KEGG   PATHWAY: hsa04144Help
Entry
hsa04144                    Pathway                                

Name
Endocytosis - Homo sapiens (human)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Endocytosis
hsa04144

All organismsOrtholog table
Module
ESCRT-0 complex [PATH:hsa04144]
ESCRT-I complex [PATH:hsa04144]
ESCRT-II complex [PATH:hsa04144]
ESCRT-III complex [PATH:hsa04144]
Disease
H00078  
Frontotemporal lobar degeneration (FTLD)
H00155  
Hypercholesterolemia
H00265  
Hereditary sensory and autonomic neuropathy (HSAN)
H00567  
Caveolinopathies
H00593  
Limb-girdle muscular dystrophy (LGMD)
H00642  
Lacrimo-auriculo-dento-digital syndrome (LADD)
H00700  
Centronuclear myopathy
H00800  
Loeys-Dietz syndrome (LDS)
H00865  
Lethal congenital contractural syndrome (LCCS)
H01202  
Cataract
H01232  
Syndromic multisystem autoimmune disease
H01295  
Neurodegeneration due to cerebral folate transport deficiency
H01383  
LDL Receptor Disorder
Drug
D00095  
Adrenaline (JP16)
D00598  
Betaxolol hydrochloride (JP16/USP)
D00599  
Carteolol hydrochloride (JP16/USP)
D00603  
Timolol maleate (JP16/USP)
D00684  
Bitolterol mesilate (JAN)
D00685  
Orciprenaline sulfate (JP16)
D00686  
Pirbuterol acetate (USAN)
D00687  
Salmeterol xinafoate (JAN/USAN)
D00688  
Terbutaline sulfate (JP16/USP)
D01025  
Levobunolol hydrochloride (JAN/USP)
D01349  
Pirbuterol hydrochloride (JAN/USAN)
D01360  
Clenbuterol hydrochloride (JAN/USP)
D01362  
Tulobuterol hydrochloride (JP16)
D01373  
Formoterol fumarate (USAN)
D01428  
Fenoterol hydrobromide (JAN)
D01589  
Mabuterol hydrochloride (JAN)
D01635  
Methoxyphenamine hydrochloride (JAN)
D01691  
Nipradilol (JAN/INN)
D01748  
Isoxsuprine hydrochloride (JP16/USP)
D01835  
Clorprenaline hydrochloride (JAN/USAN)
D01978  
Trimetoquinol hydrochloride
D02093  
Isoetharine hydrochloride (USP)
D02147  
Albuterol (USP)
D02151  
Tulobuterol (JAN/INN)
D02281  
Levalbuterol hydrochloride (USAN)
D02396  
Hexoprenaline sulfate (USAN)
D02404  
Procaterol hydrochloride (USAN)
D02981  
Arformoterol tartrate (USAN)
D03058  
Basiliximab (genetical recombination) (JAN)
D03198  
Butoxamine hydrochloride (USAN)
D03210  
Ancriviroc (USAN/INN)
D03297  
Mecasermin (genetical recombination) (JAN)
D03402  
Carbuterol hydrochloride (USAN)
D03587  
Colterol mesylate (USAN)
D03639  
Daclizumab (USAN/INN)
D03682  
Denileukin diftitox (USAN/INN)
D03891  
Dopexamine (USAN/INN)
D04157  
Fenoterol (USAN/INN)
D04625  
Isoetharine (USP)
D04626  
Isoetharine mesylate (USP)
D04701  
Levalbuterol sulfate (USAN)
D04703  
Levalbuterol tartrate (USAN)
D04710  
Levobetaxolol hydrochloride (USAN)
D04870  
Mecasermin rinfabate (USAN/INN)
D04954  
Metaproterenol polistirex (USAN)
D05037  
Trimetoquinol hydrochloride hydrate (JP16)
D05277  
Formoterol fumarate hydrate (JP16)
D05366  
Procaterol hydrochloride hydrate (JP16)
D05476  
Picumeterol fumarate (USAN)
D05691  
Ractopamine hydrochloride (USAN)
D05718  
Reproterol hydrochloride (USAN)
D05730  
Rimiterol hydrobromide (USAN)
D05792  
Salmeterol (USAN/INN)
D05832  
Sibenadet hydrochloride (USAN)
D05879  
Solabegron hydrochloride (USAN)
D05902  
Soterenol hydrochloride (USAN)
D06297  
Vicriviroc maleate (USAN)
D06374  
Zinterol hydrochloride (USAN)
D06557  
Aplaviroc hydrochloride (USAN)
D06670  
Maraviroc (JAN/INN)
D07377  
Bambuterol (INN)
D07463  
Arformoterol (INN)
D07489  
Bambuterol hydrochloride
D07526  
Betaxolol (INN)
D07534  
Bitolterol (INN)
D07608  
Carazolol (INN)
D07624  
Carteolol (INN)
D07713  
Clenbuterol (INN)
D07990  
Formoterol (INN)
D08039  
Hexoprenaline (INN)
D08092  
Isoxsuprine (INN)
D08093  
Isoxsuprine lactate
D08115  
Levobunolol (INN)
D08124  
Levosalbutamol (INN)
D08300  
Orciprenaline (INN)
D08387  
Pirbuterol (INN)
D08424  
Procaterol (INN)
D08474  
Reproterol (INN)
D08570  
Terbutaline (INN)
D08629  
Tretoquinol (INN)
D09318  
Indacaterol (USAN/INN)
D09319  
Indacaterol maleate (JAN/USAN)
D09535  
Mirabegron (USAN/JAN)
D09732  
Ritobegron ethyl hydrochloride (JAN)
D09926  
Icrucumab (USAN/INN)
D10434  
Vintafolide (USAN/INN)
D10465  
Golvatinib tartrate (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
7040  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
7042  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
7043  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
7046  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
9372  
ZFYVE9; zinc finger, FYVE domain containing 9 [KO:K04679]
9765  
