KEGG   Homo sapiens (human): 10000Help
Entry
10000             CDS       T01001                                 

Gene name
AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Definition
(RefSeq) AKT serine/threonine kinase 3
  KO
K04456  
RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Relaxin signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Carbohydrate digestion and absorption
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Network
N00030  
EGF-EGFR-RAS-PI3K signaling pathway
N00031  
Duplication-activated FLT3 to RAS-PI3K signaling pathway
N00032  
Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  
EGF-EGFR-PI3K signaling pathway
N00034  
ERBB2-overexpression to PI3K signaling pathway
N00035  
Amplified EGFR to PI3K signaling pathway
N00036  
Mutation-activated EGFR to PI3K signaling pathway
N00037  
FGF-FGFR-PI3K signaling pathway
N00038  
Amplified FGFR to PI3K signaling pathway
N00039  
PDGF-PDGFR-PI3K signaling pathway
N00040  
Amplified PDGFR to PI3K signaling pathway
N00042  
EGFR-overexpression to PI3K signaling pathway
N00043  
HGF-MET-PI3K signaling pathway
N00044  
Mutation-activated MET to PI3K signaling pathway
N00045  
KITLG-KIT-PI3K signaling pathway
N00046  
Mutation-activated KIT to PI3K signaling pathway
N00047  
EML4-ALK fusion kinase to PI3K signaling pathway
N00048  
BCR-ABL fusion kinase to PI3K signaling pathway
N00049  
Mutation-activated PI3K to PI3K signaling pathway
N00050  
Amplified PI3K to PI3K signaling pathway
N00051  
Deleted PTEN to PI3K signaling pathway
N00052  
Mutation-inactivated PTEN to PI3K signaling pathway
N00082  
Loss of NKX3-1 to PI3K signaling pathway
N00154  
CXCR-GNB/G-PI3K-AKT signaling pathway
N00158  
KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00159  
KSHV K1 to PI3K signaling pathway
N00179  
KSHV K1 to PI3K-NFKB signaling pathway
N00182  
IGF-IGFR-PI3K-NFKB signaling pathway
N00218  
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220  
PTEN-PI3K-AKT signaling pathway
N00231  
TGFA-EGFR-PI3K signaling pathway
N00232  
TGFA-overexpression to PI3K signaling pathway
N00234  
IGF2-IGF1R-PI3K signaling pathway
N00236  
IGF2-overexpression to PI3K signaling pathway
N00238  
IGF1R-overexpression to PI3K signaling pathway
N00247  
HGF-overexpression to PI3K signaling pathway
N00249  
MET-overexpression to PI3K signaling pathway
N00253  
Amplified ERBB2 to PI3K signaling pathway
N00260  
Amplified MET to PI3K signaling pathway
Disease
H01885  
Megalencephaly-capillary malformation syndrome (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH)
Drug target
Afuresertib (DG01408): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    10000 (AKT3)
   04015 Rap1 signaling pathway
    10000 (AKT3)
   04010 MAPK signaling pathway
    10000 (AKT3)
   04012 ErbB signaling pathway
    10000 (AKT3)
   04370 VEGF signaling pathway
    10000 (AKT3)
   04371 Apelin signaling pathway
    10000 (AKT3)
   04630 Jak-STAT signaling pathway
    10000 (AKT3)
   04668 TNF signaling pathway
    10000 (AKT3)
   04066 HIF-1 signaling pathway
    10000 (AKT3)
   04068 FoxO signaling pathway
    10000 (AKT3)
   04072 Phospholipase D signaling pathway
    10000 (AKT3)
   04071 Sphingolipid signaling pathway
    10000 (AKT3)
   04024 cAMP signaling pathway
    10000 (AKT3)
   04022 cGMP - PKG signaling pathway
    10000 (AKT3)
   04151 PI3K-Akt signaling pathway
    10000 (AKT3)
   04152 AMPK signaling pathway
    10000 (AKT3)
   04150 mTOR signaling pathway
    10000 (AKT3)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    10000 (AKT3)
  Cell growth and death
   04210 Apoptosis
    10000 (AKT3)
   04218 Cellular senescence
    10000 (AKT3)
  Cellular community - eukaryotes
   04510 Focal adhesion
    10000 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    10000 (AKT3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    10000 (AKT3)
   04620 Toll-like receptor signaling pathway
    10000 (AKT3)
   04660 T cell receptor signaling pathway
    10000 (AKT3)
   04662 B cell receptor signaling pathway
    10000 (AKT3)
   04664 Fc epsilon RI signaling pathway
    10000 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    10000 (AKT3)
   04062 Chemokine signaling pathway
    10000 (AKT3)
  Endocrine system
   04910 Insulin signaling pathway
