KEGG   PATHWAY: hsa04151Help
Entry
hsa04151                    Pathway                                

Name
PI3K-Akt signaling pathway - Homo sapiens (human)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
PI3K-Akt signaling pathway
hsa04151

All organismsOrtholog table
Module
PI3K-Akt signaling [PATH:hsa04151]
Disease
H01338  
Myosclerosis
H01340  
Bethlem myopathy
H01341  
Collagen VI myopathy
H01370  
SHORT syndrome
H01387  
Activated PI3K-delta syndrome (APDS)
H01388  
Hyperprolactinemia
H01511  
Mast-cell leukemia
Drug
D08503  
Toceranib (USAN)
D08544  
Toceranib phosphate (USAN)
D10189  
Pictilisib (USAN)
D10224  
Golvatinib (USAN)
D10229  
Masitinib (INN)
D10242  
Lipegfilgrastim (USAN)
D10354  
Dupilumab (USAN)
D10365  
Gandotinib (USAN)
D10381  
Afuresertib (USAN)
D10382  
Afuresertib hydrochloride (USAN)
D10395  
Nesvacumab (USAN)
D10465  
Golvatinib tartrate (USAN)
D10635  
Gedatolisib (USAN/INN)
D10641  
Ipatasertib (USAN/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
1950  
EGF; epidermal growth factor [KO:K04357]
2246  
FGF1; fibroblast growth factor 1 [KO:K18496]
2247  
FGF2; fibroblast growth factor 2 [KO:K18497]
2248  
FGF3; fibroblast growth factor 3 [KO:K04358]
2249  
FGF4; fibroblast growth factor 4 [KO:K04358]
8822  
FGF17; fibroblast growth factor 17 [KO:K04358]
2251  
FGF6; fibroblast growth factor 6 [KO:K04358]
2252  
FGF7; fibroblast growth factor 7 [KO:K04358]
2253  
FGF8; fibroblast growth factor 8 [KO:K04358]
2254  
FGF9; fibroblast growth factor 9 [KO:K04358]
2255  
FGF10; fibroblast growth factor 10 [KO:K04358]
2256  
FGF11; fibroblast growth factor 11 [KO:K04358]
2257  
FGF12; fibroblast growth factor 12 [KO:K04358]
2258  
FGF13; fibroblast growth factor 13 [KO:K04358]
2259  
FGF14; fibroblast growth factor 14 [KO:K04358]
8823  
FGF16; fibroblast growth factor 16 [KO:K04358]
2250  
FGF5; fibroblast growth factor 5 [KO:K04358]
8817  
FGF18; fibroblast growth factor 18 [KO:K04358]
9965  
FGF19; fibroblast growth factor 19 [KO:K04358]
26281  
FGF20; fibroblast growth factor 20 [KO:K04358]
26291  
FGF21; fibroblast growth factor 21 [KO:K04358]
27006  
FGF22; fibroblast growth factor 22 [KO:K04358]
8074  
FGF23; fibroblast growth factor 23 [KO:K04358]
4803  
NGF; nerve growth factor [KO:K02582]
3630  
INS; insulin [KO:K04526]
3479  
IGF1; insulin like growth factor 1 [KO:K05459]
5154  
PDGFA; platelet derived growth factor subunit A [KO:K04359]
5155  
PDGFB; platelet derived growth factor subunit B [KO:K17386]
56034  
PDGFC; platelet derived growth factor C [KO:K05450]
80310  
PDGFD; platelet derived growth factor D [KO:K05450]
1435  
CSF1; colony stimulating factor 1 [KO:K05453]
4254  
KITLG; KIT ligand [KO:K05461]
7422  
VEGFA; vascular endothelial growth factor A [KO:K05448]
7423  
VEGFB; vascular endothelial growth factor B [KO:K16858]
5228  
PGF; placental growth factor [KO:K16859]
7424  
VEGFC; vascular endothelial growth factor C [KO:K05449]
2277  
FIGF; c-fos induced growth factor [KO:K05449]
3082  
HGF; hepatocyte growth factor [KO:K05460]
284  
ANGPT1; angiopoietin 1 [KO:K05465]
285  
ANGPT2; angiopoietin 2 [KO:K05466]
51378  
ANGPT4; angiopoietin 4 [KO:K05467]
1942  
EFNA1; ephrin A1 [KO:K05462]
1943  
EFNA2; ephrin A2 [KO:K05462]
1944  
EFNA3; ephrin A3 [KO:K05462]
1945  
EFNA4; ephrin A4 [KO:K05462]
1946  
EFNA5; ephrin A5 [KO:K05462]
1956  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2260  
FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
2263  
FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261  
FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264  
FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
4804  
NGFR; nerve growth factor receptor [KO:K02583]
3643  
INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
3480  
IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
5156  
PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
5159  
PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
1436  
CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
3815  
KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
2321  
FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
2324  
FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
3791  
KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
4233  
MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
7010  
TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
1969  
EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
2885  
GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  
SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  
SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  
HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  
KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
3667  
IRS1; insulin receptor substrate 1 [KO:K16172]
7097  
TLR2; toll like receptor 2 [KO:K10159]
7099  
TLR4; toll like receptor 4 [KO:K10160]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
6850  
SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
