KEGG   Homo sapiens (human): 317Help
Entry
317               CDS       T01001                                 

Gene name
APAF1, APAF-1, CED4
Definition
apoptotic peptidase activating factor 1
Orthology
K02084  
apoptotic protease-activating factor
Organism
hsa  Homo sapiens (human)
Pathway
p53 signaling pathway
Apoptosis
Alzheimer's disease
Parkinson's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Legionellosis
Tuberculosis
Hepatitis B
Small cell lung cancer
Module
Apoptotic machinery
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    317 (APAF1)
   04115 p53 signaling pathway
    317 (APAF1)
 Human Diseases
  Cancers
   05222 Small cell lung cancer
    317 (APAF1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    317 (APAF1)
   05012 Parkinson's disease
    317 (APAF1)
   05014 Amyotrophic lateral sclerosis (ALS)
    317 (APAF1)
   05016 Huntington's disease
    317 (APAF1)
  Infectious diseases
   05134 Legionellosis
    317 (APAF1)
   05152 Tuberculosis
    317 (APAF1)
   05161 Hepatitis B
    317 (APAF1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
12q23
AA seq 1194 aa AA seqDB search
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG
SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG
QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD
EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT
GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA
FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS
AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt
atggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatc
aagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagag
gaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgata
cttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatat
aaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtgtaagg
acagtcctgtgtgaaggtggagtaccacagaggccagttgtttttgtcacaaggaagaag
ctggtgaatgcaattcagcagaagctctccaaattgaaaggtgaaccaggatgggtcacc
atacatggaatggcaggctgtgggaagtctgtattagctgcagaagctgttagagatcat
tcccttttagaaggttgtttcccagggggagtgcattgggtttcagttgggaaacaagac
aaatctgggcttctgatgaaactgcagaatctttgcacacggttggatcaggatgagagt
ttttcccagaggcttccacttaatattgaagaggctaaagaccgtctccgcattctgatg
cttcgcaaacacccaaggtctctcttgatcttggatgatgtttgggactcttgggtgttg
aaagcttttgacagtcagtgtcagattcttcttacaaccagagacaagagtgttacagat
tcagtaatgggtcctaaatatgtagtccctgtggagagttccttaggaaaggaaaaagga
cttgaaattttatccctttttgttaatatgaagaaggcagatttgccagaacaagctcat
agtattataaaagaatgtaaaggctctccccttgtagtatctttaattggtgcactttta
cgtgattttcccaatcgctgggagtactacctcaaacagcttcagaataagcagtttaag
agaataaggaaatcttcgtcttatgattatgaggctctagatgaagccatgtctataagt
gttgaaatgctcagagaagacatcaaagattattacacagatctttccatccttcagaag
gacgttaaggtgcctacaaaggtgttatgtattctctgggacatggaaactgaagaagtt
gaagacatactgcaggagtttgtaaataagtctcttttattctgtgatcggaatggaaag
tcgtttcgttattatttacatgatcttcaagtagattttcttacagagaagaattgcagc
cagcttcaggatctacataagaagataatcactcagtttcagagatatcaccagccgcat
actctttcaccagatcaggaagactgtatgtattggtacaactttctggcctatcacatg
gccagtgccaagatgcacaaggaactttgtgctttaatgttttccctggattggattaaa
gcaaaaacagaacttgtaggccctgctcatctgattcatgaatttgtggaatacagacat
atactagatgaaaaggattgtgcagtcagtgagaattttcaggagtttttatctttaaat
ggacaccttcttggacgacagccatttcctaatattgtacaactgggtctctgtgagccg
gaaacttcagaagtttatcagcaagctaagctgcaggccaagcaggaggtcgataatgga
atgctttacctggaatggataaacaaaaaaaacatcacgaatctttcccgcttagttgtc
cgcccccacacagatgctgtttaccatgcctgcttttctgaggatggtcagagaatagct
tcttgtggagctgataaaaccttacaggtgttcaaagctgaaacaggagagaaacttcta
gaaatcaaggctcatgaggatgaagtgctttgttgtgcattctctacagatgacagattt
atagcaacctgctcagtggataaaaaagtgaagatttggaattctatgactggggaacta
gtacacacctatgatgagcactcagagcaagtcaattgctgccatttcaccaacagtagt
catcatcttctcttagccactgggtcaagtgactgcttcctcaaactttgggatttgaat
caaaaagaatgtcgaaataccatgtttggtcatacaaattcagtcaatcactgcagattt
tcaccagatgataagcttttggctagttgttcagctgatggaaccttaaagctttgggat
gcgacatcagcaaatgagaggaaaagcattaatgtgaaacagttcttcctaaatttggag
gaccctcaagaggatatggaagtgatagtgaagtgttgttcgtggtctgctgatggtgca
aggataatggtggcagcaaaaaataaaatctttttgtggaatacagactcacgttcaaag
gtggctgattgcagaggacatttaagttgggttcatggtgtgatgttttctcctgatgga
tcatcatttttgacatcttctgatgaccagacaatcaggctctgggagacaaagaaagta
tgtaagaactctgctgtaatgttaaagcaagaagtagatgttgtgtttcaagaaaatgaa
gtgatggtccttgcagttgaccatataagacgtctgcaactcattaatggaagaacaggt
cagattgattatctgactgaagctcaagttagctgctgttgcttaagtccacatcttcag
tacattgcatttggagatgaaaatggagccattgagattttagaacttgtaaacaataga
atcttccagtccaggtttcagcacaagaaaactgtatggcacatccagttcacagccgat
gagaagactcttatttcaagttctgatgatgctgaaattcaggtatggaattggcaattg
gacaaatgtatctttctacgaggccatcaggaaacagtgaaagactttagactcttgaaa
aattcaagactgctttcttggtcatttgatggaacagtgaaggtatggaatattattact
ggaaataaagaaaaagactttgtctgtcaccagggtacagtactttcttgtgacatttct
cacgatgctaccaagttttcatctacctctgctgacaagactgcaaagatctggagtttt
gatctccttttgccacttcatgaattgaggggccacaacggctgtgtgcgctgctctgcc
ttctctgtggacagtaccctgctggcaacgggagatgacaatggagaaatcaggatatgg
aatgtctcaaacggtgagcttcttcatttgtgtgctccgctttcagaagaaggagctgct
acccatggaggctgggtgactgacctttgcttttctccagatggcaaaatgcttatctct
gctggaggatatattaagtggtggaacgttgtcactggggaatcctcacagaccttctac
acaaatggaaccaatcttaagaaaatacacgtgtcccctgacttcaaaacatatgtgact
gtggataatcttggtattttatatattttacagactttagaataa

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