KEGG   Homo sapiens (human): 3683Help
Entry
3683              CDS       T01001                                 

Gene name
ITGAL, CD11A, LFA-1, LFA1A
Definition
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Orthology
K05718  
integrin alpha L
Organism
hsa  Homo sapiens (human)
Pathway
Rap1 signaling pathway
Cell adhesion molecules (CAMs)
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Malaria
Staphylococcus aureus infection
HTLV-I infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditis
Drug target
Efalizumab: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    3683 (ITGAL)
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    3683 (ITGAL)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    3683 (ITGAL)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    3683 (ITGAL)
   04670 Leukocyte transendothelial migration
    3683 (ITGAL)
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    3683 (ITGAL)
  Cardiovascular diseases
   05416 Viral myocarditis
    3683 (ITGAL)
  Infectious diseases
   05150 Staphylococcus aureus infection
    3683 (ITGAL)
   05166 HTLV-I infection
    3683 (ITGAL)
   05169 Epstein-Barr virus infection
    3683 (ITGAL)
   05144 Malaria
    3683 (ITGAL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3683 (ITGAL)
Cell adhesion molecules and their ligands [BR:hsa04516]
 1. Immunoglobulin Superfamily
  Immune system
   ICAM family
    ICAM1; intercellular adhesion molecule 1 [KO:K06490]
     LFA-1 Cell adhesion molecules (CAMs)
      3683 (ITGAL)
    ICAM2; intercellular adhesion molecule 2 [KO:K06523]
      3683 (ITGAL)
    ICAM3; intercellular adhesion molecule 3 [KO:K06486]
      3683 (ITGAL)
   Others
    CD226, DNAM1; CD226 antigen [KO:K06567]
      3683 (ITGAL)
  Neural system
   N/0 subfamily
    ICAM5, TLCN; intercellular adhesion molecule 5 [KO:K06769]
      3683 (ITGAL)
Cellular antigens [BR:hsa04090]
 Proteins
  3683 (ITGAL)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
16p11.2
AA seq 1086 aa AA seqDB search
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILFAAVQFSTSYK
TEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIIT
DGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDL
FTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKAD
LQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGG
HWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLG
FEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSP
QPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMS
FSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTR
RRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQ
RAGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVE
LSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVS
SPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPIN
ILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPI
THQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIE
ASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLL
LLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSE
SGGGKD
NT seq 3261 nt NT seq  +upstreamnt  +downstreamnt
atgaaggattcctgcatcactgtgatggccatggcgctgctgtctgggttctttttcttc
gcgccggcctcgagctacaacctggacgtgcggggcgcgcggagcttctccccaccgcgc