930  
CD19; CD19 molecule [KO:K06465]
118788  
PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
2688  
GH1; growth hormone 1 [KO:K05438]
2689  
GH2; growth hormone 2 [KO:K05438]
1442  
CSH1; chorionic somatomammotropin hormone 1 [KO:K05438]
1443  
CSH2; chorionic somatomammotropin hormone 2 [KO:K05438]
5617  
PRL; prolactin [KO:K05439]
5008  
OSM; oncostatin M [KO:K05418]
3558  
IL2; interleukin 2 [KO:K05429]
3562  
IL3; interleukin 3 [KO:K04736]
3569  
IL6; interleukin 6 [KO:K05405]
3565  
IL4; interleukin 4 [KO:K05430]
3574  
IL7; interleukin 7 [KO:K05431]
3439  
IFNA1; interferon alpha 1 [KO:K05414]
3440  
IFNA2; interferon alpha 2 [KO:K05414]
3441  
IFNA4; interferon alpha 4 [KO:K05414]
3442  
IFNA5; interferon alpha 5 [KO:K05414]
3443  
IFNA6; interferon alpha 6 [KO:K05414]
3444  
IFNA7; interferon alpha 7 [KO:K05414]
3445  
IFNA8; interferon alpha 8 [KO:K05414]
3446  
IFNA10; interferon alpha 10 [KO:K05414]
3447  
IFNA13; interferon alpha 13 [KO:K05414]
3448  
IFNA14; interferon alpha 14 [KO:K05414]
3449  
IFNA16; interferon alpha 16 [KO:K05414]
3451  
IFNA17; interferon alpha 17 [KO:K05414]
3452  
IFNA21; interferon alpha 21 [KO:K05414]
3456  
IFNB1; interferon beta 1 [KO:K05415]
2056  
EPO; erythropoietin [KO:K05437]
1440  
CSF3; colony stimulating factor 3 [KO:K05423]
2690  
GHR; growth hormone receptor [KO:K05080]
5618  
PRLR; prolactin receptor [KO:K05081]
9180  
OSMR; oncostatin M receptor [KO:K05057]
3559  
IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
3560  
IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
3561  
IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
3563  
IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
3570  
IL6R; interleukin 6 receptor [KO:K05055]
3566  
IL4R; interleukin 4 receptor [KO:K05071]
3575  
IL7R; interleukin 7 receptor [KO:K05072]
3454  
IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
3455  
IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
2057  
EPOR; erythropoietin receptor [KO:K05079]
1441  
CSF3R; colony stimulating factor 3 receptor [KO:K05061]
3716  
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
3717  
JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
3718  
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
1277  
COL1A1; collagen type I alpha 1 [KO:K06236]
1278  
COL1A2; collagen type I alpha 2 chain [KO:K06236]
1280  
COL2A1; collagen type II alpha 1 chain [KO:K19719]
1284  
COL4A2; collagen type IV alpha 2 [KO:K06237]
1286  
COL4A4; collagen type IV alpha 4 chain [KO:K06237]
1288  
COL4A6; collagen type IV alpha 6 chain [KO:K06237]
1282  
COL4A1; collagen type IV alpha 1 chain [KO:K06237]
1287  
COL4A5; collagen type IV alpha 5 chain [KO:K06237]
1285  
COL4A3; collagen type IV alpha 3 chain [KO:K06237]
1291  
COL6A1; collagen type VI alpha 1 [KO:K06238]
1292  
COL6A2; collagen type VI alpha 2 [KO:K06238]
1293  
COL6A3; collagen type VI alpha 3 chain [KO:K06238]
131873  
COL6A6; collagen type VI alpha 6 [KO:K06238]
256076  
COL6A5; collagen type VI alpha 5 [KO:K06238]
1297  
COL9A1; collagen type IX alpha 1 [KO:K08131]
1298  
COL9A2; collagen type IX alpha 2 [KO:K08131]
1299  
COL9A3; collagen type IX alpha 3 [KO:K08131]
284217  
LAMA1; laminin subunit alpha 1 [KO:K05637]
3908  
LAMA2; laminin subunit alpha 2 [KO:K05637]
3909  
LAMA3; laminin subunit alpha 3 [KO:K06240]
3911  
LAMA5; laminin subunit alpha 5 [KO:K06240]
3910  
LAMA4; laminin subunit alpha 4 [KO:K06241]
3912  
LAMB1; laminin subunit beta 1 [KO:K05636]
3913  
LAMB2; laminin subunit beta 2 [KO:K06243]
3914  
LAMB3; laminin subunit beta 3 [KO:K06244]
22798  
LAMB4; laminin subunit beta 4 [KO:K06245]
3915  
LAMC1; laminin subunit gamma 1 [KO:K05635]
3918  
LAMC2; laminin subunit gamma 2 [KO:K06246]
10319  
LAMC3; laminin subunit gamma 3 [KO:K06247]
1101  
CHAD; chondroadherin [KO:K06248]
5649  
RELN; reelin [KO:K06249] [EC:3.4.21.-]
7057  
THBS1; thrombospondin 1 [KO:K16857]
1311  
COMP; cartilage oligomeric matrix protein [KO:K04659]
7058  
THBS2; thrombospondin 2 [KO:K04659]
7059  
THBS3; thrombospondin 3 [KO:K04659]
7060  
THBS4; thrombospondin 4 [KO:K04659]
2335  
FN1; fibronectin 1 [KO:K05717]
6696  
SPP1; secreted phosphoprotein 1 [KO:K06250]
7448  
VTN; vitronectin [KO:K06251]
3371  
TNC; tenascin C [KO:K06252]
63923  
TNN; tenascin N [KO:K06252]
7143  
TNR; tenascin R [KO:K06252]
7148  
TNXB; tenascin XB [KO:K06252]
7450  
VWF; von Willebrand factor [KO:K03900]
3381  
IBSP; integrin binding sialoprotein [KO:K06253]
3672  
ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  
ITGA2; integrin subunit alpha 2 [KO:K06481]
3674  
ITGA2B; integrin subunit alpha 2b [KO:K06476]
3675  
ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  
ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  
ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  
ITGA6; integrin subunit alpha 6 [KO:K06485]
3679  
ITGA7; integrin subunit alpha 7 [KO:K06583]
8516  
ITGA8; integrin subunit alpha 8 [KO:K06584]
