KEGG   Homo sapiens (human): 3265Help
Entry
3265              CDS       T01001                                 

Gene name
HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
Definition
(RefSeq) HRas proto-oncogene, GTPase
  KO
K02833  
GTPase HRas
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Endocytosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Alcoholism
Hepatitis C
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00030  
EGF-EGFR-RAS-PI3K signaling pathway
N00031  
Duplication-activated FLT3 to RAS-PI3K signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00096  
EGF-EGFR-RAS-RASSF1 signaling pathway
N00097  
Loss of RASSF1 to EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  
EGF-EGFR-RAS-RalGDS signaling pathway
N00152  
CXCR-GNB/G-ERK signaling pathway
N00157  
KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00208  
KSHV K1 to host-cell-protein activation
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00218  
FLT3LG-FLT3-RAS-PI3K signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
N00267  
HBV HBx to host-cell-protein activation
Disease
H00022  
Bladder cancer
H00025  
Penile cancer
H00030  
Cervical cancer
H00032  
Thyroid cancer
H00040  
Squamous cell carcinoma
H00523  
Noonan syndrome and related disorders
H01470  
Giant cell tumor of bone
H01555  
Merkel cell carcinoma
H01592  
Medullary thyroid cancer
H01666  
Angiosarcoma
H01747  
Costello syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    3265 (HRAS)
   04015 Rap1 signaling pathway
    3265 (HRAS)
   04010 MAPK signaling pathway
    3265 (HRAS)
   04012 ErbB signaling pathway
    3265 (HRAS)
   04370 VEGF signaling pathway
    3265 (HRAS)
   04371 Apelin signaling pathway
    3265 (HRAS)
   04630 Jak-STAT signaling pathway
    3265 (HRAS)
   04068 FoxO signaling pathway
    3265 (HRAS)
   04072 Phospholipase D signaling pathway
    3265 (HRAS)
   04071 Sphingolipid signaling pathway
    3265 (HRAS)
   04151 PI3K-Akt signaling pathway
    3265 (HRAS)
   04150 mTOR signaling pathway
    3265 (HRAS)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    3265 (HRAS)
   04140 Autophagy - animal
    3265 (HRAS)
   04137 Mitophagy - animal
    3265 (HRAS)
  Cell growth and death
   04210 Apoptosis
    3265 (HRAS)
   04218 Cellular senescence
    3265 (HRAS)
  Cellular community - eukaryotes
   04510 Focal adhesion
    3265 (HRAS)
   04540 Gap junction
    3265 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3265 (HRAS)
  Cell motility
   04810 Regulation of actin cytoskeleton
    3265 (HRAS)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    3265 (HRAS)
   04660 T cell receptor signaling pathway
    3265 (HRAS)
   04662 B cell receptor signaling pathway
    3265 (HRAS)
   04664 Fc epsilon RI signaling pathway
    3265 (HRAS)
   04062 Chemokine signaling pathway
    3265 (HRAS)
  Endocrine system
   04910 Insulin signaling pathway
    3265 (HRAS)
   04912 GnRH signaling pathway
    3265 (HRAS)
   04915 Estrogen signaling pathway
    3265 (HRAS)
   04917 Prolactin signaling pathway
    3265 (HRAS)
   04921 Oxytocin signaling pathway
    3265 (HRAS)
   04926 Relaxin signaling pathway
    3265 (HRAS)
   04919 Thyroid hormone signaling pathway
    3265 (HRAS)
   04916 Melanogenesis
    3265 (HRAS)
  Nervous system
   04725 Cholinergic synapse
    3265 (HRAS)
   04726 Serotonergic synapse
    3265 (HRAS)
   04720 Long-term potentiation
    3265 (HRAS)
   04730 Long-term depression
    3265 (HRAS)
   04722 Neurotrophin signaling pathway
    3265 (HRAS)
  Development
   04360 Axon guidance
    3265 (HRAS)
  Aging
   04211 Longevity regulating pathway - mammal
    3265 (HRAS)
   04213 Longevity regulating pathway - multiple species
    3265 (HRAS)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3265 (HRAS)
   05230 Central carbon metabolism in cancer
    3265 (HRAS)
   05231 Choline metabolism in cancer
    3265 (HRAS)
   05206 MicroRNAs in cancer
    3265 (HRAS)
   05205 Proteoglycans in cancer
    3265 (HRAS)
   05203 Viral carcinogenesis
    3265 (HRAS)
   05225 Hepatocellular carcinoma
    3265 (HRAS)
   05226 Gastric cancer
    3265 (HRAS)
   05214 Glioma
    3265 (HRAS)
   05216 Thyroid cancer
    3265 (HRAS)
   05221 Acute myeloid leukemia
    3265 (HRAS)
   05220 Chronic myeloid leukemia
    3265 (HRAS)
   05218 Melanoma
    3265 (HRAS)
   05211 Renal cell carcinoma
    3265 (HRAS)
   05219 Bladder cancer
    3265 (HRAS)
   05215 Prostate cancer
    3265 (HRAS)
   05213 Endometrial cancer
    3265 (HRAS)
   05224 Breast cancer
    3265 (HRAS)
   05223 Non-small cell lung cancer
    3265 (HRAS)
  Substance dependence
   05034 Alcoholism
    3265 (HRAS)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    3265 (HRAS)
  Infectious diseases
   05166 HTLV-I infection
    3265 (HRAS)
   05161 Hepatitis B
    3265 (HRAS)
   05160 Hepatitis C
    3265 (HRAS)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3265 (HRAS)
   05165 Human papillomavirus infection
    3265 (HRAS)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    3265 (HRAS)
   01522 Endocrine resistance
    3265 (HRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    3265 (HRAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3265 (HRAS)
  Exosomal proteins of colorectal cancer cells
   3265 (HRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3265 (HRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P01112(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
11p15.5
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgacggaatataagctggtggtggtgggcgccggcggtgtgggcaagagtgcgctgacc
atccagctgatccagaaccattttgtggacgaatacgaccccactatagaggattcctac
cggaagcaggtggtcattgatggggagacgtgcctgttggacatcctggataccgccggc
caggaggagtacagcgccatgcgggaccagtacatgcgcaccggggagggcttcctgtgt
gtgtttgccatcaacaacaccaagtcttttgaggacatccaccagtacagggagcagatc
aaacgggtgaaggactcggatgacgtgcccatggtgctggtggggaacaagtgtgacctg
gctgcacgcactgtggaatctcggcaggctcaggacctcgcccgaagctacggcatcccc
tacatcgagacctcggccaagacccggcagggagtggaggatgccttctacacgttggtg
cgtgagatccggcagcacaagctgcggaagctgaaccctcctgatgagagtggccccggc
tgcatgagctgcaagtgtgtgctctcctga

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