KEGG T01001: 2194

Homo sapiens (human): 2194

Entry

2194 CDS T01001

Gene name

FASN, FAS, OA-519, SDR27X1

Definition

fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 1.3.1.10 4.2.1.59 1.1.1.100)

Orthology

K00665

fatty acid synthase, animal type [EC:2.3.1.85]

Organism

hsa Homo sapiens (human)

Pathway

hsa00061	Fatty acid biosynthesis
hsa01100	Metabolic pathways
hsa04910	Insulin signaling pathway

Module

hsa_M00083

Fatty acid biosynthesis, elongation

Class

Metabolism; Lipid metabolism; Fatty acid biosynthesis [PATH:hsa00061]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]

SSDB

Motif

Pfam:

Acyl_transf_1 ketoacyl-synt Thioesterase KR adh_short Ketoacyl-synt_C PS-DH ADH_zinc_N ADH_zinc_N_2 PP-binding Methyltransf_12 Methyltransf_31 Methyltransf_11 Methyltransf_23 Methyltransf_18 Thiolase_N YjeF_N PE-PPE MTS AlaDh_PNT_C

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3TJM 3HHD 2PX6 1XKT 2JFD 2JFK 2CG5

Position

17q25

AA seq 2511 aa
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRF
DASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEAL
SRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQC
PAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLAR
RVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVG
DPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFH
SPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATL
PRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGP
EVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLS
TDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAV
LAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFE
FVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEA
QWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCT
IIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSL
AWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLA
RALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQ
WDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRL
LWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVV
SRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQL
CKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQ
VLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLL
SPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVA
ALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESL
FSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRP
VWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGD
LVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPG
AQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAK
GLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGV
GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKG
VDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFF
NESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEE
PEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGI
RTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLL
ENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSA
MERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLN
QPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSV
EVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLR
SLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLD
SIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGS
PTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAA
VDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGA
DYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG

