KEGG T01001: 2317

Homo sapiens (human): 2317

Entry

2317 CDS T01001

Gene name

FLNB, ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP

Definition

filamin B, beta

Orthology

K04437

filamin

Organism

hsa Homo sapiens (human)

Pathway

hsa04010	MAPK signaling pathway
hsa04510	Focal adhesion
hsa05132	Salmonella infection
hsa05205	Proteoglycans in cancer

Disease

H00461	FLNB-related disorders
H00499	Spondylocarpotarsal synostosis syndrome

Class

Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:hsa04010]
Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:hsa05205]
Human Diseases; Infectious diseases; Salmonella infection [PATH:hsa05132]

SSDB

Motif

Pfam:

Filamin CH Big_1 Y_Y_Y Big_3_4

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2WA7 2WA5 2WA6 4B7L 3FER 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2E9I 2E9J 2DMB 2DMC 2DLG 2DJ4 2DI8 2DI9 2DIA 2DIB 2DIC

Position

3p14.3

AA seq 2633 aa
MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK
RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH
YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP
GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA
KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK
EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK
GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP
MQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTK
AAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFE
VQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQN
DGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGC
IVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAV
VWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVG
IKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD
PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID
NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGK
DQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTY
DGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGP
CEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASG
PGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAG
MYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQ
VGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV
AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKD
GSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVL
QSFTVDSSKAGLAPLEVRVLGPRADDTDSQSWRSPLKALSEFFKGDPKGDFNKTGLVEPV
NVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSS
YGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYM
IGVTYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVT
CTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEV
TAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSG
KTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGP
GLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYS
ILVKYNDKHIPGSPFTAKITDDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRD
EPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYG
RGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVY
IVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDM
SAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLG
EGGAHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCG
VSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFA
IRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGS
PFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKM
DCQETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSIL
VESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGV
HGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP

