KEGG   Homo sapiens (human): 4193Help
Entry
4193              CDS       T01001                                 

Gene name
MDM2, ACTFS, HDMX, hdm2
Definition
MDM2 oncogene, E3 ubiquitin protein ligase
Orthology
K06643  
E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
Organism
hsa  Homo sapiens (human)
Pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
Ubiquitin mediated proteolysis
Endocytosis
PI3K-Akt signaling pathway
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Disease
H00025  
Penile cancer
H00028  
Choriocarcinoma
H00036  
Osteosarcoma
H00037  
Alveolar rhabdomyosarcoma
H00042  
Glioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    4193 (MDM2)
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    4193 (MDM2)
   04151 PI3K-Akt signaling pathway
    4193 (MDM2)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    4193 (MDM2)
  Cell growth and death
   04110 Cell cycle
    4193 (MDM2)
   04115 p53 signaling pathway
    4193 (MDM2)
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    4193 (MDM2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    4193 (MDM2)
   05202 Transcriptional misregulation in cancers
    4193 (MDM2)
   05206 MicroRNAs in cancer
    4193 (MDM2)
   05205 Proteoglycans in cancer
    4193 (MDM2)
   05203 Viral carcinogenesis
    4193 (MDM2)
   05214 Glioma
    4193 (MDM2)
   05220 Chronic myeloid leukemia
    4193 (MDM2)
   05218 Melanoma
    4193 (MDM2)
   05219 Bladder cancer
    4193 (MDM2)
   05215 Prostate cancer
    4193 (MDM2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    4193 (MDM2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.19  ubiquitin---protein ligase
     4193 (MDM2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
12q14.3-q15
AA seq 444 aa AA seqDB search
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVYQVTVYQAGESD
TDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKL
ENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSS
QEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKK
LKKRNKPCPVCRQPIQMIVLTYFP
NT seq 1335 nt NT seq  +upstreamnt  +downstreamnt
atgtgcaataccaacatgtctgtacctactgatggtgctgtaaccacctcacagattcca
gcttcggaacaagagaccctggttagaccaaagccattgcttttgaagttattaaagtct
gttggtgcacaaaaagacacttatactatgaaagaggttcttttttatcttggccagtat
attatgactaaacgattatatgatgagaagcaacaacatattgtatattgttcaaatgat
cttctaggagatttgtttggcgtgccaagcttctctgtgaaagagcacaggaaaatatat
accatgatctacaggaacttggtagtagtcaatcagcaggaatcatcggactcaggtaca
tctgtgagtgagaacaggtgtcaccttgaaggtgggagtgatcaaaaggaccttgtacaa
gagcttcaggaagagaaaccttcatcttcacatttggtttctagaccatctacctcatct
agaaggagagcaattagtgagacagaagaaaattcagatgaattatctggtgaacgacaa
agaaaacgccacaaatctgatagtatttccctttcctttgatgaaagcctggctctgtgt
gtaataagggagatatgttgtgaaagaagcagtagcagtgaatctacagggacgccatcg
aatccggatcttgatgctggtgtatatcaagttactgtgtatcaggcaggggagagtgat
acagattcatttgaagaagatcctgaaatttccttagctgactattggaaatgcacttca
tgcaatgaaatgaatcccccccttccatcacattgcaacagatgttgggcccttcgtgag
aattggcttcctgaagataaagggaaagataaaggggaaatctctgagaaagccaaactg
gaaaactcaacacaagctgaagagggctttgatgttcctgattgtaaaaaaactatagtg
aatgattccagagagtcatgtgttgaggaaaatgatgataaaattacacaagcttcacaa
tcacaagaaagtgaagactattctcagccatcaacttctagtagcattatttatagcagc
caagaagatgtgaaagagtttgaaagggaagaaacccaagacaaagaagagagtgtggaa
tctagtttgccccttaatgccattgaaccttgtgtgatttgtcaaggtcgacctaaaaat
ggttgcattgtccatggcaaaacaggacatcttatggcctgctttacatgtgcaaagaag
ctaaagaaaaggaataagccctgcccagtatgtagacaaccaattcaaatgattgtgcta
acttatttcccctag

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