KEGG   Homo sapiens (human): 23517
Entry
23517             CDS       T01001                                 
Symbol
MTREX, Dob1, KIAA0052, Mtr4, SKIV2L2, fSAP118
Name
(RefSeq) Mtr4 exosome RNA helicase
  KO
K12598  ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    23517 (MTREX)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    23517 (MTREX)
   03041 Spliceosome [BR:hsa03041]
    23517 (MTREX)
   03009 Ribosome biogenesis [BR:hsa03009]
    23517 (MTREX)
   03016 Transfer RNA biogenesis [BR:hsa03016]
    23517 (MTREX)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     23517 (MTREX)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    TRAMP complex
     23517 (MTREX)
Spliceosome [BR:hsa03041]
 Complex B
  U4/U6.U5 tri-snRNP components
   U4/U6.U5 tri-snRNP related factors
    23517 (MTREX)
 Complex C
   U4/U6.U5 tri-SnRNP related factors
    23517 (MTREX)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  Pre-60S particles
   Helicases
    23517 (MTREX)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA degradation factors
   TRAMP complex
    23517 (MTREX)
SSDB
Motif
Pfam: MTR4_beta-barrel DSHCT DEAD MTR4-like_stalk Helicase_C ResIII nSTAND3 AAA_22
Other DBs
NCBI-GeneID: 23517
NCBI-ProteinID: NP_056175
OMIM: 618122
HGNC: 18734
Ensembl: ENSG00000039123
UniProt: P42285 Q3MHC9
Structure
Position
5:55307989..55425579
AA seq 1042 aa
MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNG
KNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEE
DYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALR
EKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGS
EVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLH
KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD
QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV
EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF
ATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD
EKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPG
VVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLV
KVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKP
DEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPI
DDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK
KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDL
SAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS
SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELE
NKFAEGITKIKRDIVFAASLYL
NT seq 3129 nt   +upstreamnt  +downstreamnt
atggcggacgcattcggagatgagctgttcagcgtgttcgagggcgactcgaccactgcg
gcgggaaccaaaaaagacaaggaaaaggacaaggggaaatggaaggggcctccagggtct
gcagacaaggcagggaaacgttttgatggtaaattacaatcagaatcaactaataatgga
aaaaataagagagatgtagatttcgaaggtacagatgaacccatttttggaaagaagccc
aggatagaagagtcaataactgaagacttaagtttggcagacctgatgcccagagtcaag
gtacaatcagttgaaactgttgaagggtgtacacatgaggttgcacttcctgcagaagag
gattatttaccacttaaaccacgagttggaaaagctgctaaggaatacccgttcattctt
gatgcttttcaaagagaggccattcagtgtgttgacaataatcagtctgttctagtatct
gcacatacctcagcgggaaaaacagtatgcgccgagtatgccattgcattggccttaagg
gaaaagcagcgtgtaatatttaccagcccaattaaggctctgagtaaccaaaaataccgt
gaaatgtatgaagaatttcaagatgttggtttgatgactggtgatgttactattaatcct
acggcatcttgtcttgttatgaccacagagattttgagaagtatgctttacagaggttcc
gaagttatgagagaagttgcttgggttatatttgatgaaattcattatatgagagattca
gaacgtggtgtagtatgggaagaaactattattttgcttcctgataacgtccactatgtc
tttctttcggctactattccaaatgcccgacagtttgctgaatggatttgccatttacat
aaacagccttgtcatgttatttacacagattatcggcccactccattgcaacactacatt
tttccagcagggggagatggcctgcatcttgtggttgatgaaaatggtgacttcagagaa
gataattttaatactgcaatgcaagtgcttcgagatgcaggtgatttggccaaaggagac
cagaaagggcggaaaggaggaacaaaaggaccatcaaatgttttcaaaattgtgaagatg
attatggaaagaaatttccaacctgtgattattttcagttttagtaagaaagattgtgaa
gcctatgcacttcaaatgaccaaattagatttcaacacagatgaagaaaagaagatggtt
gaagaagtattcagtaatgcaattgattgcttatccgatgaagataaaaaactccctcag
gtagaacatgtacttcctcttttgaagaggggaattggtattcaccatggtggtttactt
cctattttgaaagaaactatagaaattctcttttctgaaggattgataaaggccttattt
gccacggagacctttgctatgggaattaacatgccagctagaactgttttatttacaaat
gcccgcaaatttgatgggaaggatttccgatggatttcttctggtgaatacattcagatg
tctggtcgtgctggaaggagaggaatggatgatagaggaattgtaattcttatggtagat
gaaaagatgagcccaacaattggaaaacaattacttaagggctccgctgatcctctaaat
agtgctttccatttgacctacaacatggttttgaacttactacgtgtagaagaaattaat
cctgagtacatgttggaaaaatccttctaccagtttcagcattatagagcaattccagga
gtagtagagaaggtaaagaattcagaagaacagtataataaaatagtaattcccaatgaa
gaaagtgtggttatctattataagattagacagcagcttgccaaattgggtaaagaaatt
gaagaatatattcacaaaccaaaatactgcttaccttttctacaaccaggtcgtttggta
aaggtaaagaatgaaggagatgactttggctggggagtagtggtgaatttctcaaaaaag
tcaaatgttaagcctaactctggtgaactggatcctttgtatgtagtagaagtacttctg
cgctgtagcaaagagagcttgaaaaattcagctacagaagctgcaaaaccagctaaacct
gatgagaaaggagagatgcaggttgtcccagttttggtgcatctcctgtctgctatcagc
agtgttaggctttacattcctaaagaccttcggccggtggacaatagacagagtgtttta
aaatcaatacaggaagttcagaaacgttttcctgacggcatccccttattagaccctatt
gatgatatgggcattcaagatcaagggctgaaaaaagtcattcagaaagtagaagctttt
gagcatcgaatgtattctcatccacttcacaatgatccaaatttggaaactgtgtatacg
ctttgtgaaaaaaaagcacagattgcaatagatattaaatctgcaaagcgagaactgaag
aaagcaagaacagtcctacaaatggatgaactcaaatgtcgcaaacgtgttttaagaagg
ttgggatttgctacttcttctgatgtaatagagatgaaaggacgagtggcttgtgagata
agcagtgctgatgagctccttctaactgagatgatgtttaatggccttttcaatgacctt
tctgcagaacaggcaacagcattattaagctgctttgtgtttcaagagaattctagtgag
atgcccaaattaacagaacaattagcaggaccacttcgtcaaatgcaggaatgtgctaaa
agaattgcaaaagtttcagcagaagccaaattggaaattgatgaggaaacttatctaagc
tcatttaaacctcacttaatggatgtagtatatacctgggcaactggagctacatttgcc
catatctgcaaaatgacagatgtctttgaaggcagcataattcgttgtatgaggcgcctg
gaagaattgcttcgacaaatgtgtcaagcagcaaaagccattggaaacactgagctggaa
aataaatttgcagaaggaatcaccaaaatcaagagagatattgtgtttgctgccagcctc
tacttgtag

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
3D Structure (11)   
   PDB (11)   
Protein domain (8)   
   Pfam (8)   
All databases (95)   

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