KEGG   Homo sapiens (human): 3551Help
Entry
3551              CDS       T01001                                 

Gene name
IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Definition
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)
Orthology
K07209  
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Class
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:hsa04014]
Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH:hsa04010]
Environmental Information Processing; Signal transduction; NF-kappa B signaling pathway [PATH:hsa04064]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:hsa04668]
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:hsa04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:hsa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:hsa04150]
Cellular Processes; Cell growth and death; Apoptosis [PATH:hsa04210]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:hsa04620]
Organismal Systems; Immune system; NOD-like receptor signaling pathway [PATH:hsa04621]
Organismal Systems; Immune system; RIG-I-like receptor signaling pathway [PATH:hsa04622]
Organismal Systems; Immune system; Cytosolic DNA-sensing pathway [PATH:hsa04623]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:hsa04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:hsa04662]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:hsa04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:hsa04920]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:hsa04722]
Organismal Systems; Development; Osteoclast differentiation [PATH:hsa04380]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:hsa05206]
Human Diseases; Cancers; Pancreatic cancer [PATH:hsa05212]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:hsa05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:hsa05220]
Human Diseases; Cancers; Prostate cancer [PATH:hsa05215]
Human Diseases; Cancers; Small cell lung cancer [PATH:hsa05222]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:hsa04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
Human Diseases; Infectious diseases; Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
Human Diseases; Infectious diseases; Shigellosis [PATH:hsa05131]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:hsa05166]
Human Diseases; Infectious diseases; Influenza A [PATH:hsa05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:hsa05161]
Human Diseases; Infectious diseases; Hepatitis C [PATH:hsa05160]
Human Diseases; Infectious diseases; Herpes simplex infection [PATH:hsa05168]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:hsa05169]
Human Diseases; Infectious diseases; Toxoplasmosis [PATH:hsa05145]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:hsa05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
8p11.2
AA seq 754 aa AA seqDB search
MFSGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEI
QIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAI
LTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSF
VGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVD
IVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKA
LDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALI
PDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLA
FFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAK
LDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQT
DIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFE
KKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIAC
SKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENA
IQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
NT seq 2265 nt NT seq  +upstreamnt  +downstreamnt
atgttttcaggggggtgtcatagccccgggtttggccgccccagccccgccttccccgcc
ccggggagcccgccccctgccccgcgtccctgccgacaggaaacaggtgagcagattgcc
atcaagcagtgccggcaggagctcagcccccggaaccgagagcggtggtgcctggagatc
cagatcatgagaaggctgacccaccccaatgtggtggctgcccgagatgtccctgagggg
atgcagaacttggcgcccaatgacctgcccctgctggccatggagtactgccaaggagga
gatctccggaagtacctgaaccagtttgagaactgctgtggtctgcgggaaggtgccatc
ctcaccttgctgagtgacattgcctctgcgcttagataccttcatgaaaacagaatcatc
catcgggatctaaagccagaaaacatcgtcctgcagcaaggagaacagaggttaatacac
aaaattattgacctaggatatgccaaggagctggatcagggcagtctttgcacatcattc
gtggggaccctgcagtacctggccccagagctactggagcagcagaagtacacagtgacc
gtcgactactggagcttcggcaccctggcctttgagtgcatcacgggcttccggcccttc
ctccccaactggcagcccgtgcagtggcattcaaaagtgcggcagaagagtgaggtggac
attgttgttagcgaagacttgaatggaacggtgaagttttcaagctctttaccctacccc
aataatcttaacagtgtcctggctgagcgactggagaagtggctgcaactgatgctgatg
tggcacccccgacagaggggcacggatcccacgtatgggcccaatggctgcttcaaggcc
ctggatgacatcttaaacttaaagctggttcatatcttgaacatggtcacgggcaccatc
cacacctaccctgtgacagaggatgagagtctgcagagcttgaaggccagaatccaacag
gacacgggcatcccagaggaggaccaggagctgctgcaggaagcgggcctggcgttgatc
cccgataagcctgccactcagtgtatttcagacggcaagttaaatgagggccacacattg
gacatggatcttgtttttctctttgacaacagtaaaatcacctatgagactcagatctcc
ccacggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaatctcgcc
ttcttccagctgaggaaggtgtggggccaggtctggcacagcatccagaccctgaaggaa
gattgcaaccggctgcagcagggacagcgagccgccatgatgaatctcctccgaaacaac
agctgcctctccaaaatgaagaattccatggcttccatgtctcagcagctcaaggccaag
ttggatttcttcaaaaccagcatccagattgacctggagaagtacagcgagcaaaccgag
tttgggatcacatcagataaactgctgctggcctggagggaaatggagcaggctgtggag
ctctgtgggcgggagaacgaagtgaaactcctggtagaacggatgatggctctgcagacc
gacattgtggacttacagaggagccccatgggccggaagcaggggggaacgctggacgac
ctagaggagcaagcaagggagctgtacaggagactaagggaaaaacctcgagaccagcga
actgagggtgacagtcaggaaatggtacggctgctgcttcaggcaattcagagcttcgag
aagaaagtgcgagtgatctatacgcagctcagtaaaactgtggtttgcaagcagaaggcg
ctggaactgttgcccaaggtggaagaggtggtgagcttaatgaatgaggatgagaagact
gttgtccggctgcaggagaagcggcagaaggagctctggaatctcctgaagattgcttgt
agcaaggtccgtggtcctgtcagtggaagcccggatagcatgaatgcctctcgacttagc
cagcctgggcagctgatgtctcagccctccacggcctccaacagcttacctgagccagcc
aagaagagtgaagaactggtggctgaagcacataacctctgcaccctgctagaaaatgcc
atacaggacactgtgagggaacaagaccagagtttcacggccctagactggagctggtta
cagacggaagaagaagagcacagctgcctggagcaggcctcatga

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