KEGG   Homo sapiens (human): 2335Help
Entry
2335              CDS       T01001                                 

Gene name
FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
Definition
fibronectin 1
Orthology
K05717  
fibronectin 1
Organism
hsa  Homo sapiens (human)
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Amoebiasis
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Disease
H01260  
Glomerulopathy with fibronectin deposits (GFND)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    2335 (FN1)
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    2335 (FN1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    2335 (FN1)
  Cellular commiunity
   04510 Focal adhesion
    2335 (FN1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    2335 (FN1)
   05205 Proteoglycans in cancer
    2335 (FN1)
   05222 Small cell lung cancer
    2335 (FN1)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    2335 (FN1)
   05146 Amoebiasis
    2335 (FN1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   2335 (FN1)
Heparan sulfate/heparin binding proteins [BR:hsa00536]
 Extracellular matrix molecules (General comment) Storage depot, cell adhesion and motility, ECM/barrier formation
  2335 (FN1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
2q34
AA seq 2355 aa AA seqDB search
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGQEALSQTTISWAPFQDTSE
YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQQRHKVREEVVTVG
NSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWC
HDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKE
YLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIEC
FMPLDVQADREDSRE
NT seq 7068 nt NT seq  +upstreamnt  +downstreamnt
atgcttaggggtccggggcccgggctgctgctgctggccgtccagtgcctggggacagcg
gtgccctccacgggagcctcgaagagcaagaggcaggctcagcaaatggttcagccccag
tccccggtggctgtcagtcaaagcaagcccggttgttatgacaatggaaaacactatcag
ataaatcaacagtgggagcggacctacctaggcaatgcgttggtttgtacttgttatgga
ggaagccgaggttttaactgcgagagtaaacctgaagctgaagagacttgctttgacaag
tacactgggaacacttaccgagtgggtgacacttatgagcgtcctaaagactccatgatc
tgggactgtacctgcatcggggctgggcgagggagaataagctgtaccatcgcaaaccgc
tgccatgaagggggtcagtcctacaagattggtgacacctggaggagaccacatgagact
ggtggttacatgttagagtgtgtgtgtcttggtaatggaaaaggagaatggacctgcaag
cccatagctgagaagtgttttgatcatgctgctgggacttcctatgtggtcggagaaacg
tgggagaagccctaccaaggctggatgatggtagattgtacttgcctgggagaaggcagc
ggacgcatcacttgcacttctagaaatagatgcaacgatcaggacacaaggacatcctat
agaattggagacacctggagcaagaaggataatcgaggaaacctgctccagtgcatctgc
acaggcaacggccgaggagagtggaagtgtgagaggcacacctctgtgcagaccacatcg
agcggatctggccccttcaccgatgttcgtgcagctgtttaccaaccgcagcctcacccc
cagcctcctccctatggccactgtgtcacagacagtggtgtggtctactctgtggggatg
cagtggctgaagacacaaggaaataagcaaatgctttgcacgtgcctgggcaacggagtc
agctgccaagagacagctgtaacccagacttacggtggcaactcaaatggagagccatgt
gtcttaccattcacctacaatggcaggacgttctactcctgcaccacagaagggcgacag
gacggacatctttggtgcagcacaacttcgaattatgagcaggaccagaaatactctttc
tgcacagaccacactgttttggttcagactcgaggaggaaattccaatggtgccttgtgc