NT seq 7902 nt +upstreamnt +downstreamnt
atgccggtaaccgagaaggatctagctgaggacgcgccttggaagaagatccagcagaac
acgttcacacgctggtgcaacgagcacctcaagtgcgtgaacaaacgcatcggcaacctg
cagaccgacctgagcgacgggctgcggctcatcgcgctgctcgaggtgctcagccagaag
cgcatgtaccgcaagtaccatcagcggcccacctttcgccagatgcagctcgagaatgtg
tccgtggcgctcgagttcctggaccgtgagagcatcaagctcgtgtccatcgatagcaaa
gccattgtggatgggaacctgaagctcatcttgggtctggtgtggacgctgatcctccac
tactccatctccatgcccgtgtgggaggatgaaggggatgatgatgccaagaagcagacg
ccaaagcagaggctgctggggtggattcagaacaagatcccctacttgcccatcaccaac
tttaaccagaactggcaagacggcaaagccctgggagccctggtagacagctgtgctcca
ggtctgtgcccagactgggaatcctgggacccgcagaagcctgtggataatgcacgagaa
gccatgcagcaggcagatgactggctgggtgtcccacaggtcatcactcctgaagaaatc
attcacccggatgtggacgagcactcagttatgacttacctgtcccagttccccaaagcc
aagctcaagccgggggctcctctcaaacccaaactcaacccgaagaaagccagggcctat
ggcagaggaatcgagcccactggaaacatggtgaagcagccagccaagttcactgtggac
accatcagcgccgggcaaggagacgtgatggtgtttgttgaggacccagaagggaacaaa
gaggaggcacaagtgacccctgacagtgacaagaacaagacatactctgtggagtatctg
cccaaggtcaccgggctacacaaagtcacagtcctctttgcaggacagcacatctccaag
agcccatttgaagtgagtgttgacaaggcccagggagatgccagtaaagtcactgcaaaa
ggtccagggttggaagctgtagggaacatcgccaataagcccacctactttgacatctat
acggcaggagctggtgtgggtgacattggtgtggaggtggaagatccccaggggaagaac
accgtggagttgctcgtggaagacaaaggaaaccaggtgtatcgatgtgtgtacaaaccc
atgcagcctggccctcacgtggtcaagatcttctttgctggggacactattcctaagagt
cccttcgttgtgcaggttggggaagcctgcaatccaaatgcctgccgggccagtggccga
ggcctacaacccaaaggcgtccgtatccgggagaccacagatttcaaggttgacaccaaa
gctgcaggaagtggggagctcggtgtaaccatgaagggtcctaagggtctggaggagctg
gtgaagcagaaagactttctggatggggtctacgcattcgagtattaccccagcaccccg
gggagatacagcattgccatcacatgggggggacaccacattccaaagagcccctttgaa
gttcaagttggccctgaagcgggtatgcagaaagtccgtgcttggggccctgggctccat
ggtgggattgtcgggcggtcagcggacttcgtggtagaatccattggctctgaagtgggg
tctctggggtttgccattgaaggcccctctcaggcaaagattgagtacaacgaccagaat
gatggatcgtgtgatgtcaaatactggcccaaggagcctggcgaatatgctgttcacatc
atgtgtgacgacgaagacatcaaggacagcccgtacatggccttcatccacccagccacg
ggaggctacaaccctgatctggttcgagcatacgggccaggtttggagaaatctggatgc
attgtcaacaacctggccgagttcactgtggatcctaaggatgctggaaaagctccctta
aagatatttgctcaggatggggaaggccaacgcattgacatccagatgaagaaccggatg
gacggcacatatgcatgctcatacaccccggtgaaggccatcaagcacaccattgctgtg
gtctggggaggcgtgaacatcccgcacagcccctacagggtcaacatcgggcaaggtagc
catcctcagaaggtcaaagtgtttgggccaggtgtggagagaagtggtctgaaggcaaat
gaacctacacacttcacggtggactgtactgaggctggggaaggtgatgtcagtgttggc
attaagtgtgatgcccgggtgttaagtgaagatgaggaagacgtggattttgacattatt
cacaatgccaatgatacgttcacagtcaaatatgtgcctcctgctgctgggcgatacact
atcaaagttctctttgcatctcaggaaatccccgccagccctttcagagtcaaagttgac
ccttcccacgatgccagcaaagtgaaggcagaaggcccagggctcagcaaagcaggtgtg
gaaaatgggaaaccgacccacttcactgtctacaccaagggggctgggaaagccccgctc
aacgtgcagttcaacagccctcttcctggcgatgcagtgaaggatttggatatcatcgat
aattatgactactctcacacggttaaatatacacccacccaacagggcaacatgcaggtt
ctggtgacttacggtggcgatcccatccctaaaagccctttcactgtgggtgttgctgca
ccgctggatctgagcaagataaaactcaatgggctggaaaacagggtggaagttgggaag
gatcaggagttcaccgttgataccaggggggcaggaggccaggggaagctggacgtgaca
atcctcagcccctctcggaaggtcgtgccatgcctagtgacacctgtgacaggccgggag
aacagcacggccaagttcatccctcgggaggaggggctgtatgctgtagacgtgacctac
gatggacaccctgtgcccgggagcccctacacagtggaggcctcgctgccaccagatccc
agcaaggtgaaggcccacggtcccggcctcgaaggtggtctcgtgggcaagcctgccgag
ttcaccatcgataccaaaggagctggtactggaggtctgggcttaacggtggaaggtccg
tgcgaggccaaaatcgagtgctccgacaatggtgatgggacctgctccgtctcttacctt
cccacaaaacccggggagtacttcgtcaacatcctctttgaagaagtccacatacctggg
tctcccttcaaagctgacattgaaatgccctttgacccctctaaagtcgtggcatcgggg
ccaggtctcgagcacgggaaggtgggtgaagctggcctccttagcgtcgactgctcggaa
gcgggaccgggggccctgggcctggaagctgtctcggactcgggaacaaaagccgaagtc
agtattcagaacaacaaagatggcacctacgcggtgacctacgtgcccctgacggccggc
atgtacacgttgaccatgaagtatggtggcgaactcgtgccacacttccccgcccgggtc
aaggtggagcccgccgtggacaccagcaggatcaaagtctttggaccaggaatagaaggg
aaagatgtgttccgggaagctaccaccgactttacagttgactctcggccgctgacccag
gttgggggtgaccacatcaaggcccacattgccaacccctcaggggcctccaccgagtgc
tttgtcacagacaatgcggatgggacctaccaggtggaatacacaccctttgagaaaggt
ctccatgtagtggaggtgacatatgatgacgtgcctatcccaaacagtcccttcaaggtg
gctgtcactgaaggctgccagccatctagggtgcaagcccaaggacctggattgaaagag
gcctttaccaacaagcccaatgtcttcaccgtggttaccagaggcgcaggaattggtggg
cttggcataactgttgagggaccatcagagtcgaagataaattgcagagacaacaaggat
