KEGG   Homo sapiens (human): 23411Help
Entry
23411             CDS       T01001                                 

Gene name
SIRT1, SIR2L1
Definition
sirtuin 1
Orthology
K11411  
NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-]
Organism
hsa  Homo sapiens (human)
Pathway
FoxO signaling pathway
AMPK signaling pathway
Amphetamine addiction
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    23411 (SIRT1)
   04152 AMPK signaling pathway
    23411 (SIRT1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    23411 (SIRT1)
  Substance dependence
   05031 Amphetamine addiction
    23411 (SIRT1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     23411 (SIRT1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    23411 (SIRT1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
10q21.3
AA seq 452 aa AA seqDB search
MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG
IQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFG
ENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFD
VELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVS
EDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQM
ENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGA
EVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGA
GFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
NT seq 1359 nt NT seq  +upstreamnt  +downstreamnt
atgtttgatattgaatatttcagaaaagatccaagaccattcttcaagtttgcaaaggaa
atatatcctggacaattccagccatctctctgtcacaaattcatagccttgtcagataag
gaaggaaaactacttcgcaactatacccagaacatagacacgctggaacaggttgcggga
atccaaaggataattcagtgtcatggttcctttgcaacagcatcttgcctgatttgtaaa
tacaaagttgactgtgaagctgtacgaggagatatttttaatcaggtagttcctcgatgt
cctaggtgcccagctgatgaaccgcttgctatcatgaaaccagagattgtgttttttggt
gaaaatttaccagaacagtttcatagagccatgaagtatgacaaagatgaagttgacctc
ctcattgttattgggtcttccctcaaagtaagaccagtagcactaattccaagttccata
ccccatgaagtgcctcagatattaattaatagagaacctttgcctcatctgcattttgat
gtagagcttcttggagactgtgatgtcataattaatgaattgtgtcataggttaggtggt
gaatatgccaaactttgctgtaaccctgtaaagctttcagaaattactgaaaaacctcca
cgaacacaaaaagaattggcttatttgtcagagttgccacccacacctcttcatgtttca
gaagactcaagttcaccagaaagaacttcaccaccagattcttcagtgattgtcacactt
ttagaccaagcagctaagagtaatgatgatttagatgtgtctgaatcaaaaggttgtatg
gaagaaaaaccacaggaagtacaaacttctaggaatgttgaaagtattgctgaacagatg
gaaaatccggatttgaagaatgttggttctagtactggggagaaaaatgaaagaacttca
gtggctggaacagtgagaaaatgctggcctaatagagtggcaaaggagcagattagtagg
cggcttgatggtaatcagtatctgtttttgccaccaaatcgttacattttccatggcgct
gaggtatattcagactctgaagatgacgtcttatcctctagttcttgtggcagtaacagt
gatagtgggacatgccagagtccaagtttagaagaacccatggaggatgaaagtgaaatt
gaagaattctacaatggcttagaagatgagcctgatgttccagagagagctggaggagct
ggatttgggactgatggagatgatcaagaggcaattaatgaagctatatctgtgaaacag
gaagtaacagacatgaactatccatcaaacaaatcatag

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