KEGG   Homo sapiens (human): 1869Help
Entry
1869              CDS       T01001                                 

Gene name
E2F1, E2F-1, RBAP1, RBBP3, RBP3
Definition
(RefSeq) E2F transcription factor 1
  KO
K17454  
transcription factor E2F1
Organism
hsa  Homo sapiens (human)
Pathway
Endocrine resistance
Cell cycle
Mitophagy - animal
Cellular senescence
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Module
Cell cycle - G1/S transition
Network
N00066  
p21-Cell cycle G1/S
N00067  
Deleted p14(ARF) to p21-cell cycle G1/S
N00068  
Amplified MDM2 to p21-cell cycle G1/S
N00069  
p16-Cell cycle G1/S
N00070  
Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  
Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  
Amplified CDK4 to cell cycle G1/S
N00073  
Mutation-activated CDK4 to cell cycle G1/S
N00074  
Loss of RB1 to cell cycle G1/S
N00075  
Mutation-inactivated RB1 to cell cycle G1/S
N00076  
Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  
Amplified MYC to p15-cell cycle G1/S
N00089  
Amplified MYC to cell cycle G1/S
N00090  
p15-Cell cycle G1/S
N00091  
p27-Cell cycle G1/S
N00092  
Amplified MYC to p27-cell cycle G1/S
N00093  
Loss of CDKN1B to p27-cell cycle G1/S
N00167  
KSHV vIRF1/3 to p21-cell cycle G1/S
N00168  
KSHV vCyclin to cell cycle G1/S
N00169  
KSHV LANA to p21-cell cycle G1/S
N00170  
KSHV LANA to cell cycle G1/S
N00254  
CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  
Amplified CCNE to cell cycle G1/S
N00275  
Amplified CCND1 to cell cycle G1/S
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Cellular Processes
  Transport and catabolism
   04137 Mitophagy - animal
    1869 (E2F1)
  Cell growth and death
   04110 Cell cycle
    1869 (E2F1)
   04218 Cellular senescence
    1869 (E2F1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    1869 (E2F1)
   05206 MicroRNAs in cancer
    1869 (E2F1)
   05212 Pancreatic cancer
    1869 (E2F1)
   05225 Hepatocellular carcinoma
    1869 (E2F1)
   05226 Gastric cancer
    1869 (E2F1)
   05214 Glioma
    1869 (E2F1)
   05220 Chronic myeloid leukemia
    1869 (E2F1)
   05218 Melanoma
    1869 (E2F1)
   05219 Bladder cancer
    1869 (E2F1)
   05215 Prostate cancer
    1869 (E2F1)
   05224 Breast cancer
    1869 (E2F1)
   05222 Small cell lung cancer
    1869 (E2F1)
   05223 Non-small cell lung cancer
    1869 (E2F1)
  Infectious diseases
   05166 HTLV-I infection
    1869 (E2F1)
   05161 Hepatitis B
    1869 (E2F1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    1869 (E2F1)
   05165 Human papillomavirus infection
    1869 (E2F1)
  Drug resistance
   01522 Endocrine resistance
    1869 (E2F1)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1869 (E2F1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q01094(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
20q11.22
AA seq 437 aa AA seqDB search
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
NT seq 1314 nt NT seq  +upstreamnt  +downstreamnt
atggccttggccggggcccctgcgggcggcccatgcgcgccggcgctggaggccctgctc
ggggccggcgcgctgcggctgctcgactcctcgcagatcgtcatcatctccgccgcgcag
gacgccagcgccccgccggctcccaccggccccgcggcgcccgccgccggcccctgcgac
cctgacctgctgctcttcgccacaccgcaggcgccccggcccacacccagtgcgccgcgg
cccgcgctcggccgcccgccggtgaagcggaggctggacctggaaactgaccatcagtac
ctggccgagagcagtgggccagctcggggcagaggccgccatccaggaaaaggtgtgaaa
tccccgggggagaagtcacgctatgagacctcactgaatctgaccaccaagcgcttcctg
gagctgctgagccactcggctgacggtgtcgtcgacctgaactgggctgccgaggtgctg
aaggtgcagaagcggcgcatctatgacatcaccaacgtccttgagggcatccagctcatt
gccaagaagtccaagaaccacatccagtggctgggcagccacaccacagtgggcgtcggc
ggacggcttgaggggttgacccaggacctccgacagctgcaggagagcgagcagcagctg
gaccacctgatgaatatctgtactacgcagctgcgcctgctctccgaggacactgacagc
cagcgcctggcctacgtgacgtgtcaggaccttcgtagcattgcagaccctgcagagcag
atggttatggtgatcaaagcccctcctgagacccagctccaagccgtggactcttcggag
aactttcagatctcccttaagagcaaacaaggcccgatcgatgttttcctgtgccctgag
gagaccgtaggtgggatcagccctgggaagaccccatcccaggaggtcacttctgaggag
gagaacagggccactgactctgccaccatagtgtcaccaccaccatcatctcccccctca
tccctcaccacagatcccagccagtctctactcagcctggagcaagaaccgctgttgtcc
cggatgggcagcctgcgggctcccgtggacgaggaccgcctgtccccgctggtggcggcc
gactcgctcctggagcatgtgcgggaggacttctccggcctcctccctgaggagttcatc
agcctttccccaccccacgaggccctcgactaccacttcggcctcgaggagggcgagggc
atcagagacctcttcgactgtgactttggggacctcacccccctggatttctga

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