ZFYVE16; zinc finger, FYVE domain containing 16 [KO:K04679]
5371  
PML; promyelocytic leukemia [KO:K10054]
4087  
SMAD2; SMAD family member 2 [KO:K04500]
4088  
SMAD3; SMAD family member 3 [KO:K04500]
7037  
TFRC; transferrin receptor [KO:K06503]
1956  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2321  
FLT1; fms-related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
3791  
KDR; kinase insert domain receptor (a type III receptor tyrosine kinase) [KO:K05098] [EC:2.7.10.1]
5156  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
2263  
FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261  
FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264  
FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
3480  
IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
4233  
MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
4914  
NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
2065  
ERBB3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 [KO:K05084] [EC:2.7.10.1]
2066  
ERBB4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 [KO:K05085] [EC:2.7.10.1]
3815  
KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO:K05091] [EC:2.7.10.1]
5979  
RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
1436  
CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
1950  
EGF; epidermal growth factor [KO:K04357]
1759  
DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
1785  
DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
26052  
DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
382  
ARF6; ADP-ribosylation factor 6 [KO:K07941]
23396  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
8394  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
8395  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
138429  
PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase-like 1 [KO:K13712] [EC:2.7.1.68]
5337  
PLD1; phospholipase D1, phosphatidylcholine-specific [KO:K01115] [EC:3.1.4.4]
5338  
PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
1211  
CLTA; clathrin, light chain A [KO:K04644]
1212  
CLTB; clathrin, light chain B [KO:K04645]
1213  
CLTC; clathrin, heavy chain (Hc) [KO:K04646]
8218  
CLTCL1; clathrin, heavy chain-like 1 [KO:K04646]
161  
AP2A2; adaptor-related protein complex 2, alpha 2 subunit [KO:K11824]
160  
AP2A1; adaptor-related protein complex 2, alpha 1 subunit [KO:K11824]
163  
AP2B1; adaptor-related protein complex 2, beta 1 subunit [KO:K11825]
1173  
AP2M1; adaptor-related protein complex 2, mu 1 subunit [KO:K11826]
1175  
AP2S1; adaptor-related protein complex 2, sigma 1 subunit [KO:K11827]
30846  
EHD2; EH-domain containing 2 [KO:K12469]
23624  
CBLC; Cbl proto-oncogene C, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
867  
CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
868  
CBLB; Cbl proto-oncogene B, E3 ubiquitin protein ligase [KO:K04707] [EC:6.3.2.19]
4734  
NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:6.3.2.19]
23327  
NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:6.3.2.19]
4193  
MDM2; MDM2 proto-oncogene, E3 ubiquitin protein ligase [KO:K06643] [EC:6.3.2.19]
7189  
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
10193  
RNF41; ring finger protein 41, E3 ubiquitin protein ligase [KO:K11981] [EC:6.3.2.19]
83737  
ITCH; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:6.3.2.19]
57154  
SMURF1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:6.3.2.19]
64750  
SMURF2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:6.3.2.19]
11059  
WWP1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:6.3.2.19]
30011  
SH3KBP1; SH3-domain kinase binding protein 1 [KO:K12470]
6457  
SH3GL3; SH3-domain GRB2-like 3 [KO:K11247]
6456  
SH3GL2; SH3-domain GRB2-like 2 [KO:K11247]
6455  
SH3GL1; SH3-domain GRB2-like 1 [KO:K11247]
51100  
SH3GLB1; SH3-domain GRB2-like endophilin B1 [KO:K11248]
56904  
SH3GLB2; SH3-domain GRB2-like endophilin B2 [KO:K11248]
29924  
EPN1; epsin 1 [KO:K12471]
55040  
EPN3; epsin 3 [KO:K12471]
22905  
EPN2; epsin 2 [KO:K12471]
2060  
EPS15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
3949  
LDLR; low density lipoprotein receptor [KO:K12473]
26119  
LDLRAP1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
1601  
DAB2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) [KO:K12475]
1234  
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene) [KO:K04180]
3577  
CXCR1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
3579  