gccgggaggcactttggataccgcgtcctgcaggtcggaaacggggtcatcgtgggagct
ccaggggaggggaacagcacaggaagcctctatcagtgccagtcgggcacaggacactgc
ctgccagtcaccctgagaggttccaactatacctccaagtacttgggaatgaccttggca
acagaccccacagatggaagcattttgtttgctgctgttcagttttccacaagctacaaa
acagaatttgatttctcagattatgttaaacggaaggaccctgatgctctgctgaagcat
gtaaagcacatgttgctgttgaccaatacctttggtgccatcaattatgtcgcgacagag
gtgttccgggaggagctgggggcccggccagatgccaccaaagtgcttatcatcatcacg
gatggggaggccactgacagtggcaacatcgatgcggccaaagacatcatccgctacatc
atcgggattggaaagcattttcagaccaaggagagtcaggagaccctccacaaatttgca
tcaaaacccgcgagcgagtttgtgaaaattctggacacatttgagaagctgaaagatcta
ttcactgagctgcagaagaagatctatgtcattgagggcacaagcaaacaggacctgact
tccttcaacatggagctgtcctccagcggcatcagtgctgacctcagcaggggccatgca
gtcgtgggggcagtaggagccaaggactgggctgggggctttcttgacctgaaggcagac
ctgcaggatgacacatttattgggaatgaaccattgacaccagaagtgagagcaggctat
ttgggttacaccgtgacctggctgccctcccggcaaaagacttcgttgctggcctcggga
gcccctcgataccagcacatgggccgagtgctgctgttccaagagccacagggcggagga
cactggagccaggtccagacaatccatgggacccagattggctcttatttcggtggggag
ctgtgtggcgtcgacgtggaccaagatggggagacagagctgctgctgattggtgcccca
ctgttctatggggagcagagaggaggccgggtgtttatctaccagagaagacagttgggg
tttgaagaagtctcagagctgcagggggaccccggctacccactcgggcggtttggagaa
gccatcactgctctgacagacatcaacggcgatgggctggtagacgtggctgtgggggcc
cctctggaggagcagggggctgtgtacatcttcaatgggaggcacggggggcttagtccc
cagccaagtcagcggatagaagggacccaagtgctctcaggaattcagtggtttggacgc
tccatccatggggtgaaggaccttgaaggggatggcttggcagatgtggctgtgggggct
gagagccagatgatcgtgctgagctcccggcccgtggtggatatggtcaccctgatgtcc
ttctctccagctgagatcccagtgcatgaagtggagtgctcctattcaaccagtaacaag
atgaaagaaggagttaatatcacaatctgtttccagatcaagtctctcatcccccagttc
caaggccgcctggttgccaatctcacttacactctgcagctggatggccaccggaccaga
agacgggggttgttcccaggagggagacatgaactcagaaggaatatagctgtcaccacc
agcatgtcatgcactgacttctcatttcatttcccggtatgtgttcaagacctcatctcc
cccatcaatgtttccctgaatttctctctttgggaggaggaagggacaccgagggaccaa
agggcgggcaaggacataccgcccatcctgagaccctccctgcactcggaaacctgggag
atcccttttgagaagaactgtggggaggacaagaagtgtgaggcaaacttgagagtgtcc
ttctctcctgcaagatccagagccctgcgtctaactgcttttgccagcctctctgtggag
ctgagcctgagtaacttggaagaagatgcttactgggtccagctggacctgcacttcccc
ccgggactctccttccgcaaggtggagatgctgaagccccatagccagatacctgtgagc
tgcgaggagcttcctgaagagtccaggcttctgtccagggcattatcttgcaatgtgagc
tctcccatcttcaaagcaggccactcggttgctctgcagatgatgtttaatacactggta
aacagctcctggggggactcggttgaattgcacgccaatgtgacctgtaacaatgaggac
tcagacctcctggaggacaactcagccactaccatcatccccatcctgtaccccatcaac
atcctcatccaggaccaagaagactccacactctatgtcagtttcacccccaaaggcccc
aagatccaccaagtcaagcacatgtaccaggtgaggatccagccttccatccacgaccac
aacatacccaccctggaggctgtggttggggtgccacagcctcccagcgaggggcccatc
acacaccagtggagcgtgcagatggagcctcccgtgccctgccactatgaggatctggag
aggctcccggatgcagctgagccttgtctccccggagccctgttccgctgccctgttgtc
ttcaggcaggagatcctcgtccaagtgatcgggactctggagctggtgggagagatcgag
gcctcttccatgttcagcctctgcagctccctctccatctccttcaacagcagcaagcat
ttccacctctatggcagcaacgcctccctggcccaggttgtcatgaaggttgacgtggtg
tatgagaagcagatgctctacctctacgtgctgagcggcatcggggggctgctgctgctg
ctgctcattttcatagtgctgtacaaggttggtttcttcaaacggaacctgaaggagaag
atggaggctggcagaggtgtcccgaatggaatccctgcagaagactctgagcagctggca
tctgggcaagaggctggggatcccggctgcctgaagcccctccatgagaaggactctgag
agtggtggtggcaaggactga

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