KEGG T01001: 351

Homo sapiens (human): 351

Entry

351 CDS T01001

Gene name

APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2

Definition

amyloid beta (A4) precursor protein

Orthology

K04520

amyloid beta A4 protein

Organism

hsa Homo sapiens (human)

Pathway

hsa04726	Serotonergic synapse
hsa05010	Alzheimer's disease

Disease

H00056	Alzheimer's disease (AD)
H01185	Cerebral amyloid angiopathy (CAA)

Class

Organismal Systems; Nervous system; Serotonergic synapse [PATH:hsa04726]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:hsa05010]

SSDB

Motif

Pfam:

APP_E2 APP_N APP_amyloid Beta-APP APP_Cu_bd Kunitz_BPTI Exonuc_VII_L Activator-TraM

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

P05067 B4DGD0 B4DJT9 E9PEV0 E9PG40

Structure

PDB:

2FMA 3IFN 1AAP 2FK1 2FJZ 2FK2 1MWP 1TAW 3UMH 3DXE 3DXC 1CA0 4HIX 3DXD 3L3T 3UMI 2FK3 3L33 2FKL 2WK3 3UMK 1ZJD 3KTM 3NYL 3NYJ 2LP1 2LOH 2LNQ 2LMQ 2LMN 2LMO 2LMP 2LLM 2LFM 2OTK 2BEG 1TKN 1OWT 1BJB 1BJC 1BA6 1BA4 1AML 1AMC 1AMB

Position

21q21.3

AA seq 770 aa
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

NT seq 2313 nt +upstreamnt +downstreamnt
atgctgcccggtttggcactgctcctgctggccgcctggacggctcgggcgctggaggta
cccactgatggtaatgctggcctgctggctgaaccccagattgccatgttctgtggcaga
ctgaacatgcacatgaatgtccagaatgggaagtgggattcagatccatcagggaccaaa
acctgcattgataccaaggaaggcatcctgcagtattgccaagaagtctaccctgaactg
cagatcaccaatgtggtagaagccaaccaaccagtgaccatccagaactggtgcaagcgg
ggccgcaagcagtgcaagacccatccccactttgtgattccctaccgctgcttagttggt
gagtttgtaagtgatgcccttctcgttcctgacaagtgcaaattcttacaccaggagagg
atggatgtttgcgaaactcatcttcactggcacaccgtcgccaaagagacatgcagtgag
aagagtaccaacttgcatgactacggcatgttgctgccctgcggaattgacaagttccga
ggggtagagtttgtgtgttgcccactggctgaagaaagtgacaatgtggattctgctgat
gcggaggaggatgactcggatgtctggtggggcggagcagacacagactatgcagatggg
agtgaagacaaagtagtagaagtagcagaggaggaagaagtggctgaggtggaagaagaa
gaagccgatgatgacgaggacgatgaggatggtgatgaggtagaggaagaggctgaggaa
ccctacgaagaagccacagagagaaccaccagcattgccaccaccaccaccaccaccaca
gagtctgtggaagaggtggttcgagaggtgtgctctgaacaagccgagacggggccgtgc
cgagcaatgatctcccgctggtactttgatgtgactgaagggaagtgtgccccattcttt
tacggcggatgtggcggcaaccggaacaactttgacacagaagagtactgcatggccgtg
tgtggcagcgccatgtcccaaagtttactcaagactacccaggaacctcttgcccgagat
cctgttaaacttcctacaacagcagccagtacccctgatgccgttgacaagtatctcgag
acacctggggatgagaatgaacatgcccatttccagaaagccaaagagaggcttgaggcc
aagcaccgagagagaatgtcccaggtcatgagagaatgggaagaggcagaacgtcaagca
aagaacttgcctaaagctgataagaaggcagttatccagcatttccaggagaaagtggaa
tctttggaacaggaagcagccaacgagagacagcagctggtggagacacacatggccaga
gtggaagccatgctcaatgaccgccgccgcctggccctggagaactacatcaccgctctg
caggctgttcctcctcggcctcgtcacgtgttcaatatgctaaagaagtatgtccgcgca
gaacagaaggacagacagcacaccctaaagcatttcgagcatgtgcgcatggtggatccc
aagaaagccgctcagatccggtcccaggttatgacacacctccgtgtgatttatgagcgc
atgaatcagtctctctccctgctctacaacgtgcctgcagtggccgaggagattcaggat
gaagttgatgagctgcttcagaaagagcaaaactattcagatgacgtcttggccaacatg
attagtgaaccaaggatcagttacggaaacgatgctctcatgccatctttgaccgaaacg
aaaaccaccgtggagctccttcccgtgaatggagagttcagcctggacgatctccagccg
tggcattcttttggggctgactctgtgccagccaacacagaaaacgaagttgagcctgtt
gatgcccgccctgctgccgaccgaggactgaccactcgaccaggttctgggttgacaaat
atcaagacggaggagatctctgaagtgaagatggatgcagaattccgacatgactcagga
tatgaagttcatcatcaaaaattggtgttctttgcagaagatgtgggttcaaacaaaggt
gcaatcattggactcatggtgggcggtgttgtcatagcgacagtgatcgtcatcaccttg
gtgatgctgaagaagaaacagtacacatccattcatcatggtgtggtggaggttgacgcc
gctgtcaccccagaggagcgccacctgtccaagatgcagcagaacggctacgaaaatcca
acctacaagttctttgagcagatgcagaactag

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (29)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (15)   
   UniProt (5)   
   RefSeq(pep) (10)   
DNA sequence (84)   
   RefSeq(nuc) (10)   
   GenBank (37)   
   EMBL (37)   
3D Structure (45)   
   PDB (45)   
Protein domain (8)   
   Pfam (8)   
All databases (201)   

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