KEGG   Homo sapiens (human): 10840
Entry
10840             CDS       T01001                                 
Symbol
ALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD
Name
(RefSeq) aldehyde dehydrogenase 1 family member L1
  KO
K00289  formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    10840 (ALDH1L1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.6  formyltetrahydrofolate dehydrogenase
     10840 (ALDH1L1)
SSDB
Motif
Pfam: Aldedh Formyl_trans_N Formyl_trans_C PP-binding DUF1487
Other DBs
NCBI-GeneID: 10840
NCBI-ProteinID: NP_036322
OMIM: 600249
HGNC: 3978
Ensembl: ENSG00000144908
UniProt: O75891 Q53H87
Structure
Position
3:complement(126103570..126197945)
AA seq 902 aa
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR
AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN
WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV
RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ
KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI
LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL
VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM
PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI
SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI
QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ
VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK
SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH
DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP
RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT
RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF
EY
NT seq 2709 nt   +upstreamnt  +downstreamnt
atgaagattgcagtgattggacagagcctgtttggccaggaagtttactgccacctgagg
aaggagggccacgaagtggtgggtgtgttcactgttccagacaaggatggaaaggccgac
cccctgggtctggaagctgagaaggatggagtgccggtattcaagtactcccggtggcgt
gcaaaaggacaggctttgcctgatgtggtggcaaaataccaggctttgggggccgagctc
aacgtcctgcccttctgcagccaattcatccccatggagataatcagtgccccccggcat
ggctccatcatctatcacccgtcactgctccctaggcaccgaggggcctcggccatcaac
tggaccctcattcacggagataagaaaggggggttttccatcttctgggcggatgatggt
ctggacaccggagacctgctgctgcagaaggagtgtgaggtgctcccggacgacaccgtg
agcacgctgtacaaccgcttcctcttccctgaaggcatcaaagggatggtgcaggccgtg
aggctgatcgctgagggcaaagcccccagactccctcagcctgaggaaggagccacctat
gaggggattcagaagaaggagacagccaagatcaactgggaccagccggcagaggccatt
cacaactggatccgcgggaacgacaaggtgccgggagcctggacagaggcctgtgaacag
aaactgacatttttcaactcaacgctgaacacttcaggcctggtgcccgagggagacgct
ttgcccatcccaggagcccatcggccaggggtggtcaccaaagcaggactcatcctcttt
gggaatgatgacaaaatgctgctggtgaagaatattcagctggaggatggcaaaatgatc
ctggcctcgaacttctttaagggggcagccagcagtgtccttgagctgacagaggcagag
ctggttactgcggaggctgtgcggagtgtttggcagcggatcctccccaaagtcctggag
gttgaagactccactgatttcttcaagtcaggggccgcgtctgtggacgttgtgaggctg
gtggaggaagtgaaggagctgtgtgatggcctggagttagaaaatgaagatgtgtacatg
gcatccacctttggggacttcatccagctgttagtgaggaagctgcgaggggacgatgag
gagggcgagtgcagcattgactacgtggaaatggcagtgaacaagcgcactgtccgcatg
ccccaccagctcttcattgggggggagttcgtggatgccgagggcgccaagacctctgag
accatcaatcccaccgatggaagtgtcatctgccaggtatccctggcccaagtcaccgac
gtcgacaaggcagtggccgcagccaaggatgcctttgagaatggacggtgggggaagatc
agtgcgcgggaccggggccggctgatgtacaggttggcagatctcatggagcagcaccag
gaggagctggccaccattgaggccctggatgcgggtgccgtctacacgctggccctgaag
acccacgtgggcatgtccatccagaccttccgctactttgctggctggtgtgacaagatc
cagggctccaccatccccatcaaccaggccagacccaaccgcaacctgaccttgaccagg
aaggagcctgttggggtttgtggcatcatcatcccctggaactatcccctgatgatgctg
tcctggaagacagctgcctgcctggctgccgggaacacagtggtgatcaagcctgctcag
gtgaccccactcacagccttgaagtttgcagagctgacattaaaggccggcattcccaaa
ggtgtggttaacgtcctcccaggatctggctccctggtcggccagagactctcagaccat
cctgatgtgaggaaaatcgggttcacaggctccacagaggtgggcaagcacatcatgaaa
agctgtgccataagtaacgtgaagaaggtgtccctggaactgggcgggaagtcacccctc
atcatctttgctgactgtgacctcaacaaggctgtgcagatggggatgagttctgttttc
ttcaacaaaggagagaattgcattgcagcaggccgactctttgtggaggactccattcat
gatgagttcgtgcggagagtggtagaagaggtgcggaagatgaaggtgggcaacccgctg
gacagggacaccgaccacgggccgcagaatcaccatgcccaccttgtgaagctgatggag
tactgccagcatggcgtgaaggaaggggccacactggtctgcggcgggaatcaggtccct
cggccagggttcttctttgagccaactgttttcacagacgtggaagaccacatgttcata
gccaaggaggagtccttcgggcctgtcatgatcatctctcggtttgctgatggggacttg
gatgccgtgctgtctcgggccaatgccacggaatttggcctggcttctggtgtcttcacc
agggacatcaacaaggccctgtatgtcagtgacaagctccaggcaggcactgtgtttgtc
aacacgtacaacaagaccgacgtggccgctcccttcggaggattcaaacagtctggattt
ggcaaagatctaggagaggcggctctgaacgagtacctgcgggtcaagacagtgaccttc
gaatactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (55)   
   RefSeq(nuc) (15)   
   GenBank (20)   
   EMBL (20)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (113)   

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