2931  
GSK3A; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
3702  
ITK; IL2-inducible T-cell kinase [KO:K07363] [EC:2.7.10.2]
10451  
VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
7409  
VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
7410  
VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5058  
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
998  
CDC42; cell division cycle 42 [KO:K04393]
7454  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
8976  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
387  
RHOA; ras homolog family member A [KO:K04513]
6093  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
2782  
GNB1; guanine nucleotide binding protein (G protein), beta polypeptide 1 [KO:K04536]
2783  
GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 [KO:K04537]
2784  
GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 [KO:K07825]
59345  
GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4 [KO:K04538]
10681  
GNB5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
54331  
GNG2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
2785  
GNG3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
2786  
GNG4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
2787  
GNG5; guanine nucleotide binding protein (G protein), gamma 5 [KO:K04542]
2788  
GNG7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
94235  
GNG8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
2790  
GNG10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
2791  
GNG11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
55970  
GNG12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
648044  
guanine nucleotide binding protein (G protein); K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
51764  
GNG13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
2792  
GNGT1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
2793  
GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
57580  
PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [KO:K12365]
9844  
ELMO1; engulfment and cell motility 1 [KO:K12366]
1794  
DOCK2; dedicator of cytokinesis 2 [KO:K12367]
5747  
PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
5829  
PXN; paxillin [KO:K05760]
9564  
BCAR1; breast cancer anti-estrogen resistance 1 [KO:K05726]
1398  
CRK; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
1399  
CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
2185  
PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
23236  
PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
10235  
RASGRP2; RAS guanyl releasing protein 2 (calcium and DAG-regulated) [KO:K12361]
5906  
RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
5908  
RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
56288  
PARD3; par-3 family cell polarity regulator [KO:K04237]
7074  
TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
653361  
NCF1; neutrophil cytosolic factor 1 [KO:K08011]
131890  
GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
6011  
GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
156  
ADRBK1; adrenergic, beta, receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
157  
ADRBK2; adrenergic, beta, receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
2868  
GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
2869  
GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
2870  
GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
408  
ARRB1; arrestin, beta 1 [KO:K04439]
409  
ARRB2; arrestin, beta 2 [KO:K04439]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5580  
PRKCD; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
5590  
PRKCZ; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
Reference
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
Reference
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
Reference
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
Reference
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
Reference
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
Reference
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
Reference
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
Reference
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
Reference
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
Reference
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
Reference
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
Reference
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
Reference
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
Reference
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
Reference
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
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Ann Biomed Eng 30:356-70 (2002)
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J Immunol 179:2223-7 (2007)
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KO pathway
 

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