KEGG T01001: 3683

Homo sapiens (human): 3683

Entry

3683 CDS T01001

Gene name

ITGAL, CD11A, LFA-1, LFA1A

Definition

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Orthology

K05718

integrin alpha L

Organism

hsa Homo sapiens (human)

Pathway

hsa04514	Cell adhesion molecules (CAMs)
hsa04650	Natural killer cell mediated cytotoxicity
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton
hsa05144	Malaria
hsa05150	Staphylococcus aureus infection
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05323	Rheumatoid arthritis
hsa05416	Viral myocarditis

Drug target

Efalizumab:

D03959

Other:

D04045 D08993

Class

Environmental Information Processing; Signaling molecules and interaction; Cell adhesion molecules (CAMs) [PATH:hsa04514]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:hsa04810]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:hsa04650]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:hsa04670]
Human Diseases; Immune diseases; Rheumatoid arthritis [PATH:hsa05323]
Human Diseases; Cardiovascular diseases; Viral myocarditis [PATH:hsa05416]
Human Diseases; Infectious diseases; Staphylococcus aureus infection [PATH:hsa05150]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:hsa05166]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:hsa05169]
Human Diseases; Infectious diseases; Malaria [PATH:hsa05144]

SSDB

Motif

Pfam:

Integrin_alpha2 VWA FG-GAP VCBS FG-GAP_2 VWA_2 Integrin_alpha

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1MJN 2ICA 3F78 1T0P 3F74 2O7N 3BQN 1XUO 1LFA 3M6F 3BQM 3E2M 1MQ9 1ZOP 1ZON 3BN3 1XDG 1XDD 3HI6 1RD4 1MQA 1CQP 3EOA 1ZOO 1MQ8 3TCX 3EOB 2K8O 1DGQ

Position

16p11.2

AA seq 1086 aa
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGA
PGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILFAAVQFSTSYK
TEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIIT
DGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDL
FTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKAD
LQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGG
HWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLG
FEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSP
QPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMS
FSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTR
RRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQ
RAGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVE
LSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVS
SPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPIN
ILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPI
THQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIE
ASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLL
LLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSE
SGGGKD

