KEGG T01001: 2566

Homo sapiens (human): 2566

Entry

2566 CDS T01001

Gene name

GABRG2, CAE2, ECA2, GEFSP3

Definition

gamma-aminobutyric acid (GABA) A receptor, gamma 2

Orthology

K05186

gmma-aminobutyric acid receptor subunit gamma

Organism

hsa Homo sapiens (human)

Pathway

hsa04080	Neuroactive ligand-receptor interaction
hsa04723	Retrograde endocannabinoid signaling
hsa04727	GABAergic synapse
hsa05032	Morphine addiction
hsa05033	Nicotine addiction

Disease

H00783	Febrile seizures
H00808	Idiopathic generalized epilepsies (IGEs)

Drug target

Hexobarbital:

Thiopental:

Propofol:

Methylphenobarbital:

Phenobarbital:

Clonazepam:

Aminobutyric acid:

Diazepam:

Chlordiazepoxide:

Medazepam:

Potassium clorazepate:

Lorazepam:

Bromazepam:

Clobazam:

Prazepam:

Alprazolam:

Nordazepam:

Fludiazepam:

Ethyl loflazepate:

Etizolam:

Clotiazepam:

Cloxazolam:

Tofisopam:

Meprobamate:

Pentobarbital:

Amobarbital:

Barbital:

Secobarbital:

Flurazepam:

Nitrazepam:

Flunitrazepam:

Estazolam:

Triazolam:

Lormetazepam:

Temazepam:

Midazolam:

Brotizolam:

Quazepam:

Loprazolam:

Glutethimide:

Zopiclone:

Zolpidem:

Eszopiclone:

Methaqualone:

Pentetrazol:

Flumazenil:

Other:

D00713 D01278 D01279 D01286 D01316 D01564 D01593 D01758 D02283 D02594 D02616 D02617 D03155 D03737 D04282 D04300 D04721 D06106 D07784 D08481 D08507 D08840 D10194

Class

Environmental Information Processing; Signaling molecules and interaction; Neuroactive ligand-receptor interaction [PATH:hsa04080]
Organismal Systems; Nervous system; GABAergic synapse [PATH:hsa04727]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:hsa04723]
Human Diseases; Substance dependence; Morphine addiction [PATH:hsa05032]
Human Diseases; Substance dependence; Nicotine addiction [PATH:hsa05033]

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

5q34

AA seq 467 aa
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC
FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

NT seq 1404 nt +upstreamnt +downstreamnt
atgagttcgccaaatatatggagcacaggaagctcagtctactcgactcctgtattttca
cagaaaatgacggtgtggattctgctcctgctgtcgctctaccctggcttcactagccag
aaatctgatgatgactatgaagattatgcttctaacaaaacatgggtcttgactccaaaa
gttcctgagggtgatgtcactgtcatcttaaacaacctgctggaaggatatgacaataaa
cttcggcctgatataggagtgaagccaacgttaattcacacagacatgtatgtgaatagc
attggtccagtgaacgctatcaatatggaatacactattgatatattttttgcgcaaacg
tggtatgacagacgtttgaaatttaacagcaccattaaagtcctccgattgaacagcaac
atggtggggaaaatctggattccagacactttcttcagaaattccaaaaaagctgatgca
cactggatcaccacccccaacaggatgctgagaatttggaatgatggtcgagtgctctac
accctaaggttgacaattgatgctgagtgccaattacaattgcacaactttccaatggat
gaacactcctgccccttggagttctccagttatggctatccacgtgaagaaattgtttat
caatggaagcgaagttctgttgaagtgggcgacacaagatcctggaggctttatcaattc
tcatttgttggtctaagaaataccaccgaagtagtgaagacaacttccggagattatgtg
gtcatgtctgtctactttgatctgagcagaagaatgggatactttaccatccagacctat
atcccctgcacactcattgtcgtcctatcctgggtgtctttctggatcaataaggatgct
gttccagccagaacatctttaggtatcaccactgtcctgacaatgaccaccctcagcacc
attgcccggaaatcgctccccaaggtctcctatgtcacagcgatggatctctttgtatct
gtttgtttcatctttgtcttctctgctctggtggagtatggcaccttgcattattttgtc
agcaaccggaaaccaagcaaggacaaagataaaaagaagaaaaaccctgcccctaccatt
gatatccgcccaagatcagcaaccattcaaatgaataatgctacacaccttcaagagaga
gatgaagagtacggctatgagtgtctggacggcaaggactgtgccagttttttctgctgt
tttgaagattgtcgaacaggagcttggagacatgggaggatacatatccgcattgccaaa
atggactcctatgctcggatcttcttccccactgccttctgcctgtttaatctggtctat
tgggtctcctacctctacctgtga

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (7)   
   KEGG DISEASE (2)   
   OMIM (5)   
Drug (86)   
   KEGG DRUG (86)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   RefSeq(pep) (3)   
DNA sequence (27)   
   RefSeq(nuc) (3)   
   GenBank (12)   
   EMBL (12)   
Protein domain (2)   
   Pfam (2)   
All databases (152)   

Download RDF

DBGET integrated database retrieval system