cacttccccttcctatacaacaaccacaattacactgattgcacttctgagggcagaaga
gacaacatgaagtggtgtgggaccacacagaactatgatgccgaccagaagtttgggttc
tgccccatggctgcccacgaggaaatctgcacaaccaatgaaggggtcatgtaccgcatt
ggagatcagtgggataagcagcatgacatgggtcacatgatgaggtgcacgtgtgttggg
aatggtcgtggggaatggacatgcattgcctactcgcagcttcgagatcagtgcattgtt
gatgacatcacttacaatgtgaacgacacattccacaagcgtcatgaagaggggcacatg
ctgaactgtacatgcttcggtcagggtcggggcaggtggaagtgtgatcccgtcgaccaa
tgccaggattcagagactgggacgttttatcaaattggagattcatgggagaagtatgtg
catggtgtcagataccagtgctactgctatggccgtggcattggggagtggcattgccaa
cctttacagacctatccaagctcaagtggtcctgtcgaagtatttatcactgagactccg
agtcagcccaactcccaccccatccagtggaatgcaccacagccatctcacatttccaag
tacattctcaggtggagacctaaaaattctgtaggccgttggaaggaagctaccatacca
ggccacttaaactcctacaccatcaaaggcctgaagcctggtgtggtatacgagggccag
ctcatcagcatccagcagtacggccaccaagaagtgactcgctttgacttcaccaccacc
agcaccagcacacctgtgaccagcaacaccgtgacaggagagacgactcccttttctcct
cttgtggccacttctgaatctgtgaccgaaatcacagccagtagctttgtggtctcctgg
gtctcagcttccgacaccgtgtcgggattccgggtggaatatgagctgagtgaggaggga
gatgagccacagtacctggatcttccaagcacagccacttctgtgaacatccctgacctg
cttcctggccgaaaatacattgtaaatgtctatcagatatctgaggatggggagcagagt
ttgatcctgtctacttcacaaacaacagcgcctgatgcccctcctgacccgactgtggac
caagttgatgacacctcaattgttgttcgctggagcagaccccaggctcccatcacaggg
tacagaatagtctattcgccatcagtagaaggtagcagcacagaactcaaccttcctgaa
actgcaaactccgtcaccctcagtgacttgcaacctggtgttcagtataacatcactatc
tatgctgtggaagaaaatcaagaaagtacacctgttgtcattcaacaagaaaccactggc
accccacgctcagatacagtgccctctcccagggacctgcagtttgtggaagtgacagac
gtgaaggtcaccatcatgtggacaccgcctgagagtgcagtgaccggctaccgtgtggat
gtgatccccgtcaacctgcctggcgagcacgggcagaggctgcccatcagcaggaacacc
tttgcagaagtcaccgggctgtcccctggggtcacctattacttcaaagtctttgcagtg
agccatgggagggagagcaagcctctgactgctcaacagacaaccaaactggatgctccc
actaacctccagtttgtcaatgaaactgattctactgtcctggtgagatggactccacct
cgggcccagataacaggataccgactgaccgtgggccttacccgaagaggacagcccagg
cagtacaatgtgggtccctctgtctccaagtacccactgaggaatctgcagcctgcatct
gagtacaccgtatccctcgtggccataaagggcaaccaagagagccccaaagccactgga
gtctttaccacactgcagcctgggagctctattccaccttacaacaccgaggtgactgag
accaccattgtgatcacatggacgcctgctccaagaattggttttaagctgggtgtacga
ccaagccagggaggagaggcaccacgagaagtgacttcagactcaggaagcatcgttgtg
tccggcttgactccaggagtagaatacgtctacaccatccaagtcctgagagatggacag
gaaagagatgcgccaattgtaaacaaagtggtgacaccattgtctccaccaacaaacttg
catctggaggcaaaccctgacactggagtgctcacagtctcctgggagaggagcaccacc
ccagacattactggttatagaattaccacaacccctacaaacggccagcagggaaattct
ttggaagaagtggtccatgctgatcagagctcctgcacttttgataacctgagtcccggc
ctggagtacaatgtcagtgtttacactgtcaaggatgacaaggaaagtgtccctatctct
gataccatcatcccagctgttcctcctcccactgacctgcgattcaccaacattggtcca
gacaccatgcgtgtcacctgggctccacccccatccattgatttaaccaacttcctggtg
cgttactcacctgtgaaaaatgaggaagatgttgcagagttgtcaatttctccttcagac
aatgcagtggtcttaacaaatctcctgcctggtacagaatatgtagtgagtgtctccagt
gtctacgaacaacatgagagcacacctcttagaggaagacagaaaacaggtcttgattcc
ccaactggcattgacttttctgatattactgccaactcttttactgtgcactggattgct
cctcgagccaccatcactggctacaggatccgccatcatcccgagcacttcagtgggaga
