KEGG T01001: 3978

Homo sapiens (human): 3978

Entry

3978 CDS T01001

Gene name

LIG1

Definition

ligase I, DNA, ATP-dependent (EC:6.5.1.1)

Orthology

K10747

DNA ligase 1 [EC:6.5.1.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa03030	DNA replication
hsa03410	Base excision repair
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair

Disease

H00094

DNA repair defects

Class

Genetic Information Processing; Replication and repair; DNA replication [PATH:hsa03030]
Genetic Information Processing; Replication and repair; Base excision repair [PATH:hsa03410]
Genetic Information Processing; Replication and repair; Nucleotide excision repair [PATH:hsa03420]
Genetic Information Processing; Replication and repair; Mismatch repair [PATH:hsa03430]

SSDB

Motif

Pfam:

DNA_ligase_A_M DNA_ligase_A_N DNA_ligase_A_C mRNA_cap_enzyme

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1X9N

Position

19q13.2-q13.3

AA seq 919 aa
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY

NT seq 2760 nt +upstreamnt +downstreamnt
atgcagcgaagtatcatgtcatttttccaccccaagaaagagggtaaagcaaagaagcct
gagaaggaggcatccaatagcagcagagagacggagccccctccaaaggcggcactgaag
gagtggaatggagtggtgtccgagagtgactctccggtgaagaggccagggaggaaggcg
gcccgggtcctgggcagcgaaggggaagaggaggatgaagcccttagccctgctaaaggc
cagaagcctgccctggactgctcacaggtctccccgccccgtcctgccacatctcctgag
aacaatgcttccctctctgacacctctcccatggacagttccccatcagggattccgaag
cgtcgcacagctcggaagcagctcccgaaacggaccattcaggaagtcctggaagagcag
agtgaggacgaggacagagaagccaagaggaagaaggaggaggaagaagaggagaccccg
aaagaaagcctcacagaggctgaagtggcaacagagaaggaaggagaagacggggaccag
cccaccacgcctcccaagcccctaaagacctccaaagcagagaccccgacggaaagcgtt
tcagagcctgaggtggccacgaagcaggaactgcaggaggaggaagagcagaccaagcct
ccccgcagagctcccaagacgctcagcagcttcttcaccccccggaagccagcagtcaaa
aaagaagtgaaggaagaggagccaggggctccaggaaaggagggagctgctgagggaccc
ctggatccatctggttacaatcctgccaagaacaactatcatcccgtggaagatgcctgc
tggaaaccgggccagaaggttccttacctggctgtggcccggacgtttgagaagatcgag
gaggtgtctgctcggctccggatggtggagacgctgagcaacttgctgcgctccgtggtg
gccctgtcgcctccagacctcctccctgtcctctacctcagcctcaaccaccttgggcca
ccccagcagggcctggagcttggcgtgggtgatggtgtccttctcaaggcagtggcccag
gccacaggtcggcagctggagtccgtccgggctgaggcagccgagaaaggcgacgtgggg
ctggtggccgagaacagccgcagcacccagaggctcatgctgccaccacctccgctcact
gcctccggggtcttcagcaagttccgcgacatcgccaggctcactggcagtgcttccaca
gccaagaagatagacatcatcaaaggcctctttgtggcctgccgccactcagaagcccgg
ttcatcgctaggtccctgagcggacggctgcgccttgggctggcagagcagtcggtgctg
gctgccctctcccaggcagtgagcctcacgcccccgggccaagaattcccaccagccatg
gtggatgctgggaagggcaagacagcagaggccagaaagacgtggctggaggagcaaggc
atgatcctgaagcagacgttctgcgaggttcccgacctggaccgaattatccccgtgctg
ctggagcacggcctggaacgtctcccggagcactgcaagctgagcccagggattcccctg
aaaccaatgttggcccatcccacccggggcatcagcgaggtcctgaaacgctttgaggag
gcagctttcacctgcgaatacaaatatgacgggcagagggcacagatccacgccctggaa
ggcggggaggtgaagatcttcagcaggaatcaggaagacaacactgggaagtacccggac
atcatcagccgcatccccaagattaaactcccatcggtcacatccttcatcctggacacc
gaagccgtggcttgggaccgggaaaagaagcagatccagccattccaagtgctcaccacc
cgcaaacgcaaggaggtggatgcgtctgagatccaggtgcaggtgtgtttgtacgccttc
gacctcatctacctcaatggagagtccctggtacgtgagcccctttcccggcgccggcag
ctgctccgggagaactttgtggagacagagggcgagtttgtcttcgccacctccctggac
accaaggacatcgagcagatcgccgagttcctggagcagtcagtgaaagactcctgcgag
gggctgatggtgaagaccctggatgttgatgccacctacgagatcgccaagagatcgcac
aactggctcaagctgaagaaggactaccttgatggcgtgggtgacaccctggacctggtg
gtgatcggcgcctacctgggccgggggaagcgggccggccggtacgggggcttcctgctg
gcctcctacgacgaggacagtgaggagctgcaggccatatgcaagcttggaactggcttc
agtgatgaggagctggaggagcatcaccagagcctcaaggcgctggtgctgcccagccca
cgcccttacgtgcggatagatggcgctgtgattcccgaccactggctggaccccagcgct
gtgtgggaggtgaagtgcgctgacctctccctctctcccatctaccctgctgcgcggggc
ctggtggatagtgacaagggcatctcccttcgcttccctcggtttattcgagtccgtgaa
gacaagcagccggagcaggccaccaccagtgctcaggtggcctgtttgtaccggaagcaa
agtcagattcagaaccaacaaggcgaggactcaggctctgaccctgaagatacctactaa

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (10)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (55)   

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