KEGG   Homo sapiens (human): 3108Help
Entry
3108              CDS       T01001                                 

Gene name
HLA-DMA, D6S222E, DMA, HLADM, RING6
Definition
(RefSeq) major histocompatibility complex, class II, DM alpha
  KO
K06752  major histocompatibility complex, class II
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04514  Cell adhesion molecules (CAMs)
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05140  Leishmaniasis
hsa05145  Toxoplasmosis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05164  Influenza A
hsa05166  HTLV-I infection
hsa05168  Herpes simplex infection
hsa05310  Asthma
hsa05320  Autoimmune thyroid disease
hsa05321  Inflammatory bowel disease (IBD)
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Disease
H00083  Allograft rejection
Drug target
Glatiramer acetate: D04318
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    3108 (HLA-DMA)
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    3108 (HLA-DMA)
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    3108 (HLA-DMA)
   04612 Antigen processing and presentation
    3108 (HLA-DMA)
   04658 Th1 and Th2 cell differentiation
    3108 (HLA-DMA)
   04659 Th17 cell differentiation
    3108 (HLA-DMA)
   04672 Intestinal immune network for IgA production
    3108 (HLA-DMA)
 Human Diseases
  Immune diseases
   05310 Asthma
    3108 (HLA-DMA)
   05322 Systemic lupus erythematosus
    3108 (HLA-DMA)
   05323 Rheumatoid arthritis
    3108 (HLA-DMA)
   05320 Autoimmune thyroid disease
    3108 (HLA-DMA)
   05321 Inflammatiory bowel disease (IBD)
    3108 (HLA-DMA)
   05330 Allograft rejection
    3108 (HLA-DMA)
   05332 Graft-versus-host disease
    3108 (HLA-DMA)
  Cardiovascular diseases
   05416 Viral myocarditis
    3108 (HLA-DMA)
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    3108 (HLA-DMA)
  Infectious diseases
   05150 Staphylococcus aureus infection
    3108 (HLA-DMA)
   05152 Tuberculosis
    3108 (HLA-DMA)
   05166 HTLV-I infection
    3108 (HLA-DMA)
   05164 Influenza A
    3108 (HLA-DMA)
   05168 Herpes simplex infection
    3108 (HLA-DMA)
   05145 Toxoplasmosis
    3108 (HLA-DMA)
   05140 Leishmaniasis
    3108 (HLA-DMA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3108 (HLA-DMA)
  Exosomal proteins of epithelial cells
   3108 (HLA-DMA)
  Exosomal proteins of breast milk
   3108 (HLA-DMA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: MHC_II_alpha C1-set SKG6 FAST_1
Motif
Other DBs
NCBI-GeneID: 3108
NCBI-ProteinID: NP_006111
OMIM: 142855
HGNC: 4934
Ensembl: ENSG00000204257
Vega: OTTHUMG00000031173
UniProt: Q31604 Q6ICR9
Structure
PDB: 

Jmol
Position
6p21.32
AA seq 261 aa AA seqDB search
MGHEQNQGAALLQMLPLLWLLPHSWAVPEAPTPMWPDDLQNHTFLHTVYCQDGSPSVGLS
EAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEWMIQQIGPKLDGKI
PVSRGFPIAEVFTLKPLEFGKPNTLVCFVSNLFPPMLTVNWQHHSVPVEGFGPTFVSAVD
GLSFQAFSYLNFTPEPSDIFSCIVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLG
VLGIIVGIVLIIYFRKPCSGD
NT seq 786 nt NT seq  +upstreamnt  +downstreamnt
atgggtcatgaacagaaccaaggagctgcgctgctacagatgttaccacttctgtggctg
ctaccccactcctgggccgtccctgaagctcctactccaatgtggccagatgacctgcaa
aaccacacattcctgcacacagtgtactgccaggatgggagtcccagtgtgggactctct
gaggcctacgacgaggaccagcttttcttcttcgacttttcccagaacactcgggtgcct
cgcctgcccgaatttgctgactgggctcaggaacagggagatgctcctgccattttattt
gacaaagagttctgcgagtggatgatccagcaaatagggccaaaacttgatgggaaaatc
ccggtgtccagagggtttcctatcgctgaagtgttcacgctgaagcccctggagtttggc
aagcccaacactttggtctgttttgtcagtaatctcttcccacccatgctgacagtgaac
tggcagcatcattccgtccctgtggaaggatttgggcctacttttgtctcagctgtcgat
ggactcagcttccaggccttttcttacttaaacttcacaccagaaccttctgacattttc
tcctgcattgtgactcacgaaattgaccgctacacagcaattgcctattgggtaccccgg
aacgcactgccctcagatctgctggagaatgtgctgtgtggcgtggcctttggcctgggt
gtgctgggcatcatcgtgggcattgttctcatcatctacttccggaagccttgctcaggt
gactga

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