KEGG PATHWAY: hsa04144

PATHWAY: hsa04144

Entry

hsa04144 Pathway

Name

Endocytosis - Homo sapiens (human)

Description

Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.

Class

Cellular Processes; Transport and catabolism

Pathway map

hsa04144

Endocytosis

Module

hsa_M00408	ESCRT-0 complex [PATH:hsa04144]
hsa_M00409	ESCRT-I complex [PATH:hsa04144]
hsa_M00410	ESCRT-II complex [PATH:hsa04144]
hsa_M00412	ESCRT-III complex [PATH:hsa04144]

Disease

H00078	Frontotemporal lobar degeneration (FTLD)
H00155	Hypercholesterolemia
H00567	Caveolinopathies
H00593	Limb-girdle muscular dystrophy (LGMD)
H00642	Lacrimo-auriculo-dento-digital syndrome (LADD)
H00700	Centronuclear myopathy
H00800	Loeys-Dietz syndrome (LDS)
H00865	Lethal congenital contractural syndrome (LCCS)
H01202	Cataract
H01232	Syndromic multisystem autoimmune disease
H01295	Neurodegeneration due to cerebral folate transport deficiency

Drug

D00095	Adrenaline (JP16)
D00598	Betaxolol hydrochloride (JP16/USP)
D00599	Carteolol hydrochloride (JP16/USP)
D00603	Timolol maleate (JP16/USP)
D00684	Bitolterol mesilate (JAN)
D00685	Orciprenaline sulfate (JP16)
D00686	Pirbuterol acetate (USAN)
D00687	Salmeterol xinafoate (JAN/USAN)
D00688	Terbutaline sulfate (JP16/USP)
D01025	Levobunolol hydrochloride (JAN/USP)
D01349	Pirbuterol hydrochloride (JAN/USAN)
D01360	Clenbuterol hydrochloride (JAN/USP)
D01362	Tulobuterol hydrochloride (JP16)
D01373	Formoterol fumarate (USAN)
D01428	Fenoterol hydrobromide (JAN)
D01589	Mabuterol hydrochloride (JAN)
D01635	Methoxyphenamine hydrochloride (JAN)
D01691	Nipradilol (JAN/INN)
D01748	Isoxsuprine hydrochloride (JP16/USP)
D01835	Clorprenaline hydrochloride (JAN/USAN)
D01978	Trimetoquinol hydrochloride
D02093	Isoetharine hydrochloride (USP)
D02147	Albuterol (USP)
D02151	Tulobuterol (JAN/INN)
D02281	Levalbuterol hydrochloride (USAN)
D02396	Hexoprenaline sulfate (USAN)
D02404	Procaterol hydrochloride (USAN)
D02981	Arformoterol tartrate (USAN)
D03058	Basiliximab (genetical recombination) (JAN)
D03198	Butoxamine hydrochloride (USAN)
D03210	Ancriviroc (USAN/INN)
D03297	Mecasermin (genetical recombination) (JAN)
D03402	Carbuterol hydrochloride (USAN)
D03587	Colterol mesylate (USAN)
D03639	Daclizumab (USAN/INN)
D03682	Denileukin diftitox (USAN/INN)
D03891	Dopexamine (USAN/INN)
D04157	Fenoterol (USAN/INN)
D04625	Isoetharine (USP)
D04626	Isoetharine mesylate (USP)
D04701	Levalbuterol sulfate (USAN)
D04703	Levalbuterol tartrate (USAN)
D04710	Levobetaxolol hydrochloride (USAN)
D04870	Mecasermin rinfabate (USAN/INN)
D04954	Metaproterenol polistirex (USAN)
D05037	Trimetoquinol hydrochloride hydrate (JP16)
D05277	Formoterol fumarate hydrate (JP16)
D05366	Procaterol hydrochloride hydrate (JP16)
D05476	Picumeterol fumarate (USAN)
D05691	Ractopamine hydrochloride (USAN)
D05718	Reproterol hydrochloride (USAN)
D05730	Rimiterol hydrobromide (USAN)
D05792	Salmeterol (USAN/INN)
D05832	Sibenadet hydrochloride (USAN)
D05879	Solabegron hydrochloride (USAN)
D05902	Soterenol hydrochloride (USAN)
D06297	Vicriviroc maleate (USAN)
D06374	Zinterol hydrochloride (USAN)
D06557	Aplaviroc hydrochloride (USAN)
D06670	Maraviroc (JAN/INN)
D07377	Bambuterol (INN)
D07463	Arformoterol (INN)
D07489	Bambuterol hydrochloride
D07526	Betaxolol (INN)
D07534	Bitolterol (INN)
D07608	Carazolol (INN)
D07624	Carteolol (INN)
D07713	Clenbuterol (INN)
D07990	Formoterol (INN)
D08039	Hexoprenaline (INN)
D08092	Isoxsuprine (INN)
D08093	Isoxsuprine lactate
D08115	Levobunolol (INN)
D08124	Levosalbutamol (INN)
D08300	Orciprenaline (INN)
D08387	Pirbuterol (INN)
D08424	Procaterol (INN)
D08474	Reproterol (INN)
D08570	Terbutaline (INN)
D08629	Tretoquinol (INN)
D09318	Indacaterol (USAN/INN)
D09319	Indacaterol maleate (JAN/USAN)
D09535	Mirabegron (USAN/JAN)
D09732	Ritobegron ethyl hydrochloride (JAN)
D09926	Icrucumab (USAN/INN)

