KEGG   Homo sapiens (human): 3454Help
Entry
3454              CDS       T01001                                 

Gene name
IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Definition
(RefSeq) interferon alpha and beta receptor subunit 1
  KO
K05130  
interferon receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Necroptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Pathways in cancer
Network
N00053  
Cytokine-Jak-STAT signaling pathway
N00150  
Type I IFN signaling pathway
Drug target
Albinterferon alfa-2b: 
Interferon alfa natural: 
Interferon alfa-2a: 
Interferon alfa-2b: 
Interferon alfa-n1: 
Interferon alfacon-1: 
Interferon beta natural: 
Interferon beta-1a: 
Interferon beta-1b: 
Peginterferon alfa-2a: 
Peginterferon alfa-2b: 
Peginterferon beta-1a: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    3454 (IFNAR1)
   04151 PI3K-Akt signaling pathway
    3454 (IFNAR1)
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3454 (IFNAR1)
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    3454 (IFNAR1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    3454 (IFNAR1)
   04621 NOD-like receptor signaling pathway
    3454 (IFNAR1)
   04650 Natural killer cell mediated cytotoxicity
    3454 (IFNAR1)
  Development
   04380 Osteoclast differentiation
    3454 (IFNAR1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3454 (IFNAR1)
  Infectious diseases
   05162 Measles
    3454 (IFNAR1)
   05164 Influenza A
    3454 (IFNAR1)
   05161 Hepatitis B
    3454 (IFNAR1)
   05160 Hepatitis C
    3454 (IFNAR1)
   05168 Herpes simplex infection
    3454 (IFNAR1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    3454 (IFNAR1)
   05165 Human papillomavirus infection
    3454 (IFNAR1)
Cytokine receptors [BR:hsa04050]
 Class II cytokine receptor (interferon/IL-10 family receptor)
  3454 (IFNAR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P17181(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
21q22.11
AA seq 557 aa AA seqDB search
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVT
FSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSF
TPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERI
ENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQ
NQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQK
GIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTP
VIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSV
FSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDE
YFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSN
EDESESKTSEELQQDFV
NT seq 1674 nt NT seq  +upstreamnt  +downstreamnt
atgatggtcgtcctcctgggcgcgacgaccctagtgctcgtcgccgtggcgccatgggtg
ttgtccgcagccgcaggtggaaaaaatctaaaatctcctcaaaaagtagaggtcgacatc
atagatgacaactttatcctgaggtggaacaggagcgatgagtctgtcgggaatgtgact
ttttcattcgattatcaaaaaactgggatggataattggataaaattgtctgggtgtcag
aatattactagtaccaaatgcaacttttcttcactcaagctgaatgtttatgaagaaatt
aaattgcgtataagagcagaaaaagaaaacacttcttcatggtatgaggttgactcattt
acaccatttcgcaaagctcagattggtcctccagaagtacatttagaagctgaagataag
gcaatagtgatacacatctctcctggaacaaaagatagtgttatgtgggctttggatggt
ttaagctttacatatagcttagttatctggaaaaactcttcaggtgtagaagaaaggatt
gaaaatatttattccagacataaaatttataaactctcaccagagactacttattgtcta
aaagttaaagcagcactacttacgtcatggaaaattggtgtctatagtccagtacattgt
ataaagaccacagttgaaaatgaactacctccaccagaaaatatagaagtcagtgtccaa
aatcagaactatgttcttaaatgggattatacatatgcaaacatgacctttcaagttcag
tggctccacgcctttttaaaaaggaatcctggaaaccatttgtataaatggaaacaaata
cctgactgtgaaaatgtcaaaactacccagtgtgtctttcctcaaaacgttttccaaaaa
ggaatttaccttctccgcgtacaagcatctgatggaaataacacatctttttggtctgaa
gagataaagtttgatactgaaatacaagctttcctacttcctccagtctttaacattaga
tcccttagtgattcattccatatctatatcggtgctccaaaacagtctggaaacacgcct
gtgatccaggattatccactgatttatgaaattattttttgggaaaacacttcaaatgct
gagagaaaaattatcgagaaaaaaactgatgttacagttcctaatttgaaaccactgact
gtatattgtgtgaaagccagagcacacaccatggatgaaaagctgaataaaagcagtgtt
tttagtgacgctgtatgtgagaaaacaaaaccaggaaatacctctaaaatttggcttata
gttggaatttgtattgcattatttgctctcccgtttgtcatttatgctgcgaaagtcttc
ttgagatgcatcaattatgtcttctttccatcacttaaaccttcttccagtatagatgag
tatttctctgaacagccattgaagaatcttctgctttcaacttctgaggaacaaatcgaa
aaatgtttcataattgaaaatataagcacaattgctacagtagaagaaactaatcaaact
gatgaagatcataaaaaatacagttcccaaactagccaagattcaggaaattattctaat
gaagatgaaagcgaaagtaaaacaagtgaagaactacagcaggactttgtatga

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