KEGG   Homo sapiens (human): 1576Help
Entry
1576              CDS       T01001                                 

Gene name
CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Definition
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)
Orthology
K17689  
cytochrome P450, family 3, subfamily A, polypeptide 4 [EC:1.14.13.32 1.14.13.67 1.14.13.97 1.14.13.157 1.14.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
Steroid hormone biosynthesis
Linoleic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Bile secretion
Chemical carcinogenesis
Drug target
Cobicistat: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    1576 (CYP3A4)
   00591 Linoleic acid metabolism
    1576 (CYP3A4)
  Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1576 (CYP3A4)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1576 (CYP3A4)
   00982 Drug metabolism - cytochrome P450
    1576 (CYP3A4)
   00983 Drug metabolism - other enzymes
    1576 (CYP3A4)
 Organismal Systems
  Digestive system
   04976 Bile secretion
    1576 (CYP3A4)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    1576 (CYP3A4)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     1576 (CYP3A4)
    1.14.13.67  quinine 3-monooxygenase
     1576 (CYP3A4)
    1.14.13.97  taurochenodeoxycholate 6alpha-hydroxylase
     1576 (CYP3A4)
    1.14.13.157  1,8-cineole 2-exo-monooxygenase
     1576 (CYP3A4)
    1.14.13.-  
     1576 (CYP3A4)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP3 family
   1576 (CYP3A4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
Structure
PDB: 

Jmol
Position
7q21.1
AA seq 502 aa AA seqDB search
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIIFPFLIPILEVLNICVF
PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII
FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN
ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK
KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG
LLQPEKPVVLKVESRDGTVSGA
NT seq 1509 nt NT seq  +upstreamnt  +downstreamnt
atggctctcatcccagacttggccatggaaacctggcttctcctggctgtcagcctggtg
ctcctctatctatatggaacccattcacatggactttttaagaagcttggaattccaggg
cccacacctctgccttttttgggaaatattttgtcctaccataagggcttttgtatgttt
gacatggaatgtcataaaaagtatggaaaagtgtggggcttttatgatggtcaacagcct
gtgctggctatcacagatcctgacatgatcaaaacagtgctagtgaaagaatgttattct
gtcttcacaaaccggaggccttttggtccagtgggatttatgaaaagtgccatctctata
gctgaggatgaagaatggaagagattacgatcattgctgtctccaaccttcaccagtgga
aaactcaaggagatggtccctatcattgcccagtatggagatgtgttggtgagaaatctg
aggcgggaagcagagacaggcaagcctgtcaccttgaaagacgtctttggggcctacagc
atggatgtgatcactagcacatcatttggagtgaacatcgactctctcaacaatccacaa
gacccctttgtggaaaacaccaagaagcttttaagatttgattttttggatccattcttt
ctctcaataatctttccattcctcatcccaattcttgaagtattaaatatctgtgtgttt
ccaagagaagttacaaattttttaagaaaatctgtaaaaaggatgaaagaaagtcgcctc
gaagatacacaaaagcaccgagtggatttccttcagctgatgattgactctcagaattca
aaagaaactgagtcccacaaagctctgtccgatctggagctcgtggcccaatcaattatc
tttatttttgctggctatgaaaccacgagcagtgttctctccttcattatgtatgaactg
gccactcaccctgatgtccagcagaaactgcaggaggaaattgatgcagttttacccaat
aaggcaccacccacctatgatactgtgctacagatggagtatcttgacatggtggtgaat
gaaacgctcagattattcccaattgctatgagacttgagagggtctgcaaaaaagatgtt
gagatcaatgggatgttcattcccaaaggggtggtggtgatgattccaagctatgctctt
caccgtgacccaaagtactggacagagcctgagaagttcctccctgaaagattcagcaag
aagaacaaggacaacatagatccttacatatacacaccctttggaagtggacccagaaac
tgcattggcatgaggtttgctctcatgaacatgaaacttgctctaatcagagtccttcag
aacttctccttcaaaccttgtaaagaaacacagatccccctgaaattaagcttaggagga
cttcttcaaccagaaaaacccgttgttctaaaggttgagtcaagggatggcaccgtaagt
ggagcctga

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