3680  
ITGA9; integrin subunit alpha 9 [KO:K06585]
8515  
ITGA10; integrin subunit alpha 10 [KO:K06586]
22801  
ITGA11; integrin subunit alpha 11 [KO:K06587]
3685  
ITGAV; integrin subunit alpha V [KO:K06487]
3688  
ITGB1; integrin subunit beta 1 [KO:K05719]
3690  
ITGB3; integrin subunit beta 3 [KO:K06493]
3691  
ITGB4; integrin subunit beta 4 [KO:K06525]
3693  
ITGB5; integrin subunit beta 5 [KO:K06588]
3694  
ITGB6; integrin subunit beta 6 [KO:K06589]
3695  
ITGB7; integrin subunit beta 7 [KO:K06590]
3696  
ITGB8; integrin subunit beta 8 [KO:K06591]
5747  
PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
2149  
F2R; coagulation factor II thrombin receptor [KO:K03914]
1128  
CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
1129  
CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
1902  
LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
9170  
LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
23566  
LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
2846  
LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
57121  
LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
10161  
LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
2782  
GNB1; G protein subunit beta 1 [KO:K04536]
2783  
GNB2; G protein subunit beta 2 [KO:K04537]
2784  
GNB3; G protein subunit beta 3 [KO:K07825]
59345  
GNB4; G protein subunit beta 4 [KO:K04538]
10681  
GNB5; G protein subunit beta 5 [KO:K04539]
54331  
GNG2; G protein subunit gamma 2 [KO:K07826]
2785  
GNG3; G protein subunit gamma 3 [KO:K04540]
2786  
GNG4; G protein subunit gamma 4 [KO:K04541]
2787  
GNG5; G protein subunit gamma 5 [KO:K04542]
2788  
GNG7; G protein subunit gamma 7 [KO:K04543]
94235  
GNG8; G protein subunit gamma 8 [KO:K04544]
2790  
GNG10; G protein subunit gamma 10 [KO:K04545]
2791  
GNG11; G protein subunit gamma 11 [KO:K04546]
55970  
GNG12; G protein subunit gamma 12 [KO:K04347]
51764  
GNG13; G protein subunit gamma 13 [KO:K04547]
2792  
GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
2793  
GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
5170  
PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
6794  
STK11; serine/threonine kinase 11 [KO:K07298]
5562  
PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.11]
5563  
PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.11]
54541  
DDIT4; DNA damage inducible transcript 4 [KO:K08270]
7248  
TSC1; tuberous sclerosis 1 [KO:K07206]
7249  
TSC2; tuberous sclerosis 2 [KO:K07207]
6009  
RHEB; Ras homolog enriched in brain [KO:K07208]
64223  
MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
2475  
MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
57521  
RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
1978  
EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
1977  
EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
9470  
EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
253314  
EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
6198  
RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
6199  
RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
1975  
EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
6194  
RPS6; ribosomal protein S6 [KO:K02991]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5585  
PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
29941  
PKN3; protein kinase N3 [KO:K06071] [EC:2.7.11.13]
5586  
PKN2; protein kinase N2 [KO:K06071] [EC:2.7.11.13]
6446  
SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
10110  
SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
23678  
SGK3; serum/glucocorticoid regulated kinase family member 3 [KO:K13304] [EC:2.7.11.1]
C8orf44-SGK3; C8orf44-SGK3 readthrough [KO:K13304] [EC:2.7.11.1]
207  
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
5728  
PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
117145  
THEM4; thioesterase superfamily member 4 [KO:K16339]
5515  
PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
5516  
PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
5519  
PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
5518  
PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
5520  
PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
5521  
PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
5522  
PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
55844  
PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
28227  
PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
55012  
PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
5523  
PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
5526  
PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
5527  
PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
5528  
PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
5529  
PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
5525  
PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
3320  
HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
3326  
HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
7184  
HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
11140  
CDC37; cell division cycle 37 [KO:K09554]
200186  
CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
23239  
PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
23035  
PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
8115  
TCL1A; T-cell leukemia/lymphoma 1A [KO:K10167]
9623  
TCL1B; T-cell leukemia/lymphoma 1B [KO:K16836]
4515  
MTCP1; mature T-cell proliferation 1 [KO:K16837]
4846  
NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
672  
BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
2932  
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
2998  
GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
2997  
GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
5105  
PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
5106  
PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
2538  
G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
57818  
G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
92579  
G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
4609  
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
595  
CCND1; cyclin D1 [KO:K04503]
1026  
CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
1027  
CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
1017  
CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
1019  
CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
1021  
CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
894  
CCND2; cyclin D2 [KO:K10151]
896  
CCND3; cyclin D3 [KO:K10152]
898  
CCNE1; cyclin E1 [KO:K06626]
9134  
CCNE2; cyclin E2 [KO:K06626]
2309  
FOXO3; forkhead box O3 [KO:K09408]
5934  
RBL2; RB transcriptional corepressor like 2 [KO:K16332]
356  
FASLG; Fas ligand [KO:K04389]
10018  
BCL2L11; BCL2 like 11 [KO:K16341]
7534  
YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
7529  
YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
10971  
YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
7531  
YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
7533  
YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
7532  
YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
572  
BAD; BCL2 associated agonist of cell death [KO:K02158]
598  
BCL2L1; BCL2 like 1 [KO:K04570]
596  
BCL2; BCL2, apoptosis regulator [KO:K02161]
842  
CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
1385  
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
1386  
ATF2; activating transcription factor 2 [KO:K04450]
468  
ATF4; activating transcription factor 4 [KO:K04374]
10488  
CREB3; cAMP responsive element binding protein 3 [KO:K09048]
90993  
CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
64764  
CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
84699  
CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
148327  
CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
9586  
CREB5; cAMP responsive element binding protein 5 [KO:K09047]
1388  
ATF6B; activating transcription factor 6 beta [KO:K09049]
4170  
MCL1; BCL2 family apoptosis regulator [KO:K02539]
6256  
RXRA; retinoid X receptor alpha [KO:K08524]
3164  
NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
5970  
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
4790  
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
4602  
MYB; MYB proto-oncogene, transcription factor [KO:K09420]
4193  
MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
7157  
TP53; tumor protein p53 [KO:K04451]
5290  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5294  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
5295  
PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
23533  
PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K02649]
5296  
PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  
PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
Compound
C00020  
AMP
C00533  
Nitric oxide
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
Reference
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
Reference
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
Reference
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
Reference
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
Reference
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
Reference
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
Reference
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
Reference
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
Reference
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
Reference
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
Reference
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
Reference
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
Reference
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
Reference
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
KO pathway
 

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