NT seq 7536 nt +upstreamnt +downstreamnt
atggaggaggtggtgattgccggcatgtccgggaagctgccagagtcggagaacttgcag
gagttctgggacaacctcatcggcggtgtggacatggtcacggacgatgaccgtcgctgg
aaggcggggctctacggcctgccccggcggtccggcaagctgaaggacctgtctaggttt
gatgcctccttcttcggagtccaccccaagcaggcacacacgatggaccctcagctgcgg
ctgctgctggaagtcacctatgaagccatcgtggacggaggcatcaacccagattcactc
cgaggaacacacactggcgtctgggtgggcgtgagcggctctgagacctcggaggccctg
agccgagaccccgagacactcgtgggctacagcatggtgggctgccagcgagcgatgatg
gccaaccggctctccttcttcttcgacttcagagggcccagcatcgcactggacacagcc
tgctcctccagcctgatggccctgcagaacgcctaccaggccatccacagcgggcagtgc
cctgccgccatcgtggggggcatcaatgtcctgctgaagcccaacacctccgtgcagttc
ttgaggctggggatgctcagccccgagggcacctgcaaggccttcgacacagcggggaat
gggtactgccgctcggagggtgtggtggccgtcctgctgaccaagaagtccctggcccgg
cgggtgtacgccaccatcctgaacgccggcaccaatacagatggcttcaaggagcaaggc
gtgaccttcccctcaggggatatccaggagcagctcatccgctcgttgtaccagtcggcc
ggagtggcccctgagtcatttgaatacatcgaagcccacggcacaggcaccaaggtgggc
gacccccaggagctgaatggcatcacccgagccctgtgcgccacccgccaggagccgctg
ctcatcggctccaccaagtccaacatggggcacccggagccagcctcggggctggcagcc
ctggccaaggtgctgctgtccctggagcacgggctctgggcccccaacctgcacttccat
agccccaaccctgagatcccagcgctgttggatgggcggctgcaggtggtggaccagccc
ctgcccgtccgtggcggcaacgtgggcatcaactcctttggcttcgggggctccaacgtg
cacatcatcctgaggcccaacacgcagccgccccccgcacccgccccacatgccaccctg
ccccgtctgctgcgggccagcggacgcacccctgaggccgtgcagaagctgctggagcag
ggcctccggcacagccaggacctggctttcctgagcatgctgaacgacatcgcggctgtc
cccgccaccgccatgcccttccgtggctacgctgtgctgggtggtgagcgcggtggccca
gaggtgcagcaggtgcccgctggcgagcgcccgctctggttcatctgctctgggatgggc
acacagtggcgcgggatggggctgagcctcatgcgcctggaccgcttccgagattccatc
ctacgctccgatgaggctgtgaagccattcggcctgaaggtgtcacagctgctgctgagc
acagacgagagcacctttgatgacatcgtccattcgtttgtgagcctgactgccatccag
ataggcctcatagacctgctgagctgcatggggctgaggccagatggcatcgtcggccac
tccctgggggaggtggcctgtggctacgccgacggctgcctgtcccaggaggaggccgtc
ctcgctgcctactggaggggacagtgcatcaaagaagcccatctcccgccgggcgccatg
gcagccgtgggcttgtcctgggaggagtgtaaacagcgctgccccccgggcgtggtgccc
gcctgccacaactccaaggacacagtcaccatctcgggacctcaggccccggtgtttgag
ttcgtggagcagctgaggaaggagggtgtgtttgccaaggaggtgcggaccggcggtatg
gccttccactcctacttcatggaggccatcgcacccccactgctgcaggagctcaagaag
gtgatccgggagccgaagccacgttcagcccgctggctcagcacctctatccccgaggcc
cagtggcacagcagcctggcacgcacgtcctccgccgagtacaatgtcaacaacctggtg
agccctgtgctgttccaggaggccctgtggcacgtgcctgagcacgcggtggtgctggag
atcgcgccccacgccctgctgcaggctgtcctgaagcgtggcctgaagccgagctgcacc
atcatccccctgatgaagaaggatcacagggacaacctggagttcttcctggccggcatc
ggcaggctgcacctctcaggcatcgacgccaaccccaatgccttgttcccacctgtggag
ttcccagctccccgaggaactcccctcatctccccactcatcaagtgggaccacagcctg
gcctgggacgtgccggccgccgaggacttccccaacggttcaggttccccctcagccgcc
atctacaacatcgacaccagctccgagtctcctgaccactacctggtggaccacaccctc
gacggtcgcgtcctcttccccgccactggctacctgagcatagtgtggaagacgctggcc
cgcgccctgggcctgggcgtcgagcagctgcctgtggtgtttgaggatgtggtgctgcac
caggccaccatcctgcccaagactgggacagtgtccctggaggtacggctcctggaggcc
tcccgtgccttcgaggtgtcagagaacggcaacctggtagtgagtgggaaggtgtaccag
tgggatgaccctgaccccaggctcttcgaccacccggaaagccccacccccaaccccacg
gagcccctcttcctggcccaggctgaagtttacaaggagctgcgtctgcgtggctacgac
tacggccctcatttccagggcatcctggaggccagcctggaaggtgactcggggaggctg
ctgtggaaggataactgggtgagcttcatggacaccatgctgcagatgtccatcctgggc
tcggccaagcacggcctgtacctgcccacccgtgtcaccgccatccacatcgaccctgcc
acccacaggcagaagctgtacacactgcaggacaaggcccaagtggctgacgtggtggtg
agcaggtggctgagggtcacagtggccggaggcgtccacatctccgggctccacactgag
tcggccccgcggcggcagcaggagcagcaggtgcccatcctggagaagttttgcttcact
ccccacacggaggaggggtgcctgtctgagcgcgctgccctgcaggaggagctgcaactg
tgcaaggggctggtgcaggcactgcagaccaaggtgacccagcaggggctgaagatggtg
gtgcccggactggatggggcccagatcccccgggacccctcacagcaggaactgccccgg
ctgttgtcggctgcctgcaggcttcagctcaacgggaacctgcagctggagctggcgcag
gtgctggcccaggagaggcccaagctgccagaggaccctctgctcagcggcctcctggac
tccccggcactcaaggcctgcctggacactgccgtggagaacatgcccagcctgaagatg
aaggtggtggaggtgctggctggccacggtcacctgtattcccgcatcccaggcctgctc
agcccccatcccctgctgcagctgagctacacggccaccgaccgccacccccaggccctg
gaggctgcccaggccgagctgcagcagcacgacgttgcccagggccagtgggatcccgca
gaccctgcccccagcgccctgggcagcgccgacctcctggtgtgcaactgtgctgtggct
