KEGG T01001: 2335

Homo sapiens (human): 2335

Entry

2335 CDS T01001

Gene name

FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF

Definition

fibronectin 1

Orthology

K05717

fibronectin 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04151	PI3K-Akt signaling pathway
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04810	Regulation of actin cytoskeleton
hsa05100	Bacterial invasion of epithelial cells
hsa05146	Amoebiasis
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05222	Small cell lung cancer

Disease

H01260

Glomerulopathy with fibronectin deposits (GFND)

Class

Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signaling molecules and interaction; ECM-receptor interaction [PATH:hsa04512]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:hsa04810]
Cellular Processes; Cell communication; Focal adhesion [PATH:hsa04510]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:hsa05205]
Human Diseases; Cancers; Small cell lung cancer [PATH:hsa05222]
Human Diseases; Infectious diseases; Bacterial invasion of epithelial cells [PATH:hsa05100]
Human Diseases; Infectious diseases; Amoebiasis [PATH:hsa05146]

SSDB

Motif

Pfam:

fn3 fn1 fn2 DUF2369

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

P02751 E9PG29 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6

Structure

PDB:

2CG6 3ZRZ 3CAL 2RKY 1FNA 2RKZ 2RL0 1FNF 3EJH 3T1W 3R8Q 3M7P 4GH7 3GXE 1FNH 3MQL 2EC3 2HA1 2H41 2H45 2CKU 2CG7 1Q38 1OWW 1O9A 1J8K 1E88 1E8B 1QO6 1QGB 2FN2 1FBR 1TTF 1TTG

Position

2q34

AA seq 2355 aa
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGQEALSQTTISWAPFQDTSE
YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQQRHKVREEVVTVG
NSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWC
HDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKE
YLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIEC
FMPLDVQADREDSRE