ggcagctgcagtgctgagtacattcctttcgcaccgggggattacgatgttaatatcaca
tatggaggagcccacatccccggcagccccttcagggttcctgtgaaggatgttgtggac
cccagcaaggtcaagattgccggccccgggctgggctcaggcgtccgagcccgtgtcctg
cagtccttcacggtggacagcagcaaggctggcctggctccgctggaagtgagggttctg
ggcccacgagctgacgacacggattcccagtcatggcgcagccccttgaaagccctttca
gagttctttaaaggtgacccgaagggtgactttaataagacaggcttggtggagccagtg
aacgtggtggacaatggagatggcacacacacagtaacctacaccccatctcaggaggga
ccttacatggtctcagttaaatatgctgatgaagagattcctcgcagtcccttcaaggtc
aaggtccttcccacatatgatgccagcaaagtgactgccagtggccccggccttagttcc
tatggtgtgcctgccagtctacctgtggactttgcaattgatgcccgagatgccggggaa
ggcctgcttgctgttcaaataacggaccaagaaggaaaacccaaaagagccattgtccat
gacaataaagatggcacgtatgctgtcacctacatccccgacaagactgggcgctatatg
attggagtcacctacgggggtgacgacatcccactttctccttatcgcatccgagccaca
cagacgggtgatgccagcaagtgcctggccacgggtcctggaatcgcctccactgtgaaa
actggcgaagaagtaggctttgtggttgatgccaagactgccgggaagggtaaagtgacc
tgcacggttctgaccccagatggcactgaggccgaggccgatgtcattgagaatgaagat
ggaacctatgacatcttctacacagctgccaagccgggcacatatgtgatctatgtgcgc
ttcggtggtgttgatattcctaacagccccttcactgtcatggccacagatggggaagtc
acagccgtggaggaggcaccggtaaatgcatgtccccctggattcaggccctgggtgacc
gaagaggcctatgtcccagtgagtgacatgaacggcctgggatttaagccttttgacctg
gtcattccgtttgctgtcaggaaaggagaaatcactggagaggtccacatgccttctggg
aagacagccacacctgagattgtggacaacaaggacggcacggtcactgttagatatgcc
cccactgaggtcgggctccatgagatgcacatcaaatacatgggcagccacatccctgag
agcccactccagttctacgtgaactaccccaacagtggaagtgtttctgcatacggtcca
ggcctcgtgtatggagtggccaacaaaactgccaccttcaccatcgtcacagaggatgca
ggagaaggtggtctggacttggctattgagggcccctcaaaagcagaaatcagctgcatt
gacaataaagatgggacatgcacagtgacctacctgccgactctgccaggcgactacagc
attctggtcaagtacaatgacaagcacatccctggcagccccttcacagccaagatcaca
gatgacagcaggcggtgctcccaggtgaagttgggctcagccgctgacttcctgctcgac
atcagtgagactgacctcagcagcctgacggccagcattaaggccccatctggccgagac
gagccctgtctcctgaagaggctgcccaacaaccacattggcatctccttcatcccccgg
gaagtgggcgaacatctggtcagcatcaagaaaaatggcaaccatgtggccaacagcccc
gtgtctatcatggtggtccagtcggagattggtgacgcccgccgagccaaagtctatggc
cgcggcctgtcagaaggccggactttcgagatgtctgacttcatcgtggacacaagggat
gcaggttatggtggcatatccttggcggtggaaggccccagcaaagtggacatccagacg
gaggacctggaagatggcacctgcaaagtctcctacttccctaccgtgcctggggtttat
atcgtctccaccaaattcgctgacgagcacgtgcctgggagcccatttaccgtgaagatc
agtggggagggaagagtcaaagagagcatcacccgcaccagtcgggccccgtccgtggcc
actgtcgggagcatttgtgacctgaacctgaaaatcccagaaatcaacagcagtgatatg
tcggcccacgtcaccagcccctctggccgtgtgactgaggcagagattgtgcccatgggg
aagaactcacactgcgtccggtttgtgccccaggagatgggcgtgcacacggtcagcgtc
aagtaccgtgggcagcacgtcaccggcagccccttccagttcaccgtggggccacttggt
gaaggaggcgcccacaaggtgcgggcaggaggccctggcctggagagaggagaagcggga
gtcccagctgagttcagcatttggacccgggaagcaggcgctggaggcctctccatcgct
gttgagggccccagtaaggccgagattacattcgatgaccataaaaatgggtcgtgcggt
gtatcttatattgcccaagagcctggtaactacgaggtgtccatcaagttcaatgatgag
cacatcccggaaagcccctacctggtgccggtcatcgcaccctccgacgacgcccgccgc
ctcactgttatgagccttcaggaatcgggattaaaagttaaccagccagcatcctttgct
ataaggttgaatggcgcaaaaggcaagattgatgcaaaggtgcacagcccctctggagcc
gtggaggagtgccacgtgtctgagctggagccagataagtatgctgttcgcttcatccct
catgagaatggtgtccacaccatcgatgtcaagttcaatgggagccacgtggttggaagc
cccttcaaagtgcgcgttggggagcctggacaagcggggaaccctgccctggtgtccgcc
tatggcacgggactcgaagggggcaccacaggtatccagtcggaattctttattaacacc
acccgagcaggtccagggacattatccgtcaccatcgaaggcccatccaaggttaaaatg
gattgccaggaaacacctgaagggtacaaagtcatgtacacccccatggctcctggtaac
tacctgatcagcgtcaaatacggtgggcccaaccacatcgtgggcagtcccttcaaggcc
aaggtgacaggccagcgtctagttagccctggctcagccaacgagacctcatccatcctg
gtggagtcagtgaccaggtcgtctacagagacctgctatagcgccattcccaaggcatcc
tcggacgccagcaaggtgacctctaagggggcagggctctcaaaggcctttgtgggccag
aagagttccttcctggtggactgcagcaaagctggctccaacatgctgctgatcggggtc
catgggcccaccaccccctgcgaggaggtctccatgaagcatgtaggcaaccagcaatac
aacgtcacatacgtcgtcaaggagaggggcgattatgtgctggctgtgaagtggggggag
gaacacatccctggcagcccttttcatgtcacagtgccttaa

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (8)   
   KEGG DISEASE (2)   
   OMIM (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (15)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (38)   
   RefSeq(nuc) (4)   
   GenBank (17)   
   EMBL (17)   
3D Structure (22)   
   PDB (22)   
Protein domain (5)   
   Pfam (5)   
All databases (107)   

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