KEGG T01001: 2161

Homo sapiens (human): 2161

Entry

2161 CDS T01001

Gene name

F12, HAE3, HAEX, HAF

Definition

coagulation factor XII (Hageman factor) (EC:3.4.21.38)

Orthology

K01328

coagulation factor XII (Hageman factor) [EC:3.4.21.38]

Organism

hsa Homo sapiens (human)

Pathway

hsa04610

Complement and coagulation cascades

Disease

H00941	Factor XII deficiency
H01006	Hereditary angioedema

Class

Organismal Systems; Immune system; Complement and coagulation cascades [PATH:hsa04610]

SSDB

Motif

Pfam:

Trypsin Kringle fn2 EGF fn1 Trypsin_2 hEGF DUF1986 EGF_2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

4BDX 4BDW

Position

5q33-qter

AA seq 615 aa
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS

NT seq 1848 nt +upstreamnt +downstreamnt
atgagggctctgctgctcctggggttcctgctggtgagcttggagtcaacactttcgatt
ccaccttgggaagcccccaaggagcataagtacaaagctgaagagcacacagtcgttctc
actgtcaccggggagccctgccacttccccttccagtaccaccggcagctgtaccacaaa
tgtacccacaagggccggccaggccctcagccctggtgtgctaccacccccaactttgat
caggaccagcgatggggatactgtttggagcccaagaaagtgaaagaccactgcagcaaa
cacagcccctgccagaaaggagggacctgtgtgaacatgccaagcggcccccactgtctc
tgtccacaacacctcactggaaaccactgccagaaagagaagtgctttgagcctcagctt
ctccggtttttccacaagaatgagatatggtatagaactgagcaagcagctgtggccaga
tgccagtgcaagggtcctgatgcccactgccagcggctggccagccaggcctgccgcacc
aacccgtgcctccatgggggtcgctgcctagaggtggagggccaccgcctgtgccactgc
ccggtgggctacaccggagccttctgcgacgtggacaccaaggcaagctgctatgatggc
cgcgggctcagctaccgcggcctggccaggaccacgctctcgggtgcgccctgtcagccg
tgggcctcggaggccacctaccggaacgtgactgccgagcaagcgcggaactggggactg
ggcggccacgccttctgccggaacccggacaacgacatccgcccgtggtgcttcgtgctg
aaccgcgaccggctgagctgggagtactgcgacctggcacagtgccagaccccaacccag
gcggcgcctccgaccccggtgtcccctaggcttcatgtcccactcatgcccgcgcagccg
gcaccgccgaagcctcagcccacgacccggaccccgcctcagtcccagaccccgggagcc
ttgccggcgaagcgggagcagccgccttccctgaccaggaacggcccactgagctgcggg
cagcggctccgcaagagtctgtcttcgatgacccgcgtcgttggcgggctggtggcgcta
cgcggggcgcacccctacatcgccgcgctgtactggggccacagtttctgcgccggcagc
ctcatcgccccctgctgggtgctgacggccgctcactgcctgcaggaccggcccgcaccc
gaggatctgacggtggtgctcggccaggaacgccgtaaccacagctgtgagccgtgccag
acgttggccgtgcgctcctaccgcttgcacgaggccttctcgcccgtcagctaccagcac
gacctggctctgttgcgccttcaggaggatgcggacggcagctgcgcgctcctgtcgcct
tacgttcagccggtgtgcctgccaagcggcgccgcgcgaccctccgagaccacgctctgc
caggtggccggctggggccaccagttcgagggggcggaggaatatgccagcttcctgcag
gaggcgcaggtaccgttcctctccctggagcgctgctcagccccggacgtgcacggatcc
tccatcctccccggcatgctctgcgcagggttcctcgagggcggcaccgatgcgtgccag
ggtgattccggaggcccgctggtgtgtgaggaccaagctgcagagcgccggctcaccctg
caaggcatcatcagctggggatcgggctgtggtgaccgcaacaagccaggcgtctacacc
gatgtggcctactacctggcctggatccgggagcacaccgtttcctga

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (9)   
   Pfam (9)   
All databases (56)   

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