KEGG   PATHWAY: hsa04150Help
Entry
hsa04150                    Pathway                                

Name
mTOR signaling pathway - Homo sapiens (human)
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
mTOR signaling pathway
hsa04150

All organismsOrtholog table
Disease
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00666  
Peutz-Jeghers syndrome
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H01112  
Polyhydramnios, megalencephaly, and symptomatic epilepsy
H01251  
Focal cortical dysplasia of Taylor
Drug
D00595  
Buformin (USAN/INN)
D00753  
Sirolimus (JAN/USAN/INN)
D00944  
Metformin hydrochloride (JP16/USP)
D02206  
Buformin hydrochloride (JP16)
D02714  
Everolimus (JAN/USAN/INN)
D03647  
Dapiclermin (USAN/INN)
D04966  
Metformin (USAN/INN)
D05393  
Pegsunercept (USAN)
D06068  
Temsirolimus (JAN/USAN/INN)
D06272  
Sorafenib tosilate (JAN)
D06409  
Bevacizumab (genetical recombination) (JAN)
D08351  
Phenformin (BAN)
D08352  
Phenformin hydrochloride
D08524  
Sorafenib (USAN/INN)
D08900  
Ridaforolimus (JAN/USAN)
D10076  
Olcorolimus (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
3630  
INS; insulin [KO:K04526]
3479  
IGF1; insulin-like growth factor 1 (somatomedin C) [KO:K05459]
3667  
IRS1; insulin receptor substrate 1 [KO:K16172]
5295  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
84335  
AKT1S1; AKT1 substrate 1 (proline-rich) [KO:K16184]
7248  
TSC1; tuberous sclerosis 1 [KO:K07206]
7249  
TSC2; tuberous sclerosis 2 [KO:K07207]
6009  
RHEB; Ras homolog enriched in brain [KO:K07208]
64223  
MLST8; MTOR associated protein, LST8 homolog (S. cerevisiae) [KO:K08266]
10670  
RRAGA; Ras-related GTP binding A [KO:K16185]
10325  
RRAGB; Ras-related GTP binding B [KO:K16185]
64121  
RRAGC; Ras-related GTP binding C [KO:K16186]
58528  
RRAGD; Ras-related GTP binding D [KO:K16186]
2475  
MTOR; mechanistic target of rapamycin (serine/threonine kinase) [KO:K07203]
57521  
RPTOR; regulatory associated protein of MTOR, complex 1 [KO:K07204]
253260  
RICTOR; RPTOR independent companion of MTOR, complex 2 [KO:K08267]
3091  
HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [KO:K08268]
7422  
VEGFA; vascular endothelial growth factor A [KO:K05448]
6198  
RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
6199  
RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2 [KO:K04688] [EC:2.7.11.1]
1975  
EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
6194  
RPS6; ribosomal protein S6 [KO:K02991]
1978  
EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
1977  
EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
9470  
EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
253314  
EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
25989  
ULK3; unc-51 like kinase 3 [KO:K08269] [EC:2.7.11.1]
8408  
ULK1; unc-51 like autophagy activating kinase 1 [KO:K08269] [EC:2.7.11.1]
9706  
ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
6197  
RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3 [KO:K04373] [EC:2.7.11.1]
6195  
RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
6196  
RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
27330  
RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
54541  
DDIT4; DNA-damage-inducible transcript 4 [KO:K08270]
7124  
TNF; tumor necrosis factor [KO:K03156]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
6794  
STK11; serine/threonine kinase 11 [KO:K07298]
92335  
STRADA; STE20-related kinase adaptor alpha [KO:K08271]
51719  
CAB39; calcium binding protein 39 [KO:K08272]
81617  
CAB39L; calcium binding protein 39-like [KO:K08272]
5562  
PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.11]
5563  
PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.11]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
Compound
C00020  
AMP
C04677  
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C15181  
Wortmannin
C15182  
Temsirolimus
C15183  
AP 23573
C15195  
LY 294002
D00753  
Sirolimus (JAN/USAN/INN)
D00944  
Metformin hydrochloride (JP16/USP)
D02714  
Everolimus (JAN/USAN/INN)
Reference
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
Reference
  Authors
Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N.
