Entry |
|
Gene name |
HGF, DFNB39, F-TCF, HGFB, HPTA, SF
|
Definition |
(RefSeq) hepatocyte growth factor
|
KO |
|
Organism |
|
Pathway |
| EGFR tyrosine kinase inhibitor resistance | | MAPK signaling pathway | | Ras signaling pathway | | Rap1 signaling pathway | | Cytokine-cytokine receptor interaction | | PI3K-Akt signaling pathway | | Focal adhesion | | Malaria | | Pathways in cancer | | Proteoglycans in cancer | | Renal cell carcinoma | | Melanoma | | Hepatocellular carcinoma | | Gastric cancer |
|
Network |
| HGF-MET-PI3K signaling pathway | | HGF-MET-RAS-ERK signaling pathway | | HGF-overexpression to RAS-ERK signaling pathway | | HGF-overexpression to PI3K signaling pathway |
|
Disease |
| Hepatocellular carcinoma | | Deafness, autosomal recessive |
|
Drug target |
Ficlatuzumab: Rilotumumab: |
Brite |
KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
Signal transduction
04014 Ras signaling pathway
3082 (HGF)
04015 Rap1 signaling pathway
3082 (HGF)
04010 MAPK signaling pathway
3082 (HGF)
04151 PI3K-Akt signaling pathway
3082 (HGF)
Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3082 (HGF)
Cellular Processes
Cellular community - eukaryotes
04510 Focal adhesion
3082 (HGF)
Human Diseases
Cancers
05200 Pathways in cancer
3082 (HGF)
05205 Proteoglycans in cancer
3082 (HGF)
05225 Hepatocellular carcinoma
3082 (HGF)
05226 Gastric cancer
3082 (HGF)
05218 Melanoma
3082 (HGF)
05211 Renal cell carcinoma
3082 (HGF)
Infectious diseases
05144 Malaria
3082 (HGF)
Drug resistance
01521 EGFR tyrosine kinase inhibitor resistance
3082 (HGF)
Cytokines [BR:hsa04052]
PDGF family
Other growth factors
3082 (HGF)
Cell adhesion molecules and their ligands [BR:hsa04516]
7. Others
SDC1; syndecan 1 [KO:K06257]
3082 (HGF)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate/Haparin
Growth factors/receptors (General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis
3082 (HGF)
 |
SSDB |
   |
Motif |
 |
Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
Structure |
PDB: |
Position |
7q21.11
|
AA seq |
728 aa  
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIK
TKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYE
NKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNP
RGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTP
HRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPL
ETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGS
ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME
DLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNL
DHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRD
LKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLP
NYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAG
AEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKII
LTYKVPQS |
NT seq |
2187 nt  +upstreamnt +downstreamnt
atgtgggtgaccaaactcctgccagccctgctgctgcagcatgtcctcctgcatctcctc
ctgctccccatcgccatcccctatgcagagggacaaaggaaaagaagaaatacaattcat
gaattcaaaaaatcagcaaagactaccctaatcaaaatagatccagcactgaagataaaa
accaaaaaagtgaatactgcagaccaatgtgctaatagatgtactaggaataaaggactt
ccattcacttgcaaggcttttgtttttgataaagcaagaaaacaatgcctctggttcccc
ttcaatagcatgtcaagtggagtgaaaaaagaatttggccatgaatttgacctctatgaa
aacaaagactacattagaaactgcatcattggtaaaggacgcagctacaagggaacagta
tctatcactaagagtggcatcaaatgtcagccctggagttccatgataccacacgaacac
agctttttgccttcgagctatcggggtaaagacctacaggaaaactactgtcgaaatcct
cgaggggaagaagggggaccctggtgtttcacaagcaatccagaggtacgctacgaagtc
tgtgacattcctcagtgttcagaagttgaatgcatgacctgcaatggggagagttatcga
ggtctcatggatcatacagaatcaggcaagatttgtcagcgctgggatcatcagacacca
caccggcacaaattcttgcctgaaagatatcccgacaagggctttgatgataattattgc
cgcaatcccgatggccagccgaggccatggtgctatactcttgaccctcacacccgctgg
gagtactgtgcaattaaaacatgcgctgacaatactatgaatgacactgatgttcctttg
gaaacaactgaatgcatccaaggtcaaggagaaggctacaggggcactgtcaataccatt
tggaatggaattccatgtcagcgttgggattctcagtatcctcacgagcatgacatgact
cctgaaaatttcaagtgcaaggacctacgagaaaattactgccgaaatccagatgggtct
gaatcaccctggtgttttaccactgatccaaacatccgagttggctactgctcccaaatt
ccaaactgtgatatgtcacatggacaagattgttatcgtgggaatggcaaaaattatatg
ggcaacttatcccaaacaagatctggactaacatgttcaatgtgggacaagaacatggaa
gacttacatcgtcatatcttctgggaaccagatgcaagtaagctgaatgagaattactgc
cgaaatccagatgatgatgctcatggaccctggtgctacacgggaaatccactcattcct
tgggattattgccctatttctcgttgtgaaggtgataccacacctacaatagtcaattta
gaccatcccgtaatatcttgtgccaaaacgaaacaattgcgagttgtaaatgggattcca
acacgaacaaacataggatggatggttagtttgagatacagaaataaacatatctgcgga
ggatcattgataaaggagagttgggttcttactgcacgacagtgtttcccttctcgagac
ttgaaagattatgaagcttggcttggaattcatgatgtccacggaagaggagatgagaaa
tgcaaacaggttctcaatgtttcccagctggtatatggccctgaaggatcagatctggtt
ttaatgaagcttgccaggcctgctgtcctggatgattttgttagtacgattgatttacct
aattatggatgcacaattcctgaaaagaccagttgcagtgtttatggctggggctacact
ggattgatcaactatgatggcctattacgagtggcacatctctatataatgggaaatgag
aaatgcagccagcatcatcgagggaaggtgactctgaatgagtctgaaatatgtgctggg
gctgaaaagattggatcaggaccatgtgagggggattatggtggcccacttgtttgtgag
caacataaaatgagaatggttcttggtgtcattgttcctggtcgtggatgtgccattcca
aatcgtcctggtatttttgtccgagtagcatattatgcaaaatggatacacaaaattatt
ttaacatataaggtaccacagtcatag |