    10000 (AKT3)
   04922 Glucagon signaling pathway
    10000 (AKT3)
   04923 Regulation of lipolysis in adipocyte
    10000 (AKT3)
   04920 Adipocytokine signaling pathway
    10000 (AKT3)
   04915 Estrogen signaling pathway
    10000 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    10000 (AKT3)
   04917 Prolactin signaling pathway
    10000 (AKT3)
   04926 Relaxin signaling pathway
    10000 (AKT3)
   04919 Thyroid hormone signaling pathway
    10000 (AKT3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    10000 (AKT3)
  Digestive system
   04973 Carbohydrate digestion and absorption
    10000 (AKT3)
  Nervous system
   04725 Cholinergic synapse
    10000 (AKT3)
   04728 Dopaminergic synapse
    10000 (AKT3)
   04722 Neurotrophin signaling pathway
    10000 (AKT3)
  Development
   04380 Osteoclast differentiation
    10000 (AKT3)
  Aging
   04211 Longevity regulating pathway - mammal
    10000 (AKT3)
   04213 Longevity regulating pathway - multiple species
    10000 (AKT3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    10000 (AKT3)
   05230 Central carbon metabolism in cancer
    10000 (AKT3)
   05231 Choline metabolism in cancer
    10000 (AKT3)
   05205 Proteoglycans in cancer
    10000 (AKT3)
   05210 Colorectal cancer
    10000 (AKT3)
   05212 Pancreatic cancer
    10000 (AKT3)
   05225 Hepatocellular carcinoma
    10000 (AKT3)
   05226 Gastric cancer
    10000 (AKT3)
   05214 Glioma
    10000 (AKT3)
   05221 Acute myeloid leukemia
    10000 (AKT3)
   05220 Chronic myeloid leukemia
    10000 (AKT3)
   05218 Melanoma
    10000 (AKT3)
   05211 Renal cell carcinoma
    10000 (AKT3)
   05215 Prostate cancer
    10000 (AKT3)
   05213 Endometrial cancer
    10000 (AKT3)
   05224 Breast cancer
    10000 (AKT3)
   05222 Small cell lung cancer
    10000 (AKT3)
   05223 Non-small cell lung cancer
    10000 (AKT3)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    10000 (AKT3)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    10000 (AKT3)
   04931 Insulin resistance
    10000 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    10000 (AKT3)
  Infectious diseases
   05152 Tuberculosis
    10000 (AKT3)
   05166 HTLV-I infection
    10000 (AKT3)
   05162 Measles
    10000 (AKT3)
   05164 Influenza A
    10000 (AKT3)
   05161 Hepatitis B
    10000 (AKT3)
   05160 Hepatitis C
    10000 (AKT3)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    10000 (AKT3)
   05169 Epstein-Barr virus infection
    10000 (AKT3)
   05165 Human papillomavirus infection
    10000 (AKT3)
   05145 Toxoplasmosis
    10000 (AKT3)
   05142 Chagas disease (American trypanosomiasis)
    10000 (AKT3)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    10000 (AKT3)
   01524 Platinum drug resistance
    10000 (AKT3)
   01522 Endocrine resistance
    10000 (AKT3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10000 (AKT3)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  AKT/PKB family
   10000 (AKT3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q9Y243(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
1q43-q44
AA seq 479 aa AA seqDB search
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt NT seq  +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatacttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttataatcagatgtctccagtggact
actgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacagactgcagaggcaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcctctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatactatgctatgaagattctgaag
aaagaagtcattattgcaaaggatgaagtggcacacactctaactgaaagcagagtatta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggcgagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctaatgctggac
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca
gccaccatgaagacattctgtggcactccagaatatctggcaccagaggtgttagaagat
aatgactatggccgagcagtagactggtggggcctaggggttgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggaccatgagaaactttttgaattaatattaatg
gaagacattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttctctggagtaaactggcaagatgtatatgataaaaagcttgtacct
ccttttaaacctcaagtaacatctgagacagatactagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg
gacaatgagaggcggccgcatttccctcaattttcctactctgcaagtggacgagaataa

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