KEGG T01001: 203068

Homo sapiens (human): 203068

Entry

203068            CDS       T01001

Symbol

TUBB, CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5

Name

(RefSeq) tubulin beta class I

K07375

tubulin beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04540

Gap junction

hsa04814

Motor proteins

hsa05010

Alzheimer disease

hsa05012

Parkinson disease

hsa05014

Amyotrophic lateral sclerosis

hsa05016

Huntington disease

hsa05020

Prion disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

Network

nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions

Element

N00976

Retrograde axonal transport

N00977

Mutation-caused aberrant Htt to retrograde axonal transport

N00978

Anterograde axonal transport

N00979

Mutation-caused aberrant Htt to anterograde axonal transport

N01018

Mutation-caused aberrant Abeta to anterograde axonal transport

N01055

Mutation-caused aberrant SNCA to anterograde axonal transport

N01158

Mutation-caused aberrant DCTN1 to retrograde axonal transport

N01285

Microtubule-RHOA signaling pathway

N01286

Escherichia EspG to Microtubule-RHOA signaling pathway

N01295

Rab7-regulated microtubule minus-end directed transport

N01297

Arl8-regulated microtubule plus-end directed transport

N01298

Salmonella SifA to microtubule plus-end directed transport

N01299

Salmonella PipB2 to microtubule plus-end directed transport

N01403

Zn to anterograde axonal transport

N01414

Iron to anterograde axonal transport

N01535

Kinetochore microtubule attachment

N01544

Microtubule nucleation

N01547

Kinetochore fiber organization

N01549

Branching microtubule nucleation

N01553

Promotion of microtubule growth

N01561

Microtubule depolymerization

N01562

Microtubule depolymerization at the minus ends

Disease

H01579

Congenital symmetric circumferential skin creases

H01881

Complex cortical dysplasia with other brain malformations

Drug target

Anvatabart opadotin:

D12583

Avanbulin:

D11681

Batabulin (DG01412):

D03059 D06560

Belantamab mafodotin:

D11595<US>

Brentuximab vedotin:

D09587<JP/US>

Cabazitaxel (DG00695):

D09755 D10452<JP/US>

Cantuzumab mertansine:

D03364

Cantuzumab ravtansine:

D10454

Cevipabulin (DG01413):

D06576 D08889

Colchicine:

D00570<JP/US>

Denintuzumab mafodotin:

D11232

Docetaxel (DG00694):

D02165<JP/US> D07866<JP/US>

Enfortumab vedotin:

D11525<JP/US>

Eribulin:

D08914<JP/US>

Estramustine (DG00724):

D02398 D04066 D06397<JP/US>

Farletuzumab ecteribulin:

D12183

Glembatumumab vedotin:

D09912

Indibulin:

D10013

Ixabepilone:

D04645<US>

Lexibulin:

D10073

Lifastuzumab vedotin:

D11238

Lisavanbulin:

D11494

Lorvotuzumab mertansine:

D09927

Maytansine:

D04864

Mecbotamab vedotin:

D12220

Mirvetuximab soravtansine:

D10954<US>

Mivobulin isethionate:

D05062

Opadotin:

D12582

Ozuriftmab vedotin:

D12210

Paclitaxel:

D00491<JP/US>

Paclitaxel poliglumex:

D05333

Sabizabulin (DG03253):

Soblidotin:

Soravtansine:

Taltobulin:

Tasidotin hydrochloride:

D06009

Tirbanibulin (DG03082):

D11691<US> D11692

Tisotumab vedotin:

D11814<US>

Trastuzumab emtansine:

D09980<JP/US>

Tusamitamab ravtansine:

D12310

Vedotin:

D09691

Verubulin (DG01411):

D10029 D10030

Vinblastine (DG00689):

D01068<JP/US> D08675

Vincristine (DG00690):

D02197<JP/US> D08679

Vindesine (DG00691):

D01769<JP> D06304

Vinepidine sulfate:

D06305

Vinflunine:

D09032

Vinglycinate sulfate:

D06306

Vinleurosine sulfate:

D06307

Vinorelbine (DG00692):

D01935<JP/US> D08680

Vinrosidine sulfate:

D06308

Vinzolidine sulfate:

D06309

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    203068 (TUBB)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    203068 (TUBB)
  09142 Cell motility
   04814 Motor proteins
    203068 (TUBB)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    203068 (TUBB)
   05132 Salmonella infection
    203068 (TUBB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    203068 (TUBB)
   05012 Parkinson disease
    203068 (TUBB)
   05014 Amyotrophic lateral sclerosis
    203068 (TUBB)
   05016 Huntington disease
    203068 (TUBB)
   05020 Prion disease
    203068 (TUBB)
   05022 Pathways of neurodegeneration - multiple diseases
    203068 (TUBB)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    203068 (TUBB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    203068 (TUBB)
   04147 Exosome [BR:hsa04147]
    203068 (TUBB)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Other tubulins
     203068 (TUBB)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    203068 (TUBB)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   203068 (TUBB)
  Exosomal proteins of colorectal cancer cells
   203068 (TUBB)
  Exosomal proteins of bladder cancer cells
   203068 (TUBB)

SSDB

Motif

Pfam:

Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

6:30720352..30725422

AA seq 444 aa
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA

NT seq 1335 nt +upstreamnt +downstreamnt
atgagggaaatcgtgcacatccaggctggtcagtgtggcaaccagatcggtgccaagttc
tgggaggtgatcagtgatgaacatggcatcgaccccaccggcacctaccacggggacagc
gacctgcagctggaccgcatctctgtgtactacaatgaagccacaggtggcaaatatgtt
cctcgtgccatcctggtggatctagaacctgggaccatggactctgttcgctcaggtcct
tttggccagatctttagaccagacaactttgtatttggtcagtctggggcaggtaacaac
tgggccaaaggccactacacagagggcgccgagctggttgattctgtcctggatgtggta
cggaaggaggcagagagctgtgactgcctgcagggcttccagctgacccactcactgggc
gggggcacaggctctggaatgggcactctccttatcagcaagatccgagaagaataccct
gatcgcatcatgaataccttcagtgtggtgccttcacccaaagtgtctgacaccgtggtc
gagccctacaatgccaccctctccgtccatcagttggtagagaatactgatgagacctat
tgcattgacaacgaggccctctatgatatctgcttccgcactctgaagctgaccacacca
acctacggggatctgaaccaccttgtctcagccaccatgagtggtgtcaccacctgcctc
cgtttccctggccagctcaatgctgacctccgcaagttggcagtcaacatggtccccttc
ccacgtctccatttctttatgcctggctttgcccctctcaccagccgtggaagccagcag
tatcgagctctcacagtgccggaactcacccagcaggtcttcgatgccaagaacatgatg
gctgcctgtgacccccgccacggccgatacctcaccgtggctgctgtcttccgtggtcgg
atgtccatgaaggaggtcgatgagcagatgcttaacgtgcagaacaagaacagcagctac
tttgtggaatggatccccaacaatgtcaagacagccgtctgtgacatcccacctcgtggc
ctcaagatggcagtcaccttcattggcaatagcacagccatccaggagctcttcaagcgc
atctcggagcagttcactgccatgttccgccggaaggccttcctccactggtacacaggc
gagggcatggacgagatggagttcaccgaggctgagagcaacatgaacgacctcgtctct
gagtatcagcagtaccaggatgccaccgcagaagaggaggaggatttcggtgaggaggcc
gaagaggaggcctaa

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