NT seq 7068 nt +upstreamnt +downstreamnt
atgcttaggggtccggggcccgggctgctgctgctggccgtccagtgcctggggacagcg
gtgccctccacgggagcctcgaagagcaagaggcaggctcagcaaatggttcagccccag
tccccggtggctgtcagtcaaagcaagcccggttgttatgacaatggaaaacactatcag
ataaatcaacagtgggagcggacctacctaggcaatgcgttggtttgtacttgttatgga
ggaagccgaggttttaactgcgagagtaaacctgaagctgaagagacttgctttgacaag
tacactgggaacacttaccgagtgggtgacacttatgagcgtcctaaagactccatgatc
tgggactgtacctgcatcggggctgggcgagggagaataagctgtaccatcgcaaaccgc
tgccatgaagggggtcagtcctacaagattggtgacacctggaggagaccacatgagact
ggtggttacatgttagagtgtgtgtgtcttggtaatggaaaaggagaatggacctgcaag
cccatagctgagaagtgttttgatcatgctgctgggacttcctatgtggtcggagaaacg
tgggagaagccctaccaaggctggatgatggtagattgtacttgcctgggagaaggcagc
ggacgcatcacttgcacttctagaaatagatgcaacgatcaggacacaaggacatcctat
agaattggagacacctggagcaagaaggataatcgaggaaacctgctccagtgcatctgc
acaggcaacggccgaggagagtggaagtgtgagaggcacacctctgtgcagaccacatcg
agcggatctggccccttcaccgatgttcgtgcagctgtttaccaaccgcagcctcacccc
cagcctcctccctatggccactgtgtcacagacagtggtgtggtctactctgtggggatg
cagtggctgaagacacaaggaaataagcaaatgctttgcacgtgcctgggcaacggagtc
agctgccaagagacagctgtaacccagacttacggtggcaactcaaatggagagccatgt
gtcttaccattcacctacaatggcaggacgttctactcctgcaccacagaagggcgacag
gacggacatctttggtgcagcacaacttcgaattatgagcaggaccagaaatactctttc
tgcacagaccacactgttttggttcagactcgaggaggaaattccaatggtgccttgtgc
cacttccccttcctatacaacaaccacaattacactgattgcacttctgagggcagaaga
gacaacatgaagtggtgtgggaccacacagaactatgatgccgaccagaagtttgggttc
tgccccatggctgcccacgaggaaatctgcacaaccaatgaaggggtcatgtaccgcatt
ggagatcagtgggataagcagcatgacatgggtcacatgatgaggtgcacgtgtgttggg
aatggtcgtggggaatggacatgcattgcctactcgcagcttcgagatcagtgcattgtt
gatgacatcacttacaatgtgaacgacacattccacaagcgtcatgaagaggggcacatg
ctgaactgtacatgcttcggtcagggtcggggcaggtggaagtgtgatcccgtcgaccaa
tgccaggattcagagactgggacgttttatcaaattggagattcatgggagaagtatgtg
catggtgtcagataccagtgctactgctatggccgtggcattggggagtggcattgccaa
cctttacagacctatccaagctcaagtggtcctgtcgaagtatttatcactgagactccg
agtcagcccaactcccaccccatccagtggaatgcaccacagccatctcacatttccaag
tacattctcaggtggagacctaaaaattctgtaggccgttggaaggaagctaccatacca
ggccacttaaactcctacaccatcaaaggcctgaagcctggtgtggtatacgagggccag
ctcatcagcatccagcagtacggccaccaagaagtgactcgctttgacttcaccaccacc
agcaccagcacacctgtgaccagcaacaccgtgacaggagagacgactcccttttctcct
cttgtggccacttctgaatctgtgaccgaaatcacagccagtagctttgtggtctcctgg
gtctcagcttccgacaccgtgtcgggattccgggtggaatatgagctgagtgaggaggga
gatgagccacagtacctggatcttccaagcacagccacttctgtgaacatccctgacctg
cttcctggccgaaaatacattgtaaatgtctatcagatatctgaggatggggagcagagt
ttgatcctgtctacttcacaaacaacagcgcctgatgcccctcctgacccgactgtggac
caagttgatgacacctcaattgttgttcgctggagcagaccccaggctcccatcacaggg
tacagaatagtctattcgccatcagtagaaggtagcagcacagaactcaaccttcctgaa
actgcaaactccgtcaccctcagtgacttgcaacctggtgttcagtataacatcactatc
tatgctgtggaagaaaatcaagaaagtacacctgttgtcattcaacaagaaaccactggc
accccacgctcagatacagtgccctctcccagggacctgcagtttgtggaagtgacagac
gtgaaggtcaccatcatgtggacaccgcctgagagtgcagtgaccggctaccgtgtggat
gtgatccccgtcaacctgcctggcgagcacgggcagaggctgcccatcagcaggaacacc
tttgcagaagtcaccgggctgtcccctggggtcacctattacttcaaagtctttgcagtg
agccatgggagggagagcaagcctctgactgctcaacagacaaccaaactggatgctccc
actaacctccagtttgtcaatgaaactgattctactgtcctggtgagatggactccacct
cgggcccagataacaggataccgactgaccgtgggccttacccgaagaggacagcccagg
cagtacaatgtgggtccctctgtctccaagtacccactgaggaatctgcagcctgcatct
gagtacaccgtatccctcgtggccataaagggcaaccaagagagccccaaagccactgga
gtctttaccacactgcagcctgggagctctattccaccttacaacaccgaggtgactgag
accaccattgtgatcacatggacgcctgctccaagaattggttttaagctgggtgtacga
ccaagccagggaggagaggcaccacgagaagtgacttcagactcaggaagcatcgttgtg
tccggcttgactccaggagtagaatacgtctacaccatccaagtcctgagagatggacag
gaaagagatgcgccaattgtaaacaaagtggtgacaccattgtctccaccaacaaacttg
catctggaggcaaaccctgacactggagtgctcacagtctcctgggagaggagcaccacc
ccagacattactggttatagaattaccacaacccctacaaacggccagcagggaaattct
ttggaagaagtggtccatgctgatcagagctcctgcacttttgataacctgagtcccggc
ctggagtacaatgtcagtgtttacactgtcaaggatgacaaggaaagtgtccctatctct