Other DBs

BSID:

102279

GO:

0006897

Organism

Homo sapiens (human) [GN:hsa]

Gene

7040	TGFB1; transforming growth factor, beta 1 [KO:K13375]
7042	TGFB2; transforming growth factor, beta 2 [KO:K13376]
7043	TGFB3; transforming growth factor, beta 3 [KO:K13377]
7046	TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048	TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
9372	ZFYVE9; zinc finger, FYVE domain containing 9 [KO:K04679]
9765	ZFYVE16; zinc finger, FYVE domain containing 16 [KO:K04679]
5371	PML; promyelocytic leukemia [KO:K10054]
4087	SMAD2; SMAD family member 2 [KO:K04500]
4088	SMAD3; SMAD family member 3 [KO:K04500]
7037	TFRC; transferrin receptor (p90, CD71) [KO:K06503]
1956	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2321	FLT1; fms-related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
3791	KDR; kinase insert domain receptor (a type III receptor tyrosine kinase) [KO:K05098] [EC:2.7.10.1]
5156	PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
2263	FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261	FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264	FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
3480	IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
4233	MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
4914	NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
2065	ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [KO:K05084] [EC:2.7.10.1]
2066	ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [KO:K05085] [EC:2.7.10.1]
3815	KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO:K05091] [EC:2.7.10.1]
5979	RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
1436	CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
1950	EGF; epidermal growth factor [KO:K04357]
1759	DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785	DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
26052	DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
382	ARF6; ADP-ribosylation factor 6 [KO:K07941]
23396	PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394	PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395	PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
138429	PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like 1 [KO:K13712] [EC:2.7.1.68]
5337	PLD1; phospholipase D1, phosphatidylcholine-specific [KO:K01115] [EC:3.1.4.4]
5338	PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
1211	CLTA; clathrin, light chain A [KO:K04644]
1212	CLTB; clathrin, light chain B [KO:K04645]
1213	CLTC; clathrin, heavy chain (Hc) [KO:K04646]
8218	CLTCL1; clathrin, heavy chain-like 1 [KO:K04646]
161	AP2A2; adaptor-related protein complex 2, alpha 2 subunit [KO:K11824]
160	AP2A1; adaptor-related protein complex 2, alpha 1 subunit [KO:K11824]
163	AP2B1; adaptor-related protein complex 2, beta 1 subunit [KO:K11825]
1173	AP2M1; adaptor-related protein complex 2, mu 1 subunit [KO:K11826]
1175	AP2S1; adaptor-related protein complex 2, sigma 1 subunit [KO:K11827]
30846	EHD2; EH-domain containing 2 [KO:K12469]
23624	CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C [KO:K04707] [EC:6.3.2.19]
867	CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
868	CBLB; Cbl proto-oncogene, E3 ubiquitin protein ligase B [KO:K04707] [EC:6.3.2.19]
4734	NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:6.3.2.19]
23327	NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:6.3.2.19]
4193	MDM2; MDM2 oncogene, E3 ubiquitin protein ligase [KO:K06643] [EC:6.3.2.19]
7189	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
10193	RNF41; ring finger protein 41 [KO:K11981] [EC:6.3.2.19]
83737	ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:6.3.2.19]
57154	SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
64750	SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
11059	WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
30011	SH3KBP1; SH3-domain kinase binding protein 1 [KO:K12470]
6457	SH3GL3; SH3-domain GRB2-like 3 [KO:K11247]
6456	SH3GL2; SH3-domain GRB2-like 2 [KO:K11247]
6455	SH3GL1; SH3-domain GRB2-like 1 [KO:K11247]
51100	SH3GLB1; SH3-domain GRB2-like endophilin B1 [KO:K11248]
56904	SH3GLB2; SH3-domain GRB2-like endophilin B2 [KO:K11248]
29924	EPN1; epsin 1 [KO:K12471]
55040	EPN3; epsin 3 [KO:K12471]
22905	EPN2; epsin 2 [KO:K12471]
2060	EPS15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
3949	LDLR; low density lipoprotein receptor [KO:K12473]
26119	LDLRAP1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
1601	DAB2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) [KO:K12475]
1234	CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene) [KO:K04180]
3577	CXCR1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
3579	CXCR2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
7852	CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
2149	F2R; coagulation factor II (thrombin) receptor [KO:K03914]
153	ADRB1; adrenoceptor beta 1 [KO:K04141]
154	ADRB2; adrenoceptor beta 2, surface [KO:K04142]
155	ADRB3; adrenoceptor beta 3 [KO:K04143]
131890	GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
6011	GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
156	ADRBK1; adrenergic, beta, receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
157	ADRBK2; adrenergic, beta, receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
2868	GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
2869	GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
2870	GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
408	ARRB1; arrestin, beta 1 [KO:K04439]
409	ARRB2; arrestin, beta 2 [KO:K04439]
4091	SMAD6; SMAD family member 6 [KO:K04677]
4092	SMAD7; SMAD family member 7 [KO:K04677]
2348	FOLR1; folate receptor 1 (adult) [KO:K13649]
2350	FOLR2; folate receptor 2 (fetal) [KO:K13649]
2352	FOLR3; folate receptor 3 (gamma) [KO:K13649]
390243	FOLR4; folate receptor 4, delta (putative) [KO:K13649]
857	CAV1; caveolin 1, caveolae protein, 22kDa [KO:K06278]
858	CAV2; caveolin 2 [KO:K12958]
859	CAV3; caveolin 3 [KO:K12959]
3105	HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106	HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107	HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134	HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135	HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133	HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3559	IL2RA; interleukin 2 receptor, alpha [KO:K05068]