cctcgagaagatcgggtgccccactctcggaattccatcaccctcaccaacctcactcca
ggcacagagtatgtggtcagcatcgttgctcttaatggcagagaggaaagtcccttattg
attggccaacaatcaacagtttctgatgttccgagggacctggaagttgttgctgcgacc
cccaccagcctactgatcagctgggatgctcctgctgtcacagtgagatattacaggatc
acttacggagagacaggaggaaatagccctgtccaggagttcactgtgcctgggagcaag
tctacagctaccatcagcggccttaaacctggagttgattataccatcactgtgtatgct
gtcactggccgtggagacagccccgcaagcagcaagccaatttccattaattaccgaaca
gaaattgacaaaccatcccagatgcaagtgaccgatgttcaggacaacagcattagtgtc
aagtggctgccttcaagttcccctgttactggttacagagtaaccaccactcccaaaaat
ggaccaggaccaacaaaaactaaaactgcaggtccagatcaaacagaaatgactattgaa
ggcttgcagcccacagtggagtatgtggttagtgtctatgctcagaatccaagcggagag
agtcagcctctggttcagactgcagtaaccaacattgatcgccctaaaggactggcattc
actgatgtggatgtcgattccatcaaaattgcttgggaaagcccacaggggcaagtttcc
aggtacagggtgacctactcgagccctgaggatggaatccatgagctattccctgcacct
gatggtgaagaagacactgcagagctgcaaggcctcagaccgggttctgagtacacagtc
agtgtggttgccttgcacgatgatatggagagccagcccctgattggaacccagtccaca
gctattcctgcaccaactgacctgaagttcactcaggtcacacccacaagcctgagcgcc
cagtggacaccacccaatgttcagctcactggatatcgagtgcgggtgacccccaaggag
aagaccggaccaatgaaagaaatcaaccttgctcctgacagctcatccgtggttgtatca
ggacttatggtggccaccaaatatgaagtgagtgtctatgctcttaaggacactttgaca
agcagaccagctcagggagttgtcaccactctggagaatgtcagcccaccaagaagggct
cgtgtgacagatgctactgagaccaccatcaccattagctggagaaccaagactgagacg
atcactggcttccaagttgatgccgttccagccaatggccagactccaatccagagaacc
atcaagccagatgtcagaagctacaccatcacaggtttacaaccaggcactgactacaag
atctacctgtacaccttgaatgacaatgctcggagctcccctgtggtcatcgacgcctcc
actgccattgatgcaccatccaacctgcgtttcctggccaccacacccaattccttgctg
gtatcatggcagccgccacgtgccaggattaccggctacatcatcaagtatgagaagcct
gggtctcctcccagagaagtggtccctcggccccgccctggtgtcacagaggctactatt
actggcctggaaccgggaaccgaatatacaatttatgtcattgccctgaagaataatcag
aagagcgagcccctgattggaaggaaaaagacagacgagcttccccaactggtaaccctt
ccacaccccaatcttcatggaccagagatcttggatgttccttccacagttcaaaagacc
cctttcgtcacccaccctgggtatgacactggaaatggtattcagcttcctggcacttct
ggtcagcaacccagtgttgggcaacaaatgatctttgaggaacatggttttaggcggacc
acaccgcccacaacggccacccccataaggcataggccaagaccatacccgccgaatgta
ggacaagaagctctctctcagacaaccatctcatgggccccattccaggacacttctgag
tacatcatttcatgtcatcctgttggcactgatgaagaacccttacagttcagggttcct
ggaacttctaccagtgccactctgacaggcctcaccagaggtgccacctacaacatcata
gtggaggcactgaaagaccagcagaggcataaggttcgggaagaggttgttaccgtgggc
aactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgacccctacaca
gtttcccattatgccgttggagatgagtgggaacgaatgtctgaatcaggctttaaactg
ttgtgccagtgcttaggctttggaagtggtcatttcagatgtgattcatctagatggtgc
catgacaatggtgtgaactacaagattggagagaagtgggaccgtcagggagaaaatggc
cagatgatgagctgcacatgtcttgggaacggaaaaggagaattcaagtgtgaccctcat
gaggcaacgtgttatgatgatgggaagacataccacgtaggagaacagtggcagaaggaa
tatctcggtgccatttgctcctgcacatgctttggaggccagcggggctggcgctgtgac
aactgccgcagacctgggggtgaacccagtcccgaaggcactactggccagtcctacaac
cagtattctcagagataccatcagagaacaaacactaatgttaattgcccaattgagtgc
ttcatgcctttagatgtacaggctgacagagaagattcccgagagtaa

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