KEGG   Homo sapiens (human): 11253
Entry
11253             CDS       T01001                                 
Symbol
MAN1B1, ERMAN1, ERManI, MANA-ER, MRT15
Name
(RefSeq) mannosidase alpha class 1B member 1
  KO
K23741  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa01100  Metabolic pathways
hsa04141  Protein processing in endoplasmic reticulum
Module
hsa_M00073  N-glycan precursor trimming
Network
nt06015  N-Glycan biosynthesis
  Element
N00820  N-Glycan biosynthesis
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    11253 (MAN1B1)
   00513 Various types of N-glycan biosynthesis
    11253 (MAN1B1)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    11253 (MAN1B1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    11253 (MAN1B1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.209  endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
     11253 (MAN1B1)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    11253 (MAN1B1)
SSDB
Motif
Pfam: Glyco_hydro_47
Other DBs
NCBI-GeneID: 11253
NCBI-ProteinID: NP_057303
OMIM: 604346
HGNC: 6823
Ensembl: ENSG00000177239
UniProt: Q9UKM7
Structure
Position
9:137086985..137109183
AA seq 699 aa
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
NT seq 2100 nt   +upstreamnt  +downstreamnt
atggctgcctgcgagggcaggagaagcggagctctcggttcctctcagtcggacttcctg
acgccgccagtgggcggggccccttgggccgtcgccaccactgtagtcatgtacccaccg
ccgccgccgccgcctcatcgggacttcatctcggtgacgctgagctttggcgagaactat
gacaacagcaagagttggcggcggcgctcgtgctggaggaaatggaagcaactgtcgaga
ttgcagcggaatatgattctcttcctccttgcctttctgcttttctgtggactcctcttc
tacatcaacttggctgaccattggaaagctctggctttcaggctagaggaagagcagaag
atgaggccagaaattgctgggttaaaaccagcaaatccacccgtcttaccagctcctcag
aaggcggacaccgaccctgagaacttacctgagatttcgtcacagaagacacaaagacac
atccagcggggaccacctcacctgcagattagacccccaagccaagacctgaaggatggg
acccaggaggaggccacaaaaaggcaagaagcccctgtggatccccgcccggaaggagat
ccgcagaggacagtcatcagctggaggggagcggtgatcgagcctgagcagggcaccgag
ctcccttcaagaagagcagaagtgcccaccaagcctcccctgccaccggccaggacacag
ggcacaccagtgcatctgaactatcgccagaagggcgtgattgacgtcttcctgcatgca
tggaaaggataccgcaagtttgcatggggccatgacgagctgaagcctgtgtccaggtcc
ttcagtgagtggtttggcctcggtctcacactgatcgacgcgctggacaccatgtggatc
ttgggtctgaggaaagaatttgaggaagccaggaagtgggtgtcgaagaagttacacttt
gaaaaggacgtggacgtcaacctgtttgagagcacgatccgcatcctgggggggctcctg
agtgcctaccacctgtctggggacagcctcttcctgaggaaagctgaggattttggaaat
cggctaatgcctgccttcagaacaccatccaagattccttactcggatgtgaacatcggt
actggagttgcccacccgccacggtggacctccgacagcactgtggccgaggtgaccagc
attcagctggagttccgggagctctcccgtctcacaggggataagaagtttcaggaggca
gtggagaaggtgacacagcacatccacggcctgtctgggaagaaggatgggctggtgccc
atgttcatcaatacccacagtggcctcttcacccacctgggcgtattcacgctgggcgcc
agggccgacagctactatgagtacctgctgaagcagtggatccagggcgggaagcaggag
acacagctgctggaagactacgtggaagccatcgagggtgtcagaacgcacctgctgcgg
cactccgagcccagtaagctcacctttgtgggggagcttgcccacggccgcttcagtgcc
aagatggaccacctggtgtgcttcctgccagggacgctggctctgggcgtctaccacggc
ctgcccgccagccacatggagctggcccaggagctcatggagacttgttaccagatgaac
cggcagatggagacggggctgagtcccgagatcgtgcacttcaacctttacccccagccg
ggccgtcgggacgtggaggtcaagccagcagacaggcacaacctgctgcggccagagacc
gtggagagcctgttctacctgtaccgcgtcacaggggaccgcaaataccaggactggggc
tgggagattctgcagagcttcagccgattcacacgggtcccctcgggtggctattcttcc
atcaacaatgtccaggatcctcagaagcccgagcctagggacaagatggagagcttcttc
ctgggggagacgctcaagtatctgttcttgctcttctccgatgacccaaacctgctcagc
ctggatgcctacgtgttcaacaccgaagcccaccctctgcctatctggacccctgcctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (39)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (37)   
DNA sequence (94)   
   RefSeq(nuc) (40)   
   GenBank (27)   
   EMBL (27)   
3D Structure (6)   
   PDB (6)   
Protein domain (1)   
   Pfam (1)   
All databases (189)   

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