| Entry |
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| Gene name |
HPSE, HPA, HPA1, HPR1, HPSE1, HSE1
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| Definition |
heparanase (EC:3.2.1.166)
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| Orthology |
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| Organism |
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| Pathway |
| Glycosaminoglycan degradation | | Metabolic pathways | | Proteoglycans in cancer |
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| Module |
| Heparan sulfate degradation |
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| Class |
Metabolism; Glycan biosynthesis and metabolism; Glycosaminoglycan degradation [PATH: hsa00531]
Human Diseases; Cancers; Proteoglycans in cancer [PATH: hsa05205]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Position |
4q21.3
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| AA seq |
543 aa  
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI |
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| NT seq |
1632 nt  +upstreamnt +downstreamnt
atgctgctgcgctcgaagcctgcgctgccgccgccgctgatgctgctgctcctggggccg
ctgggtcccctctcccctggcgccctgccccgacctgcgcaagcacaggacgtcgtggac
ctggacttcttcacccaggagccgctgcacctggtgagcccctcgttcctgtccgtcacc
attgacgccaacctggccacggacccgcggttcctcatcctcctgggttctccaaagctt
cgtaccttggccagaggcttgtctcctgcgtacctgaggtttggtggcaccaagacagac
ttcctaattttcgatcccaagaaggaatcaacctttgaagagagaagttactggcaatct
caagtcaaccaggatatttgcaaatatggatccatccctcctgatgtggaggagaagtta
cggttggaatggccctaccaggagcaattgctactccgagaacactaccagaaaaagttc
aagaacagcacctactcaagaagctctgtagatgtgctatacacttttgcaaactgctca
ggactggacttgatctttggcctaaatgcgttattaagaacagcagatttgcagtggaac
agttctaatgctcagttgctcctggactactgctcttccaaggggtataacatttcttgg
gaactaggcaatgaacctaacagtttccttaagaaggctgatattttcatcaatgggtcg
cagttaggagaagattttattcaattgcataaacttctaagaaagtccaccttcaaaaat
gcaaaactctatggtcctgatgttggtcagcctcgaagaaagacggctaagatgctgaag
agcttcctgaaggctggtggagaagtgattgattcagttacatggcatcactactatttg
aatggacggactgctaccaaggaagattttctaaaccctgatgtattggacatttttatt
tcatctgtgcaaaaagttttccaggtggttgagagcaccaggcctggcaagaaggtctgg
ttaggagaaacaagctctgcatatggaggcggagcgcccttgctatccgacacctttgca
gctggctttatgtggctggataaattgggcctgtcagcccgaatgggaatagaagtggtg
atgaggcaagtattctttggagcaggaaactaccatttagtggatgaaaacttcgatcct
ttacctgattattggctatctcttctgttcaagaaattggtgggcaccaaggtgttaatg
gcaagcgtgcaaggttcaaagagaaggaagcttcgagtataccttcattgcacaaacact
gacaatccaaggtataaagaaggagatttaactctgtatgccataaacctccataatgtc
accaagtacttgcggttaccctatcctttttctaacaagcaagtggataaataccttcta
agacctttgggacctcatggattactttccaaatctgtccaactcaatggtctaactcta
aagatggtggatgatcaaaccttgccacctttaatggaaaaacctctccggccaggaagt
tcactgggcttgccagctttctcatatagtttttttgtgataagaaatgccaaagttgct
gcttgcatctga |
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