KEGG T01001: 4125

Homo sapiens (human): 4125

Entry

4125 CDS T01001

Gene name

MAN2B1, LAMAN, MANB

Definition

mannosidase, alpha, class 2B, member 1 (EC:3.2.1.24)

Orthology

K12311

lysosomal alpha-mannosidase [EC:3.2.1.24]

Organism

hsa Homo sapiens (human)

Pathway

hsa00511	Other glycan degradation
hsa04142	Lysosome

Disease

H00139

alpha-Mannosidosis

Class

Metabolism; Glycan biosynthesis and metabolism; Other glycan degradation [PATH:hsa00511]
Cellular Processes; Transport and catabolism; Lysosome [PATH:hsa04142]

SSDB

Motif

Pfam:

Glyco_hydro_38C Glyco_hydro_38 Alpha-mann_mid

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

19cen-q13.1

AA seq 1011 aa
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG

NT seq 3036 nt +upstreamnt +downstreamnt
atgggcgcctacgcgcgggcttcgggggtctgcgctcgcggctgcctggactcagcaggc
ccctggaccatgtcccgcgccctgcggccaccgctcccgcctctctgctttttccttttg
ttgctggcggctgccggtgctcgggccgggggatacgagacatgccccacagtgcagccg
aacatgctgaacgtgcacctgctgcctcacacacatgatgacgtgggctggctcaaaacc
gtggaccagtacttttatggaatcaagaatgacatccagcacgccggtgtgcagtacatc
ctggactcggtcatctctgccttgctggcagatcccacccgtcgcttcatttacgtggag
attgccttcttctcccgttggtggcaccagcagacaaatgccacacaggaagtcgtgcga
gaccttgtgcgccaggggcgcctggagttcgccaatggtggctgggtgatgaacgatgag
gcagccacccactacggtgccatcgtggaccagatgacacttgggctgcgctttctggag
gacacatttggcaatgatgggcgaccccgtgtggcctggcacattgaccccttcggccac
tctcgggagcaggcctcgctgtttgcgcagatgggcttcgacggcttcttctttgggcgc
cttgattatcaagataagtgggtacggatgcagaagctggagatggagcaggtgtggcgg
gccagcaccagcctgaagcccccgaccgcggacctcttcactggtgtgcttcccaatggt
tacaacccgccaaggaatctgtgctgggatgtgctgtgtgtcgatcagccgctggtggag
gaccctcgcagccccgagtacaacgccaaggagctggtcgattacttcctaaatgtggcc
actgcccagggccggtattaccgcaccaaccacactgtgatgaccatgggctcggacttc
caatatgagaatgccaacatgtggttcaagaaccttgacaagctcatccggctggtaaat
gcgcagcaggcaaaaggaagcagtgtccatgttctctactccacccccgcttgttacctc
tgggagctgaacaaggccaacctcacctggtcagtgaaacatgacgacttcttcccttac
gcggatggcccccaccagttctggaccggttacttttccagtcggccggccctcaaacgc
tacgagcgcctcagctacaacttcctgcaggtgtgcaaccagctggaggcgctggtgggc
ctggcggccaacgtgggaccctatggctccggagacagtgcacccctcaatgaggcgatg
gctgtgctccagcatcacgacgccgtcagcggcacctcccgccagcacgtggccaacgac
tacgcgcgccagcttgcggcaggctgggggccttgcgaggttcttctgagcaacgcgctg
gcgcggctcagaggcttcaaagatcacttcaccttttgccaacagctaaacatcagcatc
tgcccgctcagccagacggcggcgcgcttccaggtcatcgtttataatcccctggggcgg
aaggtgaattggatggtacggctgccggtcagcgaaggcgttttcgttgtgaaggacccc
aatggcaggacagtgcccagcgatgtggtaatatttcccagctcagacagccaggcgcac
cctccggagctgctgttctcagcctcactgcccgccctgggcttcagcacctattcagta
gcccaggtgcctcgctggaagccccaggcccgcgcaccacagcccatccccagaagatcc
tggtcccctgctttaaccatcgaaaatgagcacatccgggcaacgtttgatcctgacaca
gggctgttgatggagattatgaacatgaatcagcaactcctgctgcctgttcgccagacc
ttcttctggtacaacgccagtataggtgacaacgaaagtgaccaggcctcaggtgcctac
atcttcagacccaaccaacagaaaccgctgcctgtgagccgctgggctcagatccacctg
gtgaagacacccttggtgcaggaggtgcaccagaacttctcagcttggtgttcccaggtg
gttcgcctgtacccaggacagcggcacctggagctagagtggtcggtggggccgatacct
gtgggcgacacctgggggaaggaggtcatcagccgttttgacacaccgctggagacaaag
ggacgcttctacacagacagcaatggccgggagatcctggagaggaggcgggattatcga
cccacctggaaactgaaccagacggagcccgtggcaggaaactactatccagtcaacacc
cggatttacatcacggatggaaacatgcagctgactgtgctgactgaccgctcccagggg
ggcagcagcctgagagatggctcgctggagctcatggtgcaccgaaggctgctgaaggac
gatggacgcggagtatcggagccactaatggagaacgggtcgggggcgtgggtgcgaggg
cgccacctggtgctgctggacacagcccaggctgcagccgccggacaccggctcctggcg
gagcaggaggtcctggcccctcaggtggtgctggccccgggtggcggcgccgcctacaat
ctcggggctcctccgcgcacgcagttctcagggctgcgcagggacctgccgccctcggtg
cacctgctcacgctggccagctggggccccgaaatggtgctgctgcgcttggagcaccag
tttgccgtaggagaggattccggacgtaacctgagcgcccccgttaccttgaacttgagg
gacctgttctccaccttcaccatcacccgcctgcaggagaccacgctggtggccaaccag
ctccgcgaggcagcctccaggctcaagtggacaacaaacacaggccccacaccccaccaa
actccgtaccagctggacccggccaacatcacgctggaacccatggaaatccgcactttc
ctggcctcagttcaatggaaggaggtggatggttag

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (11)   
   UniGene (2)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (3)   
   RefSeq(pep) (2)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
Protein domain (3)   
   Pfam (3)   
All databases (78)   

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