KEGG   PATHWAY: hsa04726Help
Entry
hsa04726                    Pathway                                

Name
Serotonergic synapse - Homo sapiens (human)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Serotonergic synapse
hsa04726

All organismsOrtholog table
Disease
H00833  
Neurodegeneration with brain iron accumulation (NBIA)
H01161  
Aromatic L-amino acid decarboxylase (AADC) deficiency
H01185  
Cerebral amyloid angiopathy (CAA)
Drug
D00110  
Cocaine (USP)
D00197  
Reserpine (JP16/USP/INN)
D00270  
Chlorpromazine (USP/INN)
D00274  
Cisapride (USAN/INN)
D00283  
Clozapine (JAN/USP/INN)
D00326  
Fluoxetine (USAN/INN)
D00367  
Mazindol (JAN/USP/INN)
D00394  
Trimipramine (USAN/INN)
D00403  
Levomepromazine (USAN/INN)
D00405  
Methyldopa hydrate (JP16)
D00415  
Zolmitriptan (JAN/USAN/INN)
D00451  
Sumatriptan (JAN/USP/INN)
D00505  
Phenelzine sulfate (USP)
D00558  
Carbidopa hydrate (JP16)
D00561  
Sertindole (USAN/INN)
D00674  
Naratriptan hydrochloride (JAN/USAN)
D00675  
Rizatriptan benzoate (JAN/USAN)
D00676  
Sumatriptan succinate (JAN/USAN)
D00680  
Methylergometrine maleate (JP16)
D00681  
Methysergide maleate (USP)
D00726  
Metoclopramide (JP16/INN)
D00785  
Selegiline hydrochloride (JAN/USP)
D00789  
Chlorpromazine hydrochloride (JP16/USP)
D00809  
Amitriptyline hydrochloride (JP16/USP)
D00811  
Clomipramine hydrochloride (JP16/USP)
D00816  
Nortriptyline hydrochloride (JP16/USP/INN)
D00819  
Nefazodone hydrochloride (USAN)
D00820  
Trazodone hydrochloride (JAN/USP)
D00821  
Venlafaxine hydrochloride (JAN/USAN)
D00822  
Citalopram hydrobromide (USAN)
D00823  
Fluoxetine hydrochloride (JAN/USP)
D00824  
Fluvoxamine maleate (JP16/USAN)
D00825  
Sertraline hydrochloride (JAN/USAN)
D00826  
Tranylcypromine sulfate (USP XXI)
D01097  
Lazabemide hydrochloride (JAN/USAN)
D01107  
Milnacipran hydrochloride (JAN/USAN)
D01163  
Ergometrine maleate (JP16)
D01176  
Blonanserin (JAN/INN)
D01179  
Duloxetine hydrochloride (JAN/USAN)
D01285  
Lofepramine hydrochloride (JAN/USAN)
D01304  
Amezinium metilsulfate (JAN)
D01358  
Mianserin hydrochloride (JAN/USAN)
D01462  
Lisuride maleate (JAN)
D01477  
Opipramol hydrochloride (JAN/USAN)
D01548  
Mosapramine hydrochloride (JAN)
D01624  
Sarpogrelate hydrochloride (JP16)
D01888  
Safrazine hydrochloride (JAN)
D01939  
Ziprasidone hydrochloride hydrate (JAN)
D01973  
Eletriptan hydrobromide (JAN/USAN)
D01992  
Tandospirone citrate (JAN/USAN)
D01994  
Mosapride citrate hydrate (JP16)
D02016  
Ramosetron hydrochloride (JAN)
D02041  
Tropisetron hydrochloride (JAN)
D02074  
Amphetamine sulfate (USP)
D02078  
Dextroamphetamine sulfate (USP)
D02100  
Ziprasidone mesylate (USAN)
D02182  
Cocaine hydrochloride (JP16/USP)
D02242  
Methamphetamine hydrochloride (JP16/USP)
D02260  
Paroxetine hydrochloride hydrate (JP16)
D02360  
Sertraline (INN)
D02362  
Paroxetine (USP/INN)
D02363  
Ketanserin (USAN/INN)
D02408  
Trimipramine maleate (JAN/USAN)
D02559  
Toloxatone (INN)
D02560  
Brofaromine (INN)
D02561  
Moclobemide (USAN/INN)
D02562  
Rasagiline mesylate (USAN)
D02563  
Befloxatone (INN)
D02564  
Pargyline hydrochloride (USAN)
D02567  
Escitalopram oxalate (JAN/USAN)
D02570  
Desvenlafaxine succinate hydrate (JAN)
D02571  
Sibutramine hydrochloride hydrate (JAN)
D02572  
Viloxazine hydrochloride (USAN)
D02577  
Flibanserin (USAN/INN)
D02578  
Agomelatine (INN)
D02579  
Iproniazid (INN)
D02580  
Isocarboxazid (INN)
D02581  
Cimoxatone (INN)
D02632  
Indisetron hydrochloride (JAN)
D02656  
Fananserin (USAN/INN)
D02767  
Adatanserin hydrochloride (USAN)
D02824  
Almotriptan (USAN)
D02825  
Almotriptan malate (USAN)
D02836  
Altanserin tartrate (USAN)
D03005  
Atiprosin maleate (USAN)
D03110  
Bicifadine hydrochloride (USAN)
D03239  
Ladostigil tartrate (USAN)
D03248  
Clorgiline (INN)
D03274  
Chlorpromazine hibenzate (JAN)
D03409  
Caroxazone (USAN/INN)
D03506  
Cinanserin hydrochloride (USAN)
D03649  
Dapoxetine hydrochloride (USAN)
D03713  
Dexfenfluramine hydrochloride (USAN)