CXCR2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
7852  
CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
2149  
F2R; coagulation factor II (thrombin) receptor [KO:K03914]
153  
ADRB1; adrenoceptor beta 1 [KO:K04141]
154  
ADRB2; adrenoceptor beta 2, surface [KO:K04142]
155  
ADRB3; adrenoceptor beta 3 [KO:K04143]
131890  
GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
6011  
GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
156  
ADRBK1; adrenergic, beta, receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
157  
ADRBK2; adrenergic, beta, receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
2868  
GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
2869  
GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
2870  
GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
408  
ARRB1; arrestin, beta 1 [KO:K04439]
409  
ARRB2; arrestin, beta 2 [KO:K04439]
4091  
SMAD6; SMAD family member 6 [KO:K04677]
4092  
SMAD7; SMAD family member 7 [KO:K04677]
2348  
FOLR1; folate receptor 1 (adult) [KO:K13649]
2350  
FOLR2; folate receptor 2 (fetal) [KO:K13649]
2352  
FOLR3; folate receptor 3 (gamma) [KO:K13649]
390243  
FOLR4; folate receptor 4, delta (putative) [KO:K13649]
857  
CAV1; caveolin 1, caveolae protein, 22kDa [KO:K06278]
858  
CAV2; caveolin 2 [KO:K12958]
859  
CAV3; caveolin 3 [KO:K12959]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
3559  
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
3560  
IL2RB; interleukin 2 receptor, beta [KO:K05069]
3561  
IL2RG; interleukin 2 receptor, gamma [KO:K05070]
6714  
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
387  
RHOA; ras homolog family member A [KO:K04513]
3312  
HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303  
HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306  
HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305  
HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304  
HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310  
HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
9829  
DNAJC6; DnaJ (Hsp40) homolog, subfamily C, member 6 [KO:K09526]
9101  
USP8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.4.19.12]
10617  
STAMBP; STAM binding protein [KO:K11866] [EC:3.4.19.12]
7879  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
9146  
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
10254  
STAM2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705]
8027  
STAM; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705]
7251  
TSG101; tumor susceptibility 101 [KO:K12183]
93343  
MVB12A; multivesicular body subunit 12A [KO:K12186]
89853  
MVB12B; multivesicular body subunit 12B [KO:K12186]
51160  
VPS28; vacuolar protein sorting 28 homolog (S. cerevisiae) [KO:K12184]
155382  
VPS37D; vacuolar protein sorting 37 homolog D (S. cerevisiae) [KO:K12185]
137492  
VPS37A; vacuolar protein sorting 37 homolog A (S. cerevisiae) [KO:K12185]
79720  
VPS37B; vacuolar protein sorting 37 homolog B (S. cerevisiae) [KO:K12185]
55048  
VPS37C; vacuolar protein sorting 37 homolog C (S. cerevisiae) [KO:K12185]
11267  
SNF8; SNF8, ESCRT-II complex subunit [KO:K12188]
51028  
VPS36; vacuolar protein sorting 36 homolog (S. cerevisiae) [KO:K12190]
84313  
VPS25; vacuolar protein sorting 25 homolog (S. cerevisiae) [KO:K12189]
79643  
CHMP6; charged multivesicular body protein 6 [KO:K12195]
92421  
CHMP4C; charged multivesicular body protein 4C [KO:K12194]
128866  
CHMP4B; charged multivesicular body protein 4B [KO:K12194]
29082  
CHMP4A; charged multivesicular body protein 4A [KO:K12194]
51652  
CHMP3; charged multivesicular body protein 3 [KO:K12193]
RNF103-CHMP3; RNF103-CHMP3 readthrough [KO:K12193]
27243  
CHMP2A; charged multivesicular body protein 2A [KO:K12191]
25978  
CHMP2B; charged multivesicular body protein 2B [KO:K12192]
91782  
CHMP7; charged multivesicular body protein 7 [KO:K15053]
9525  
VPS4B; vacuolar protein sorting 4 homolog B (S. cerevisiae) [KO:K12196]
27183  
VPS4A; vacuolar protein sorting 4 homolog A (S. cerevisiae) [KO:K12196]
51534  
VTA1; vesicle (multivesicular body) trafficking 1 [KO:K12199]
57132  
CHMP1B; charged multivesicular body protein 1B [KO:K12197]
51510  
CHMP5; charged multivesicular body protein 5 [KO:K12198]
10015  
PDCD6IP; programmed cell death 6 interacting protein [KO:K12200]
30845  
EHD3; EH-domain containing 3 [KO:K12476]
30844  
EHD4; EH-domain containing 4 [KO:K12477]
8411  
EEA1; early endosome antigen 1 [KO:K12478]
5868  
