KEGG   Homo sapiens (human): 1723Help
Entry
1723              CDS       T01001                                 

Gene name
DHODH, DHOdehase, POADS, URA1
Definition
dihydroorotate dehydrogenase (quinone) (EC:1.3.5.2)
Orthology
K00254  
dihydroorotate dehydrogenase [EC:1.3.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
Pyrimidine metabolism
Metabolic pathways
Module
Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
Disease
H01376  
Acrofacial dysostosis
Drug target
Leflunomide: 
Teriflunomide: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    1723 (DHODH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.2  dihydroorotate dehydrogenase (quinone)
     1723 (DHODH)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
16q22
AA seq 395 aa AA seqDB search
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
NT seq 1188 nt NT seq  +upstreamnt  +downstreamnt
atggcgtggagacacctgaaaaagcgggcccaggatgctgtgatcatcctggggggagga
ggacttctcttcgcctcctacctgatggccacgggagatgagcgtttctatgctgaacac
ctgatgccgactctgcaggggctgctggacccggagtcagcccacagactggctgttcgc
ttcacctccctggggctccttccacgggccagatttcaagactctgacatgctggaagtg
agagttctgggccataaattccgaaatccagtaggaattgctgcaggatttgacaagcat
ggggaagccgtggacggactttataagatgggctttggttttgttgagataggaagtgtg
actccaaaacctcaggaaggaaaccctagacccagagtcttccgcctccctgaggaccaa
gctgtcattaacaggtatggatttaacagtcacgggctttcagtggtggaacacaggtta
cgggccagacagcagaagcaggccaagctcacagaagatggactgcctctgggggtcaac
ttggggaagaacaagacctcagtggacgccgcggaggactacgcagaaggggtgcgcgta
ctgggccccctggccgactacctggtggtgaatgtgtccagccccaacactgccgggctg
cggagccttcagggaaaggccgagctgcgccgcctgctgaccaaggtgctgcaggagagg
gatggcttgcggagagtgcacaggccggcagtcctggtgaagatcgctcctgacctcacc
agccaggataaggaggacattgccagtgtggtcaaagagttgggcatcgatgggctgatt
gttacgaacaccaccgtgagtcgccctgcgggcctccagggtgccctgcgctctgaaaca
ggagggctgagtgggaagcccctccgggatttatcaactcaaaccattcgggagatgtat
gcactcacccaaggccgagttcccataattggggttggtggtgtgagcagcgggcaggac
gcgctggagaagatccgggcaggggcctccctggtgcagctgtacacggccctcaccttc
tgggggccacccgttgtgggcaaagtcaagcgggaactggaggcccttctgaaagagcag
ggctttggcggagtcacagatgccattggagcagatcatcggaggtga

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