3560	IL2RB; interleukin 2 receptor, beta [KO:K05069]
3561	IL2RG; interleukin 2 receptor, gamma [KO:K05070]
6714	SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
3265	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
387	RHOA; ras homolog family member A [KO:K04513]
3312	HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303	HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306	HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305	HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304	HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310	HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
9829	DNAJC6; DnaJ (Hsp40) homolog, subfamily C, member 6 [KO:K09526]
9101	USP8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.1.2.15]
10617	STAMBP; STAM binding protein [KO:K11866] [EC:3.1.2.15]
7879	RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
9146	HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
10254	STAM2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705]
8027	STAM; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705]
7251	TSG101; tumor susceptibility gene 101 [KO:K12183]
93343	MVB12A; multivesicular body subunit 12A [KO:K12186]
89853	MVB12B; multivesicular body subunit 12B [KO:K12186]
51160	VPS28; vacuolar protein sorting 28 homolog (S. cerevisiae) [KO:K12184]
155382	VPS37D; vacuolar protein sorting 37 homolog D (S. cerevisiae) [KO:K12185]
137492	VPS37A; vacuolar protein sorting 37 homolog A (S. cerevisiae) [KO:K12185]
79720	VPS37B; vacuolar protein sorting 37 homolog B (S. cerevisiae) [KO:K12185]
55048	VPS37C; vacuolar protein sorting 37 homolog C (S. cerevisiae) [KO:K12185]
11267	SNF8; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) [KO:K12188]
51028	VPS36; vacuolar protein sorting 36 homolog (S. cerevisiae) [KO:K12190]
84313	VPS25; vacuolar protein sorting 25 homolog (S. cerevisiae) [KO:K12189]
79643	CHMP6; charged multivesicular body protein 6 [KO:K12195]
92421	CHMP4C; charged multivesicular body protein 4C [KO:K12194]
128866	CHMP4B; charged multivesicular body protein 4B [KO:K12194]
29082	CHMP4A; charged multivesicular body protein 4A [KO:K12194]
51652	CHMP3; charged multivesicular body protein 3 [KO:K12193]
100526767	RNF103-CHMP3; RNF103-CHMP3 readthrough [KO:K12193]
27243	CHMP2A; charged multivesicular body protein 2A [KO:K12191]
25978	CHMP2B; charged multivesicular body protein 2B [KO:K12192]
91782	CHMP7; charged multivesicular body protein 7 [KO:K15053]
9525	VPS4B; vacuolar protein sorting 4 homolog B (S. cerevisiae) [KO:K12196]
27183	VPS4A; vacuolar protein sorting 4 homolog A (S. cerevisiae) [KO:K12196]
51534	VTA1; Vps20-associated 1 homolog (S. cerevisiae) [KO:K12199]
57132	CHMP1B; charged multivesicular body protein 1B [KO:K12197]
51510	CHMP5; charged multivesicular body protein 5 [KO:K12198]
10015	PDCD6IP; programmed cell death 6 interacting protein [KO:K12200]
30845	EHD3; EH-domain containing 3 [KO:K12476]
30844	EHD4; EH-domain containing 4 [KO:K12477]
8411	EEA1; early endosome antigen 1 [KO:K12478]
5868	RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869	RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878	RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
11311	VPS45; vacuolar protein sorting 45 homolog (S. cerevisiae) [KO:K12479]
9135	RABEP1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
64145	ZFYVE20; zinc finger, FYVE domain containing 20 [KO:K12481]
5867	RAB4A; RAB4A, member RAS oncogene family [KO:K07879]
80230	RUFY1; RUN and FYVE domain containing 1 [KO:K12482]
10938	EHD1; EH-domain containing 1 [KO:K12483]
8766	RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
9230	RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
22841	RAB11FIP2; RAB11 family interacting protein 2 (class I) [KO:K12484]
80223	RAB11FIP1; RAB11 family interacting protein 1 (class I) [KO:K12484]
26056	RAB11FIP5; RAB11 family interacting protein 5 (class I) [KO:K12484]
84440	RAB11FIP4; RAB11 family interacting protein 4 (class II) [KO:K12485]
9727	RAB11FIP3; RAB11 family interacting protein 3 (class II) [KO:K12485]
57403	RAB22A; RAB22A, member RAS oncogene family [KO:K07891]
11031	RAB31; RAB31, member RAS oncogene family [KO:K07892]
56288	PARD3; par-3 partitioning defective 3 homolog (C. elegans) [KO:K04237]
50855	PARD6A; par-6 partitioning defective 6 homolog alpha (C. elegans) [KO:K06093]
84552	PARD6G; par-6 partitioning defective 6 homolog gamma (C. elegans) [KO:K06093]
84612	PARD6B; par-6 partitioning defective 6 homolog beta (C. elegans) [KO:K06093]
5584	PRKCI; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
5590	PRKCZ; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
998	CDC42; cell division cycle 42 [KO:K04393]
64744	SMAP2; small ArfGAP2 [KO:K12486]
60682	SMAP1; small ArfGAP 1 [KO:K12486]
28964	GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 [KO:K05737]
9815	GIT2; G protein-coupled receptor kinase interacting ArfGAP 2 [KO:K12487]
50807	ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
55616	ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
8853	ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
116983	ACAP3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
23527	ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
9744	ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
116985	ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K12490]
116984	ARAP2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K12490]
64411	ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
116986	AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K12491]
116987	AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
116988	AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
55738	ARFGAP1; ADP-ribosylation factor GTPase activating protein 1 [KO:K12492]
26286	ARFGAP3; ADP-ribosylation factor GTPase activating protein 3 [KO:K12493]
84364	ARFGAP2; ADP-ribosylation factor GTPase activating protein 2 [KO:K12493]
23362	PSD3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
23550	PSD4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
5662	PSD; pleckstrin and Sec7 domain containing [KO:K12494]
84249	PSD2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
23096	IQSEC2; IQ motif and Sec7 domain 2 [KO:K12495]
9922	IQSEC1; IQ motif and Sec7 domain 1 [KO:K12495]
440073	IQSEC3; IQ motif and Sec7 domain 3 [KO:K12495]

