KEGG   Homo sapiens (human): 23405
Entry
23405             CDS       T01001                                 
Symbol
DICER1, DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2, aviD
Name
(RefSeq) dicer 1, ribonuclease III
  KO
K11592  endoribonuclease Dicer [EC:3.1.26.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05206  MicroRNAs in cancer
Disease
H00037  Rhabdomyosarcoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    23405 (DICER1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23405 (DICER1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    23405 (DICER1)
   microRNA pathway
    RISC loading complex
     23405 (DICER1)
SSDB
Motif
Pfam: Dicer_platform Dicer_dsRBD Ribonuclease_3 Dicer_PBD Ribonucleas_3_3 Dicer_dimer PAZ Helicase_C ResIII DEAD
Other DBs
NCBI-GeneID: 23405
NCBI-ProteinID: NP_001258211
OMIM: 606241
HGNC: 17098
Ensembl: ENSG00000100697
UniProt: Q9UPY3
Structure
Position
14:complement(95086228..95158010)
AA seq 1922 aa
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT
IVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLK
VGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA
ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL
VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK
QILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCE
EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDE
DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFIT
GHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLP
TEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETD
IDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPD
GTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETV
KYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTP
LPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSL
QMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDI
EKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKF
PSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKR
KAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGV
GVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRT
SSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGN
QLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAV
MPGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD
SFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNW
LPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYED
DFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFED
FDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIA
DCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVS
CAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNK
AYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALV
NNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEE
DIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEM
EPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVP
NS
NT seq 5769 nt   +upstreamnt  +downstreamnt
atgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgct
tcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataac
atttatacgccaagaaaatatcaggttgaactgcttgaagcagctctggatcataatacc
atcgtctgtttaaacactggctcagggaagacatttattgcagtactactcactaaagag
ctgtcctatcagatcaggggagacttcagcagaaatggaaaaaggacggtgttcttggtc
aactctgcaaaccaggttgctcaacaagtgtcagctgtcagaactcattcagatctcaag
gttggggaatactcaaacctagaagtaaatgcatcttggacaaaagagagatggaaccaa
gagtttactaagcaccaggttctcattatgacttgctatgtcgccttgaatgttttgaaa
aatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgca
atcctagaccacccctatcgagaaattatgaagctctgtgaaaattgtccatcatgtcct
cgcattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaa
gaaaagattcagaaactagagaaaattcttaagagtaatgctgaaactgcaactgacctg
gtggtcttagacaggtatacttctcagccatgtgagattgtggtggattgtggaccattt
actgacagaagtgggctttatgaaagactgctgatggaattagaagaagcacttaatttt
atcaatgattgtaatatatctgtacattcaaaagaaagagattctactttaatttcgaaa
cagatactatcagactgtcgtgccgtattggtagttctgggaccctggtgtgcagataaa
gtagctggaatgatggtaagagaactacagaaatacatcaaacatgagcaagaggagctg
cacaggaaatttttattgtttacagacactttcctaaggaaaatacatgcactatgtgaa
gagcacttctcacctgcctcacttgacctgaaatttgtaactcctaaagtaatcaaactg
ctcgaaatcttacgcaaatataaaccatatgagcgacagcagtttgaaagcgttgagtgg
tataataatagaaatcaggataattatgtgtcatggagtgattctgaggatgatgatgag
gatgaagaaattgaagaaaaagagaagccagagacaaattttccttctccttttaccaac
attttgtgcggaattatttttgtggaaagaagatacacagcagttgtcttaaacagattg
ataaaggaagctggcaaacaagatccagagctggcttatatcagtagcaatttcataact
ggacatggcattgggaagaatcagcctcgcaacaaacagatggaagcagaattcagaaaa
caggaagaggtacttaggaaatttcgagcacatgagaccaacctgcttattgcaacaagt
attgtagaagagggtgttgatataccaaaatgcaacttggtggttcgttttgatttgccc
acagaatatcgatcctatgttcaatctaaaggaagagcaagggcacccatctctaattat