  Title
mTOR signaling: implications for cancer and anticancer therapy.
  Journal
Br J Cancer 94:195-9 (2006)
Reference
  Authors
Sarbassov dos D, Ali SM, Sabatini DM.
  Title
Growing roles for the mTOR pathway.
  Journal
Curr Opin Cell Biol 17:596-603 (2005)
Reference
  Authors
Wullschleger S, Loewith R, Hall MN.
  Title
TOR signaling in growth and metabolism.
  Journal
Cell 124:471-84 (2006)
Reference
  Authors
Plas DR, Thompson CB.
  Title
Akt-dependent transformation: there is more to growth than just surviving.
  Journal
Oncogene 24:7435-42 (2005)
Reference
  Authors
Levine AJ, Feng Z, Mak TW, You H, Jin S
  Title
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
  Journal
Genes Dev 20:267-75 (2006)
Reference
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
Reference
  Authors
Hardie DG.
  Title
New roles for the LKB1-->AMPK pathway.
  Journal
Curr Opin Cell Biol 17:167-73 (2005)
Reference
  Authors
Astrinidis A, Henske EP.
  Title
Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.
  Journal
Oncogene 24:7475-81 (2005)
Reference
  Authors
Feng Z, Zhang H, Levine AJ, Jin S.
  Title
The coordinate regulation of the p53 and mTOR pathways in cells.
  Journal
Proc Natl Acad Sci U S A 102:8204-9 (2005)
Reference
  Authors
Altomare DA, Testa JR.
  Title
Perturbations of the AKT signaling pathway in human cancer.
  Journal
Oncogene 24:7455-64 (2005)
Reference
  Authors
Kwiatkowski DJ, Manning BD.
  Title
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.
  Journal
Hum Mol Genet 14 Spec No. 2:R251-8 (2005)
Reference
  Authors
Guertin DA, Sabatini DM.
  Title
An expanding role for mTOR in cancer.
  Journal
Trends Mol Med 11:353-61 (2005)
Reference
  Authors
Tokunaga C, Yoshino K, Yonezawa K.
  Title
mTOR integrates amino acid- and energy-sensing pathways.
  Journal
Biochem Biophys Res Commun 313:443-6 (2004)
Reference
  Authors
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB.
  Title
Exploiting the PI3K/AKT pathway for cancer drug discovery.
  Journal
Nat Rev Drug Discov 4:988-1004 (2005)
Reference
  Authors
Luo Z, Saha AK, Xiang X, Ruderman NB.
  Title
AMPK, the metabolic syndrome and cancer.
  Journal
Trends Pharmacol Sci 26:69-76 (2005)
Reference
  Authors
Tee AR, Blenis J.
  Title
mTOR, translational control and human disease.
  Journal
Semin Cell Dev Biol 16:29-37 (2005)
Reference
  Authors
Proud CG.
  Title
Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy.
  Journal
Cardiovasc Res 63:403-13 (2004)
Reference
  Authors
Sofer A, Lei K, Johannessen CM, Ellisen LW.
  Title
Regulation of mTOR and cell growth in response to energy stress by REDD1.
  Journal
Mol Cell Biol 25:5834-45 (2005)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Brugarolas J, Kaelin WG Jr.
  Title
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.
  Journal
Cancer Cell 6:7-10 (2004)
Reference
  Authors
Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA.
  Title
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.
  Journal
J Biol Chem 280:35829-35 (2005)
Reference
  Authors
Hall MN
  Title
mTOR-what does it do?
  Journal
Transplant Proc 40:S5-8 (2008)
Reference
  Authors
Rosner M, Hanneder M, Siegel N, Valli A, Fuchs C, Hengstschlager M
  Title
The mTOR pathway and its role in human genetic diseases.
  Journal
Mutat Res 659:284-92 (2008)
Reference
  Authors
Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL
  Title
Regulation of TORC1 by Rag GTPases in nutrient response.
  Journal
Nat Cell Biol 10:935-45 (2008)
Reference
  Authors
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM
  Title
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
  Journal
Science 320:1496-501 (2008)
Reference
  Authors
Hoeffer CA, Klann E
  Title
mTOR signaling: at the crossroads of plasticity, memory and disease.
  Journal
Trends Neurosci 33:67-75 (2010)
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