| Entry |
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| Gene name |
KCNMA1, BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1
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| Definition |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
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| Orthology |
| potassium large conductance calcium-activated channel subfamily M alpha member 1 |
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| Organism |
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| Pathway |
| Vascular smooth muscle contraction | | Insulin secretion | | Salivary secretion | | Pancreatic secretion |
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| Disease |
| Generalized epilepsy and paroxysmal dyskinesia (GEPD) |
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| Class |
Organismal Systems; Endocrine system; Insulin secretion [PATH: hsa04911]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH: hsa04270]
Organismal Systems; Digestive system; Salivary secretion [PATH: hsa04970]
Organismal Systems; Digestive system; Pancreatic secretion [PATH: hsa04972]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
10q22.3
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| AA seq |
1182 aa  
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGG
MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAA
MTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH
NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ
FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFL
DQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA
LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC
FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSH
SSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQNRKEMVYR |
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| NT seq |
3549 nt  +upstreamnt +downstreamnt
atggcaaatggtggcggcggcggcggcggcagcagcggcggcggcggcggcggcggaggc
agcagtcttagaatgagtagcaatatccacgcgaaccatctcagcctagacgcgtcctcc
tcctcctcctcctcctcttcctcttcttcttcttcctcctcctcttcctcctcgtcctcg
gtccacgagcccaagatggatgcgctcatcatcccggtgaccatggaggtgccgtgcgac
agccggggccaacgcatgtggtgggctttcctggcctcctccatggtgactttcttcggg
ggcctcttcatcatcttgctctggcggacgctcaagtacctgtggaccgtgtgctgccac
tgcgggggcaagacgaaggaggcccagaagattaacaatggctcaagccaggcggatggc
actctcaaaccagtggatgaaaaagaggaggcagtggccgccgaggtcggctggatgacc
tccgtgaaggactgggcgggggtgatgatatccgcccagacactgactggcagagtcctg
gttgtcttagtctttgctctcagcatcggtgcacttgtaatatacttcatagattcatca
aacccaatagaatcctgccagaatttctacaaagatttcacattacagatcgacatggct
ttcaacgtgttcttccttctctacttcggcttgcggtttattgcagccaacgataaattg
tggttctggctggaagtgaactctgtagtggatttcttcacggtgccccccgtgtttgtg
tctgtgtacttaaacagaagttggcttggtttgagatttttaagagctctgagactgata
cagttttcagaaattttgcagtttctgaatattcttaaaacaagtaattccatcaagctg
gtgaatctgctctccatatttatcagcacgtggctgactgcagccgggttcatccatttg
gtggagaattcaggggacccatgggaaaatttccaaaacaaccaggctctcacctactgg
gaatgtgtctatttactcatggtcacaatgtccaccgttggttatggggatgtttatgca
aaaaccacacttgggcgcctcttcatggtcttcttcatcctcgggggactggccatgttt
gccagctacgtccctgaaatcatagagttaataggaaaccgcaagaaatacgggggctcc
tatagtgcggttagtggaagaaagcacattgtggtctgcggacacatcactctggagagt
gtttccaacttcctgaaggactttctgcacaaggaccgggatgacgtcaatgtggagatc
gtttttcttcacaacatctcccccaacctggagcttgaagctctgttcaaacgacatttt
actcaggtggaattttatcagggttccgtcctcaatccacatgatcttgcaagagtcaag
atagagtcagcagatgcatgcctgatccttgccaacaagtactgcgctgacccggatgcg
gaggatgcctcgaatatcatgagagtaatctccataaagaactaccatccgaagataaga
atcatcactcaaatgctgcagtatcacaacaaggcccatctgctaaacatcccgagctgg
aattggaaagaaggtgatgacgcaatctgcctcgcagagttgaagttgggcttcatagcc
cagagctgcctggctcaaggcctctccaccatgcttgccaacctcttctccatgaggtca
ttcataaagattgaggaagacacatggcagaaatactacttggaaggagtctcaaatgaa
atgtacacagaatatctctccagtgccttcgtgggtctgtccttccctactgtttgtgag
ctgtgttttgtgaagctcaagctcctaatgatagccattgagtacaagtctgccaaccga
gagagccgaagccgaaagcgtatattaattaatcctggaaaccatcttaagatccaagaa
ggtactttaggatttttcatcgcaagtgatgccaaagaagttaaaagggcatttttttac
tgcaaggcctgtcatgatgacatcacagatcccaaaagaataaaaaaatgtggctgcaaa
cggcttgaagatgagcagccgtcaacactatcaccaaaaaaaaagcaacggaatggaggc
atgcggaactcacccaacacctcgcctaagctgatgaggcatgaccccttgttaattcct
ggcaatgatcagattgacaacatggactccaatgtgaagaagtacgactctactgggatg
tttcactggtgtgcacccaaggagatagagaaagtcatcctgactcgaagtgaagctgcc
atgaccgtcctgagtggccatgtcgtggtctgcatctttggcgacgtcagctcagccctg
atcggcctccggaacctggtgatgccgctccgtgccagcaactttcattaccatgagctc
aagcacattgtgtttgtgggctctattgagtacctcaagcgggaatgggagacgcttcat
aacttccccaaagtgtccatattgcctggtacgccattaagtcgggctgatttaagggct
gtcaacatcaacctctgtgacatgtgcgttatcctgtcagccaatcagaataatattgat
gatacttcgctgcaggacaaggaatgcatcttggcgtcactcaacatcaaatctatgcag
tttgatgacagcatcggagtcttgcaggctaattcccaagggttcacacctccaggaatg
gatagatcctctccagataacagcccagtgcacgggatgttacgtcaaccatccatcaca
actggggtcaacatccccatcatcactgaactagtgaacgatactaatgttcagtttttg
gaccaagacgatgatgatgaccctgatacagaactgtacctcacgcagccctttgcctgt
gggacagcatttgccgtcagtgtcctggactcactcatgagcgcgacgtacttcaatgac
aatatcctcaccctgatacggaccctggtgaccggaggagccacgccggagctggaggct
ctgattgctgaggaaaacgcccttagaggtggctacagcaccccgcagacactggccaat
agggaccgctgccgcgtggcccagttagctctgctcgatgggccatttgcggacttaggg
gatggtggttgttatggtgatctgttctgcaaagctctgaaaacatataatatgctttgt
tttggaatttaccggctgagagatgctcacctcagcacccccagtcagtgcacaaagagg
tatgtcatcaccaacccgccctatgagtttgagctcgtgccgacggacctgatcttctgc
ttaatgcagtttgaccacaatgccggccagtcccgggccagcctgtcccattcctcccac
tcgtcgcagtcctccagcaagaagagctcctctgttcactccatcccatccacagcaaac
cgacagaaccggcccaagtccagggagtcccgggacaaacagaacagaaaagaaatggtt
tacagatga |
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