D03731  
Selegiline (USAN/INN)
D03740  
Dextroamphetamine (USAN)
D03982  
Elzasonan citrate (USAN)
D03983  
Elzasonan hydrochloride (USAN)
D04034  
Chlorpromazine phenolphthalinate (JAN)
D04092  
Etryptamine acetate (USAN)
D04320  
Glemanserin (USAN/INN)
D04681  
Lazabemide (USAN/INN)
D04788  
Lubazodone hydrochloride (USAN)
D04820  
Lurasidone hydrochloride (JAN/USAN)
D05015  
Metrenperone (USAN/INN)
D05033  
Milacemide hydrochloride (USAN)
D05107  
Nafronyl oxalate (USAN)
D05374  
Paroxetine hydrochloride (USP)
D05375  
Paroxetine mesylate (USAN)
D05395  
Pelanserin hydrochloride (USAN)
D05523  
Pizotyline (USAN)
D05685  
Quipazine maleate (USAN)
D05738  
Ritanserin (USAN/INN)
D06253  
Tropanserin hydrochloride (USAN)
D06566  
Bifeprunox (USAN/INN)
D06567  
Bifeprunox mesylate (USAN)
D06613  
Lorcaserin hydrochloride (USAN)
D06632  
Pruvanserin (USAN/INN)
D06633  
Pruvanserin hydrochloride (USAN)
D07218  
Metergoline (INN)
D07337  
Nialamide (INN)
D07338  
Iproclozide (INN)
D07445  
Amfetamine (INN)
D07448  
Amitriptyline (INN)
D07449  
Amitriptylinoxide (INN)
D07704  
Citalopram (USP/INN)
D07705  
Citalopram hydrochloride
D07727  
Clomipramine (INN)
D07793  
Desvenlafaxine (INN)
D07805  
Dexfenfluramine (INN)
D07913  
Escitalopram (INN)
D07984  
Fluvoxamine (INN)
D08085  
Iproniazid phosphate
D08099  
Ketanserin tartrate
D08132  
Lisuride (INN)
D08140  
Lofepramine (INN)
D08187  
Metamfetamine (INN)
D08205  
Methyldopa (INN)
D08216  
Mianserin (INN)
D08222  
Milnacipran (INN)
D08235  
Mosapramine (INN)
D08236  
Mosapride (INN)
D08244  
Naftidrofuryl (INN)
D08255  
Naratriptan (INN)
D08257  
Nefazodone (INN)
D08288  
Nortriptyline (INN)
D08297  
Opipramol (INN)
D08349  
Phenelzine (BAN)
D08392  
Pirlindole (INN)
D08393  
Pirlindole hydrochloride
D08397  
Pizotifen malate
D08453  
Pargyline (INN)
D08466  
Ramosetron (INN)
D08469  
Rasagiline (USAN/INN)
D08508  
Sarpogrelate (INN)
D08513  
Sibutramine (INN)
D08561  
Tandospirone (INN)
D08575  
Tetrabenazine (JAN/INN)
D08625  
Tranylcypromine (INN)
D08626  
Trazodone (INN)
D08670  
Venlafaxine (INN)
D08673  
Viloxazine (INN)
D08687  
Ziprasidone (INN)
D08969  
Pimavanserin tartrate (USAN)
D09358  
Naluzotan (USAN/INN)
D09359  
Naluzotan hydrochloride (USAN)
D09366  
Pardoprunox hydrochloride (USAN)
D09397  
Pardoprunox (USAN/INN)
D09645  
Nelotanserin (USAN/INN)
D09693  
Velusetrag (USAN/INN)
D09694  
Velusetrag hydrochloride (USAN)
D09698  
Vilazodone (USAN/INN)
D09699  
Vilazodone hydrochloride (USAN)
D09819  
Chlorpromazine tannate (JAN)
D09933  
Naronapride (USAN/INN)
D09934  
Naronapride dihydrochloride (USAN)
D10006  
Eplivanserin (USAN/INN)
D10072  
Levomilnacipran (USAN/INN)
D10088  
Amitifadine (USAN)
D10089  
Amitifadine hydrochloride (USAN)
D10099  
Cerlapirdine (USAN)
D10100  
Cerlapirdine hydrochloride (USAN)
D10133  
Levomilnacipran hydrochloride (USAN)
D10170  
Tedatioxetine (USAN)
D10171  
Tedatioxetine hydrobromide (USAN)
D10184  
Vortioxetine (USAN)
D10185  
Vortioxetine hydrobromide (JAN/USAN)
D10338  
Lasmiditan (USAN/INN)
D10364  
Aripiprazole lauroxil (USAN)
D10424  
Lasmiditan succinate (USAN)
D10516  
Aripiprazole hydrate (JAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
121278  
TPH2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
7166  
TPH1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
1644  
DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) [KO:K01593] [EC:4.1.1.28]
6570  
SLC18A1; solute carrier family 18 (vesicular monoamine transporter), member 1 [KO:K08155]
6571  
SLC18A2; solute carrier family 18 (vesicular monoamine transporter), member 2 [KO:K08155]
775  
CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
776  
CACNA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
778  
CACNA1F; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
779  
CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
3356  
HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled [KO:K04157]
3357  
HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [KO:K04157]
3358  
HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [KO:K04157]
2776  
GNAQ; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
23236  
PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
3708  
ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
3709  
ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
3710  
ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123745  
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
1558  
CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8 [KO:K17718] [EC:1.14.14.1]
1559  
CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 [KO:K17719] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1562  
CYP2C18; cytochrome P450, family 2, subfamily C, polypeptide 18 [KO:K17720] [EC:1.14.14.1]
1557  
CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19 [KO:K17721] [EC:1.14.13.- 1.14.13.80 1.14.13.49 1.14.13.48]
1565  
CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6 [KO:K17712] [EC:1.14.14.1]
1573  
CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2 [KO:K07418] [EC:1.14.14.1]
260293  
CYP4X1; cytochrome P450, family 4, subfamily X, polypeptide 1 [KO:K07428] [EC:1.14.14.1]
240  
ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
239  
ALOX12; arachidonate 12-lipoxygenase [KO:K00458] [EC:1.13.11.31]
242  
ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
246  
ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
247  
ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.- 1.13.11.33]
5742  
PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [KO:K00509] [EC:1.14.99.1]
5743  
PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [KO:K11987] [EC:1.14.99.1]
3359  
HTR3A; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic [KO:K04819]
285242  
HTR3E; 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic [KO:K04819]
200909  
HTR3D; 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic [KO:K04819]
170572  
HTR3C; 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic [KO:K04819]
9177  
HTR3B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic [KO:K04819]
3360  
HTR4; 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled [KO:K04160]
3362  
HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled [KO:K04162]
3363  
HTR7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [KO:K04163]
2778  
GNAS; GNAS complex locus [KO:K04632]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
3781  
KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 [KO:K04943]
3751  
KCND2; potassium voltage-gated channel, Shal-related subfamily, member 2 [KO:K04892]
2560  
GABRB1; gamma-aminobutyric acid (GABA) A receptor, beta 1 [KO:K05181]
2562  
GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 [KO:K05181]
2561  
GABRB2; gamma-aminobutyric acid (GABA) A receptor, beta 2 [KO:K05181]
10411  
RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3 [KO:K08014]
351  
APP; amyloid beta (A4) precursor protein [KO:K04520]
3350  
HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [KO:K04153]
3351  
HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled [KO:K04153]
3352  
HTR1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled [KO:K04153]
3354  
HTR1E; 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled [KO:K04153]
3355  
HTR1F; 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled [KO:K04153]
3361  
HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled [KO:K04161]
2770  
GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [KO:K04630]
2773  
GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
2771  
GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
2775  
GNAO1; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O [KO:K04534]
2782  
GNB1; guanine nucleotide binding protein (G protein), beta polypeptide 1 [KO:K04536]
2783  
GNB2; guanine nucleotide binding protein (G protein), beta polypeptide 2 [KO:K04537]
2784  
GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 [KO:K07825]
