KEGG   Homo sapiens (human): 3551Help
Entry
3551              CDS       T01001                                 

Gene name
IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB
Definition
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)
Orthology
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Class
Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:hsa04010]
Environmental Information Processing; Signal transduction; NF-kappa B signaling pathway [PATH:hsa04064]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:hsa04668]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:hsa04150]
Cellular Processes; Cell growth and death; Apoptosis [PATH:hsa04210]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:hsa04620]
Organismal Systems; Immune system; NOD-like receptor signaling pathway [PATH:hsa04621]
Organismal Systems; Immune system; RIG-I-like receptor signaling pathway [PATH:hsa04622]
Organismal Systems; Immune system; Cytosolic DNA-sensing pathway [PATH:hsa04623]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:hsa04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:hsa04662]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:hsa04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:hsa04920]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:hsa04722]
Organismal Systems; Development; Osteoclast differentiation [PATH:hsa04380]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Pancreatic cancer [PATH:hsa05212]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:hsa05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:hsa05220]
Human Diseases; Cancers; Prostate cancer [PATH:hsa05215]
Human Diseases; Cancers; Small cell lung cancer [PATH:hsa05222]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:hsa04930]
Human Diseases; Infectious diseases; Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
Human Diseases; Infectious diseases; Shigellosis [PATH:hsa05131]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:hsa05166]
Human Diseases; Infectious diseases; Influenza A [PATH:hsa05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:hsa05161]
Human Diseases; Infectious diseases; Hepatitis C [PATH:hsa05160]
Human Diseases; Infectious diseases; Herpes simplex infection [PATH:hsa05168]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:hsa05169]
Human Diseases; Infectious diseases; Toxoplasmosis [PATH:hsa05145]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:hsa05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
Position
8p11.2
AA seq 754 aa AA seqDB search
MFSGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEI
QIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAI
LTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSF
VGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVD
IVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKA
LDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALI
PDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLA
FFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAK
LDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQT
DIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFE
KKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIAC
SKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENA
IQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
NT seq 2265 nt NT seq  +upstreamnt  +downstreamnt
atgttttcaggggggtgtcatagccccgggtttggccgccccagccccgccttccccgcc
ccggggagcccgccccctgccccgcgtccctgccgacaggaaacaggtgagcagattgcc
atcaagcagtgccggcaggagctcagcccccggaaccgagagcggtggtgcctggagatc
cagatcatgagaaggctgacccaccccaatgtggtggctgcccgagatgtccctgagggg
atgcagaacttggcgcccaatgacctgcccctgctggccatggagtactgccaaggagga
gatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaaggtgccatc
ctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaacagaatcatc
catcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagaggttaatacac
aaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcacatcattc
gtggggaccctgcagtacctggccccagagctactggagcagcagaagtacacagtgacc
gtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttccggcccttc
ctccccaactggcagcccgtgcagtggcattcaaaagtgcggcagaagagtgaggtggac
attgttgttagcgaagacttgaatggaacggtgaagttttcaagctctttaccctacccc
aataatcttaacagtgtcctggctgagcgactggagaagtggctgcaactgatgctgatg
tggcacccccgacagaggggcacggatcccacgtatgggcccaatggctgcttcaaggcc
ctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacgggcaccatc
cacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccagaatccaacag
gacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcgttgatc
cccgataagcctgccactcagtgtatttcagacggcaagttaaatgagggccacacattg
gacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcagatctcc
ccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaatctcgcc
ttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctgaaggaa
gattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccgaaacaac
agctgcctctccaaaatgaagaattccatggcttccatgtctcagcagctcaaggccaag
ttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaaaccgag
tttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggctgtggag
ctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctgcagacc
gacattgtggacttacagaggagccccatgggccggaagcaggggggaacgctggacgac
ctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcgagaccagcga
actgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagcttcgag
aagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaagcagaaggcg
ctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgagaagact
gttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagattgcttgt
agcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcgacttagc
cagcctgggcagctgatgtctcagccctccacggcctccaacagcttacctgagccagcc
aagaagagtgaagaactggtggctgaagcacataacctctgcaccctgctagaaaatgcc
atacaggacactgtgagggaacaagaccagagtttcacggccctagactggagctggtta
cagacggaagaagaagagcacagctgcctggagcaggcctcatga

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