ataatgttagcggatacagacaaaataaaaagttttgaagaagaccttaaaacctacaaa
gctattgaaaagatcttgagaaacaagtgttccaagtcggttgatactggtgagactgac
attgatcctgtcatggatgatgatgacgttttcccaccatatgtgttgaggcctgacgat
ggtggtccacgagtcacaatcaacacggccattggacacatcaatagatactgtgctaga
ttaccaagtgatccgtttactcatctagctcctaaatgcagaacccgagagttgcctgat
ggtacattttattcaactctttatctgccaattaactcacctcttcgagcctccattgtt
ggtccaccaatgagctgtgtacgattggctgaaagagttgtagctctcatttgctgtgag
aaactgcacaaaattggcgaactggatgaccatttgatgccagttgggaaagagactgtt
aaatatgaagaggagcttgatttgcatgatgaagaagagaccagtgttccaggaagacca
ggttccacgaaacgaaggcagtgctacccaaaagcaattccagagtgtttgagggatagt
tatcccagacctgatcagccctgttacctgtatgtgataggaatggttttaactacacct
ttacctgatgaactcaactttagaaggcggaagctctatcctcctgaagataccacaaga
tgctttggaatactgacggccaaacccatacctcagattccacactttcctgtgtacaca
cgctctggagaggttaccatatccattgagttgaagaagtctggtttcatgttgtctcta
caaatgcttgagttgattacaagacttcaccagtatatattctcacatattcttcggctt
gaaaaacctgcactagaatttaaacctacagacgctgattcagcatactgtgttctacct
cttaatgttgttaatgactccagcactttggatattgactttaaattcatggaagatatt
gagaagtctgaagctcgcataggcattcccagtacaaagtatacaaaagaaacacccttt
gtttttaaattagaagattaccaagatgccgttatcattccaagatatcgcaattttgat
cagcctcatcgattttatgtagctgatgtgtacactgatcttaccccactcagtaaattt
ccttcccctgagtatgaaacttttgcagaatattataaaacaaagtacaaccttgaccta
accaatctcaaccagccactgctggatgtggaccacacatcttcaagacttaatcttttg
acacctcgacatttgaatcagaaggggaaagcgcttcctttaagcagtgctgagaagagg
aaagccaaatgggaaagtctgcagaataaacagatactggttccagaactctgtgctata
catccaattccagcatcactgtggagaaaagctgtttgtctccccagcatactttatcgc
cttcactgccttttgactgcagaggagctaagagcccagactgccagcgatgctggcgtg
ggagtcagatcacttcctgcggattttagataccctaacttagacttcgggtggaaaaaa
tctattgacagcaaatctttcatctcaatttctaactcctcttcagctgaaaatgataat
tactgtaagcacagcacaattgtccctgaaaatgctgcacatcaaggtgctaatagaacc
tcctctctagaaaatcatgaccaaatgtctgtgaactgcagaacgttgctcagcgagtcc
cctggtaagctccacgttgaagtttcagcagatcttacagcaattaatggtctttcttac
aatcaaaatctcgccaatggcagttatgatttagctaacagagacttttgccaaggaaat
cagctaaattactacaagcaggaaatacccgtgcaaccaactacctcatattccattcag
aatttatacagttacgagaaccagccccagcccagcgatgaatgtactctcctgagtaat
aaataccttgatggaaatgctaacaaatctacctcagatggaagtcctgtgatggccgta
atgcctggtacgacagacactattcaagtgctcaagggcaggatggattctgagcagagc
ccttctattgggtactcctcaaggactcttggccccaatcctggacttattcttcaggct
ttgactctgtcaaacgctagtgatggatttaacctggagcggcttgaaatgcttggcgac
tcctttttaaagcatgccatcaccacatatctattttgcacttaccctgatgcgcatgag
ggccgcctttcatatatgagaagcaaaaaggtcagcaactgtaatctgtatcgccttgga
aaaaagaagggactacccagccgcatggtggtgtcaatatttgatccccctgtgaattgg
cttcctcctggttatgtagtaaatcaagacaaaagcaacacagataaatgggaaaaagat
gaaatgacaaaagactgcatgctggcgaatggcaaactggatgaggattacgaggaggag
gatgaggaggaggagagcctgatgtggagggctccgaaggaagaggctgactatgaagat
gatttcctggagtatgatcaggaacatatcagatttatagataatatgttaatggggtca
ggagcttttgtaaagaaaatctctctttctcctttttcaaccactgattctgcatatgaa
tggaaaatgcccaaaaaatcctccttaggtagtatgccattttcatcagattttgaggat
tttgactacagctcttgggatgcaatgtgctatctggatcctagcaaagctgttgaagaa
gatgactttgtggtggggttctggaatccatcagaagaaaactgtggtgttgacacggga
aagcagtccatttcttacgacttgcacactgagcagtgtattgctgacaaaagcatagcg
gactgtgtggaagccctgctgggctgctatttaaccagctgtggggagagggctgctcag
cttttcctctgttcactggggctgaaggtgctcccggtaattaaaaggactgatcgggaa
aaggccctgtgccctactcgggagaatttcaacagccaacaaaagaacctttcagtgagc
tgtgctgctgcttctgtggccagttcacgctcttctgtattgaaagactcggaatatggt
tgtttgaagattccaccaagatgtatgtttgatcatccagatgcagataaaacactgaat
caccttatatcggggtttgaaaattttgaaaagaaaatcaactacagattcaagaataag
gcttaccttctccaggcttttacacatgcctcctaccactacaatactatcactgattgt
taccagcgcttagaattcctgggagatgcgattttggactacctcataaccaagcacctt
tatgaagacccgcggcagcactccccgggggtcctgacagacctgcggtctgccctggtc
aacaacaccatctttgcatcgctggctgtaaagtacgactaccacaagtacttcaaagct
gtctctcctgagctcttccatgtcattgatgactttgtgcagtttcagcttgagaagaat
gaaatgcaaggaatggattctgagcttaggagatctgaggaggatgaagagaaagaagag
gatattgaagttccaaaggccatgggggatatttttgagtcgcttgctggtgccatttac
atggatagtgggatgtcactggagacagtctggcaggtgtactatcccatgatgcggcca
ctaatagaaaagttttctgcaaatgtaccccgttcccctgtgcgagaattgcttgaaatg
gaaccagaaactgccaaatttagcccggctgagagaacttacgacgggaaggtcagagtc
actgtggaagtagtaggaaaggggaaatttaaaggtgttggtcgaagttacaggattgcc
aaatctgcagcagcaagaagagccctccgaagcctcaaagctaatcaacctcaggttccc
aatagctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (6)   
   KEGG DISEASE (1)   
   OMIM (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (30)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (88)   
   RefSeq(nuc) (34)   
   GenBank (27)   
   EMBL (27)   
3D Structure (16)   
   PDB (16)   
Protein domain (10)   
   Pfam (10)   
All databases (183)   

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