59345  
GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4 [KO:K04538]
10681  
GNB5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
54331  
GNG2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
2785  
GNG3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
2786  
GNG4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
2787  
GNG5; guanine nucleotide binding protein (G protein), gamma 5 [KO:K04542]
2788  
GNG7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
94235  
GNG8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
2790  
GNG10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
2791  
GNG11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
55970  
GNG12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
648044  
guanine nucleotide binding protein (G protein); K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
51764  
GNG13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
2792  
GNGT1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
2793  
GNGT2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
836  
CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
369  
ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
773  
CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
774  
CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
3760  
KCNJ3; potassium inwardly-rectifying channel, subfamily J, member 3 [KO:K04997]
3763  
KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6 [KO:K05000]
3765  
KCNJ9; potassium inwardly-rectifying channel, subfamily J, member 9 [KO:K05002]
3762  
KCNJ5; potassium inwardly-rectifying channel, subfamily J, member 5 [KO:K04999]
7220  
TRPC1; transient receptor potential cation channel, subfamily C, member 1 [KO:K04964]
6532  
SLC6A4; solute carrier family 6 (neurotransmitter transporter), member 4 [KO:K05037]
4129  
MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  
MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
1843  
DUSP1; dual specificity phosphatase 1 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
Compound
C00076  
Calcium cation
C00078  
L-Tryptophan
C00165  
Diacylglycerol
C00219  
Arachidonate
C00238  
Potassium cation
C00427  
Prostaglandin H2
C00575  
3',5'-Cyclic AMP
C00584  
Prostaglandin E2
C00639  
Prostaglandin F2alpha
C00643  
5-Hydroxy-L-tryptophan
C00696  
Prostaglandin D2
C00780  
Serotonin
C00909  
Leukotriene A4
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01330  
Sodium cation
C02165  
Leukotriene B4
C02166  
Leukotriene C4
C02198  
Thromboxane A2
C04822  
8(R)-HPETE
C05356  
5(S)-HPETE
C05635  
5-Hydroxyindoleacetate
C05953  
Prostaglandin A2
C05954  
Prostaglandin B2
C05955  
Prostaglandin C2
C05956  
Prostaglandin G2
C05957  
Prostaglandin J2
C05963  
Thromboxane B2
C05964  
11-Dehydro-thromboxane B2
C05965  
12(S)-HPETE
C05966  
15(S)-HPETE
C14768  
5,6-EET
C14769  
8,9-EET
C14770  
11,12-EET
C14771  
14,15-EET
C14772  
5,6-DHET
C14773  
8,9-DHET
C14774  
11,12-DHET
C14775  
14,15-DHET
C14812  
12(R)-HPETE
C14820  
11(R)-HPETE
C14821  
9(S)-HPETE
C14823  
8(S)-HPETE
Reference
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
Reference
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling,  and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
Reference
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
Reference
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
Reference
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
Reference
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
Reference
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
Reference
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
Reference
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
Reference
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
Reference
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
Reference
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
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