gccctcggggacccggcctcagctctcagcaacatggtggctgccctgagagaagggggc
tttctgctcctgcacacactgctccgggggcaccccctcggggacatcgtggccttcctc
acctccactgagccgcagtatggccagggcatcctgagccaggacgcgtgggagagcctc
ttctccagggtgtcgctgcgcctggtgggcctgaagaagtccttctacggctccacgctc
ttcctgtgccgccggcccaccccgcaggacagccccatcttcctgccggtggacgatacc
agcttccgctgggtggagtctctgaagggcatcctggctgacgaagactcttcccggcct
gtgtggctgaaggccatcaactgtgccacctcgggcgtggtgggcttggtgaactgtctc
cgccgagagcccggcgggaaccgcctccggtgtgtgctgctctccaacctcagcagcacc
tcccacgtcccggaggtggacccgggctccgcagaactgcagaaggtgttgcagggagac
ctggtgatgaacgtctaccgcgacggggcctggggggctttccgccacttcctgctggag
gaggacaagcctgaggagccgacggcacatgcctttgtgagcaccctcacccggggggac
ctgtcctccatccgctgggtctgctcctcgctgcgccatgcccagcccacctgccctggc
gcccagctctgcacggtctactacgcctccctcaacttccgcgacatcatgctggccact
ggcaagctgtcccctgatgccatcccagggaagtggacctcccaggacagcctgctaggt
atggagttctcgggccgagacgccagcggcaagcgtgtgatgggactggtgcctgccaag
ggcctggccacctctgtcctgctgtcaccggacttcctctgggatgtgccttccaactgg
acgctggaggaggcggcctcggtgcctgtcgtctacagcacggcctactacgcgctggtg
gtgcgtgggcgggtgcgccccggggagacgctgctcatccactcgggctcgggcggcgtg
ggccaggccgccatcgccatcgccctcagtctgggctgccgcgtcttcaccaccgtgggg
tcggctgagaagcgggcgtacctccaggccaggttcccccagctcgacagcaccagcttc
gccaactcccgggacacatccttcgagcagcatgtgctgtggcacacgggcgggaagggc
gttgacctggtcttgaactccttggcggaagagaagctgcaggccagcgtgaggtgcttg
gctacgcacggtcgcttcctggaaattggcaaattcgacctttctcagaaccacccgctc
ggcatggctatcttcctgaagaacgtgacattccacggggtcctactggatgcgttcttc
aacgagagcagtgctgactggcgggaggtgtgggcgcttgtgcaggccggcatccgggat
ggggtggtacggcccctcaagtgcacggtgttccatggggcccaggtggaggacgccttc
cgctacatggcccaagggaagcacattggcaaagtcgtcgtgcaggtgcttgcggaggag
ccggaggcagtgctgaagggggccaaacccaagctgatgtcggccatctccaagaccttc
tgcccggcccacaagagctacatcatcgctggtggtctgggtggcttcggcctggagttg
gcgcagtggctgatacagcgtggggtgcagaagctcgtgttgacttctcgctccgggatc
cggacaggctaccaggccaagcaggtccgccggtggaggcgccagggcgtacaggtgcag
gtgtccaccagcaacatcagctcactggagggggcccggggcctcattgccgaggcggcg
cagcttgggcccgtgggcggcgtcttcaacctggccgtggtcttgagagatggcttgctg
gagaaccagaccccagagttcttccaggacgtctgcaagcccaagtacagcggcaccctg
aacctggacagggtgacccgagaggcgtgccctgagctggactactttgtggtcttctcc
tctgtgagctgcgggcgtggcaatgcgggacagagcaactacggctttgccaattccgcc
atggagcgtatctgtgagaaacgccggcacgaaggcctcccaggcctggccgtgcagtgg
ggcgccatcggcgacgtgggcattttggtggagacgatgagcaccaacgacacgatcgtc
agtggcacgctgccccagcgcatggcgtcctgcctggaggtgctggacctcttcctgaac
cagccccacatggtcctgagcagctttgtgctggctgagaaggctgcggcctatagggac
agggacagccagcgggacctggtggaggccgtggcacacatcctgggcatccgcgacttg
gctgctgtcaacctggacagctcactggcggacctgggcctggactcgctcatgagcgtg
gaggtgcgccagacgctggagcgtgagctcaacctggtgctgtccgtgcgcgaggtgcgg
caactcacgctccggaaactgcaggagctgtcctcaaaggcggatgaggccagcgagctg
gcatgccccacgcccaaggaggatggtctggcccagcagcagactcagctgaacctgcgc
tccctgctggtgaacccggagggccccaccctgatgcggctcaactccgtgcagagctcg
gagcggcccctgttcctggtgcacccaatcgagggctccaccaccgtgttccacagcctg
gcctcccggctcagcatccccacctatggcctgcagtgcacccgagctgcgccccttgac
agcatccacagcctggctgcctactacatcgactgcatcaggcaggtgcagcccgagggc
ccctaccgcgtggccggctactcctacggggcctgcgtggcctttgaaatgtgctcccag
ctgcaggcccagcagagcccagcccccacccacaacagcctcttcctgttcgacggctcg
cccacctacgtactggcctacacccagagctaccgggcaaagctgaccccaggctgtgag
gctgaggctgagacggaggccatatgcttcttcgtgcagcagttcacggacatggagcac
aacagggtgctggaggcgctgctgccgctgaagggcctagaggagcgtgtggcagccgcc
gtggacctgatcatcaagagccaccagggcctggaccgccaggagctgagctttgcggcc
cggtccttctactacaagctgcgtgccgctgagcagtacacacccaaggccaagtaccat
ggcaacgtgatgctactgcgcgccaagacgggtggcgcctacggcgaggacctgggcgcg
gactacaacctctcccaggtatgcgacgggaaagtatccgtccacgtcatcgagggtgac
caccgcacgctgctggagggcagcggcctggagtccatcatcagcatcatccacagctcc
ctggctgagccacgcgtgagcgtgcgggagggctag

All links

Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (41)   
   KEGG COMPOUND (41)   
Chemical reaction (32)   
   KEGG ENZYME (1)   
   KEGG REACTION (31)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (11)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (7)   
   PDB (7)   
Protein domain (20)   
   Pfam (20)   
All databases (152)   

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