NT seq 3261 nt +upstreamnt +downstreamnt
atgaaggattcctgcatcactgtgatggccatggcgctgctgtctgggttctttttcttc
gcgccggcctcgagctacaacctggacgtgcggggcgcgcggagcttctccccaccgcgc
gccgggaggcactttggataccgcgtcctgcaggtcggaaacggggtcatcgtgggagct
ccaggggaggggaacagcacaggaagcctctatcagtgccagtcgggcacaggacactgc
ctgccagtcaccctgagaggttccaactatacctccaagtacttgggaatgaccttggca
acagaccccacagatggaagcattttgtttgctgctgttcagttttccacaagctacaaa
acagaatttgatttctcagattatgttaaacggaaggaccctgatgctctgctgaagcat
gtaaagcacatgttgctgttgaccaatacctttggtgccatcaattatgtcgcgacagag
gtgttccgggaggagctgggggcccggccagatgccaccaaagtgcttatcatcatcacg
gatggggaggccactgacagtggcaacatcgatgcggccaaagacatcatccgctacatc
atcgggattggaaagcattttcagaccaaggagagtcaggagaccctccacaaatttgca
tcaaaacccgcgagcgagtttgtgaaaattctggacacatttgagaagctgaaagatcta
ttcactgagctgcagaagaagatctatgtcattgagggcacaagcaaacaggacctgact
tccttcaacatggagctgtcctccagcggcatcagtgctgacctcagcaggggccatgca
gtcgtgggggcagtaggagccaaggactgggctgggggctttcttgacctgaaggcagac
ctgcaggatgacacatttattgggaatgaaccattgacaccagaagtgagagcaggctat
ttgggttacaccgtgacctggctgccctcccggcaaaagacttcgttgctggcctcggga
gcccctcgataccagcacatgggccgagtgctgctgttccaagagccacagggcggagga
cactggagccaggtccagacaatccatgggacccagattggctcttatttcggtggggag
ctgtgtggcgtcgacgtggaccaagatggggagacagagctgctgctgattggtgcccca
ctgttctatggggagcagagaggaggccgggtgtttatctaccagagaagacagttgggg
tttgaagaagtctcagagctgcagggggaccccggctacccactcgggcggtttggagaa
gccatcactgctctgacagacatcaacggcgatgggctggtagacgtggctgtgggggcc
cctctggaggagcagggggctgtgtacatcttcaatgggaggcacggggggcttagtccc
cagccaagtcagcggatagaagggacccaagtgctctcaggaattcagtggtttggacgc
tccatccatggggtgaaggaccttgaaggggatggcttggcagatgtggctgtgggggct
gagagccagatgatcgtgctgagctcccggcccgtggtggatatggtcaccctgatgtcc
ttctctccagctgagatcccagtgcatgaagtggagtgctcctattcaaccagtaacaag
atgaaagaaggagttaatatcacaatctgtttccagatcaagtctctcatcccccagttc
caaggccgcctggttgccaatctcacttacactctgcagctggatggccaccggaccaga
agacgggggttgttcccaggagggagacatgaactcagaaggaatatagctgtcaccacc
agcatgtcatgcactgacttctcatttcatttcccggtatgtgttcaagacctcatctcc
cccatcaatgtttccctgaatttctctctttgggaggaggaagggacaccgagggaccaa
agggcgggcaaggacataccgcccatcctgagaccctccctgcactcggaaacctgggag
atcccttttgagaagaactgtggggaggacaagaagtgtgaggcaaacttgagagtgtcc
ttctctcctgcaagatccagagccctgcgtctaactgcttttgccagcctctctgtggag
ctgagcctgagtaacttggaagaagatgcttactgggtccagctggacctgcacttcccc
ccgggactctccttccgcaaggtggagatgctgaagccccatagccagatacctgtgagc
tgcgaggagcttcctgaagagtccaggcttctgtccagggcattatcttgcaatgtgagc
tctcccatcttcaaagcaggccactcggttgctctgcagatgatgtttaatacactggta
aacagctcctggggggactcggttgaattgcacgccaatgtgacctgtaacaatgaggac
tcagacctcctggaggacaactcagccactaccatcatccccatcctgtaccccatcaac
atcctcatccaggaccaagaagactccacactctatgtcagtttcacccccaaaggcccc
aagatccaccaagtcaagcacatgtaccaggtgaggatccagccttccatccacgaccac
aacatacccaccctggaggctgtggttggggtgccacagcctcccagcgaggggcccatc
acacaccagtggagcgtgcagatggagcctcccgtgccctgccactatgaggatctggag
aggctcccggatgcagctgagccttgtctccccggagccctgttccgctgccctgttgtc
ttcaggcaggagatcctcgtccaagtgatcgggactctggagctggtgggagagatcgag
gcctcttccatgttcagcctctgcagctccctctccatctccttcaacagcagcaagcat
ttccacctctatggcagcaacgcctccctggcccaggttgtcatgaaggttgacgtggtg
tatgagaagcagatgctctacctctacgtgctgagcggcatcggggggctgctgctgctg
ctgctcattttcatagtgctgtacaaggttggtttcttcaaacggaacctgaaggagaag
atggaggctggcagaggtgtcccgaatggaatccctgcagaagactctgagcagctggca
tctgggcaagaggctggggatcccggctgcctgaagcccctccatgagaaggactctgag
agtggtggtggcaaggactga

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   RefSeq(pep) (2)   
DNA sequence (16)   
   RefSeq(nuc) (2)   
   GenBank (7)   
   EMBL (7)   
3D Structure (29)   
   PDB (29)   
Protein domain (7)   
   Pfam (7)   
All databases (88)   

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