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  
RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
11311  
VPS45; vacuolar protein sorting 45 homolog (S. cerevisiae) [KO:K12479]
9135  
RABEP1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
64145  
ZFYVE20; zinc finger, FYVE domain containing 20 [KO:K12481]
5867  
RAB4A; RAB4A, member RAS oncogene family [KO:K07879]
80230  
RUFY1; RUN and FYVE domain containing 1 [KO:K12482]
10938  
EHD1; EH-domain containing 1 [KO:K12483]
8766  
RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
9230  
RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
22841  
RAB11FIP2; RAB11 family interacting protein 2 (class I) [KO:K12484]
80223  
RAB11FIP1; RAB11 family interacting protein 1 (class I) [KO:K12484]
26056  
RAB11FIP5; RAB11 family interacting protein 5 (class I) [KO:K12484]
84440  
RAB11FIP4; RAB11 family interacting protein 4 (class II) [KO:K12485]
9727  
RAB11FIP3; RAB11 family interacting protein 3 (class II) [KO:K12485]
57403  
RAB22A; RAB22A, member RAS oncogene family [KO:K07891]
11031  
RAB31; RAB31, member RAS oncogene family [KO:K07891]
56288  
PARD3; par-3 family cell polarity regulator [KO:K04237]
50855  
PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
84552  
PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
84612  
PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
5584  
PRKCI; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
5590  
PRKCZ; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
998  
CDC42; cell division cycle 42 [KO:K04393]
64744  
SMAP2; small ArfGAP2 [KO:K12486]
60682  
SMAP1; small ArfGAP 1 [KO:K12486]
28964  
GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 [KO:K05737]
9815  
GIT2; G protein-coupled receptor kinase interacting ArfGAP 2 [KO:K12487]
50807  
ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
55616  
ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
8853  
ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
116983  
ACAP3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
23527  
ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
9744  
ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
116985  
ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439]
116984  
ARAP2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440]
64411  
ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
116987  
AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
116988  
AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
116986  
AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
55738  
ARFGAP1; ADP-ribosylation factor GTPase activating protein 1 [KO:K12492]
26286  
ARFGAP3; ADP-ribosylation factor GTPase activating protein 3 [KO:K12493]
84364  
ARFGAP2; ADP-ribosylation factor GTPase activating protein 2 [KO:K12493]
23362  
PSD3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
23550  
PSD4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
5662  
PSD; pleckstrin and Sec7 domain containing [KO:K12494]
84249  
PSD2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
23096  
IQSEC2; IQ motif and Sec7 domain 2 [KO:K12495]
9922  
IQSEC1; IQ motif and Sec7 domain 1 [KO:K12495]
440073  
IQSEC3; IQ motif and Sec7 domain 3 [KO:K12495]
9265  
CYTH3; cytohesin 3 [KO:K18441]
27128  
CYTH4; cytohesin 4 [KO:K18441]
9266  
CYTH2; cytohesin 2 [KO:K18441]
9267  
CYTH1; cytohesin 1 [KO:K18441]
10564  
ARFGEF2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [KO:K18442]
10565  
ARFGEF1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) [KO:K18442]
8729  
GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1 [KO:K18443]
375  
ARF1; ADP-ribosylation factor 1 [KO:K07937]
377  
ARF3; ADP-ribosylation factor 3 [KO:K07938]
381  
ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  
GDP
C00044  
GTP
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
Reference
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
Reference
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
Reference
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
Reference
(Japanese)
  Authors
Ohno H, Yoshimori T (eds).
  Title
[Current Stream in Membrane Traffic] (in Japanese)
  Journal
Tanpakushitsu Kakusan Koso 53 (2008)
Reference
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
Reference
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
Reference
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
KO pathway
 

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