Compound

C00002	ATP
C00008	ADP
C00504	Folate
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637	1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981	Phosphatidylinositol-3,4,5-trisphosphate
G00110	GM1

Reference

PMID:19007773

Authors

Acconcia F, Sigismund S, Polo S

Title

Ubiquitin in trafficking: the network at work.

Journal

Exp Cell Res 315:1610-8 (2009)

Reference

PMID:18647649

Authors

Donaldson JG, Porat-Shliom N, Cohen LA

Title

Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.

Journal

Cell Signal 21:1-6 (2009)

Reference

PMID:15261671

Authors

Sorkin A

Title

Cargo recognition during clathrin-mediated endocytosis: a team effort.

Journal

Curr Opin Cell Biol 16:392-9 (2004)

Reference

PMID:19325624

Authors

Raiborg C, Stenmark H

Title

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.

Journal

Nature 458:445-52 (2009)

Reference

(Japanese)

Authors

Ohno H, Yoshimori T (eds).

Title

[Current Stream in Membrane Traffic] (in Japanese)

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Tanpakushitsu Kakusan Koso 53 (2008)

Reference

PMID:20110990

Authors

Scita G, Di Fiore PP

Title

The endocytic matrix.

Journal

Nature 463:464-73 (2010)

Reference

PMID:15687999

Authors

Le Roy C, Wrana JL

Title

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.

Journal

Nat Rev Mol Cell Biol 6:112-26 (2005)

Reference

PMID:19924646

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Jovic M, Sharma M, Rahajeng J, Caplan S

Title

The early endosome: a busy sorting station for proteins at the crossroads.

Journal

Histol Histopathol 25:99-112 (2010)

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PMID:16203612

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Pietiainen VM, Marjomaki V, Heino J, Hyypia T

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Viral entry, lipid rafts and caveosomes.

Journal

Ann Med 37:394-403 (2005)

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