KEGG T01001: 1977

Homo sapiens (human): 1977

Entry

1977 CDS T01001

Gene name

EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F

Definition

eukaryotic translation initiation factor 4E

Orthology

K03259

translation initiation factor 4E

Organism

hsa Homo sapiens (human)

Pathway

hsa03013	RNA transport
hsa04066	HIF-1 signaling pathway
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04910	Insulin signaling pathway

Module

hsa_M00428

eIF4F complex

Class

Genetic Information Processing; Translation; RNA transport [PATH:hsa03013]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:hsa04066]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:hsa04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]

SSDB

Motif

Pfam:

IF4E

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

UniProt:

Structure

PDB:

1IPB 1IPC 3U7X 3TF2 3SMU 2V8Y 1WKW 4AZA 3AM7 2W97 2V8W 2V8X 4DT6 4DUM 2GPQ

Position

4q21-q25

AA seq 237 aa
MLDLTSRGQVGTSRRMAEAACSAHFLETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQ
NRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP
MWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

NT seq 714 nt +upstreamnt +downstreamnt
atgttggacctgacctcccgcggacaagtggggacgtcccggaggatggccgaggcggcg
tgtagcgcacactttctggaaaccacccctactcctaatcccccgactacagaagaggag
aaaacggaatctaatcaggaggttgctaacccagaacactatattaaacatcccctacag
aacagatgggcactctggttttttaaaaatgataaaagcaaaacttggcaagcaaacctg
cggctgatctccaagtttgatactgttgaagacttttgggctctgtacaaccatatccag
ttgtctagtaatttaatgcctggctgtgactactcactttttaaggatggtattgagcct
atgtgggaagatgagaaaaacaaacggggaggacgatggctaattacattgaacaaacag
cagagacgaagtgacctcgatcgcttttggctagagacacttctgtgccttattggagaa
tcttttgatgactacagtgatgatgtatgtggcgctgttgttaatgttagagctaaaggt
gataagatagcaatatggactactgaatgtgaaaacagagaagctgttacacatataggg
agggtatacaaggaaaggttaggacttcctccaaagatagtgattggttatcagtcccac
gcagacacagctactaagagcggctccaccactaaaaataggtttgttgtttaa

All links

Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Disease (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (9)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   RefSeq(pep) (3)   
DNA sequence (29)   
   RefSeq(nuc) (3)   
   GenBank (13)   
   EMBL (13)   
3D Structure (15)   
   PDB (15)   
Protein domain (1)   
   Pfam (1)   
All databases (74)   

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