gataccatcatcccagctgttcctcctcccactgacctgcgattcaccaacattggtcca
gacaccatgcgtgtcacctgggctccacccccatccattgatttaaccaacttcctggtg
cgttactcacctgtgaaaaatgaggaagatgttgcagagttgtcaatttctccttcagac
aatgcagtggtcttaacaaatctcctgcctggtacagaatatgtagtgagtgtctccagt
gtctacgaacaacatgagagcacacctcttagaggaagacagaaaacaggtcttgattcc
ccaactggcattgacttttctgatattactgccaactcttttactgtgcactggattgct
cctcgagccaccatcactggctacaggatccgccatcatcccgagcacttcagtgggaga
cctcgagaagatcgggtgccccactctcggaattccatcaccctcaccaacctcactcca
ggcacagagtatgtggtcagcatcgttgctcttaatggcagagaggaaagtcccttattg
attggccaacaatcaacagtttctgatgttccgagggacctggaagttgttgctgcgacc
cccaccagcctactgatcagctgggatgctcctgctgtcacagtgagatattacaggatc
acttacggagagacaggaggaaatagccctgtccaggagttcactgtgcctgggagcaag
tctacagctaccatcagcggccttaaacctggagttgattataccatcactgtgtatgct
gtcactggccgtggagacagccccgcaagcagcaagccaatttccattaattaccgaaca
gaaattgacaaaccatcccagatgcaagtgaccgatgttcaggacaacagcattagtgtc
aagtggctgccttcaagttcccctgttactggttacagagtaaccaccactcccaaaaat
ggaccaggaccaacaaaaactaaaactgcaggtccagatcaaacagaaatgactattgaa
ggcttgcagcccacagtggagtatgtggttagtgtctatgctcagaatccaagcggagag
agtcagcctctggttcagactgcagtaaccaacattgatcgccctaaaggactggcattc
actgatgtggatgtcgattccatcaaaattgcttgggaaagcccacaggggcaagtttcc
aggtacagggtgacctactcgagccctgaggatggaatccatgagctattccctgcacct
gatggtgaagaagacactgcagagctgcaaggcctcagaccgggttctgagtacacagtc
agtgtggttgccttgcacgatgatatggagagccagcccctgattggaacccagtccaca
gctattcctgcaccaactgacctgaagttcactcaggtcacacccacaagcctgagcgcc
cagtggacaccacccaatgttcagctcactggatatcgagtgcgggtgacccccaaggag
aagaccggaccaatgaaagaaatcaaccttgctcctgacagctcatccgtggttgtatca
ggacttatggtggccaccaaatatgaagtgagtgtctatgctcttaaggacactttgaca
agcagaccagctcagggagttgtcaccactctggagaatgtcagcccaccaagaagggct
cgtgtgacagatgctactgagaccaccatcaccattagctggagaaccaagactgagacg
atcactggcttccaagttgatgccgttccagccaatggccagactccaatccagagaacc
atcaagccagatgtcagaagctacaccatcacaggtttacaaccaggcactgactacaag
atctacctgtacaccttgaatgacaatgctcggagctcccctgtggtcatcgacgcctcc
actgccattgatgcaccatccaacctgcgtttcctggccaccacacccaattccttgctg
gtatcatggcagccgccacgtgccaggattaccggctacatcatcaagtatgagaagcct
gggtctcctcccagagaagtggtccctcggccccgccctggtgtcacagaggctactatt
actggcctggaaccgggaaccgaatatacaatttatgtcattgccctgaagaataatcag
aagagcgagcccctgattggaaggaaaaagacagacgagcttccccaactggtaaccctt
ccacaccccaatcttcatggaccagagatcttggatgttccttccacagttcaaaagacc
cctttcgtcacccaccctgggtatgacactggaaatggtattcagcttcctggcacttct
ggtcagcaacccagtgttgggcaacaaatgatctttgaggaacatggttttaggcggacc
acaccgcccacaacggccacccccataaggcataggccaagaccatacccgccgaatgta
ggacaagaagctctctctcagacaaccatctcatgggccccattccaggacacttctgag
tacatcatttcatgtcatcctgttggcactgatgaagaacccttacagttcagggttcct
ggaacttctaccagtgccactctgacaggcctcaccagaggtgccacctacaacatcata
gtggaggcactgaaagaccagcagaggcataaggttcgggaagaggttgttaccgtgggc
aactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgacccctacaca
gtttcccattatgccgttggagatgagtgggaacgaatgtctgaatcaggctttaaactg
ttgtgccagtgcttaggctttggaagtggtcatttcagatgtgattcatctagatggtgc
catgacaatggtgtgaactacaagattggagagaagtgggaccgtcagggagaaaatggc
cagatgatgagctgcacatgtcttgggaacggaaaaggagaattcaagtgtgaccctcat
gaggcaacgtgttatgatgatgggaagacataccacgtaggagaacagtggcagaaggaa
tatctcggtgccatttgctcctgcacatgctttggaggccagcggggctggcgctgtgac
aactgccgcagacctgggggtgaacccagtcccgaaggcactactggccagtcctacaac
cagtattctcagagataccatcagagaacaaacactaatgttaattgcccaattgagtgc
ttcatgcctttagatgtacaggctgacagagaagattcccgagagtaa

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (9)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (179)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (67)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   PROTHERM (104)   
   VEGA (1)   
Protein sequence (12)   
   UniProt (6)   
   RefSeq(pep) (6)   
DNA sequence (157)   
   RefSeq(nuc) (7)   
   GenBank (75)   
   EMBL (75)   
3D Structure (34)   
   PDB (34)   
Protein domain (4)   
   Pfam (4)   
All databases (401)   

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