KEGG   Homo sapiens (human): 10919
Entry
10919             CDS       T01001                                 
Symbol
EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
Name
(RefSeq) euchromatic histone lysine methyltransferase 2
  KO
K11420  [histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00310  Lysine degradation
hsa01100  Metabolic pathways
hsa04211  Longevity regulating pathway
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    10919 (EHMT2)
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    10919 (EHMT2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10919 (EHMT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     10919 (EHMT2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    REST complex
     10919 (EHMT2)
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     10919 (EHMT2)
SSDB
Motif
Pfam: Ank Ank_2 Ank_4 EHMT1-2_CRR Ank_3 Ank_5 SET Pre-SET CDC45 PRDM2_PR Paf1 Nop14 Sporozoite_P67 XRCC4
Other DBs
NCBI-GeneID: 10919
NCBI-ProteinID: NP_006700
OMIM: 604599
HGNC: 14129
Ensembl: ENSG00000204371
UniProt: Q96KQ7 A0A024RCN9
Structure
Position
6:complement(31879759..31897698)
AA seq 1210 aa
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
ELGSLPPVNT
NT seq 3633 nt   +upstreamnt  +downstreamnt
atggcggcggcggcgggagctgcagcggcggcggccgccgagggggaggcccccgctgag
atgggggcgctgctgctggagaaggaaaccagaggagccaccgagagagttcatggctct
ttgggggacacccctcgtagtgaagaaaccctgcccaaggccacccccgactccctggag
cctgctggcccctcatctccagcctctgtcactgtcactgttggtgatgagggggctgac
acccctgtaggggctacaccactcattggggatgaatctgagaatcttgagggagatggg
gacctccgtgggggccggatcctgctgggccatgccacaaagtcattcccctcttccccc
agcaaggggggttcctgtcctagccgggccaagatgtcaatgacaggggcgggaaaatca
cctccatctgtccagagtttggctatgaggctactgagtatgccaggagcccagggagct
gcagcagcagggtctgaaccccctccagccaccacgagcccagagggacagcccaaggtc
caccgagcccgcaaaaccatgtccaaaccaggaaatggacagcccccggtccctgagaag
cggccccctgaaatacagcatttccgcatgagtgatgatgtccactcactgggaaaggtg
acctcagatctggccaaaaggaggaagctgaactcaggaggtggcctgtcagaggagtta
ggttctgcccggcgttcaggagaagtgaccctgacgaaaggggaccccgggtccctggag
gagtgggagacggtggtgggtgatgacttcagtctctactatgattcctactctgtggat
gagcgcgtggactccgacagcaagtctgaagttgaagctctaactgaacaactaagtgaa
gaggaggaggaggaagaggaggaagaagaagaagaggaagaggaggaggaagaggaagaa
gaagaggaagatgaggagtcagggaatcagtcagataggagtggttccagtggccggcgc
aaggccaagaagaaatggcgaaaagacagcccatgggtgaagccgtctcggaaacggcgc
aagcgggagcctccgcgggccaaggagccacgaggagtgaatggtgtgggctcctcaggc
cccagtgagtacatggaggtccctctggggtccctggagctgcccagcgaggggaccctc
tcccccaaccacgctggggtgtccaatgacacatcttcgctggagacagagcgagggttt
gaggagttgcccctgtgcagctgccgcatggaggcacccaagattgaccgcatcagcgag
agggcggggcacaagtgcatggccactgagagtgtggacggagagctgtcaggctgcaat
gccgccatcctcaagcgggagaccatgaggccatccagccgtgtggccctgatggtgctc
tgtgagacccaccgcgcccgcatggtcaaacaccactgctgcccgggctgcggctacttc
tgcacggcgggcaccttcctggagtgccaccctgacttccgtgtggcccaccgcttccac
aaggcctgtgtgtctcagctgaatgggatggtcttctgtccccactgtggggaggatgct
tctgaagctcaagaggtgaccatcccccggggtgacggggtgaccccaccggccggcact
gcagctcctgcacccccacccctgtcccaggatgtccccgggagagcagacacttctcag
cccagtgcccggatgcgagggcatggggaaccccggcgcccgccctgcgatcccctggct
gacaccattgacagctcagggccctccctgaccctgcccaatgggggctgcctttcagcc
gtggggctgccactggggccaggccgggaggccctggaaaaggccctggtcatccaggag
tcagagaggcggaagaagctccgtttccaccctcggcagttgtacctgtccgtgaagcag
ggcgagctgcagaaggtgatcctgatgctgttggacaacctggaccccaacttccagagc
gaccagcagagcaagcgcacgcccctgcatgcagccgcccagaagggctccgtggagatc
tgccatgtgctgctgcaggctggagccaacataaatgcagtggacaaacagcagcggacg
ccactgatggaggccgtggtgaacaaccacctggaggtagcccgttacatggtgcagcgt
ggtggctgtgtctatagcaaggaggaggacggttccacctgcctccaccacgcagccaaa
atcgggaacttggagatggtcagcctgctgctgagcacaggacaggtggacgtcaacgcc
caggacagtggggggtggacgcccatcatctgggctgcagagcacaagcacatcgaggtg
atccgcatgctactgacgcggggcgccgacgtcaccctcactgacaacgaggagaacatc
tgcctgcactgggcctccttcacgggcagcgccgccatcgccgaagtccttctgaatgcg
cgctgtgacctccatgctgtcaactaccatggggacacccccctgcacatcgcagctcgg
gagagctaccatgactgcgtgctgttattcctgtcacgtggggccaaccctgagctgcgg
aacaaagagggggacacagcatgggacctgactcccgagcgctccgacgtgtggtttgcg
cttcaactcaaccgcaagctccgacttggggtgggaaatcgggccatccgcacagagaag
atcatctgccgggacgtggctcggggctatgagaacgtgcccattccctgtgtcaacggt
gtggatggggagccctgccctgaggattacaagtacatctcagagaactgcgagacgtcc
accatgaacatcgatcgcaacatcacccacctgcagcactgcacgtgtgtggacgactgc
tctagctccaactgcctgtgcggccagctcagcatccggtgctggtatgacaaggatggg
cgattgctccaggaatttaacaagattgagcctccgctgattttcgagtgtaaccaggcg
tgctcatgctggagaaactgcaagaaccgggtcgtacagagtggcatcaaggtgcggcta
cagctctaccgaacagccaagatgggctggggggtccgcgccctgcagaccatcccacag
gggaccttcatctgcgagtatgtcggggagctgatctctgatgctgaggctgatgtgaga
gaggatgattcttacctcttcgacttagacaacaaggatggagaggtgtactgcatagat
gcccgttactatggcaacatcagccgcttcatcaaccacctgtgtgaccccaacatcatt
cccgtccgggtcttcatgctgcaccaagacctgcgatttccacgcatcgccttcttcagt
tcccgagacatccggactggggaggagctagggtttgactatggcgaccgcttctgggac
atcaaaagcaaatatttcacctgccaatgtggctctgagaagtgcaagcactcagccgaa
gccattgccctggagcagagccgtctggcccgcctggacccacaccctgagctgctgccc
gagctcggctccctgccccctgtcaacacatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (28)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (25)   
DNA sequence (55)   
   RefSeq(nuc) (25)   
   GenBank (15)   
   EMBL (15)   
3D Structure (26)   
   PDB (26)   
Protein domain (14)   
   Pfam (14)   
All databases (183)   

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